Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000169385 Gene ID 6036 Accession 10045
Symbol RNASE2 Alias EDN;RAF3;RNS2 Full Name ribonuclease A family member 2
Status Confidence Length 950 bases Strand Plus strand
Position 14 : 20955487 - 20956436 RNA binding domain RnaseA
Summary The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000303276 RnaseA PF00074 1.7e-35 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35004689 External Validation of the Prognostic Value of an Immune-Associated Gene Panel for Clear Cell Renal Cell Carcinomas. Zhiwen Xie 2021-01-01 Frontiers in cell and developmental biology
35627105 A Risk Model of Eight Immune-Related Genes Predicting Prognostic Response to Immune Therapies for Gastric Cancer. Miao Yu 2022-04-20 Genes
37105176 RNase2 is a possible trigger of acute-on-chronic inflammation leading to mRNA vaccine-associated cardiac complication. Z Eugenia Ong 2023-06-09 Med (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
RNASE2-201 ENST00000304625 720 161aa ENSP00000303276

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000169385homo_sapiensENSP0000030232478.7569.375homo_sapiensENSP0000030327678.260968.9441
ENSG00000169385homo_sapiensENSP0000051286725.850314.2857homo_sapiensENSP0000030327623.602513.0435
ENSG00000169385homo_sapiensENSP0000029869055.769240.3846homo_sapiensENSP0000030327654.037339.1304
ENSG00000169385homo_sapiensENSP0000031139857.142943.5065homo_sapiensENSP0000030327654.658441.6149
ENSG00000169385homo_sapiensENSP0000030204655.333344.6667homo_sapiensENSP0000030327651.552841.6149
ENSG00000169385homo_sapiensENSP0000039299624.074118.0556homo_sapiensENSP0000030327632.298124.2236
ENSG00000169385homo_sapiensENSP0000045131823.115611.5578homo_sapiensENSP0000030327628.571414.2857
ENSG00000169385homo_sapiensENSP0000038107737.41524.4898homo_sapiensENSP0000030327634.161522.3602
ENSG00000169385homo_sapiensENSP0000038468326.666712.381homo_sapiensENSP0000030327634.782616.1491
ENSG00000169385homo_sapiensENSP0000038105742.948730.1282homo_sapiensENSP0000030327641.614929.1925
ENSG00000169385homo_sapiensENSP0000045224540.136127.8912homo_sapiensENSP0000030327636.64625.4658
ENSG00000169385homo_sapiensENSP0000037241027.564116.0256homo_sapiensENSP0000030327626.708115.528

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000169385homo_sapiensENSP0000030327698.757898.7578pan_paniscusENSPPAP0000001978798.757898.7578
ENSG00000169385homo_sapiensENSP0000030327696.273393.1677pongo_abeliiENSPPYP0000000634896.273393.1677
ENSG00000169385homo_sapiensENSP0000030327699.378999.3789pan_troglodytesENSPTRP0000005281099.378999.3789
ENSG00000169385homo_sapiensENSP0000030327610099.3789gorilla_gorillaENSGGOP0000000499010099.3789
ENSG00000169385homo_sapiensENSP0000030327667.080753.4161dasypus_novemcinctusENSDNOP0000001829068.789854.7771
ENSG00000169385homo_sapiensENSP0000030327661.490746.5839dasypus_novemcinctusENSDNOP0000002729663.057347.7707
ENSG00000169385homo_sapiensENSP0000030327678.260970.1863callithrix_jacchusENSCJAP0000001765179.746871.519
ENSG00000169385homo_sapiensENSP0000030327686.335480.7453macaca_fascicularisENSMFAP0000005536586.87581.25
ENSG00000169385homo_sapiensENSP0000030327625.465820.4969mus_spretusMGP_SPRETEiJ_P003822856.164445.2055
ENSG00000169385homo_sapiensENSP0000030327626.708116.7702mus_spretusMGP_SPRETEiJ_P003822632.575820.4545
ENSG00000169385homo_sapiensENSP0000030327663.975252.795equus_asinusENSEASP0000501464264.779953.4591
ENSG00000169385homo_sapiensENSP0000030327665.838552.795capra_hircusENSCHIP0000000313667.088653.7975
ENSG00000169385homo_sapiensENSP0000030327629.192522.3602ailuropoda_melanoleucaENSAMEP0000003198831.972824.4898
ENSG00000169385homo_sapiensENSP0000030327653.416142.236bos_indicus_hybridENSBIXP0000501732235.983328.4519
ENSG00000169385homo_sapiensENSP0000030327666.459653.4161bos_indicus_hybridENSBIXP0000501619658.152246.7391
ENSG00000169385homo_sapiensENSP0000030327656.521742.8571oryctolagus_cuniculusENSOCUP0000004370355.487842.0732
ENSG00000169385homo_sapiensENSP0000030327662.732947.205oryctolagus_cuniculusENSOCUP0000001982464.743648.7179
ENSG00000169385homo_sapiensENSP0000030327657.142943.4783oryctolagus_cuniculusENSOCUP0000002324854.437941.4201
ENSG00000169385homo_sapiensENSP0000030327665.217453.4161equus_caballusENSECAP0000007932566.037754.0881
ENSG00000169385homo_sapiensENSP0000030327660.248444.0994marmota_marmota_marmotaENSMMMP0000001690562.179545.5128
ENSG00000169385homo_sapiensENSP0000030327662.111845.9627marmota_marmota_marmotaENSMMMP0000001690863.291146.8354
ENSG00000169385homo_sapiensENSP0000030327667.080755.2795balaenoptera_musculusENSBMSP0001001219465.060253.6145
ENSG00000169385homo_sapiensENSP0000030327659.627345.9627monodon_monocerosENSMMNP0001501299461.935547.7419
ENSG00000169385homo_sapiensENSP0000030327662.111850.9317sus_scrofaENSSSCP0000004209464.102652.5641
ENSG00000169385homo_sapiensENSP0000030327665.838552.795ovis_aries_rambouilletENSOARP0002001741167.088653.7975
ENSG00000169385homo_sapiensENSP0000030327662.111847.205delphinapterus_leucasENSDLEP0000000233063.291148.1013
ENSG00000169385homo_sapiensENSP0000030327660.869650.3106physeter_catodonENSPCTP0000500444862.025351.2658
ENSG00000169385homo_sapiensENSP0000030327660.248446.5839mus_musculusENSMUSP0000009825662.580648.3871
ENSG00000169385homo_sapiensENSP0000030327660.248447.205mus_musculusENSMUSP0000012387262.179548.7179
ENSG00000169385homo_sapiensENSP0000030327660.869647.205mus_musculusENSMUSP0000007507463.225849.0323
ENSG00000169385homo_sapiensENSP0000030327660.869646.5839mus_musculusENSMUSP0000007438662.820548.0769
ENSG00000169385homo_sapiensENSP0000030327660.248445.3416mus_musculusENSMUSP0000005641862.580647.0968
ENSG00000169385homo_sapiensENSP0000030327662.111846.5839mus_musculusENSMUSP0000005629364.516148.3871
ENSG00000169385homo_sapiensENSP0000030327660.248447.8261mus_musculusENSMUSP0000012715262.580649.6774
ENSG00000169385homo_sapiensENSP0000030327662.732946.5839dipodomys_ordiiENSDORP0000002367963.52247.1698
ENSG00000169385homo_sapiensENSP0000030327678.88273.2919aotus_nancymaaeENSANAP0000000164780.379774.6835
ENSG00000169385homo_sapiensENSP0000030327679.503173.913saimiri_boliviensis_boliviensisENSSBOP0000000149781.012775.3165
ENSG00000169385homo_sapiensENSP0000030327686.956581.9876chlorocebus_sabaeusENSCSAP0000001765587.582.5
ENSG00000169385homo_sapiensENSP0000030327663.975252.1739mesocricetus_auratusENSMAUP0000001825265.605153.5032
ENSG00000169385homo_sapiensENSP0000030327662.111850.3106camelus_dromedariusENSCDRP0000500261562.893150.9434
ENSG00000169385homo_sapiensENSP0000030327663.975249.0683rattus_norvegicusENSRNOP0000003926266.451650.9677
ENSG00000169385homo_sapiensENSP0000030327638.509331.677rattus_norvegicusENSRNOP0000009685359.615449.0385
ENSG00000169385homo_sapiensENSP0000030327657.142949.0683rattus_norvegicusENSRNOP0000009797758.974450.641
ENSG00000169385homo_sapiensENSP0000030327660.248447.205rattus_norvegicusENSRNOP0000007649062.580649.0323
ENSG00000169385homo_sapiensENSP0000030327660.869650.3106rattus_norvegicusENSRNOP0000002164564.900753.6424
ENSG00000169385homo_sapiensENSP0000030327660.248447.205rattus_norvegicusENSRNOP0000008414562.580649.0323
ENSG00000169385homo_sapiensENSP0000030327662.732948.4472rattus_norvegicusENSRNOP0000005022565.161350.3226
ENSG00000169385homo_sapiensENSP0000030327674.534262.1118prolemur_simusENSPSMP0000001741374.534262.1118
ENSG00000169385homo_sapiensENSP0000030327667.701954.0373prolemur_simusENSPSMP0000001742368.553554.717
ENSG00000169385homo_sapiensENSP0000030327663.35451.5528peromyscus_maniculatus_bairdiiENSPEMP0000002797664.968252.8662
ENSG00000169385homo_sapiensENSP0000030327662.111846.5839mus_spicilegusENSMSIP0000000209864.516148.3871
ENSG00000169385homo_sapiensENSP0000030327655.900642.8571mus_spicilegusENSMSIP0000002668258.064544.5161
ENSG00000169385homo_sapiensENSP0000030327660.869647.205mus_spicilegusENSMSIP0000002313563.225849.0323
ENSG00000169385homo_sapiensENSP0000030327660.869648.4472mus_spicilegusENSMSIP0000002667463.225850.3226
ENSG00000169385homo_sapiensENSP0000030327660.248445.9627mus_spicilegusENSMSIP0000000780162.179547.4359
ENSG00000169385homo_sapiensENSP0000030327658.385144.0994mus_spicilegusENSMSIP0000002316160.645245.8064
ENSG00000169385homo_sapiensENSP0000030327661.490748.4472cricetulus_griseus_chok1gshdENSCGRP0000101404762.658249.3671
ENSG00000169385homo_sapiensENSP0000030327663.975253.4161cricetulus_griseus_chok1gshdENSCGRP0000101451765.605154.7771
ENSG00000169385homo_sapiensENSP0000030327662.111848.4472cricetulus_griseus_chok1gshdENSCGRP0000101463163.291149.3671
ENSG00000169385homo_sapiensENSP0000030327649.689436.646cricetulus_griseus_chok1gshdENSCGRP0000100754249.079836.1963
ENSG00000169385homo_sapiensENSP0000030327653.416143.4783myotis_lucifugusENSMLUP0000002266562.318850.7246
ENSG00000169385homo_sapiensENSP0000030327659.627348.4472myotis_lucifugusENSMLUP0000001643762.337750.6493
ENSG00000169385homo_sapiensENSP0000030327660.869649.0683rhinolophus_ferrumequinumENSRFEP0001002582460.493848.7654
ENSG00000169385homo_sapiensENSP0000030327665.217454.6584bos_taurusENSBTAP0000003609257.065247.8261
ENSG00000169385homo_sapiensENSP0000030327663.975253.4161bos_taurusENSBTAP0000005915455.978346.7391
ENSG00000169385homo_sapiensENSP0000030327643.478333.5404heterocephalus_glaber_femaleENSHGLP0000005415847.61936.7347
ENSG00000169385homo_sapiensENSP0000030327665.217450.9317sciurus_vulgarisENSSVLP0000500193664.024450
ENSG00000169385homo_sapiensENSP0000030327662.732949.0683sciurus_vulgarisENSSVLP0000500192363.52249.6855
ENSG00000169385homo_sapiensENSP0000030327662.732949.6894sciurus_vulgarisENSSVLP0000500195864.331250.9554
ENSG00000169385homo_sapiensENSP0000030327657.142948.4472catagonus_wagneriENSCWAP0000000834658.227849.3671
ENSG00000169385homo_sapiensENSP0000030327663.35447.8261ictidomys_tridecemlineatusENSSTOP0000002318064.55748.7342
ENSG00000169385homo_sapiensENSP0000030327662.732945.3416ictidomys_tridecemlineatusENSSTOP0000002545858.720942.4419
ENSG00000169385homo_sapiensENSP0000030327663.35449.6894ictidomys_tridecemlineatusENSSTOP0000001843264.55750.6329
ENSG00000169385homo_sapiensENSP0000030327670.807554.6584otolemur_garnettiiENSOGAP0000001915871.698155.3459
ENSG00000169385homo_sapiensENSP0000030327674.534259.0062otolemur_garnettiiENSOGAP0000002201075.471759.7484
ENSG00000169385homo_sapiensENSP0000030327671.428660.8696otolemur_garnettiiENSOGAP0000001193672.32761.6352
ENSG00000169385homo_sapiensENSP0000030327677.639871.4286cebus_imitatorENSCCAP0000000125679.113972.7848
ENSG00000169385homo_sapiensENSP0000030327660.869646.5839urocitellus_parryiiENSUPAP0001000233660.493846.2963
ENSG00000169385homo_sapiensENSP0000030327663.975248.4472urocitellus_parryiiENSUPAP0001000230465.189949.3671
ENSG00000169385homo_sapiensENSP0000030327665.838552.1739moschus_moschiferusENSMMSP0000001111867.088653.1646
ENSG00000169385homo_sapiensENSP0000030327640.372732.9193mus_pahariMGP_PahariEiJ_P008462661.904850.4762
ENSG00000169385homo_sapiensENSP0000030327626.708116.7702chrysemys_picta_belliiENSCPBP0000002645529.054118.2432
ENSG00000169385homo_sapiensENSP0000030327624.223616.7702chrysemys_picta_belliiENSCPBP0000002642531.967222.1311
ENSG00000169385homo_sapiensENSP0000030327630.434820.4969laticauda_laticaudataENSLLTP0000001248036.029424.2647
ENSG00000169385homo_sapiensENSP0000030327634.782621.7391laticauda_laticaudataENSLLTP000000185914025
ENSG00000169385homo_sapiensENSP0000030327629.813721.7391laticauda_laticaudataENSLLTP0000000545921.917815.9817
ENSG00000169385homo_sapiensENSP0000030327628.571420.4969notechis_scutatusENSNSUP0000002605732.167823.0769
ENSG00000169385homo_sapiensENSP0000030327630.434820.4969notechis_scutatusENSNSUP0000000552036.029424.2647
ENSG00000169385homo_sapiensENSP0000030327629.813721.118pseudonaja_textilisENSPTXP0000002409233.802823.9437
ENSG00000169385homo_sapiensENSP0000030327632.298121.118pseudonaja_textilisENSPTXP0000002317238.235325
ENSG00000169385homo_sapiensENSP0000030327627.329218.0124anas_platyrhynchos_platyrhynchosENSAPLP0000001124913.01788.57988
ENSG00000169385homo_sapiensENSP0000030327627.329216.1491gallus_gallusENSGALP0001000385321.674912.8079
ENSG00000169385homo_sapiensENSP0000030327628.571419.8758gallus_gallusENSGALP0001001560933.093523.0216
ENSG00000169385homo_sapiensENSP0000030327629.192519.8758gallus_gallusENSGALP0001001172633.81323.0216
ENSG00000169385homo_sapiensENSP0000030327625.465816.1491meleagris_gallopavoENSMGAP0000000967428.275917.931
ENSG00000169385homo_sapiensENSP0000030327628.571416.7702meleagris_gallopavoENSMGAP0000001710339.316223.0769
ENSG00000169385homo_sapiensENSP0000030327627.329219.8758meleagris_gallopavoENSMGAP0000002640335.225.6
ENSG00000169385homo_sapiensENSP0000030327626.708118.6335meleagris_gallopavoENSMGAP0000003026636.752125.641
ENSG00000169385homo_sapiensENSP0000030327623.602518.6335serinus_canariaENSSCAP0000001661826.388920.8333
ENSG00000169385homo_sapiensENSP0000030327626.708119.2547parus_majorENSPMJP0000001385729.861121.5278
ENSG00000169385homo_sapiensENSP0000030327627.950320.4969anolis_carolinensisENSACAP0000000771730.821922.6027
ENSG00000169385homo_sapiensENSP0000030327624.223616.7702naja_najaENSNNAP0000001252132.231422.314
ENSG00000169385homo_sapiensENSP0000030327632.919321.118podarcis_muralisENSPMRP0000002515638.970625
ENSG00000169385homo_sapiensENSP0000030327633.540420.4969podarcis_muralisENSPMRP0000002514739.705924.2647
ENSG00000169385homo_sapiensENSP0000030327631.055918.6335podarcis_muralisENSPMRP0000003412231.446518.8679
ENSG00000169385homo_sapiensENSP0000030327627.329218.6335podarcis_muralisENSPMRP0000002510930.985921.1268
ENSG00000169385homo_sapiensENSP0000030327638.509321.7391podarcis_muralisENSPMRP0000001903438.271621.6049
ENSG00000169385homo_sapiensENSP0000030327631.055919.2547podarcis_muralisENSPMRP0000001903841.666725.8333
ENSG00000169385homo_sapiensENSP0000030327634.161519.8758podarcis_muralisENSPMRP0000003410338.461522.3776
ENSG00000169385homo_sapiensENSP0000030327627.950320.4969taeniopygia_guttataENSTGUP0000000506231.2522.9167
ENSG00000169385homo_sapiensENSP0000030327629.813719.8758salvator_merianaeENSSMRP0000000161831.168820.7792
ENSG00000169385homo_sapiensENSP0000030327628.571421.118salvator_merianaeENSSMRP0000000846024.864918.3784
ENSG00000169385homo_sapiensENSP0000030327625.465817.3913salvator_merianaeENSSMRP0000000844929.07819.8582
ENSG00000169385homo_sapiensENSP0000030327628.571418.0124salvator_merianaeENSSMRP0000000843531.724120
ENSG00000169385homo_sapiensENSP0000030327626.708119.8758gopherus_evgoodeiENSGEVP0000502132229.452121.9178
ENSG00000169385homo_sapiensENSP0000030327626.08716.7702gopherus_evgoodeiENSGEVP0000502108534.710722.314
ENSG00000169385homo_sapiensENSP0000030327628.571422.3602chelonoidis_abingdoniiENSCABP0000001464231.081124.3243
ENSG00000169385homo_sapiensENSP0000030327622.360215.528chelonoidis_abingdoniiENSCABP0000000466622.360215.528
ENSG00000169385homo_sapiensENSP0000030327631.67720.4969chelonoidis_abingdoniiENSCABP0000001065225.516.5
ENSG00000169385homo_sapiensENSP0000030327626.708119.8758struthio_camelus_australisENSSCUP0000000922630.714322.8571
ENSG00000169385homo_sapiensENSP0000030327624.844717.3913anser_brachyrhynchusENSABRP0000000884727.586219.3103
ENSG00000169385homo_sapiensENSP0000030327624.844718.0124strigops_habroptilaENSSHBP0000500073627.97220.2797
ENSG00000169385homo_sapiensENSP0000030327629.192522.9814terrapene_carolina_triunguisENSTMTP0000000859432.191825.3425
ENSG00000169385homo_sapiensENSP0000030327620.496913.0435aquila_chrysaetos_chrysaetosENSACCP0002000548225.190816.0305
ENSG00000169385homo_sapiensENSP0000030327626.08719.2547ficedula_albicollisENSFALP0000001489229.166721.5278
ENSG00000169385homo_sapiensENSP0000030327626.708116.1491coturnix_japonicaENSCJPP0000501596830.935318.705
ENSG00000169385homo_sapiensENSP0000030327629.813719.2547coturnix_japonicaENSCJPP0000501596733.566421.6783
ENSG00000169385homo_sapiensENSP0000030327622.981416.1491coturnix_japonicaENSCJPP0000501596930.327921.3115
ENSG00000169385homo_sapiensENSP0000030327626.708117.3913coturnix_japonicaENSCJPP0000501327129.655219.3103

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001530NOT enables lipopolysaccharide binding1IMPHomo_sapiens(9606)Function
GO:0002227involved_in innate immune response in mucosa1IBAHomo_sapiens(9606)Process
GO:0003676enables nucleic acid binding1IEAHomo_sapiens(9606)Function
GO:0004522enables ribonuclease A activity1IEAHomo_sapiens(9606)Function
GO:0004540enables RNA nuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005615is_active_in extracellular space1IBAHomo_sapiens(9606)Component
GO:0006401involved_in RNA catabolic process1TASHomo_sapiens(9606)Process
GO:0006935involved_in chemotaxis2IBA,IDAHomo_sapiens(9606)Process
GO:0016829enables lyase activity1IEAHomo_sapiens(9606)Function
GO:0035578located_in azurophil granule lumen1TASHomo_sapiens(9606)Component
GO:0043152NOT involved_in induction of bacterial agglutination1IMPHomo_sapiens(9606)Process
GO:0050829NOT involved_in defense response to Gram-negative bacterium1IMPHomo_sapiens(9606)Process
GO:0050830NOT involved_in defense response to Gram-positive bacterium1IMPHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression