Functions and Diseases

RBP Type Canonical_RBPs
Diseases FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000167978 Gene ID 23524 Accession 16639
Symbol SRRM2 Alias CWF21;Cwc21;MRD72;300-KD;SRL300;SRm300;HSPC075 Full Name serine/arginine repetitive matrix 2
Status Confidence Length 18787 bases Strand Plus strand
Position 16 : 2752626 - 2771412 RNA binding domain cwf21
Summary Enables C2H2 zinc finger domain binding activity and protein N-terminus binding activity. Involved in mRNA splicing, via spliceosome. Located in Cajal body and nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Biomarker of Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000458230 cwf21 PF08312 2.3e-10 1
ENSP00000301740 cwf21 PF08312 8.8e-09 1
ENSP00000461181 cwf21 PF08312 8.8e-09 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36626563 Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation. Evan Lester 2023-01-17 Proceedings of the National Academy of Sciences of the United States of America
29789295 Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks. Mark Grimes 2018-05-22 Science signaling
35741072 The Association of MEG3 lncRNA with Nuclear Speckles in Living Cells. E Sarah Hasenson 2022-06-16 Cells
35704758 Nuclear speckle integrity and function require TAO2 kinase. Shengyan Gao 2022-06-21 Proceedings of the National Academy of Sciences of the United States of America

Transcripts

Name Transcript ID bp Protein Translation ID
SRRM2-225 ENST00000576924 9045 2752aa ENSP00000461181
SRRM2-220 ENST00000575009 1146 297aa ENSP00000458870
SRRM2-201 ENST00000301740 9044 2752aa ENSP00000301740
SRRM2-224 ENST00000576894 2210 No protein -
SRRM2-208 ENST00000571378 2870 895aa ENSP00000458647
SRRM2-218 ENST00000574340 579 115aa ENSP00000458230
SRRM2-226 ENST00000704117 2882 No protein -
SRRM2-205 ENST00000570971 1132 251aa ENSP00000484503
SRRM2-221 ENST00000575870 4432 176aa ENSP00000515703
SRRM2-213 ENST00000573451 441 No protein -
SRRM2-207 ENST00000571372 462 No protein -
SRRM2-203 ENST00000570655 575 No protein -
SRRM2-214 ENST00000573498 550 No protein -
SRRM2-211 ENST00000572952 1118 No protein -
SRRM2-222 ENST00000576674 593 No protein -
SRRM2-210 ENST00000572883 4895 1187aa ENSP00000460642
SRRM2-219 ENST00000574593 1440 No protein -
SRRM2-209 ENST00000572721 841 No protein -
SRRM2-212 ENST00000573311 732 No protein -
SRRM2-206 ENST00000571041 498 No protein -
SRRM2-204 ENST00000570705 675 No protein -
SRRM2-223 ENST00000576878 1141 No protein -
SRRM2-217 ENST00000574331 1759 No protein -
SRRM2-216 ENST00000573692 459 78aa ENSP00000461535
SRRM2-202 ENST00000570539 431 No protein -
SRRM2-215 ENST00000573583 543 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
44076Platelet Function Tests2.7502585E-007-
44295Platelet Function Tests9.7922859E-007-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000167978homo_sapiensENSP0000044192918.069410.9653homo_sapiensENSP0000030174035.029121.2573

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000167978homo_sapiensENSP0000030174096.475395.8939nomascus_leucogenysENSNLEP0000001151196.405295.8243
ENSG00000167978homo_sapiensENSP0000030174097.31196.875pan_paniscusENSPPAP0000001882997.275796.8398
ENSG00000167978homo_sapiensENSP0000030174099.309698.9462pongo_abeliiENSPPYP0000000793399.309698.9462
ENSG00000167978homo_sapiensENSP0000030174097.347496.984pan_troglodytesENSPTRP0000007443697.31296.9488
ENSG00000167978homo_sapiensENSP0000030174097.347496.984pan_troglodytesENSPTRP0000008490897.31296.9488
ENSG00000167978homo_sapiensENSP0000030174099.67399.4913gorilla_gorillaENSGGOP0000001702399.67399.4913
ENSG00000167978homo_sapiensENSP0000030174080.014573.3648ornithorhynchus_anatinusENSOANP0000000422178.755472.2103
ENSG00000167978homo_sapiensENSP0000030174084.229778.9244sarcophilus_harrisiiENSSHAP0000003963380.682275.6004
ENSG00000167978homo_sapiensENSP0000030174080.305274.782notamacropus_eugeniiENSMEUP0000001008579.754674.2692
ENSG00000167978homo_sapiensENSP0000030174091.097488.1904dasypus_novemcinctusENSDNOP0000002949292.611789.6564
ENSG00000167978homo_sapiensENSP0000030174081.213777.5073erinaceus_europaeusENSEEUP0000001292385.468581.5679
ENSG00000167978homo_sapiensENSP0000030174078.56174.673echinops_telfairiENSETEP0000001621282.582178.495
ENSG00000167978homo_sapiensENSP0000030174095.675994.2587callithrix_jacchusENSCJAP0000008656595.53794.1219
ENSG00000167978homo_sapiensENSP0000030174098.764598.0378cercocebus_atysENSCATP0000002953498.764598.0378
ENSG00000167978homo_sapiensENSP0000030174096.075695.3488macaca_fascicularisENSMFAP0000003386498.767398.0202
ENSG00000167978homo_sapiensENSP0000030174098.800998.1468macaca_mulattaENSMMUP0000006026598.800998.1468
ENSG00000167978homo_sapiensENSP0000030174098.800998.0741macaca_nemestrinaENSMNEP0000003947598.800998.0741
ENSG00000167978homo_sapiensENSP0000030174098.728298.0015papio_anubisENSPANP0000002582397.348696.632
ENSG00000167978homo_sapiensENSP0000030174098.691997.9651mandrillus_leucophaeusENSMLEP0000003556698.691997.9651
ENSG00000167978homo_sapiensENSP0000030174075.617773.4738tursiops_truncatusENSTTRP0000001462876.143473.9846
ENSG00000167978homo_sapiensENSP0000030174093.64191.2427vulpes_vulpesENSVVUP0000001187893.57391.1765
ENSG00000167978homo_sapiensENSP0000030174089.789286.3735mus_spretusMGP_SPRETEiJ_P004486991.416987.9393
ENSG00000167978homo_sapiensENSP0000030174093.713791.3881equus_asinusENSEASP0000500835393.543791.2223
ENSG00000167978homo_sapiensENSP0000030174090.879488.5538capra_hircusENSCHIP0000000798293.320990.9328
ENSG00000167978homo_sapiensENSP0000030174085.755882.4855loxodonta_africanaENSLAFP0000000052589.360185.9523
ENSG00000167978homo_sapiensENSP0000030174093.786391.4608panthera_leoENSPLOP0000003082694.231591.8949
ENSG00000167978homo_sapiensENSP0000030174094.07791.6424ailuropoda_melanoleucaENSAMEP0000001903894.008791.5759
ENSG00000167978homo_sapiensENSP0000030174093.132390.8794bos_indicus_hybridENSBIXP0000500175593.50691.2441
ENSG00000167978homo_sapiensENSP0000030174088.226785.8285oryctolagus_cuniculusENSOCUP0000003923287.495585.1171
ENSG00000167978homo_sapiensENSP0000030174092.405590.1526equus_caballusENSECAP0000005381593.492691.2132
ENSG00000167978homo_sapiensENSP0000030174093.85991.4244canis_lupus_familiarisENSCAFP0084500497294.064191.6242
ENSG00000167978homo_sapiensENSP000003017408.79368.57558panthera_pardusENSPPRP0000002071796.414394.0239
ENSG00000167978homo_sapiensENSP0000030174091.424489.6076marmota_marmota_marmotaENSMMMP0000000944793.496891.6388
ENSG00000167978homo_sapiensENSP0000030174093.42391.2427balaenoptera_musculusENSBMSP0001001701993.93591.7428
ENSG00000167978homo_sapiensENSP0000030174087.790785.0291cavia_porcellusENSCPOP0000002419892.00389.1089
ENSG00000167978homo_sapiensENSP0000030174093.604791.3154felis_catusENSFCAP0000005163492.862390.5912
ENSG00000167978homo_sapiensENSP0000030174090.588788.1177ursus_americanusENSUAMP0000002305887.106984.731
ENSG00000167978homo_sapiensENSP0000030174084.411379.1788monodelphis_domesticaENSMODP0000004229479.527674.5977
ENSG00000167978homo_sapiensENSP0000030174093.132390.843bison_bison_bisonENSBBBP0000001510193.779791.4746
ENSG00000167978homo_sapiensENSP0000030174093.132390.7703monodon_monocerosENSMMNP0001501057493.745491.368
ENSG00000167978homo_sapiensENSP0000030174091.388188.9898sus_scrofaENSSSCP0000004189591.754889.347
ENSG00000167978homo_sapiensENSP0000030174095.203593.2776microcebus_murinusENSMICP0000004695295.307493.3794
ENSG00000167978homo_sapiensENSP0000030174086.518983.5029octodon_degusENSODEP0000001845789.376986.2613
ENSG00000167978homo_sapiensENSP0000030174089.098886.1919jaculus_jaculusENSJJAP0000002349490.71487.7543
ENSG00000167978homo_sapiensENSP0000030174093.132390.843ovis_aries_rambouilletENSOARP0002003443193.882891.5751
ENSG00000167978homo_sapiensENSP0000030174094.258791.8968ursus_maritimusENSUMAP0000000062292.709190.386
ENSG00000167978homo_sapiensENSP0000030174050.617748.1105ochotona_princepsENSOPRP0000001521279.828175.8739
ENSG00000167978homo_sapiensENSP0000030174093.059690.8067delphinapterus_leucasENSDLEP0000001936293.364991.1046
ENSG00000167978homo_sapiensENSP0000030174093.277691.0247physeter_catodonENSPCTP0000502826893.823191.557
ENSG00000167978homo_sapiensENSP0000030174089.752986.2645mus_caroliMGP_CAROLIEiJ_P004296991.413887.8608
ENSG00000167978homo_sapiensENSP0000030174089.607686.3009mus_musculusENSMUSP0000013984291.23287.8653
ENSG00000167978homo_sapiensENSP000003017409.120648.72093dipodomys_ordiiENSDORP0000001840695.801591.6031
ENSG00000167978homo_sapiensENSP0000030174091.787889.3169mustela_putorius_furoENSMPUP0000001515492.021989.5446
ENSG00000167978homo_sapiensENSP0000030174097.383796.3299aotus_nancymaaeENSANAP0000003461797.4996.4351
ENSG00000167978homo_sapiensENSP0000030174097.529196.4026saimiri_boliviensis_boliviensisENSSBOP0000001616497.696.4727
ENSG00000167978homo_sapiensENSP0000030174098.728298.0015chlorocebus_sabaeusENSCSAP0000000659798.728298.0015
ENSG00000167978homo_sapiensENSP0000030174059.81157.4855tupaia_belangeriENSTBEP0000000547560.182857.8428
ENSG00000167978homo_sapiensENSP0000030174089.643986.2282mesocricetus_auratusENSMAUP0000001428891.573988.0846
ENSG00000167978homo_sapiensENSP0000030174092.950690.5523phocoena_sinusENSPSNP0000002587593.255690.8494
ENSG00000167978homo_sapiensENSP0000030174093.677391.4608camelus_dromedariusENSCDRP0000502576493.779691.5606
ENSG00000167978homo_sapiensENSP0000030174093.7592.0058carlito_syrichtaENSTSYP0000001842194.540192.7812
ENSG00000167978homo_sapiensENSP000003017408.79368.61192panthera_tigris_altaicaENSPTIP0000002056996.414394.4223
ENSG00000167978homo_sapiensENSP0000030174088.662885.2471rattus_norvegicusENSRNOP0000008606290.740187.2443
ENSG00000167978homo_sapiensENSP0000030174095.276293.1686prolemur_simusENSPSMP0000002412095.449693.3382
ENSG00000167978homo_sapiensENSP0000030174086.046582.9215microtus_ochrogasterENSMOCP0000002683289.79986.5377
ENSG00000167978homo_sapiensENSP0000030174082.049478.5247sorex_araneusENSSARP0000001242683.413479.8301
ENSG00000167978homo_sapiensENSP0000030174086.664282.9578peromyscus_maniculatus_bairdiiENSPEMP0000001009890.409486.5428
ENSG00000167978homo_sapiensENSP0000030174010.610510.3198bos_mutusENSBMUP0000001934294.498491.9094
ENSG00000167978homo_sapiensENSP0000030174089.680286.3735mus_spicilegusENSMSIP0000001715291.070187.7122
ENSG00000167978homo_sapiensENSP0000030174089.934686.5552cricetulus_griseus_chok1gshdENSCGRP0000101067291.531188.0917
ENSG00000167978homo_sapiensENSP0000030174089.425986.7369pteropus_vampyrusENSPVAP0000001015191.114488.3747
ENSG00000167978homo_sapiensENSP0000030174085.792282.5945myotis_lucifugusENSMLUP0000001342291.158387.7606
ENSG00000167978homo_sapiensENSP0000030174084.847479.3241vombatus_ursinusENSVURP0001000069481.872476.5428
ENSG00000167978homo_sapiensENSP0000030174092.369289.7529rhinolophus_ferrumequinumENSRFEP0001002137592.977390.3438
ENSG00000167978homo_sapiensENSP0000030174093.204990.7703neovison_visonENSNVIP0000003014093.476791.035
ENSG00000167978homo_sapiensENSP0000030174093.168690.9157bos_taurusENSBTAP0000006666993.542591.2806
ENSG00000167978homo_sapiensENSP0000030174091.388188.2994heterocephalus_glaber_femaleENSHGLP0000001895492.259789.1416
ENSG00000167978homo_sapiensENSP0000030174094.622193.8953rhinopithecus_bietiENSRBIP0000001991795.454594.7214
ENSG00000167978homo_sapiensENSP0000030174093.786391.3517canis_lupus_dingoENSCAFP0002003339693.786391.3517
ENSG00000167978homo_sapiensENSP0000030174094.113492.3692sciurus_vulgarisENSSVLP0000503240494.491192.7399
ENSG00000167978homo_sapiensENSP000003017409.883729.33866phascolarctos_cinereusENSPCIP0000004586285.266580.5643
ENSG00000167978homo_sapiensENSP0000030174035.537834.048procavia_capensisENSPCAP0000000906465.330762.5919
ENSG00000167978homo_sapiensENSP0000030174090.62587.3547nannospalax_galiliENSNGAP0000002293492.097588.774
ENSG00000167978homo_sapiensENSP0000030174010.574110.2834bos_grunniensENSBGRP0000002202494.174891.5858
ENSG00000167978homo_sapiensENSP0000030174053.23450.0727bos_grunniensENSBGRP0000002212786.024780.916
ENSG00000167978homo_sapiensENSP0000030174089.353286.3735chinchilla_lanigeraENSCLAP0000001890892.270289.1932
ENSG00000167978homo_sapiensENSP0000030174093.241390.9157cervus_hanglu_yarkandensisENSCHYP0000000726193.547291.214
ENSG00000167978homo_sapiensENSP0000030174091.860589.5712catagonus_wagneriENSCWAP0000001480892.094789.7996
ENSG00000167978homo_sapiensENSP0000030174089.207887.5727ictidomys_tridecemlineatusENSSTOP0000002035694.350592.6211
ENSG00000167978homo_sapiensENSP0000030174093.495691.1337otolemur_garnettiiENSOGAP0000002176394.352891.9692
ENSG00000167978homo_sapiensENSP0000030174097.601796.548cebus_imitatorENSCCAP0000002755597.637296.5831
ENSG00000167978homo_sapiensENSP0000030174093.822792.0785urocitellus_parryiiENSUPAP0001002315394.405992.6508
ENSG00000167978homo_sapiensENSP0000030174092.768990.5523moschus_moschiferusENSMMSP0000001364093.413891.1819
ENSG00000167978homo_sapiensENSP0000030174098.619298.0015rhinopithecus_roxellanaENSRROP0000001350198.619298.0015
ENSG00000167978homo_sapiensENSP0000030174089.861986.5916mus_pahariMGP_PahariEiJ_P005526091.423388.0961
ENSG00000167978homo_sapiensENSP0000030174095.348893.4593propithecus_coquereliENSPCOP0000001027395.487693.5953
ENSG00000167978homo_sapiensENSP000003017405.486924.06977astyanax_mexicanusENSAMXP0000005472172.946954.1063
ENSG00000167978homo_sapiensENSP000003017405.450584.1061electrophorus_electricusENSEEEP0000002863873.170755.122
ENSG00000167978homo_sapiensENSP0000030174015.9529.70203salmo_salarENSSSAP0000014439230.234218.3884
ENSG00000167978homo_sapiensENSP000003017406.904074.9782gadus_morhuaENSGMOP0000005973441.125529.6537
ENSG00000167978homo_sapiensENSP0000030174043.059630.9593xenopus_tropicalisENSXETP0000009346943.327231.1517
ENSG00000167978homo_sapiensENSP000003017407.776167.01308chrysemys_picta_belliiENSCPBP0000000758885.677.2
ENSG00000167978homo_sapiensENSP000003017403.633723.125sphenodon_punctatusENSSPUP0000000444386.206974.1379
ENSG00000167978homo_sapiensENSP0000030174043.495633.5392laticauda_laticaudataENSLLTP0000001090053.03540.895
ENSG00000167978homo_sapiensENSP000003017406.577035.70494notechis_scutatusENSNSUP0000001759583.027572.0183
ENSG00000167978homo_sapiensENSP0000030174043.604733.5029notechis_scutatusENSNSUP0000000963055.944142.9837
ENSG00000167978homo_sapiensENSP0000030174032.921524.4549pseudonaja_textilisENSPTXP0000001992452.705139.1507
ENSG00000167978homo_sapiensENSP0000030174043.459333.5392pseudonaja_textilisENSPTXP0000002037355.731643.0103
ENSG00000167978homo_sapiensENSP000003017405.450584.6875pseudonaja_textilisENSPTXP0000001992080.213968.984
ENSG00000167978homo_sapiensENSP0000030174011.19199.70203gallus_gallusENSGALP0001000233063.374554.9383
ENSG00000167978homo_sapiensENSP0000030174043.64134.0116anolis_carolinensisENSACAP0000000679255.912543.5754
ENSG00000167978homo_sapiensENSP0000030174011.918610.1017naja_najaENSNNAP0000001957572.087961.0989
ENSG00000167978homo_sapiensENSP0000030174043.568333.4666naja_najaENSNNAP0000000865256.054243.0575
ENSG00000167978homo_sapiensENSP0000030174044.040734.6294podarcis_muralisENSPMRP0000003245257.196844.974
ENSG00000167978homo_sapiensENSP000003017405.66864.83285taeniopygia_guttataENSTGUP0000003642975.728264.5631
ENSG00000167978homo_sapiensENSP000003017408.466576.79506erpetoichthys_calabaricusENSECRP0000001605178.451262.963
ENSG00000167978homo_sapiensENSP0000030174043.132333.7573salvator_merianaeENSSMRP0000000544855.701543.5946
ENSG00000167978homo_sapiensENSP000003017404.941863.7064amphilophus_citrinellusENSACIP0000003015775.977756.9832
ENSG00000167978homo_sapiensENSP0000030174042.623534.9564gopherus_evgoodeiENSGEVP0000502253150.085441.076
ENSG00000167978homo_sapiensENSP000003017405.486923.99709gasterosteus_aculeatusENSGACP0000002673156.343341.0448
ENSG00000167978homo_sapiensENSP000003017405.305233.99709cynoglossus_semilaevisENSCSEP0000001551871.568653.9216
ENSG00000167978homo_sapiensENSP000003017405.95935.41424strigops_habroptilaENSSHBP0000501908785.863978.0105
ENSG00000167978homo_sapiensENSP000003017404.10613.27035terrapene_carolina_triunguisENSTMTP0000002025163.128550.2793
ENSG00000167978homo_sapiensENSP000003017405.523264.06977pygocentrus_nattereriENSPNAP0000001307273.4354.1063
ENSG00000167978homo_sapiensENSP000003017406.031984.36047seriola_lalandi_dorsalisENSSLDP0000000453170.042250.6329
ENSG00000167978homo_sapiensENSP000003017404.97823.74273labrus_bergyltaENSLBEP0000000998675.274756.5934
ENSG00000167978homo_sapiensENSP000003017404.614833.08866pundamilia_nyerereiENSPNYP0000001247567.914445.4545
ENSG00000167978homo_sapiensENSP000003017405.014533.77907oncorhynchus_tshawytschaENSOTSP0000501462173.015955.0265
ENSG00000167978homo_sapiensENSP000003017404.905523.67006oncorhynchus_tshawytschaENSOTSP0000507378970.680652.8796
ENSG00000167978homo_sapiensENSP0000030174020.094511.8096paramormyrops_kingsleyaeENSPKIP0000001496830.535617.9459
ENSG00000167978homo_sapiensENSP0000030174032.412823.0741leptobrachium_leishanenseENSLLEP0000004040353.445238.0467

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000398involved_in mRNA splicing, via spliceosome2IC,IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0015030located_in Cajal body1IDAHomo_sapiens(9606)Component
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0070742enables C2H2 zinc finger domain binding1IDAHomo_sapiens(9606)Function
GO:0071005part_of U2-type precatalytic spliceosome1IDAHomo_sapiens(9606)Component
GO:0071007part_of U2-type catalytic step 2 spliceosome1IDAHomo_sapiens(9606)Component
GO:0071013part_of catalytic step 2 spliceosome1IDAHomo_sapiens(9606)Component

Expression