RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000164904	Gene ID	501	Accession	877
Symbol	ALDH7A1	Alias	EPD;PDE;ATQ1	Full Name	aldehyde dehydrogenase 7 family member A1
Status	Confidence	Length	64163 bases	Strand	Minus strand
Position	5 : 126531200 - 126595362	RNA binding domain	N.A.
Summary	The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ALDH7A1-234	ENST00000637782	1773	521aa	ENSP00000490024
ALDH7A1-216	ENST00000635851	2135	545aa	ENSP00000490819
ALDH7A1-201	ENST00000409134	4765	539aa	ENSP00000387123
ALDH7A1-226	ENST00000636872	2747	97aa	ENSP00000490919
ALDH7A1-231	ENST00000637206	2466	479aa	ENSP00000489895
ALDH7A1-232	ENST00000637272	2554	536aa	ENSP00000489686
ALDH7A1-228	ENST00000636886	2321	472aa	ENSP00000490371
ALDH7A1-227	ENST00000636879	2501	554aa	ENSP00000490811
ALDH7A1-225	ENST00000636808	2639	77aa	ENSP00000490833
ALDH7A1-224	ENST00000636743	2332	499aa	ENSP00000489725
ALDH7A1-215	ENST00000553117	1935	475aa	ENSP00000448593
ALDH7A1-208	ENST00000485852	579	No protein	-
ALDH7A1-209	ENST00000497231	2255	No protein	-
ALDH7A1-237	ENST00000638010	1755	No protein	-
ALDH7A1-223	ENST00000636482	1337	No protein	-
ALDH7A1-205	ENST00000458249	2037	97aa	ENSP00000403929
ALDH7A1-233	ENST00000637292	1222	164aa	ENSP00000490655
ALDH7A1-236	ENST00000638008	1865	77aa	ENSP00000490400
ALDH7A1-222	ENST00000636286	1431	No protein	-
ALDH7A1-221	ENST00000636225	1738	77aa	ENSP00000490797
ALDH7A1-219	ENST00000636062	1809	No protein	-
ALDH7A1-206	ENST00000476328	484	No protein	-
ALDH7A1-210	ENST00000503281	937	41aa	ENSP00000488032
ALDH7A1-235	ENST00000637964	1065	348aa	ENSP00000490291
ALDH7A1-212	ENST00000509459	538	27aa	ENSP00000487998
ALDH7A1-203	ENST00000413020	1126	294aa	ENSP00000487936
ALDH7A1-204	ENST00000433026	615	No protein	-
ALDH7A1-229	ENST00000636892	3328	No protein	-
ALDH7A1-214	ENST00000511266	1812	No protein	-
ALDH7A1-213	ENST00000510111	719	239aa	ENSP00000447388
ALDH7A1-202	ENST00000412186	555	136aa	ENSP00000414536
ALDH7A1-211	ENST00000509270	608	193aa	ENSP00000449318
ALDH7A1-220	ENST00000636190	1357	No protein	-
ALDH7A1-230	ENST00000637070	203	No protein	-
ALDH7A1-207	ENST00000479989	598	No protein	-
ALDH7A1-218	ENST00000635933	3247	No protein	-
ALDH7A1-217	ENST00000635858	887	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
29039	Cholesterol	6.7230000E-005	-
29530	Cholesterol	7.3970000E-005	-
88583	Osteoporosis	2E-9	20072603

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004029	enables aldehyde dehydrogenase (NAD+) activity	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0004043	enables L-aminoadipate-semialdehyde dehydrogenase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IEA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006081	involved_in cellular aldehyde metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0007605	involved_in sensory perception of sound	1	TAS	Homo_sapiens(9606)	Process
GO:0008802	enables betaine-aldehyde dehydrogenase activity	2	IDA,TAS	Homo_sapiens(9606)	Function
GO:0019285	involved_in glycine betaine biosynthetic process from choline	1	IEA	Homo_sapiens(9606)	Process
GO:0042426	involved_in choline catabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IDA	Homo_sapiens(9606)	Function
GO:0043878	enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	1	IEA	Homo_sapiens(9606)	Function
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component