RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000165609	Gene ID	11164	Accession	8052
Symbol	NUDT5	Alias	YSA1;YSA1H;YSAH1;hNUDT5	Full Name	nudix hydrolase 5
Status	Confidence	Length	30815 bases	Strand	Minus strand
Position	10 : 12165330 - 12196144	RNA binding domain	N.A.
Summary	This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
NUDT5-207	ENST00000491614	3195	219aa	ENSP00000419628
NUDT5-202	ENST00000378937	919	232aa	ENSP00000368219
NUDT5-204	ENST00000378952	917	No protein	-
NUDT5-206	ENST00000476462	622	137aa	ENSP00000436844
NUDT5-203	ENST00000378940	1126	186aa	ENSP00000368222
NUDT5-201	ENST00000378927	1258	180aa	ENSP00000368209
NUDT5-208	ENST00000498825	473	No protein	-
NUDT5-205	ENST00000444732	410	97aa	ENSP00000407856

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000287	enables magnesium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	3	HDA,IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006338	involved_in chromatin remodeling	1	IDA	Homo_sapiens(9606)	Process
GO:0006753	involved_in nucleoside phosphate metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0009117	involved_in nucleotide metabolic process	1	NAS	Homo_sapiens(9606)	Process
GO:0009191	involved_in ribonucleoside diphosphate catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0016779	enables nucleotidyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0019144	enables ADP-sugar diphosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0019303	involved_in D-ribose catabolic process	2	IDA,NAS	Homo_sapiens(9606)	Process
GO:0019693	involved_in ribose phosphate metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0030515	enables snoRNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0044715	enables 8-oxo-dGDP phosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0044716	enables 8-oxo-GDP phosphatase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0047631	enables ADP-ribose diphosphatase activity	3	EXP,IBA,IDA	Homo_sapiens(9606)	Function
GO:0055086	involved_in nucleobase-containing small molecule metabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0140933	NOT enables 5-(N(7)-methylguanosine 5-triphospho)-[mRNA] hydrolase activity	1	ISS	Homo_sapiens(9606)	Function
GO:1990966	involved_in ATP generation from poly-ADP-D-ribose	1	IDA	Homo_sapiens(9606)	Process