RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000169188	Gene ID	27301	Accession	17889
Symbol	APEX2	Alias	APE2;XTH2;ZGRF2;APEXL2	Full Name	apurinic/apyrimidinic endodeoxyribonuclease 2
Status	Confidence	Length	8695 bases	Strand	Plus strand
Position	X : 55000363 - 55009057	RNA binding domain	Exo_endo_phos
Summary	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000364126	Exo_endo_phos	PF03372	2.7e-19	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
31350943	Proximity labeling to detect RNA-protein interactions in live cells.	Mingxing Lu	2019-11-01	FEBS open bio
34219162	Directed evolution of orthogonal RNA-RBP pairs through library-vs-library in vitro selection.	Keisuke Fukunaga	2022-01-25	Nucleic acids research
30848125	Directed Evolution of Split APEX2 Peroxidase.	Yisu Han	2019-04-19	ACS chemical biology
35433685	Cas13d: A New Molecular Scissor for Transcriptome Engineering.	Rahul Gupta	2022-01-01	Frontiers in cell and developmental biology
36452457	Proximity-dependent biotinylation technologies for mapping RNA-protein interactions in live cells.	Roberto Giambruno	2022-01-01	Frontiers in molecular biosciences
29239719	Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking.	Pornchai Kaewsapsak	2017-12-14	eLife
30478324	Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments.	Daniel Benhalevy	2018-12-01	Nature methods

Name	Transcript ID	bp	Protein	Translation ID
APEX2-201	ENST00000374987	3239	518aa	ENSP00000364126
APEX2-202	ENST00000471758	728	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001650	located_in fibrillar center	1	IDA	Homo_sapiens(9606)	Component
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003906	enables DNA-(apurinic or apyrimidinic site) endonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004519	enables endonuclease activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IEA	Homo_sapiens(9606)	Component
GO:0006284	involved_in base-excision repair	1	IBA	Homo_sapiens(9606)	Process
GO:0006310	involved_in DNA recombination	1	IEA	Homo_sapiens(9606)	Process
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0008081	enables phosphoric diester hydrolase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0008311	enables double-stranded DNA 3-5 DNA exonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component