RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000163918	Gene ID	5984	Accession	9972
Symbol	RFC4	Alias	A1;RFC37	Full Name	replication factor C subunit 4
Status	Confidence	Length	17179 bases	Strand	Minus strand
Position	3 : 186789880 - 186807058	RNA binding domain	N.A.
Summary	The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
RFC4-207	ENST00000433496	1111	336aa	ENSP00000399769
RFC4-211	ENST00000479307	1043	No protein	-
RFC4-202	ENST00000392481	1448	363aa	ENSP00000376272
RFC4-201	ENST00000296273	1365	363aa	ENSP00000296273
RFC4-204	ENST00000417876	479	111aa	ENSP00000401429
RFC4-213	ENST00000494047	1393	No protein	-
RFC4-210	ENST00000460408	628	No protein	-
RFC4-205	ENST00000418288	701	214aa	ENSP00000411300
RFC4-209	ENST00000449502	799	97aa	ENSP00000394870
RFC4-212	ENST00000489028	533	No protein	-
RFC4-206	ENST00000427785	485	123aa	ENSP00000407982
RFC4-208	ENST00000448497	453	95aa	ENSP00000415099
RFC4-203	ENST00000411792	560	43aa	ENSP00000399314

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
65326	Adiponectin	1E-19	20876611
71085	Adiponectin	2E-22	24105470
81018	Adiponectin	4E-7	26299439
81779	Adiponectin	8E-6	26299439
90226	Adiponectin	3E-12	20011104
91261	Adiponectin	2E-42	22479202

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003689	contributes_to DNA clamp loader activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005663	part_of DNA replication factor C complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006261	involved_in DNA-templated DNA replication	1	IBA	Homo_sapiens(9606)	Process
GO:0006271	involved_in DNA strand elongation involved in DNA replication	1	TAS	Homo_sapiens(9606)	Process
GO:0006281	involved_in DNA repair	1	IBA	Homo_sapiens(9606)	Process
GO:0016887	enables ATP hydrolysis activity	1	IEA	Homo_sapiens(9606)	Function
GO:0017116	contributes_to single-stranded DNA helicase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0031390	part_of Ctf18 RFC-like complex	1	IDA	Homo_sapiens(9606)	Component
GO:0031391	part_of Elg1 RFC-like complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032508	involved_in DNA duplex unwinding	1	IEA	Homo_sapiens(9606)	Process
GO:1900264	involved_in positive regulation of DNA-directed DNA polymerase activity	1	IDA	Homo_sapiens(9606)	Process