Functions and Diseases

RBP Type Canonical_RBPs
Diseases CHIKVSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengue
Drug N.A.
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations Stress granucleP-bodyNucleoli rim
BulkPerturb-seq DataSet_01_117 DataSet_01_12

Description

Ensembl ID ENSG00000165732 Gene ID 9188 Accession 2744
Symbol DDX21 Alias RH;GUA;GURDB;II/Gu;RHII/Gu;RH-II/GU;gu-alpha;RH-II/GuA Full Name DExD-box helicase 21
Status Confidence Length 28934 bases Strand Plus strand
Position 10 : 68956135 - 68985068 RNA binding domain ResIII , DEAD , GUCT
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000480334 DEAD PF00270 1.2e-46 1
ENSP00000480334 ResIII PF04851 3.5e-08 2
ENSP00000480334 GUCT PF08152 2.1e-29 3
ENSP00000510035 DEAD PF00270 1.2e-46 1
ENSP00000510035 ResIII PF04851 3.5e-08 2
ENSP00000510035 GUCT PF08152 2.1e-29 3
ENSP00000508484 DEAD PF00270 1.3e-46 1
ENSP00000508484 ResIII PF04851 3.1e-08 2
ENSP00000508484 GUCT PF08152 2.1e-29 3
ENSP00000508639 DEAD PF00270 1.3e-46 1
ENSP00000508639 ResIII PF04851 4e-08 2
ENSP00000508639 GUCT PF08152 6.8e-17 3
ENSP00000346120 DEAD PF00270 1.4e-46 1
ENSP00000346120 ResIII PF04851 4.2e-08 2
ENSP00000346120 GUCT PF08152 2.3e-29 3
ENSP00000510328 DEAD PF00270 1.5e-46 1
ENSP00000510328 ResIII PF04851 3.7e-08 2
ENSP00000510328 GUCT PF08152 2.3e-29 3
ENSP00000508611 DEAD PF00270 1.8e-46 1
ENSP00000508611 ResIII PF04851 4.4e-08 2
ENSP00000508611 GUCT PF08152 2.1e-29 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35336874 DEAD-Box RNA Helicase 21 (DDX21) Positively Regulates the Replication of Porcine Reproductive and Respiratory Syndrome Virus via Multiple Mechanisms. Jia Li 2022-02-24 Viruses
24721576 Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein. Guifang Chen 2014-04-09 Cell host & microbe
31351877 Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Dae-Seok Kim 2019-09-19 Molecular cell
33040459 EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53. Yuki Uchihara 2021-01-01 Molecular oncology
28705764 A Survey of DDX21 Activity During Rev/RRE Complex Formation. A John Hammond 2018-02-16 Journal of molecular biology
31754723 A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus. Guifang Chen 2020-01-10 Nucleic acids research
36608661 Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation. Weili Miao 2023-01-05 Cell
29906500 Insights into the RNA quadruplex binding specificity of DDX21. S K Ewan McRae 2018-09-01 Biochimica et biophysica acta. General subjects
33505109 Downregulation of lncRNA HCP5 has inhibitory effects on gastric cancer cells by regulating DDX21 expression. Kehao Wang 2021-02-01 Cytotechnology
35852833 NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides. Lingdi Zhang 2022-08-01 Nucleic acid therapeutics
35328433 Fragments of rDNA Genes Scattered over the Human Genome Are Targets of Small RNAs. A Nickolai Tchurikov 2022-03-10 International journal of molecular sciences
36608648 Sweet splicing. Maria Carmo-Fonseca 2023-01-05 Cell
19893625 Autogenous translational regulation of the Borna disease virus negative control factor X from polycistronic mRNA using host RNA helicases. Yohei Watanabe 2009-11-01 PLoS pathogens
33052334 Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection. A Ryan Flynn 2020-10-06 bioRxiv : the preprint server for biology
35283818 Contribution of DEAD-Box RNA Helicase 21 to the Nucleolar Localization of Porcine Circovirus Type 4 Capsid Protein. Jianwei Zhou 2022-01-01 Frontiers in microbiology
28472472 Human DDX21 binds and unwinds RNA guanine quadruplexes. S K Ewan McRae 2017-06-20 Nucleic acids research
35271815 The expanding universe of PARP1-mediated molecular and therapeutic mechanisms. Dan Huang 2022-06-16 Molecular cell
33023047 Roles of the Non-Structural Proteins of Influenza A Virus. Wenzhuo Hao 2020-10-03 Pathogens (Basel, Switzerland)
36042885 Protein purification, crystallization, and structure determination of human DEAD-box RNA helicase DDX21 in different unwinding states. Zijun Chen 2022-09-16 STAR protocols
37072811 LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization. Nasha Zhang 2023-04-18 Journal of experimental & clinical cancer research : CR
32098424 The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection. Nícia Rosário-Ferreira 2020-02-22 International journal of molecular sciences
32714761 Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Zijun Chen 2020-07-01 Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Transcripts

Name Transcript ID bp Protein Translation ID
DDX21-204 ENST00000685106 3152 729aa ENSP00000510328
DDX21-208 ENST00000687162 2295 No protein -
DDX21-203 ENST00000684824 4666 808aa ENSP00000508611
DDX21-201 ENST00000354185 4664 783aa ENSP00000346120
DDX21-207 ENST00000686528 3228 768aa ENSP00000508639
DDX21-211 ENST00000690650 3324 661aa ENSP00000508484
DDX21-210 ENST00000690316 4542 715aa ENSP00000510035
DDX21-202 ENST00000620315 4776 715aa ENSP00000480334
DDX21-205 ENST00000685513 4628 No protein -
DDX21-209 ENST00000688593 4034 No protein -
DDX21-212 ENST00000692943 4228 No protein -
DDX21-206 ENST00000686366 2014 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000165732homo_sapiensENSP0000037947551.168227.8037homo_sapiensENSP0000034612027.969315.198
ENSG00000165732homo_sapiensENSP0000038553634.156420.7133homo_sapiensENSP0000034612031.800819.2848
ENSG00000165732homo_sapiensENSP0000026323940.298523.5821homo_sapiensENSP0000034612034.482820.1788
ENSG00000165732homo_sapiensENSP0000049764149.148430.6569homo_sapiensENSP0000034612025.798216.092
ENSG00000165732homo_sapiensENSP0000048268035.947719.7386homo_sapiensENSP0000034612035.121319.2848
ENSG00000165732homo_sapiensENSP000002938315031.2808homo_sapiensENSP0000034612025.925916.2197
ENSG00000165732homo_sapiensENSP0000030611743.096223.8494homo_sapiensENSP0000034612026.309114.5594
ENSG00000165732homo_sapiensENSP0000028807143.21524.2171homo_sapiensENSP0000034612026.436814.8148
ENSG00000165732homo_sapiensENSP0000048149530.733417.9278homo_sapiensENSP0000034612033.716519.6679
ENSG00000165732homo_sapiensENSP0000041653427.325615.7946homo_sapiensENSP0000034612036.015320.8174
ENSG00000165732homo_sapiensENSP0000036123231.233216.756homo_sapiensENSP0000034612029.757315.9642
ENSG00000165732homo_sapiensENSP0000049264317.44369.32331homo_sapiensENSP0000034612029.629615.8365
ENSG00000165732homo_sapiensENSP0000023814636.833321.3333homo_sapiensENSP0000034612028.224816.3474
ENSG00000165732homo_sapiensENSP0000022579241.042324.9186homo_sapiensENSP0000034612032.183919.5402
ENSG00000165732homo_sapiensENSP0000036866738.510322.504homo_sapiensENSP0000034612031.034518.1354
ENSG00000165732homo_sapiensENSP0000033046039.5821.0016homo_sapiensENSP0000034612031.289916.6028
ENSG00000165732homo_sapiensENSP0000026357641.200823.3954homo_sapiensENSP0000034612025.415114.4317
ENSG00000165732homo_sapiensENSP0000038049532.732717.7177homo_sapiensENSP0000034612027.841615.0702
ENSG00000165732homo_sapiensENSP0000031434829.714315.6571homo_sapiensENSP0000034612033.205617.4968
ENSG00000165732homo_sapiensENSP0000037457428.571416.5245homo_sapiensENSP0000034612034.227319.7957
ENSG00000165732homo_sapiensENSP0000035871628.640815.8981homo_sapiensENSP0000034612030.140516.7305
ENSG00000165732homo_sapiensENSP0000044226641.614922.9814homo_sapiensENSP0000034612025.670514.1762
ENSG00000165732homo_sapiensENSP0000036268772.455959.7015homo_sapiensENSP0000034612068.199256.1941
ENSG00000165732homo_sapiensENSP0000047950437.562621.3689homo_sapiensENSP0000034612028.735616.3474
ENSG00000165732homo_sapiensENSP0000035936139.197523.7654homo_sapiensENSP0000034612032.439319.6679
ENSG00000165732homo_sapiensENSP0000032638150.368532.9238homo_sapiensENSP0000034612026.181417.1137
ENSG00000165732homo_sapiensENSP0000025877237.842821.2066homo_sapiensENSP0000034612026.436814.8148
ENSG00000165732homo_sapiensENSP0000049404039.879224.1692homo_sapiensENSP0000034612033.716520.4342
ENSG00000165732homo_sapiensENSP0000033672539.545524.0909homo_sapiensENSP0000034612033.333320.3065
ENSG00000165732homo_sapiensENSP0000024700341.821925.6729homo_sapiensENSP0000034612025.798215.8365
ENSG00000165732homo_sapiensENSP0000033034939.067521.865homo_sapiensENSP0000034612031.034517.3691
ENSG00000165732homo_sapiensENSP0000024277650.819727.4005homo_sapiensENSP0000034612027.713914.9425
ENSG00000165732homo_sapiensENSP0000023308430.270318.5135homo_sapiensENSP0000034612028.607917.4968
ENSG00000165732homo_sapiensENSP0000030407230.19317.1396homo_sapiensENSP0000034612033.971919.2848
ENSG00000165732homo_sapiensENSP0000035069845.934127.9121homo_sapiensENSP0000034612026.692216.2197
ENSG00000165732homo_sapiensENSP0000031072331.463418.0488homo_sapiensENSP0000034612032.950218.9017
ENSG00000165732homo_sapiensENSP0000033234037.03720.5556homo_sapiensENSP0000034612025.542814.1762
ENSG00000165732homo_sapiensENSP0000042483835.773520.0276homo_sapiensENSP0000034612033.077918.5185

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000165732homo_sapiensENSP0000034612099.361498.9783nomascus_leucogenysENSNLEP0000001413699.361498.9783
ENSG00000165732homo_sapiensENSP0000034612099.872399.7446pan_paniscusENSPPAP0000002720499.872399.7446
ENSG00000165732homo_sapiensENSP0000034612099.361499.2337pongo_abeliiENSPPYP0000000277499.361499.2337
ENSG00000165732homo_sapiensENSP0000034612099.872399.8723pan_troglodytesENSPTRP0000000443199.872399.8723
ENSG00000165732homo_sapiensENSP0000034612099.872399.6169gorilla_gorillaENSGGOP0000000496899.872399.6169
ENSG00000165732homo_sapiensENSP0000034612080.715269.8595sarcophilus_harrisiiENSSHAP0000000612973.317963.4571
ENSG00000165732homo_sapiensENSP0000034612040.868537.037notamacropus_eugeniiENSMEUP0000000967052.718347.7759
ENSG00000165732homo_sapiensENSP0000034612082.630978.0332choloepus_hoffmanniENSCHOP0000000020584.135279.4538
ENSG00000165732homo_sapiensENSP0000034612089.399784.6743dasypus_novemcinctusENSDNOP0000000130191.383886.5535
ENSG00000165732homo_sapiensENSP0000034612076.500671.5198erinaceus_europaeusENSEEUP0000000543885.939780.3443
ENSG00000165732homo_sapiensENSP0000034612091.698686.0792echinops_telfairiENSETEP0000001142491.116885.533
ENSG00000165732homo_sapiensENSP0000034612097.828995.9132callithrix_jacchusENSCJAP0000002361797.828995.9132
ENSG00000165732homo_sapiensENSP0000034612098.722997.5734cercocebus_atysENSCATP0000004173698.722997.5734
ENSG00000165732homo_sapiensENSP0000034612090.293789.5275macaca_fascicularisENSMFAP0000002685098.881198.042
ENSG00000165732homo_sapiensENSP0000034612098.850697.8289macaca_mulattaENSMMUP0000007428698.850697.8289
ENSG00000165732homo_sapiensENSP0000034612098.850697.7011macaca_nemestrinaENSMNEP0000001771698.850697.7011
ENSG00000165732homo_sapiensENSP0000034612098.850697.7011papio_anubisENSPANP0000005855598.850697.7011
ENSG00000165732homo_sapiensENSP0000034612095.5394.1252mandrillus_leucophaeusENSMLEP0000000956898.550797.1014
ENSG00000165732homo_sapiensENSP0000034612092.975788.2503tursiops_truncatusENSTTRP0000001554392.975788.2503
ENSG00000165732homo_sapiensENSP0000034612093.486689.5275vulpes_vulpesENSVVUP0000002795692.191488.2872
ENSG00000165732homo_sapiensENSP0000034612088.122682.7586mus_spretusMGP_SPRETEiJ_P002427880.985976.0563
ENSG00000165732homo_sapiensENSP0000034612094.125288.7612equus_asinusENSEASP0000506205493.885488.535
ENSG00000165732homo_sapiensENSP0000034612072.669266.2835capra_hircusENSCHIP0000001229877.309870.5163
ENSG00000165732homo_sapiensENSP0000034612089.910686.2069capra_hircusENSCHIP0000000034793.368789.5225
ENSG00000165732homo_sapiensENSP0000034612066.794461.175capra_hircusENSCHIP0000000260475.035968.7231
ENSG00000165732homo_sapiensENSP0000034612093.231287.6117loxodonta_africanaENSLAFP0000000667992.757387.1665
ENSG00000165732homo_sapiensENSP0000034612093.997490.166panthera_leoENSPLOP0000002393594.238290.3969
ENSG00000165732homo_sapiensENSP0000034612087.739583.908ailuropoda_melanoleucaENSAMEP0000001900193.342489.2663
ENSG00000165732homo_sapiensENSP0000034612092.84889.1443bos_indicus_hybridENSBIXP0000503702892.729689.0306
ENSG00000165732homo_sapiensENSP0000034612093.103488.1226oryctolagus_cuniculusENSOCUP0000000250993.461588.4615
ENSG00000165732homo_sapiensENSP0000034612094.125289.0166equus_caballusENSECAP0000007073993.885488.7898
ENSG00000165732homo_sapiensENSP0000034612093.486689.3997canis_lupus_familiarisENSCAFP0084500429493.248489.172
ENSG00000165732homo_sapiensENSP0000034612093.997490.2937panthera_pardusENSPPRP0000002179194.238290.525
ENSG00000165732homo_sapiensENSP0000034612093.74289.1443marmota_marmota_marmotaENSMMMP0000001024393.622589.0306
ENSG00000165732homo_sapiensENSP0000034612093.231288.8889balaenoptera_musculusENSBMSP0001003094792.993688.6624
ENSG00000165732homo_sapiensENSP0000034612090.804685.5683cavia_porcellusENSCPOP0000001396089.209584.0652
ENSG00000165732homo_sapiensENSP0000034612093.997490.2937felis_catusENSFCAP0000003865294.238290.525
ENSG00000165732homo_sapiensENSP0000034612017.624516.8582ursus_americanusENSUAMP0000000647089.610485.7143
ENSG00000165732homo_sapiensENSP0000034612069.476461.3027monodelphis_domesticaENSMODP0000001344181.804572.1805
ENSG00000165732homo_sapiensENSP0000034612014.814813.5377bison_bison_bisonENSBBBP0000001524180.555673.6111
ENSG00000165732homo_sapiensENSP0000034612016.219714.8148bison_bison_bisonENSBBBP0000002026987.586280
ENSG00000165732homo_sapiensENSP0000034612092.84889.1443bison_bison_bisonENSBBBP0000002721592.729689.0306
ENSG00000165732homo_sapiensENSP0000034612093.103488.5057monodon_monocerosENSMMNP0001502448492.866288.2803
ENSG00000165732homo_sapiensENSP0000034612092.84888.1226sus_scrofaENSSSCP0000001092592.729688.0102
ENSG00000165732homo_sapiensENSP0000034612086.462380.7152microcebus_murinusENSMICP0000002044091.36385.2901
ENSG00000165732homo_sapiensENSP0000034612094.891490.0383microcebus_murinusENSMICP0000001378094.891490.0383
ENSG00000165732homo_sapiensENSP0000034612017.113716.092octodon_degusENSODEP0000000219293.055687.5
ENSG00000165732homo_sapiensENSP0000034612069.731864.6232octodon_degusENSODEP0000001746987.081380.7018
ENSG00000165732homo_sapiensENSP0000034612087.611781.9923jaculus_jaculusENSJJAP0000001047386.835481.2658
ENSG00000165732homo_sapiensENSP0000034612092.592689.0166ovis_aries_rambouilletENSOARP0002001236792.592689.0166
ENSG00000165732homo_sapiensENSP0000034612094.125290.5492ursus_maritimusENSUMAP0000001029092.821289.2947
ENSG00000165732homo_sapiensENSP0000034612082.503276.3729ochotona_princepsENSOPRP0000000151884.224377.9661
ENSG00000165732homo_sapiensENSP0000034612093.103488.378delphinapterus_leucasENSDLEP0000001188692.866288.1529
ENSG00000165732homo_sapiensENSP0000034612093.486689.272physeter_catodonENSPCTP0000500905393.248489.0446
ENSG00000165732homo_sapiensENSP0000034612087.867282.6309mus_caroliMGP_CAROLIEiJ_P002313388.545783.269
ENSG00000165732homo_sapiensENSP0000034612088.250382.7586mus_musculusENSMUSP0000004269181.198676.1457
ENSG00000165732homo_sapiensENSP0000034612085.951580.5875dipodomys_ordiiENSDORP0000002261286.615281.2098
ENSG00000165732homo_sapiensENSP0000034612093.869790.0383mustela_putorius_furoENSMPUP0000000456892.80389.0152
ENSG00000165732homo_sapiensENSP0000034612098.21296.8072aotus_nancymaaeENSANAP0000004165098.21296.8072
ENSG00000165732homo_sapiensENSP0000034612037.292536.0153saimiri_boliviensis_boliviensisENSSBOP0000001482789.296686.2385
ENSG00000165732homo_sapiensENSP0000034612081.098377.6501vicugna_pacosENSVPAP0000000058093.519989.5434
ENSG00000165732homo_sapiensENSP0000034612083.652678.6718tupaia_belangeriENSTBEP0000000202185.397780.3129
ENSG00000165732homo_sapiensENSP0000034612085.69680.7152mesocricetus_auratusENSMAUP0000001021584.615479.6973
ENSG00000165732homo_sapiensENSP0000034612093.231288.378phocoena_sinusENSPSNP0000002595092.993688.1529
ENSG00000165732homo_sapiensENSP0000034612092.84888.378camelus_dromedariusENSCDRP0000502590493.806489.2903
ENSG00000165732homo_sapiensENSP0000034612094.891489.9106carlito_syrichtaENSTSYP0000001035594.770489.7959
ENSG00000165732homo_sapiensENSP0000034612093.869789.9106panthera_tigris_altaicaENSPTIP0000000491394.110190.1408
ENSG00000165732homo_sapiensENSP0000034612089.144384.1635rattus_norvegicusENSRNOP0000006349489.258384.2711
ENSG00000165732homo_sapiensENSP0000034612095.274690.0383prolemur_simusENSPSMP0000001309195.274690.0383
ENSG00000165732homo_sapiensENSP0000034612087.867282.2478microtus_ochrogasterENSMOCP0000002442785.678780.1992
ENSG00000165732homo_sapiensENSP0000034612052.618148.0204sorex_araneusENSSARP0000001269253.645848.9583
ENSG00000165732homo_sapiensENSP0000034612089.144384.5466peromyscus_maniculatus_bairdiiENSPEMP0000002061889.948585.3093
ENSG00000165732homo_sapiensENSP0000034612015.453414.304bos_mutusENSBMUP0000000244783.448377.2414
ENSG00000165732homo_sapiensENSP0000034612081.864678.4163bos_mutusENSBMUP0000003024690.664886.8458
ENSG00000165732homo_sapiensENSP0000034612087.867282.5032mus_spicilegusENSMSIP0000003656684.729179.5566
ENSG00000165732homo_sapiensENSP0000034612087.228681.7369cricetulus_griseus_chok1gshdENSCGRP0000101574588.471582.9016
ENSG00000165732homo_sapiensENSP0000034612078.544172.0307cricetulus_griseus_chok1gshdENSCGRP0000101792583.446476.5265
ENSG00000165732homo_sapiensENSP0000034612093.103490.166pteropus_vampyrusENSPVAP0000000897293.103490.166
ENSG00000165732homo_sapiensENSP0000034612093.103488.6335myotis_lucifugusENSMLUP0000002114589.228984.9449
ENSG00000165732homo_sapiensENSP0000034612069.476462.1967vombatus_ursinusENSVURP0001001961581.19472.6866
ENSG00000165732homo_sapiensENSP0000034612039.080535.6322rhinolophus_ferrumequinumENSRFEP0001001091983.606676.2295
ENSG00000165732homo_sapiensENSP0000034612092.84888.2503rhinolophus_ferrumequinumENSRFEP0001001302892.966888.3632
ENSG00000165732homo_sapiensENSP0000034612093.869790.0383neovison_visonENSNVIP0000001590492.920489.1277
ENSG00000165732homo_sapiensENSP0000034612092.464988.8889bos_taurusENSBTAP0000001935192.701789.1165
ENSG00000165732homo_sapiensENSP0000034612078.927275.8621heterocephalus_glaber_femaleENSHGLP0000003718795.223491.5254
ENSG00000165732homo_sapiensENSP0000034612090.676989.0166rhinopithecus_bietiENSRBIP0000002389897.796196.0055
ENSG00000165732homo_sapiensENSP0000034612098.722997.8289rhinopithecus_bietiENSRBIP0000004062298.722997.8289
ENSG00000165732homo_sapiensENSP0000034612017.241415.7088canis_lupus_dingoENSCAFP0002002738693.103484.8276
ENSG00000165732homo_sapiensENSP0000034612015.708814.8148canis_lupus_dingoENSCAFP0002003344888.489283.4532
ENSG00000165732homo_sapiensENSP0000034612043.678241.8902canis_lupus_dingoENSCAFP0002003345293.95690.1099
ENSG00000165732homo_sapiensENSP0000034612041.762540.3576sciurus_vulgarisENSSVLP0000500648995.61492.3977
ENSG00000165732homo_sapiensENSP0000034612094.380690.166sciurus_vulgarisENSSVLP0000500499094.140189.9363
ENSG00000165732homo_sapiensENSP0000034612081.609270.1149phascolarctos_cinereusENSPCIP0000002104874.302363.8372
ENSG00000165732homo_sapiensENSP0000034612080.587574.4572procavia_capensisENSPCAP0000001564391.053484.127
ENSG00000165732homo_sapiensENSP0000034612089.782984.2912nannospalax_galiliENSNGAP0000002384985.315580.0971
ENSG00000165732homo_sapiensENSP0000034612092.720389.0166bos_grunniensENSBGRP0000001728192.720389.0166
ENSG00000165732homo_sapiensENSP0000034612091.187786.4623chinchilla_lanigeraENSCLAP0000001784092.847988.0364
ENSG00000165732homo_sapiensENSP0000034612012.771411.7497cervus_hanglu_yarkandensisENSCHYP0000001390160.975656.0976
ENSG00000165732homo_sapiensENSP0000034612092.975789.0166cervus_hanglu_yarkandensisENSCHYP0000001009292.975789.0166
ENSG00000165732homo_sapiensENSP0000034612092.84887.6117catagonus_wagneriENSCWAP0000002878792.729687.5
ENSG00000165732homo_sapiensENSP0000034612093.103488.7612ictidomys_tridecemlineatusENSSTOP0000001038992.630288.31
ENSG00000165732homo_sapiensENSP0000034612092.209485.8238otolemur_garnettiiENSOGAP0000000164685.748279.81
ENSG00000165732homo_sapiensENSP0000034612070.753567.433otolemur_garnettiiENSOGAP0000002080191.268586.9852
ENSG00000165732homo_sapiensENSP0000034612097.956696.2963cebus_imitatorENSCCAP0000001697197.956696.2963
ENSG00000165732homo_sapiensENSP0000034612093.231288.5057urocitellus_parryiiENSUPAP0001001069993.951189.1892
ENSG00000165732homo_sapiensENSP0000034612092.209487.8672moschus_moschiferusENSMMSP0000002449192.091887.7551
ENSG00000165732homo_sapiensENSP0000034612092.84888.7612moschus_moschiferusENSMMSP0000003124092.84888.7612
ENSG00000165732homo_sapiensENSP0000034612098.722997.7011rhinopithecus_roxellanaENSRROP0000001869198.722997.7011
ENSG00000165732homo_sapiensENSP0000034612087.994983.014mus_pahariMGP_PahariEiJ_P008630488.674483.6551
ENSG00000165732homo_sapiensENSP0000034612092.337287.2286propithecus_coquereliENSPCOP0000001512895.382690.1055
ENSG00000165732homo_sapiensENSP0000034612037.547931.6731callorhinchus_miliiENSCMIP0000004534275.773263.9175
ENSG00000165732homo_sapiensENSP0000034612040.868532.0562callorhinchus_miliiENSCMIP0000004533469.414354.4469
ENSG00000165732homo_sapiensENSP0000034612059.770152.4904latimeria_chalumnaeENSLACP0000000073380.412470.6186
ENSG00000165732homo_sapiensENSP0000034612067.049856.9604lepisosteus_oculatusENSLOCP0000001112667.567657.4003
ENSG00000165732homo_sapiensENSP0000034612069.731857.0881danio_rerioENSDARP0000008758169.026656.5107
ENSG00000165732homo_sapiensENSP0000034612066.155854.917carassius_auratusENSCARP0000006507971.745259.5568
ENSG00000165732homo_sapiensENSP0000034612068.837855.6833astyanax_mexicanusENSAMXP0000003040768.7555.6122
ENSG00000165732homo_sapiensENSP0000034612066.922154.5338ictalurus_punctatusENSIPUP0000001027968.496755.817
ENSG00000165732homo_sapiensENSP0000034612067.43356.3218esox_luciusENSELUP0000007053168.929557.5718
ENSG00000165732homo_sapiensENSP0000034612066.922156.1941electrophorus_electricusENSEEEP0000001375069.038257.971
ENSG00000165732homo_sapiensENSP0000034612065.517254.6616oncorhynchus_kisutchENSOKIP0000507527568.582957.2192
ENSG00000165732homo_sapiensENSP0000034612066.666755.6833oncorhynchus_kisutchENSOKIP0000511763266.666755.6833
ENSG00000165732homo_sapiensENSP0000034612065.900454.4061oncorhynchus_mykissENSOMYP0000008881768.891956.8758
ENSG00000165732homo_sapiensENSP0000034612065.772754.7893oncorhynchus_mykissENSOMYP0000008313270.163558.4469
ENSG00000165732homo_sapiensENSP0000034612066.283555.3001salmo_salarENSSSAP0000006289169.664458.1208
ENSG00000165732homo_sapiensENSP0000034612066.283555.1724salmo_salarENSSSAP0000006270166.967755.7419
ENSG00000165732homo_sapiensENSP0000034612066.155855.0447salmo_truttaENSSTUP000001091127058.2432
ENSG00000165732homo_sapiensENSP0000034612066.411255.4278salmo_truttaENSSTUP0000011610770.080958.4906
ENSG00000165732homo_sapiensENSP0000034612064.240152.4904gadus_morhuaENSGMOP0000002782366.184254.0789
ENSG00000165732homo_sapiensENSP0000034612066.666755.0447fundulus_heteroclitusENSFHEP0000003253867.441955.6848
ENSG00000165732homo_sapiensENSP0000034612064.75153.5121xiphophorus_maculatusENSXMAP0000003140268.053756.2416
ENSG00000165732homo_sapiensENSP0000034612060.664151.5964oryzias_latipesENSORLP0000001269473.189562.2496
ENSG00000165732homo_sapiensENSP0000034612064.878754.6616cyclopterus_lumpusENSCLMP0000500810268.834757.9946
ENSG00000165732homo_sapiensENSP0000034612066.53955.6833oreochromis_niloticusENSONIP0000000691064.162653.6946
ENSG00000165732homo_sapiensENSP0000034612066.283555.0447haplochromis_burtoniENSHBUP0000001573965.20154.1457
ENSG00000165732homo_sapiensENSP0000034612066.283555.4278astatotilapia_callipteraENSACLP0000001207965.119254.4542
ENSG00000165732homo_sapiensENSP0000034612065.389554.5338sparus_aurataENSSAUP0001005860562.135951.8204
ENSG00000165732homo_sapiensENSP0000034612066.53956.3218lates_calcariferENSLCAP0001005724669.559458.8785
ENSG00000165732homo_sapiensENSP0000034612070.625860.5364chrysemys_picta_belliiENSCPBP0000002818279.11367.8112
ENSG00000165732homo_sapiensENSP0000034612075.351262.963chrysemys_picta_belliiENSCPBP0000002818672.570760.6396
ENSG00000165732homo_sapiensENSP0000034612070.753560.0255sphenodon_punctatusENSSPUP0000000528577.158865.4596
ENSG00000165732homo_sapiensENSP0000034612065.134155.1724crocodylus_porosusENSCPRP0000500893683.881671.0526
ENSG00000165732homo_sapiensENSP0000034612063.984755.0447crocodylus_porosusENSCPRP0000500899982.809971.2397
ENSG00000165732homo_sapiensENSP0000034612071.775260.4087laticauda_laticaudataENSLLTP0000001841780.631367.8623
ENSG00000165732homo_sapiensENSP0000034612013.537711.1111notechis_scutatusENSNSUP0000000177667.948755.7692
ENSG00000165732homo_sapiensENSP0000034612014.176211.622notechis_scutatusENSNSUP0000000178367.682955.4878
ENSG00000165732homo_sapiensENSP0000034612047.254237.8033notechis_scutatusENSNSUP0000002055168.518554.8148
ENSG00000165732homo_sapiensENSP0000034612016.219712.6437notechis_scutatusENSNSUP0000000542465.803151.2953
ENSG00000165732homo_sapiensENSP0000034612071.392160.1533pseudonaja_textilisENSPTXP0000002502680.08667.4785
ENSG00000165732homo_sapiensENSP0000034612073.180160.1533anas_platyrhynchos_platyrhynchosENSAPLP0000001287159.874649.2163
ENSG00000165732homo_sapiensENSP0000034612071.775259.387gallus_gallusENSGALP0001003418978.932665.309
ENSG00000165732homo_sapiensENSP0000034612072.541560.4087meleagris_gallopavoENSMGAP0000000415580.681867.1875
ENSG00000165732homo_sapiensENSP0000034612068.837857.9821serinus_canariaENSSCAP0000001724279.498566.9617
ENSG00000165732homo_sapiensENSP0000034612071.775261.3027parus_majorENSPMJP0000001866978.491667.0391
ENSG00000165732homo_sapiensENSP0000034612074.712661.5581anolis_carolinensisENSACAP0000000971173.95760.9355
ENSG00000165732homo_sapiensENSP0000034612066.155855.0447neolamprologus_brichardiENSNBRP0000000794768.88357.3138
ENSG00000165732homo_sapiensENSP0000034612072.030760.7918naja_najaENSNNAP0000000653680.918268.2927
ENSG00000165732homo_sapiensENSP0000034612073.307861.175podarcis_muralisENSPMRP0000001583171.215959.4293
ENSG00000165732homo_sapiensENSP0000034612069.731859.2593geospiza_fortisENSGFOP0000000467780.294168.2353
ENSG00000165732homo_sapiensENSP0000034612072.286161.0473taeniopygia_guttataENSTGUP0000003228065.282655.1326
ENSG00000165732homo_sapiensENSP0000034612067.049856.5773erpetoichthys_calabaricusENSECRP0000000199964.655254.5567
ENSG00000165732homo_sapiensENSP0000034612018.390815.8365erpetoichthys_calabaricusENSECRP000000302687262
ENSG00000165732homo_sapiensENSP0000034612037.675627.9693erpetoichthys_calabaricusENSECRP0000002896956.297741.7939
ENSG00000165732homo_sapiensENSP0000034612030.906824.1379erpetoichthys_calabaricusENSECRP0000002298860.957247.6071
ENSG00000165732homo_sapiensENSP0000034612066.666754.2784kryptolebias_marmoratusENSKMAP0000002798469.230856.366
ENSG00000165732homo_sapiensENSP0000034612071.647559.7701salvator_merianaeENSSMRP0000001131169.516757.9926
ENSG00000165732homo_sapiensENSP0000034612064.878755.5556amphilophus_citrinellusENSACIP0000000822268.371558.5464
ENSG00000165732homo_sapiensENSP0000034612065.517255.6833dicentrarchus_labraxENSDLAP0000502250167.146657.0681
ENSG00000165732homo_sapiensENSP0000034612065.389555.0447amphiprion_perculaENSAPEP0000000988767.994757.2377
ENSG00000165732homo_sapiensENSP0000034612045.97740.2299oryzias_sinensisENSOSIP0000002996379.470269.5364
ENSG00000165732homo_sapiensENSP0000034612071.902961.3027pelodiscus_sinensisENSPSIP0000000511183.779871.4286
ENSG00000165732homo_sapiensENSP0000034612072.541561.6858gopherus_evgoodeiENSGEVP0000502206780.567468.5106
ENSG00000165732homo_sapiensENSP0000034612058.49350.0639gopherus_evgoodeiENSGEVP0000502214977.495866.3283
ENSG00000165732homo_sapiensENSP0000034612063.984755.4278chelonoidis_abingdoniiENSCABP0000003138683.919672.6968
ENSG00000165732homo_sapiensENSP0000034612073.946462.963chelonoidis_abingdoniiENSCABP0000003138482.361370.128
ENSG00000165732homo_sapiensENSP0000034612067.177555.811seriola_dumeriliENSSDUP0000002969469.576757.8042
ENSG00000165732homo_sapiensENSP0000034612065.772755.0447cottoperca_gobioENSCGOP0000002633968.758357.5434
ENSG00000165732homo_sapiensENSP0000034612065.900456.1941struthio_camelus_australisENSSCUP0000000124586.868774.0741
ENSG00000165732homo_sapiensENSP0000034612071.392158.2375anser_brachyrhynchusENSABRP0000002520176.680462.5514
ENSG00000165732homo_sapiensENSP0000034612061.430452.3627gasterosteus_aculeatusENSGACP0000002118872.113961.4693
ENSG00000165732homo_sapiensENSP0000034612065.900453.7676cynoglossus_semilaevisENSCSEP0000002182867.45155.0327
ENSG00000165732homo_sapiensENSP0000034612065.517254.917poecilia_formosaENSPFOP0000001635564.772754.2929
ENSG00000165732homo_sapiensENSP0000034612055.300147.1264myripristis_murdjanENSMMDP0000501793468.512758.3861
ENSG00000165732homo_sapiensENSP0000034612067.43356.8327myripristis_murdjanENSMMDP0000505563768.839658.0183
ENSG00000165732homo_sapiensENSP0000034612060.025551.8519sander_luciopercaENSSLUP0000003874171.320261.6085
ENSG00000165732homo_sapiensENSP0000034612071.775260.6641strigops_habroptilaENSSHBP0000501237679.154966.9014
ENSG00000165732homo_sapiensENSP0000034612065.389555.0447amphiprion_ocellarisENSAOCP0000001802567.994757.2377
ENSG00000165732homo_sapiensENSP0000034612069.604160.281terrapene_carolina_triunguisENSTMTP0000000869978.080267.6218
ENSG00000165732homo_sapiensENSP0000034612074.968162.963terrapene_carolina_triunguisENSTMTP0000000853272.290660.7143
ENSG00000165732homo_sapiensENSP0000034612066.53955.6833hucho_huchoENSHHUP0000002063767.052856.1133
ENSG00000165732homo_sapiensENSP0000034612066.283555.5556hucho_huchoENSHHUP0000008549466.19955.4847
ENSG00000165732homo_sapiensENSP0000034612065.261854.917betta_splendensENSBSLP0000003388768.775257.8735
ENSG00000165732homo_sapiensENSP0000034612062.835352.235pygocentrus_nattereriENSPNAP0000000947969.688457.932
ENSG00000165732homo_sapiensENSP0000034612066.283555.9387anabas_testudineusENSATEP0000003222568.924358.1673
ENSG00000165732homo_sapiensENSP0000034612059.642451.2133seriola_lalandi_dorsalisENSSLDP0000003355073.427763.0503
ENSG00000165732homo_sapiensENSP0000034612065.772754.6616labrus_bergyltaENSLBEP0000000158667.763256.3158
ENSG00000165732homo_sapiensENSP0000034612057.982150.1916pundamilia_nyerereiENSPNYP0000002059272.990463.1833
ENSG00000165732homo_sapiensENSP0000034612065.006453.2567mastacembelus_armatusENSMAMP0000002922868.41456.0484
ENSG00000165732homo_sapiensENSP0000034612066.283554.7893stegastes_partitusENSSPAP0000001741768.832956.8966
ENSG00000165732homo_sapiensENSP0000034612066.53955.6833oncorhynchus_tshawytschaENSOTSP0000507175166.28555.4707
ENSG00000165732homo_sapiensENSP0000034612046.743338.5696acanthochromis_polyacanthusENSAPOP0000002761467.15655.4128
ENSG00000165732homo_sapiensENSP0000034612071.392159.8978aquila_chrysaetos_chrysaetosENSACCP0002000330878.843466.1495
ENSG00000165732homo_sapiensENSP0000034612067.049854.6616nothobranchius_furzeriENSNFUP0001500886866.287954.0404
ENSG00000165732homo_sapiensENSP0000034612066.283553.5121cyprinodon_variegatusENSCVAP0000001553068.924355.6441
ENSG00000165732homo_sapiensENSP0000034612064.495555.5556denticeps_clupeoidesENSDCDP0000004425269.368159.7527
ENSG00000165732homo_sapiensENSP0000034612066.666756.1941larimichthys_croceaENSLCRP0000502324463.892353.8556
ENSG00000165732homo_sapiensENSP0000034612065.261855.4278takifugu_rubripesENSTRUP0000007978368.40758.0991
ENSG00000165732homo_sapiensENSP0000034612070.498159.8978ficedula_albicollisENSFALP0000001359778.076466.3366
ENSG00000165732homo_sapiensENSP0000034612064.878755.0447hippocampus_comesENSHCOP0000002483865.128255.2564
ENSG00000165732homo_sapiensENSP0000034612065.517254.023cyprinus_carpio_carpioENSCCRP0000013330571.052658.5873
ENSG00000165732homo_sapiensENSP0000034612066.922155.9387cyprinus_carpio_carpioENSCCRP0000011685467.525856.4433
ENSG00000165732homo_sapiensENSP0000034612070.114957.599coturnix_japonicaENSCJPP0000500318878.879364.7989
ENSG00000165732homo_sapiensENSP0000034612061.17550.7024poecilia_latipinnaENSPLAP0000001420670.029258.0409
ENSG00000165732homo_sapiensENSP0000034612063.346151.8519sinocyclocheilus_grahamiENSSGRP0000006316170.958558.083
ENSG00000165732homo_sapiensENSP0000034612059.131548.7867sinocyclocheilus_grahamiENSSGRP0000008475870.903558.4992
ENSG00000165732homo_sapiensENSP0000034612066.411255.3001maylandia_zebraENSMZEP0000501547369.057157.5033
ENSG00000165732homo_sapiensENSP0000034612059.642451.0856tetraodon_nigroviridisENSTNIP0000001680077.190166.1157
ENSG00000165732homo_sapiensENSP0000034612067.177556.0664paramormyrops_kingsleyaeENSPKIP0000003588370.320958.6898
ENSG00000165732homo_sapiensENSP0000034612066.283555.1724scleropages_formosusENSSFOP0001503816770.2358.4574
ENSG00000165732homo_sapiensENSP0000034612062.835345.8493leptobrachium_leishanenseENSLLEP0000003406156.944441.5509
ENSG00000165732homo_sapiensENSP0000034612035.121327.2031leptobrachium_leishanenseENSLLEP0000002483574.728357.8804
ENSG00000165732homo_sapiensENSP0000034612060.153343.4227leptobrachium_leishanenseENSLLEP0000003768563.734846.0081
ENSG00000165732homo_sapiensENSP0000034612065.389553.3844scophthalmus_maximusENSSMAP0000006045770.523457.5758
ENSG00000165732homo_sapiensENSP0000034612065.389554.1507oryzias_melastigmaENSOMEP0000000362066.064554.7097

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001649involved_in osteoblast differentiation1HDAHomo_sapiens(9606)Process
GO:0002735involved_in positive regulation of myeloid dendritic cell cytokine production1IEAHomo_sapiens(9606)Process
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0003724enables RNA helicase activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005694located_in chromosome1IDAHomo_sapiens(9606)Component
GO:0005730is_active_in nucleolus3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1ISSHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling1NASHomo_sapiens(9606)Process
GO:0006364involved_in rRNA processing1IEAHomo_sapiens(9606)Process
GO:0006366involved_in transcription by RNA polymerase II1IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0019843enables rRNA binding1IDAHomo_sapiens(9606)Function
GO:0030515enables snoRNA binding1IDAHomo_sapiens(9606)Function
GO:0035066involved_in positive regulation of histone acetylation1NASHomo_sapiens(9606)Process
GO:0035198enables miRNA binding1IDAHomo_sapiens(9606)Function
GO:0042802enables identical protein binding1IEAHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1ISSHomo_sapiens(9606)Process
GO:0043330involved_in response to exogenous dsRNA1IEAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0045943involved_in positive regulation of transcription by RNA polymerase I1NASHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1NASHomo_sapiens(9606)Process
GO:0045945involved_in positive regulation of transcription by RNA polymerase III1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IEAHomo_sapiens(9606)Process
GO:0062176involved_in R-loop processing1IDAHomo_sapiens(9606)Process
GO:0097322enables 7SK snRNA binding1IDAHomo_sapiens(9606)Function
GO:0110016part_of B-WICH complex1IDAHomo_sapiens(9606)Component

Expression