Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000167657 Gene ID 1613 Accession 2676
Symbol DAPK3 Alias DLK;ZIP;ZIPK Full Name death associated protein kinase 3
Status Confidence Length 12671 bases Strand Minus strand
Position 19 : 3958453 - 3971123 RNA binding domain RIO1
Summary Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000471154 RIO1 PF01163 0.00021 1
ENSP00000472988 RIO1 PF01163 0.00021 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
DAPK3-202 ENST00000545797 2286 454aa ENSP00000442973
DAPK3-201 ENST00000301264 2105 454aa ENSP00000301264
DAPK3-205 ENST00000595279 2058 No protein -
DAPK3-204 ENST00000594894 617 92aa ENSP00000470168
DAPK3-206 ENST00000596311 671 158aa ENSP00000471154
DAPK3-207 ENST00000601824 599 158aa ENSP00000472988
DAPK3-203 ENST00000593844 626 141aa ENSP00000470115

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
16441Pancreatic Neoplasms7.903E-0522523087
85985Language3E-725226531

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0004674enables protein serine/threonine kinase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006325involved_in chromatin organization1IEAHomo_sapiens(9606)Process
GO:0006355involved_in regulation of DNA-templated transcription1TASHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process2IDA,IMPHomo_sapiens(9606)Process
GO:0006940involved_in regulation of smooth muscle contraction1TASHomo_sapiens(9606)Process
GO:0007088involved_in regulation of mitotic nuclear division1TASHomo_sapiens(9606)Process
GO:0007346involved_in regulation of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:0008140enables cAMP response element binding protein binding1TASHomo_sapiens(9606)Function
GO:0008360involved_in regulation of cell shape1IEAHomo_sapiens(9606)Process
GO:0010506involved_in regulation of autophagy1TASHomo_sapiens(9606)Process
GO:0016605located_in PML body1IEAHomo_sapiens(9606)Component
GO:0017148involved_in negative regulation of translation1IDAHomo_sapiens(9606)Process
GO:0030335involved_in positive regulation of cell migration1IEAHomo_sapiens(9606)Process
GO:0031267enables small GTPase binding1IDAHomo_sapiens(9606)Function
GO:0032956involved_in regulation of actin cytoskeleton organization2IDA,TASHomo_sapiens(9606)Process
GO:0035556involved_in intracellular signal transduction2IBA,IDAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IDAHomo_sapiens(9606)Function
GO:0042981involved_in regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process2IBA,IDAHomo_sapiens(9606)Process
GO:0043519involved_in regulation of myosin II filament organization1IEAHomo_sapiens(9606)Process
GO:0043522enables leucine zipper domain binding1IPIHomo_sapiens(9606)Function
GO:0046777involved_in protein autophosphorylation2IDA,TASHomo_sapiens(9606)Process
GO:0051893involved_in regulation of focal adhesion assembly1IDAHomo_sapiens(9606)Process
GO:0071346involved_in cellular response to type II interferon1IDAHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway1IMPHomo_sapiens(9606)Process
GO:0097190involved_in apoptotic signaling pathway1IEAHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:2000145involved_in regulation of cell motility1TASHomo_sapiens(9606)Process

Expression