RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	diverse
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000167136	Gene ID	2021	Accession	3346
Symbol	ENDOG	Alias	NA	Full Name	endonuclease G
Status	Confidence	Length	4177 bases	Strand	Plus strand
Position	9 : 128818500 - 128822676	RNA binding domain	Endonuclease_NS
Summary	The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000361725	Endonuclease_NS	PF01223	9.2e-62	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
35326425	Biallelic Variants in ENDOG Associated with Mitochondrial Myopathy and Multiple mtDNA Deletions.	Alessia Nasca	2022-03-12	Cells

Name	Transcript ID	bp	Protein	Translation ID
ENDOG-201	ENST00000372642	1145	297aa	ENSP00000361725

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000014	enables single-stranded DNA endodeoxyribonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0000287	enables magnesium ion binding	1	ISS	Homo_sapiens(9606)	Function
GO:0001701	involved_in in utero embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004520	enables DNA endonuclease activity	1	IMP	Homo_sapiens(9606)	Function
GO:0004521	enables RNA endonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005743	is_active_in mitochondrial inner membrane	1	IBA	Homo_sapiens(9606)	Component
GO:0006309	involved_in apoptotic DNA fragmentation	1	IBA	Homo_sapiens(9606)	Process
GO:0006310	involved_in DNA recombination	1	TAS	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	1	IMP	Homo_sapiens(9606)	Process
GO:0009612	involved_in response to mechanical stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0010508	involved_in positive regulation of autophagy	1	IMP	Homo_sapiens(9606)	Process
GO:0032007	involved_in negative regulation of TOR signaling	1	IMP	Homo_sapiens(9606)	Process
GO:0032043	involved_in mitochondrial DNA catabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0032355	involved_in response to estradiol	1	IEA	Homo_sapiens(9606)	Process
GO:0034599	involved_in cellular response to oxidative stress	1	IEA	Homo_sapiens(9606)	Process
GO:0034612	involved_in response to tumor necrosis factor	1	IEA	Homo_sapiens(9606)	Process
GO:0042803	enables protein homodimerization activity	1	ISS	Homo_sapiens(9606)	Function
GO:0043065	involved_in positive regulation of apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0043204	located_in perikaryon	1	IEA	Homo_sapiens(9606)	Component
GO:0046677	involved_in response to antibiotic	1	IEA	Homo_sapiens(9606)	Process
GO:0048471	located_in perinuclear region of cytoplasm	1	IEA	Homo_sapiens(9606)	Component
GO:0071277	involved_in cellular response to calcium ion	1	IEA	Homo_sapiens(9606)	Process
GO:0071333	involved_in cellular response to glucose stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0071456	involved_in cellular response to hypoxia	1	IEA	Homo_sapiens(9606)	Process
GO:0090297	involved_in positive regulation of mitochondrial DNA replication	1	IMP	Homo_sapiens(9606)	Process
GO:1901300	involved_in positive regulation of hydrogen peroxide-mediated programmed cell death	1	IEA	Homo_sapiens(9606)	Process
GO:1902512	involved_in positive regulation of apoptotic DNA fragmentation	1	IEA	Homo_sapiens(9606)	Process