Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000160075 Gene ID 29101 Accession 25016
Symbol SSU72 Alias HSPC182;PNAS-120 Full Name SSU72 homolog, RNA polymerase II CTD phosphatase
Status Confidence Length 33191 bases Strand Minus strand
Position 1 : 1541673 - 1574863 RNA binding domain Ssu72
Summary Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and mRNA polyadenylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000291386 Ssu72 PF04722 1.8e-91 1
ENSP00000351955 Ssu72 PF04722 5.4e-34 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SSU72-201 ENST00000291386 1284 194aa ENSP00000291386
SSU72-204 ENST00000378726 2238 No protein -
SSU72-203 ENST00000378725 619 No protein -
SSU72-202 ENST00000359060 4176 153aa ENSP00000351955

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
27812Blood Glucose1.8920000E-005-
27841Blood Glucose8.7610000E-007-
27850Blood Glucose3.2550000E-005-
28068Blood Glucose6.4440000E-005-
28085Blood Glucose2.5370000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005847part_of mRNA cleavage and polyadenylation specificity factor complex1IBAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0006369involved_in termination of RNA polymerase II transcription1IBAHomo_sapiens(9606)Process
GO:0006378involved_in mRNA polyadenylation2IBA,IMPHomo_sapiens(9606)Process
GO:0008420enables RNA polymerase II CTD heptapeptide repeat phosphatase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0017018enables myosin phosphatase activity1IEAHomo_sapiens(9606)Function

Expression