RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000161634	Gene ID	117159	Accession	14669
Symbol	DCD	Alias	PIF;AIDD;DSEP;HCAP;DCD-1	Full Name	dermcidin
Status	Confidence	Length	3905 bases	Strand	Minus strand
Position	12 : 54644589 - 54648493	RNA binding domain	N.A.
Summary	This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
DCD-201	ENST00000293371	519	110aa	ENSP00000293371
DCD-203	ENST00000546807	773	77aa	ENSP00000450415
DCD-202	ENST00000456047	670	121aa	ENSP00000406773

Gene Model

Click here to download ENSG00000161634's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
10564	Osteoporosis	5.57768528811278E-5	17903296
30289	Calcium	1.9790000E-005	-
30301	Calcium	9.8410000E-006	-
40550	Platelet Function Tests	6.4900000E-007	-
40551	Platelet Function Tests	6.4900000E-007	-
88159	Diabetes Mellitus, Type 2	2E-7	18372903

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000161634's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000161634	homo_sapiens	ENSP00000257867	36.2319	21.0145	homo_sapiens	ENSP00000293371	45.4545	26.3636

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	85.4545	nomascus_leucogenys	ENSNLEP00000037283	80	78.3333
ENSG00000161634	homo_sapiens	ENSP00000293371	100	100	pan_paniscus	ENSPPAP00000036240	100	100
ENSG00000161634	homo_sapiens	ENSP00000293371	90.9091	88.1818	pongo_abelii	ENSPPYP00000038412	83.3333	80.8333
ENSG00000161634	homo_sapiens	ENSP00000293371	91.8182	90.9091	pan_troglodytes	ENSPTRP00000060508	84.1667	83.3333
ENSG00000161634	homo_sapiens	ENSP00000293371	90.9091	90	gorilla_gorilla	ENSGGOP00000008198	83.3333	82.5
ENSG00000161634	homo_sapiens	ENSP00000293371	82.7273	77.2727	callithrix_jacchus	ENSCJAP00000084620	65.4676	61.1511
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	81.8182	cercocebus_atys	ENSCATP00000026968	80.6723	75.6302
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	81.8182	macaca_fascicularis	ENSMFAP00000007049	80.6723	75.6302
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	81.8182	macaca_nemestrina	ENSMNEP00000019389	80.6723	75.6302
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	81.8182	papio_anubis	ENSPANP00000044714	80.6723	75.6302
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	81.8182	mandrillus_leucophaeus	ENSMLEP00000026962	80.6723	75.6302
ENSG00000161634	homo_sapiens	ENSP00000293371	84.5455	75.4545	aotus_nancymaae	ENSANAP00000035013	77.5	69.1667
ENSG00000161634	homo_sapiens	ENSP00000293371	80.9091	73.6364	saimiri_boliviensis_boliviensis	ENSSBOP00000010651	74.1667	67.5
ENSG00000161634	homo_sapiens	ENSP00000293371	90.9091	86.3636	chlorocebus_sabaeus	ENSCSAP00000001676	88.4956	84.0708
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	83.6364	rhinopithecus_bieti	ENSRBIP00000039240	80.6723	77.3109
ENSG00000161634	homo_sapiens	ENSP00000293371	81.8182	70.9091	cebus_imitator	ENSCCAP00000001454	75	65
ENSG00000161634	homo_sapiens	ENSP00000293371	87.2727	83.6364	rhinopithecus_roxellana	ENSRROP00000017817	80.6723	77.3109

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005576	is_active_in extracellular region	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0006508	involved_in proteolysis	1	IEA	Homo_sapiens(9606)	Process
GO:0008233	enables peptidase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0016020	located_in membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0042742	involved_in defense response to bacterium	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0050832	involved_in defense response to fungus	1	IEA	Homo_sapiens(9606)	Process
GO:0051873	involved_in killing by host of symbiont cells	1	IDA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component

Expression