RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000163491	Gene ID	152110	Accession	18592
Symbol	NEK10	Alias	CILD44	Full Name	NIMA related kinase 10
Status	Confidence	Length	262977 bases	Strand	Minus strand
Position	3 : 27106484 - 27369460	RNA binding domain	RIO1
Summary	Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000412651	RIO1	PF01163	2.7e-05	1
ENSP00000392344	RIO1	PF01163	3.9e-05	1
ENSP00000343847	RIO1	PF01163	0.0003	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
NEK10-213	ENST00000691995	8332	1115aa	ENSP00000509472
NEK10-201	ENST00000295720	2871	484aa	ENSP00000295720
NEK10-203	ENST00000383771	2023	474aa	ENSP00000373281
NEK10-205	ENST00000429845	4250	1172aa	ENSP00000395849
NEK10-211	ENST00000498182	858	No protein	-
NEK10-212	ENST00000574215	1601	No protein	-
NEK10-208	ENST00000460447	654	No protein	-
NEK10-202	ENST00000341435	2638	712aa	ENSP00000343847
NEK10-206	ENST00000435584	652	166aa	ENSP00000412651
NEK10-204	ENST00000424275	743	196aa	ENSP00000392344
NEK10-209	ENST00000474938	451	No protein	-
NEK10-210	ENST00000491627	3713	No protein	-
NEK10-207	ENST00000435750	671	132aa	ENSP00000395338

Gene Model

Click here to download ENSG00000163491's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
39340	Platelet Function Tests	3.2700000E-008	-
74827	Breast Neoplasms	5E-12	24493630
97155	Alzheimer Disease	7E-6	27770636
104912	Adenocarcinoma of lung	2E-9	27197191
104913	Breast Neoplasms	2E-9	27197191
104914	Carcinoma, Non-Small-Cell Lung	2E-9	27197191
104915	Lung Neoplasms	2E-9	27197191
104916	Ovarian Neoplasms	2E-9	27197191
104917	Prostatic Neoplasms	2E-9	27197191
104918	Colorectal Neoplasms	2E-9	27197191
104919	Carcinoma, Endometrioid	2E-9	27197191

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000163491's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004672	enables protein kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	IEA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0031954	involved_in positive regulation of protein autophosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0043406	involved_in positive regulation of MAP kinase activity	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0070372	involved_in regulation of ERK1 and ERK2 cascade	1	IMP	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0120197	involved_in mucociliary clearance	1	IMP	Homo_sapiens(9606)	Process
GO:1902749	involved_in regulation of cell cycle G2/M phase transition	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:1902911	part_of protein kinase complex	1	IDA	Homo_sapiens(9606)	Component

Expression