Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs ncRNA
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000164342 Gene ID 7098 Accession 11849
Symbol TLR3 Alias CD283;IIAE2;IMD83 Full Name toll like receptor 3
Status Confidence Length 19163 bases Strand Plus strand
Position 4 : 186068911 - 186088073 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
22016778 Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3. Yvonne Lai 2011-01-01 PloS one
23369718 Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors. Xiaobing He 2013-04-01 Acta biochimica et biophysica Sinica
29432957 Modulation of toll-like receptor signaling by antimicrobial peptides. Y Ernest Lee 2019-04-01 Seminars in cell & developmental biology
25754842 TLR3/TRIF signalling pathway regulates IL-32 and IFN-β secretion through activation of RIP-1 and TRAF in the human cornea. Bin Ga Park 2015-05-01 Journal of cellular and molecular medicine
26823206 The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Yan Yang 2016-03-01 Cell research
21712495 Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. Peng Zhou 2011-10-01 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
35574644 Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors. Piotr Minias 2022-05-03 Molecular biology and evolution

Transcripts

Name Transcript ID bp Protein Translation ID
TLR3-206 ENST00000698351 1589 299aa ENSP00000513674
TLR3-205 ENST00000513189 1156 351aa ENSP00000423386
TLR3-201 ENST00000296795 6015 904aa ENSP00000296795
TLR3-207 ENST00000698352 5737 74aa ENSP00000513675
TLR3-208 ENST00000698353 5761 No protein -
TLR3-209 ENST00000698354 5389 627aa ENSP00000513676
TLR3-204 ENST00000512264 2942 627aa ENSP00000513668
TLR3-202 ENST00000504367 2310 627aa ENSP00000423684
TLR3-203 ENST00000508051 2328 627aa ENSP00000513677

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
41261Platelet Function Tests2.9739664E-006-
41268Platelet Function Tests4.1571195E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164342homo_sapiensENSP0000037003435.65321.449homo_sapiensENSP0000029679541.371724.8894
ENSG00000164342homo_sapiensENSP0000030686431.203618.7221homo_sapiensENSP0000029679523.230113.9381
ENSG00000164342homo_sapiensENSP000002155394023.3058homo_sapiensENSP0000029679526.769915.5973
ENSG00000164342homo_sapiensENSP0000036308937.306321.0965homo_sapiensENSP0000029679534.623919.5796
ENSG00000164342homo_sapiensENSP0000034424236.961521.3152homo_sapiensENSP0000029679518.03110.3982
ENSG00000164342homo_sapiensENSP0000021803236.503422.1902homo_sapiensENSP0000029679542.035425.5531
ENSG00000164342homo_sapiensENSP0000029159235.797722.179homo_sapiensENSP0000029679510.1776.30531
ENSG00000164342homo_sapiensENSP0000036715736.363622.5455homo_sapiensENSP0000029679511.06196.85841
ENSG00000164342homo_sapiensENSP0000037988035.907320.0772homo_sapiensENSP0000029679510.28765.75221
ENSG00000164342homo_sapiensENSP0000032862534.682119.6532homo_sapiensENSP0000029679526.548715.0442
ENSG00000164342homo_sapiensENSP0000030892535.388420.4686homo_sapiensENSP0000029679531.747818.3628
ENSG00000164342homo_sapiensENSP0000049635540.909124.0093homo_sapiensENSP0000029679538.827422.7876
ENSG00000164342homo_sapiensENSP0000033266838.526923.5127homo_sapiensENSP0000029679515.04429.18142
ENSG00000164342homo_sapiensENSP0000029838629.310316.1804homo_sapiensENSP0000029679524.446913.4956
ENSG00000164342homo_sapiensENSP0000049442538.010220.4082homo_sapiensENSP0000029679532.964617.6991
ENSG00000164342homo_sapiensENSP0000026006135.498522.3565homo_sapiensENSP0000029679525.995616.3717
ENSG00000164342homo_sapiensENSP0000035493237.277420.8651homo_sapiensENSP0000029679532.411518.1416
ENSG00000164342homo_sapiensENSP0000036118531.272717.6364homo_sapiensENSP0000029679519.026510.7301
ENSG00000164342homo_sapiensENSP0000030324829.590517.1731homo_sapiensENSP0000029679524.778814.3805
ENSG00000164342homo_sapiensENSP0000029463512.18936.73617homo_sapiensENSP0000029679516.81429.29204
ENSG00000164342homo_sapiensENSP0000042471834.924620.1005homo_sapiensENSP0000029679530.752217.6991
ENSG00000164342homo_sapiensENSP0000025644735.400921.9365homo_sapiensENSP0000029679525.88516.0398

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164342homo_sapiensENSP0000029679598.672697.677nomascus_leucogenysENSNLEP0000001389698.672697.677
ENSG00000164342homo_sapiensENSP0000029679599.778899.115pan_paniscusENSPPAP0000001632199.778899.115
ENSG00000164342homo_sapiensENSP0000029679598.783298.3407pongo_abeliiENSPPYP0000001704298.783298.3407
ENSG00000164342homo_sapiensENSP0000029679599.889498.8938pan_troglodytesENSPTRP0000002856999.889498.8938
ENSG00000164342homo_sapiensENSP0000029679599.889499.6681gorilla_gorillaENSGGOP0000002724799.889499.6681
ENSG00000164342homo_sapiensENSP0000029679574.446958.0752ornithorhynchus_anatinusENSOANP0000000782474.364658.0111
ENSG00000164342homo_sapiensENSP0000029679583.185871.0177sarcophilus_harrisiiENSSHAP0000000921282.006570.0109
ENSG00000164342homo_sapiensENSP0000029679558.185851.2168notamacropus_eugeniiENSMEUP0000001370766.330458.3859
ENSG00000164342homo_sapiensENSP0000029679585.508979.646choloepus_hoffmanniENSCHOP0000000622285.414479.558
ENSG00000164342homo_sapiensENSP0000029679587.057577.7655dasypus_novemcinctusENSDNOP0000000576686.961377.6796
ENSG00000164342homo_sapiensENSP0000029679588.495681.0841erinaceus_europaeusENSEEUP0000000780088.397880.9945
ENSG00000164342homo_sapiensENSP0000029679586.283278.5398echinops_telfairiENSETEP0000001239986.956579.1527
ENSG00000164342homo_sapiensENSP0000029679596.238992.9204callithrix_jacchusENSCJAP0000001115096.238992.9204
ENSG00000164342homo_sapiensENSP0000029679597.345195.4646cercocebus_atysENSCATP0000001105297.345195.4646
ENSG00000164342homo_sapiensENSP0000029679597.345195.6858macaca_fascicularisENSMFAP0000004019696.491294.8465
ENSG00000164342homo_sapiensENSP0000029679597.234595.6858macaca_mulattaENSMMUP0000002865897.234595.6858
ENSG00000164342homo_sapiensENSP0000029679597.345195.6858macaca_nemestrinaENSMNEP0000001428997.345195.6858
ENSG00000164342homo_sapiensENSP0000029679597.455795.7965papio_anubisENSPANP0000000242097.455795.7965
ENSG00000164342homo_sapiensENSP0000029679596.902795.1327mandrillus_leucophaeusENSMLEP0000002870796.902795.1327
ENSG00000164342homo_sapiensENSP0000029679586.836381.0841tursiops_truncatusENSTTRP0000001479686.836381.0841
ENSG00000164342homo_sapiensENSP0000029679589.933682.7434vulpes_vulpesENSVVUP0000001721690.13382.9268
ENSG00000164342homo_sapiensENSP0000029679587.831979.2035mus_spretusMGP_SPRETEiJ_P008778187.734879.116
ENSG00000164342homo_sapiensENSP0000029679592.477986.2832equus_asinusENSEASP0000505301392.070585.9031
ENSG00000164342homo_sapiensENSP0000029679588.274381.4159capra_hircusENSCHIP0000001510286.928180.1743
ENSG00000164342homo_sapiensENSP0000029679588.93883.0752loxodonta_africanaENSLAFP0000001472988.839882.9834
ENSG00000164342homo_sapiensENSP0000029679589.712482.7434panthera_leoENSPLOP0000002477689.712482.7434
ENSG00000164342homo_sapiensENSP0000029679590.818684.4027ailuropoda_melanoleucaENSAMEP0000000547890.718284.3094
ENSG00000164342homo_sapiensENSP0000029679585.730180.1991oryctolagus_cuniculusENSOCUP0000001525689.388783.6217
ENSG00000164342homo_sapiensENSP0000029679592.035485.8407equus_caballusENSECAP0000002614988.699482.7292
ENSG00000164342homo_sapiensENSP0000029679590.929283.9602canis_lupus_familiarisENSCAFP0084502732990.828783.8674
ENSG00000164342homo_sapiensENSP0000029679589.933682.854panthera_pardusENSPPRP0000000623989.933682.854
ENSG00000164342homo_sapiensENSP0000029679592.14684.7345marmota_marmota_marmotaENSMMMP0000001189692.044284.6409
ENSG00000164342homo_sapiensENSP0000029679587.942581.4159balaenoptera_musculusENSBMSP0001003028382.298176.1905
ENSG00000164342homo_sapiensENSP0000029679590.486783.2965cavia_porcellusENSCPOP0000002620990.386783.2044
ENSG00000164342homo_sapiensENSP0000029679588.93882.0796felis_catusENSFCAP0000002883687.677280.916
ENSG00000164342homo_sapiensENSP0000029679590.929284.6239ursus_americanusENSUAMP0000001943790.828784.5304
ENSG00000164342homo_sapiensENSP0000029679584.181473.8938monodelphis_domesticaENSMODP0000000598484.088473.8122
ENSG00000164342homo_sapiensENSP0000029679589.491182.7434bison_bison_bisonENSBBBP0000000531589.491182.7434
ENSG00000164342homo_sapiensENSP0000029679587.278881.1947monodon_monocerosENSMMNP0001501681087.182381.105
ENSG00000164342homo_sapiensENSP0000029679591.150483.6283sus_scrofaENSSSCP0000001674591.251483.7209
ENSG00000164342homo_sapiensENSP0000029679593.252289.0487microcebus_murinusENSMICP0000001755693.149288.9503
ENSG00000164342homo_sapiensENSP0000029679590.929284.6239ursus_maritimusENSUMAP0000001676890.828784.5304
ENSG00000164342homo_sapiensENSP0000029679561.725755.8628ochotona_princepsENSOPRP0000000551661.725755.8628
ENSG00000164342homo_sapiensENSP0000029679587.389481.3053delphinapterus_leucasENSDLEP0000000712987.292881.2155
ENSG00000164342homo_sapiensENSP0000029679589.269981.5266physeter_catodonENSPCTP0000501092755.847851.0035
ENSG00000164342homo_sapiensENSP0000029679587.610678.8717mus_caroliMGP_CAROLIEiJ_P008430187.513878.7845
ENSG00000164342homo_sapiensENSP0000029679587.942579.4248mus_musculusENSMUSP0000003405687.845379.337
ENSG00000164342homo_sapiensENSP0000029679587.942579.0929dipodomys_ordiiENSDORP0000002627686.980378.2276
ENSG00000164342homo_sapiensENSP0000029679576.106270.9071mustela_putorius_furoENSMPUP0000001114490.052483.9005
ENSG00000164342homo_sapiensENSP0000029679596.79294.6903aotus_nancymaaeENSANAP0000000987596.471994.3771
ENSG00000164342homo_sapiensENSP0000029679597.013394.469saimiri_boliviensis_boliviensisENSSBOP0000002519497.013394.469
ENSG00000164342homo_sapiensENSP0000029679580.420475.4425vicugna_pacosENSVPAP0000001146580.957775.9465
ENSG00000164342homo_sapiensENSP0000029679597.013395.1327chlorocebus_sabaeusENSCSAP0000001509797.013395.1327
ENSG00000164342homo_sapiensENSP0000029679561.172655.8628tupaia_belangeriENSTBEP0000000520063.055957.5827
ENSG00000164342homo_sapiensENSP0000029679588.606280.1991mesocricetus_auratusENSMAUP0000002441188.508380.1105
ENSG00000164342homo_sapiensENSP0000029679587.610681.0841phocoena_sinusENSPSNP0000002995287.513880.9945
ENSG00000164342homo_sapiensENSP0000029679590.265584.6239camelus_dromedariusENSCDRP0000501734190.56684.9057
ENSG00000164342homo_sapiensENSP0000029679590.265584.5133carlito_syrichtaENSTSYP0000000825890.165784.4199
ENSG00000164342homo_sapiensENSP0000029679589.82382.9646panthera_tigris_altaicaENSPTIP0000000545389.82382.9646
ENSG00000164342homo_sapiensENSP0000029679587.942580.3097rattus_norvegicusENSRNOP0000007041585.760578.3172
ENSG00000164342homo_sapiensENSP0000029679593.362889.2699prolemur_simusENSPSMP0000001487593.259789.1713
ENSG00000164342homo_sapiensENSP0000029679586.61578.9823microtus_ochrogasterENSMOCP0000001000586.519378.895
ENSG00000164342homo_sapiensENSP0000029679589.048779.9779sorex_araneusENSSARP0000001067889.147380.0664
ENSG00000164342homo_sapiensENSP0000029679587.942580.531peromyscus_maniculatus_bairdiiENSPEMP0000000741487.845380.442
ENSG00000164342homo_sapiensENSP0000029679589.491182.7434bos_mutusENSBMUP0000000699889.491182.7434
ENSG00000164342homo_sapiensENSP0000029679587.942579.3142mus_spicilegusENSMSIP0000003243887.845379.2265
ENSG00000164342homo_sapiensENSP0000029679588.053179.7566cricetulus_griseus_chok1gshdENSCGRP0000101268787.955879.6685
ENSG00000164342homo_sapiensENSP0000029679591.039884.292pteropus_vampyrusENSPVAP0000000552791.140684.3854
ENSG00000164342homo_sapiensENSP0000029679589.380582.5221myotis_lucifugusENSMLUP0000001143789.281882.4309
ENSG00000164342homo_sapiensENSP0000029679583.185872.677vombatus_ursinusENSVURP0001000841583.093972.5967
ENSG00000164342homo_sapiensENSP0000029679591.261185.5089rhinolophus_ferrumequinumENSRFEP0001002026791.160285.4144
ENSG00000164342homo_sapiensENSP0000029679584.513377.6549neovison_visonENSNVIP0000000796887.715380.597
ENSG00000164342homo_sapiensENSP0000029679587.580.8628bos_taurusENSBTAP0000006698389.378582.5989
ENSG00000164342homo_sapiensENSP0000029679590.154983.0752heterocephalus_glaber_femaleENSHGLP0000001091188.973881.9869
ENSG00000164342homo_sapiensENSP0000029679598.008996.2389rhinopithecus_bietiENSRBIP0000000786098.117496.3455
ENSG00000164342homo_sapiensENSP0000029679590.929283.8496canis_lupus_dingoENSCAFP0002000092688.673181.7691
ENSG00000164342homo_sapiensENSP0000029679591.703585.0664sciurus_vulgarisENSSVLP0000500624791.602284.9724
ENSG00000164342homo_sapiensENSP0000029679583.960272.8982phascolarctos_cinereusENSPCIP0000004191283.132572.1796
ENSG00000164342homo_sapiensENSP0000029679551.991148.0089procavia_capensisENSPCAP0000001126051.933747.9558
ENSG00000164342homo_sapiensENSP000002967958.296467.74336nannospalax_galiliENSNGAP0000002072380.645275.2688
ENSG00000164342homo_sapiensENSP0000029679585.951377.6549bos_grunniensENSBGRP0000002631354.756949.4715
ENSG00000164342homo_sapiensENSP0000029679588.93882.4115chinchilla_lanigeraENSCLAP0000001765589.036582.5028
ENSG00000164342homo_sapiensENSP0000029679588.827481.5266cervus_hanglu_yarkandensisENSCHYP0000001991185.882478.8235
ENSG00000164342homo_sapiensENSP0000029679591.703584.5133catagonus_wagneriENSCWAP0000000477591.602284.4199
ENSG00000164342homo_sapiensENSP0000029679591.703584.292ictidomys_tridecemlineatusENSSTOP0000002223691.602284.1989
ENSG00000164342homo_sapiensENSP0000029679591.814285.5089otolemur_garnettiiENSOGAP0000001866091.712785.4144
ENSG00000164342homo_sapiensENSP0000029679597.234595.1327cebus_imitatorENSCCAP0000001630997.234595.1327
ENSG00000164342homo_sapiensENSP0000029679591.703584.4027urocitellus_parryiiENSUPAP0001000800791.602284.3094
ENSG00000164342homo_sapiensENSP0000029679589.380582.6327moschus_moschiferusENSMMSP0000002695488.113481.4613
ENSG00000164342homo_sapiensENSP0000029679598.119596.3496rhinopithecus_roxellanaENSRROP0000000166098.119596.3496
ENSG00000164342homo_sapiensENSP0000029679587.831979.7566mus_pahariMGP_PahariEiJ_P004719887.734879.6685
ENSG00000164342homo_sapiensENSP0000029679592.809788.938propithecus_coquereliENSPCOP0000000941392.707288.8398
ENSG00000164342homo_sapiensENSP0000029679556.637238.2743petromyzon_marinusENSPMAP0000000177656.387738.1057
ENSG00000164342homo_sapiensENSP0000029679550.774334.9558eptatretus_burgeriENSEBUP0000001986058.471340.2548
ENSG00000164342homo_sapiensENSP0000029679570.464652.4336callorhinchus_miliiENSCMIP0000003490470.542652.4917
ENSG00000164342homo_sapiensENSP0000029679561.283248.1195latimeria_chalumnaeENSLACP0000001295672.323856.7885
ENSG00000164342homo_sapiensENSP0000029679526.216814.0487clupea_harengusENSCHAP0000005688843.090923.0909
ENSG00000164342homo_sapiensENSP0000029679529.64615.5973danio_rerioENSDARP0000009502347.517725
ENSG00000164342homo_sapiensENSP0000029679524.336313.6062xiphophorus_maculatusENSXMAP0000002000647.516226.5659
ENSG00000164342homo_sapiensENSP0000029679530.309718.3628cyclopterus_lumpusENSCLMP0000504948142.679125.8567
ENSG00000164342homo_sapiensENSP0000029679529.756617.3673haplochromis_burtoniENSHBUP0000000909941.900324.4548
ENSG00000164342homo_sapiensENSP0000029679531.305317.5885astatotilapia_callipteraENSACLP0000004059839.142521.9917
ENSG00000164342homo_sapiensENSP0000029679529.977917.6991sparus_aurataENSSAUP0001002344242.015524.8062
ENSG00000164342homo_sapiensENSP0000029679538.716823.0089sparus_aurataENSSAUP0001005005237.23422.1277
ENSG00000164342homo_sapiensENSP0000029679537.610622.4558lates_calcariferENSLCAP0001001325638.202222.809
ENSG00000164342homo_sapiensENSP0000029679579.64664.4911chrysemys_picta_belliiENSCPBP0000001199980.357165.067
ENSG00000164342homo_sapiensENSP0000029679577.433662.0575sphenodon_punctatusENSSPUP0000002052878.12562.6116
ENSG00000164342homo_sapiensENSP0000029679576.991162.1681crocodylus_porosusENSCPRP0000501672677.247562.3751
ENSG00000164342homo_sapiensENSP0000029679566.371751.4381laticauda_laticaudataENSLLTP0000000930270.588254.7059
ENSG00000164342homo_sapiensENSP0000029679572.566456.6372notechis_scutatusENSNSUP0000001280873.625157.4635
ENSG00000164342homo_sapiensENSP0000029679572.123956.3053pseudonaja_textilisENSPTXP0000000230173.176257.1268
ENSG00000164342homo_sapiensENSP0000029679577.212461.615anas_platyrhynchos_platyrhynchosENSAPLP0000000866376.367660.9409
ENSG00000164342homo_sapiensENSP0000029679566.924852.7655gallus_gallusENSGALP0001002422162.824549.5327
ENSG00000164342homo_sapiensENSP0000029679576.769960.0664meleagris_gallopavoENSMGAP0000001195177.455460.6027
ENSG00000164342homo_sapiensENSP0000029679576.880560.8407serinus_canariaENSSCAP0000001316977.827561.5901
ENSG00000164342homo_sapiensENSP0000029679576.548760.5089parus_majorENSPMJP0000000305977.232161.0491
ENSG00000164342homo_sapiensENSP0000029679572.345156.6372anolis_carolinensisENSACAP0000000166073.400757.4635
ENSG00000164342homo_sapiensENSP0000029679571.570856.4159naja_najaENSNNAP0000001232171.968956.7297
ENSG00000164342homo_sapiensENSP0000029679572.898257.6327podarcis_muralisENSPMRP0000001402573.878958.4081
ENSG00000164342homo_sapiensENSP0000029679576.880561.0619geospiza_fortisENSGFOP0000001047977.653661.676
ENSG00000164342homo_sapiensENSP0000029679576.659360.9513taeniopygia_guttataENSTGUP0000000708977.343861.4955
ENSG00000164342homo_sapiensENSP0000029679572.123955.9734salvator_merianaeENSSMRP0000001247373.094256.7265
ENSG00000164342homo_sapiensENSP0000029679529.64617.8097amphilophus_citrinellusENSACIP0000003079236.662122.0246
ENSG00000164342homo_sapiensENSP0000029679536.946923.0089dicentrarchus_labraxENSDLAP0000503371637.65523.4498
ENSG00000164342homo_sapiensENSP0000029679577.765562.8319pelodiscus_sinensisENSPSIP0000001213478.459863.3929
ENSG00000164342homo_sapiensENSP0000029679579.314264.0487gopherus_evgoodeiENSGEVP0000500282380.022364.6205
ENSG00000164342homo_sapiensENSP0000029679578.982364.3805chelonoidis_abingdoniiENSCABP0000000545279.598764.8829
ENSG00000164342homo_sapiensENSP0000029679526.991115.2655seriola_dumeriliENSSDUP0000000379142.80724.2105
ENSG00000164342homo_sapiensENSP0000029679537.942522.677seriola_dumeriliENSSDUP0000001123538.068822.7525
ENSG00000164342homo_sapiensENSP0000029679539.159323.0089cottoperca_gobioENSCGOP0000001562939.8223.3971
ENSG00000164342homo_sapiensENSP0000029679578.429261.9469struthio_camelus_australisENSSCUP0000001060279.217962.5698
ENSG00000164342homo_sapiensENSP0000029679577.654961.5044anser_brachyrhynchusENSABRP0000002396978.435862.1229
ENSG00000164342homo_sapiensENSP0000029679528.539816.9248gasterosteus_aculeatusENSGACP0000000946439.876423.6476
ENSG00000164342homo_sapiensENSP0000029679514.04878.07522gasterosteus_aculeatusENSGACP0000000946647.924527.5472
ENSG00000164342homo_sapiensENSP0000029679576.548759.7345strigops_habroptilaENSSHBP0000501444375.217458.6957
ENSG00000164342homo_sapiensENSP0000029679579.535464.0487terrapene_carolina_triunguisENSTMTP0000000951280.245564.6205
ENSG00000164342homo_sapiensENSP0000029679529.977918.3628anabas_testudineusENSATEP0000002977642.080725.7764
ENSG00000164342homo_sapiensENSP0000029679538.274323.2301seriola_lalandi_dorsalisENSSLDP0000002539739.051923.702
ENSG00000164342homo_sapiensENSP0000029679527.101815.0442seriola_lalandi_dorsalisENSSLDP0000002235842.982523.8596
ENSG00000164342homo_sapiensENSP0000029679531.084117.5885pundamilia_nyerereiENSPNYP0000000085138.758621.931
ENSG00000164342homo_sapiensENSP0000029679530.641618.9159stegastes_partitusENSSPAP0000002161343.281226.7188
ENSG00000164342homo_sapiensENSP0000029679577.101860.6195aquila_chrysaetos_chrysaetosENSACCP0002001414577.877161.229
ENSG00000164342homo_sapiensENSP0000029679524.557512.5denticeps_clupeoidesENSDCDP0000002855938.541719.6181
ENSG00000164342homo_sapiensENSP0000029679518.805310.177denticeps_clupeoidesENSDCDP0000001362138.374720.7675
ENSG00000164342homo_sapiensENSP0000029679529.867317.9204larimichthys_croceaENSLCRP0000505935642.121725.273
ENSG00000164342homo_sapiensENSP0000029679545.35425.1106takifugu_rubripesENSTRUP0000001917039.234521.7225
ENSG00000164342homo_sapiensENSP0000029679527.986715.3761takifugu_rubripesENSTRUP0000004520844.153624.2583
ENSG00000164342homo_sapiensENSP0000029679539.933623.3407takifugu_rubripesENSTRUP0000001133140.837123.8688
ENSG00000164342homo_sapiensENSP0000029679577.212460.5089ficedula_albicollisENSFALP0000001245975.70559.3275
ENSG00000164342homo_sapiensENSP0000029679527.876116.7035hippocampus_comesENSHCOP0000001550344.133126.4448
ENSG00000164342homo_sapiensENSP0000029679565.486751.6593coturnix_japonicaENSCJPP0000500776563.11349.7868
ENSG00000164342homo_sapiensENSP0000029679531.305317.8097maylandia_zebraENSMZEP0000500667338.451121.875
ENSG00000164342homo_sapiensENSP0000029679538.38523.1195tetraodon_nigroviridisENSTNIP0000000873839.431823.75
ENSG00000164342homo_sapiensENSP0000029679545.243425tetraodon_nigroviridisENSTNIP0000001805838.584921.3208
ENSG00000164342homo_sapiensENSP0000029679569.358452.5442leptobrachium_leishanenseENSLLEP0000000169769.358452.5442
ENSG00000164342homo_sapiensENSP0000029679532.522119.1372scophthalmus_maximusENSSMAP0000000569436.981121.761

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1TASHomo_sapiens(9606)Component
GO:0001774involved_in microglial cell activation1IEAHomo_sapiens(9606)Process
GO:0002224involved_in toll-like receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0002730involved_in regulation of dendritic cell cytokine production1IEAHomo_sapiens(9606)Process
GO:0003725enables double-stranded RNA binding3IBA,IDA,NASHomo_sapiens(9606)Function
GO:0004888enables transmembrane signaling receptor activity1NASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615is_active_in extracellular space1IBAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005765located_in lysosomal membrane1HDAHomo_sapiens(9606)Component
GO:0005769is_active_in early endosome1IDAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IEAHomo_sapiens(9606)Component
GO:0006972involved_in hyperosmotic response1NASHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007250involved_in activation of NF-kappaB-inducing kinase activity1NASHomo_sapiens(9606)Process
GO:0007252involved_in I-kappaB phosphorylation1IDAHomo_sapiens(9606)Process
GO:0007254involved_in JNK cascade1IEAHomo_sapiens(9606)Process
GO:0008584involved_in male gonad development1IEAHomo_sapiens(9606)Process
GO:0009597involved_in detection of virus1NASHomo_sapiens(9606)Process
GO:0009986NOT located_in cell surface1IDAHomo_sapiens(9606)Component
GO:0010008located_in endosome membrane1TASHomo_sapiens(9606)Component
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1NASHomo_sapiens(9606)Component
GO:0031012is_active_in extracellular matrix1IBAHomo_sapiens(9606)Component
GO:0032722involved_in positive regulation of chemokine production1IDAHomo_sapiens(9606)Process
GO:0032727involved_in positive regulation of interferon-alpha production1IDAHomo_sapiens(9606)Process
GO:0032728involved_in positive regulation of interferon-beta production3IDA,IMP,ISSHomo_sapiens(9606)Process
GO:0032729involved_in positive regulation of type II interferon production1IDAHomo_sapiens(9606)Process
GO:0032735involved_in positive regulation of interleukin-12 production1ISSHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production1IDAHomo_sapiens(9606)Process
GO:0032757acts_upstream_of positive regulation of interleukin-8 production1IDAHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1ISSHomo_sapiens(9606)Process
GO:0034138involved_in toll-like receptor 3 signaling pathway1IDAHomo_sapiens(9606)Process
GO:0034343involved_in type III interferon production1IEAHomo_sapiens(9606)Process
GO:0034346involved_in positive regulation of type III interferon production1IEAHomo_sapiens(9606)Process
GO:0035458involved_in cellular response to interferon-beta1IEAHomo_sapiens(9606)Process
GO:0036020located_in endolysosome membrane1TASHomo_sapiens(9606)Component
GO:0038023enables signaling receptor activity1TASHomo_sapiens(9606)Function
GO:0038187enables pattern recognition receptor activity1IDAHomo_sapiens(9606)Function
GO:0042742involved_in defense response to bacterium1TASHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043065involved_in positive regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IEAHomo_sapiens(9606)Process
GO:0043330acts_upstream_of_or_within response to exogenous dsRNA1IDAHomo_sapiens(9606)Process
GO:0043331involved_in response to dsRNA1IBAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1TASHomo_sapiens(9606)Process
GO:0045671involved_in negative regulation of osteoclast differentiation1NASHomo_sapiens(9606)Process
GO:0045766involved_in positive regulation of angiogenesis1IEAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0046330involved_in positive regulation of JNK cascade1IDAHomo_sapiens(9606)Process
GO:0050729involved_in positive regulation of inflammatory response1ICHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IEAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus2IEP,TASHomo_sapiens(9606)Process
GO:0060907involved_in positive regulation of macrophage cytokine production1IEAHomo_sapiens(9606)Process
GO:0071260involved_in cellular response to mechanical stimulus1IEPHomo_sapiens(9606)Process
GO:0071346involved_in cellular response to type II interferon1IEAHomo_sapiens(9606)Process
GO:0071360involved_in cellular response to exogenous dsRNA1IEAHomo_sapiens(9606)Process
GO:0071466involved_in cellular response to xenobiotic stimulus1IEAHomo_sapiens(9606)Process
GO:0090594involved_in inflammatory response to wounding1IDAHomo_sapiens(9606)Process
GO:0097191involved_in extrinsic apoptotic signaling pathway1IDAHomo_sapiens(9606)Process
GO:0097527involved_in necroptotic signaling pathway1IDAHomo_sapiens(9606)Process
GO:0098586involved_in cellular response to virus1IEAHomo_sapiens(9606)Process
GO:1900017involved_in positive regulation of cytokine production involved in inflammatory response1IEAHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process

Expression