Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligaseKinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000158828 Gene ID 65018 Accession 14581
Symbol PINK1 Alias BRPK;PARK6 Full Name PTEN induced kinase 1
Status Confidence Length 18054 bases Strand Plus strand
Position 1 : 20633458 - 20651511 RNA binding domain N.A.
Summary This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35216662 Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. B Angelika Harbauer 2022-05-04 Neuron
35324667 Fumonisin B2 Induces Mitochondrial Stress and Mitophagy in Human Embryonic Kidney (Hek293) Cells-A Preliminary Study. Jivanka Mohan 2022-02-25 Toxins

Transcripts

Name Transcript ID bp Protein Translation ID
PINK1-201 ENST00000321556 2657 581aa ENSP00000364204
PINK1-203 ENST00000492302 3821 No protein -
PINK1-202 ENST00000400490 1658 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000287enables magnesium ion binding1IDAHomo_sapiens(9606)Function
GO:0000422involved_in autophagy of mitochondrion2IBA,IMPHomo_sapiens(9606)Process
GO:0000423involved_in mitophagy1IGIHomo_sapiens(9606)Process
GO:0000785part_of chromatin1IDAHomo_sapiens(9606)Component
GO:0001934involved_in positive regulation of protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0002020enables protease binding2IPI,TASHomo_sapiens(9606)Function
GO:0002082involved_in regulation of oxidative phosphorylation1IDAHomo_sapiens(9606)Process
GO:0002931involved_in response to ischemia1IEAHomo_sapiens(9606)Process
GO:0004672enables protein kinase activity1IMPHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity4IBA,IDA,ISS,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739is_active_in mitochondrion4IBA,IDA,IGI,IMPHomo_sapiens(9606)Component
GO:0005741located_in mitochondrial outer membrane3IDA,IMP,TASHomo_sapiens(9606)Component
GO:0005743located_in mitochondrial inner membrane1IDAHomo_sapiens(9606)Component
GO:0005758located_in mitochondrial intermembrane space2IDA,TASHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005856located_in cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation4IBA,IDA,IMP,TASHomo_sapiens(9606)Process
GO:0006511involved_in ubiquitin-dependent protein catabolic process1TASHomo_sapiens(9606)Process
GO:0006979involved_in response to oxidative stress1IGIHomo_sapiens(9606)Process
GO:0007005involved_in mitochondrion organization1IMPHomo_sapiens(9606)Process
GO:0010310involved_in regulation of hydrogen peroxide metabolic process1IEAHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1ISSHomo_sapiens(9606)Process
GO:0010821involved_in regulation of mitochondrion organization1IMPHomo_sapiens(9606)Process
GO:0010857enables calcium-dependent protein kinase activity1IDAHomo_sapiens(9606)Function
GO:0010952involved_in positive regulation of peptidase activity1TASHomo_sapiens(9606)Process
GO:0014046involved_in dopamine secretion1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1IDAHomo_sapiens(9606)Component
GO:0016239involved_in positive regulation of macroautophagy1IMPHomo_sapiens(9606)Process
GO:0016242involved_in negative regulation of macroautophagy1IMPHomo_sapiens(9606)Process
GO:0016301enables kinase activity2IDA,NASHomo_sapiens(9606)Function
GO:0016504enables peptidase activator activity1TASHomo_sapiens(9606)Function
GO:0016567involved_in protein ubiquitination1IMPHomo_sapiens(9606)Process
GO:0018105involved_in peptidyl-serine phosphorylation3IDA,ISS,TASHomo_sapiens(9606)Process
GO:0022904involved_in respiratory electron transport chain1IEAHomo_sapiens(9606)Process
GO:0030097acts_upstream_of_or_within hemopoiesis1IGIHomo_sapiens(9606)Process
GO:0030424located_in axon1IDAHomo_sapiens(9606)Component
GO:0030426located_in growth cone1IEAHomo_sapiens(9606)Component
GO:0031396involved_in regulation of protein ubiquitination2IDA,IMPHomo_sapiens(9606)Process
GO:0031398involved_in positive regulation of protein ubiquitination1ISSHomo_sapiens(9606)Process
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0032148involved_in activation of protein kinase B activity1ICHomo_sapiens(9606)Process
GO:0032226involved_in positive regulation of synaptic transmission, dopaminergic1IEAHomo_sapiens(9606)Process
GO:0033138involved_in positive regulation of peptidyl-serine phosphorylation3IDA,IMP,TASHomo_sapiens(9606)Process
GO:0033603involved_in positive regulation of dopamine secretion1IEAHomo_sapiens(9606)Process
GO:0034599involved_in cellular response to oxidative stress1IMPHomo_sapiens(9606)Process
GO:0035307involved_in positive regulation of protein dephosphorylation1IEAHomo_sapiens(9606)Process
GO:0035556involved_in intracellular signal transduction1IDAHomo_sapiens(9606)Process
GO:0036289involved_in peptidyl-serine autophosphorylation2IMP,TASHomo_sapiens(9606)Process
GO:0038203involved_in TORC2 signaling1ICHomo_sapiens(9606)Process
GO:0042981involved_in regulation of apoptotic process1IBAHomo_sapiens(9606)Process
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0043254involved_in regulation of protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0043422enables protein kinase B binding1IDAHomo_sapiens(9606)Function
GO:0043524involved_in negative regulation of neuron apoptotic process1IMPHomo_sapiens(9606)Process
GO:0044297located_in cell body1IDAHomo_sapiens(9606)Component
GO:0044877enables protein-containing complex binding1IMPHomo_sapiens(9606)Function
GO:0045727involved_in positive regulation of translation1IEAHomo_sapiens(9606)Process
GO:0046329involved_in negative regulation of JNK cascade1TASHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0050821involved_in protein stabilization1IMPHomo_sapiens(9606)Process
GO:0051091involved_in positive regulation of DNA-binding transcription factor activity1IEAHomo_sapiens(9606)Process
GO:0051443involved_in positive regulation of ubiquitin-protein transferase activity1TASHomo_sapiens(9606)Process
GO:0051881involved_in regulation of mitochondrial membrane potential2IGI,IMPHomo_sapiens(9606)Process
GO:0051897involved_in positive regulation of protein kinase B signaling1ICHomo_sapiens(9606)Process
GO:0055131enables C3HC4-type RING finger domain binding1IPIHomo_sapiens(9606)Function
GO:0061136involved_in regulation of proteasomal protein catabolic process1NASHomo_sapiens(9606)Process
GO:0071456involved_in cellular response to hypoxia1IMPHomo_sapiens(9606)Process
GO:0072655involved_in establishment of protein localization to mitochondrion1IMPHomo_sapiens(9606)Process
GO:0072656involved_in maintenance of protein location in mitochondrion1IMPHomo_sapiens(9606)Process
GO:0090141involved_in positive regulation of mitochondrial fission1IBAHomo_sapiens(9606)Process
GO:0090200involved_in positive regulation of release of cytochrome c from mitochondria1IMPHomo_sapiens(9606)Process
GO:0090258involved_in negative regulation of mitochondrial fission1IMPHomo_sapiens(9606)Process
GO:0097237involved_in cellular response to toxic substance1TASHomo_sapiens(9606)Process
GO:0097413located_in Lewy body1TASHomo_sapiens(9606)Component
GO:0097449located_in astrocyte projection1IDAHomo_sapiens(9606)Component
GO:0098779involved_in positive regulation of mitophagy in response to mitochondrial depolarization1IMPHomo_sapiens(9606)Process
GO:0099074involved_in mitochondrion to lysosome transport1IMPHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IMPHomo_sapiens(9606)Function
GO:1900407involved_in regulation of cellular response to oxidative stress1IMPHomo_sapiens(9606)Process
GO:1901525involved_in negative regulation of mitophagy1IMPHomo_sapiens(9606)Process
GO:1902803involved_in regulation of synaptic vesicle transport1TASHomo_sapiens(9606)Process
GO:1902902involved_in negative regulation of autophagosome assembly1IMPHomo_sapiens(9606)Process
GO:1902958involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone1TASHomo_sapiens(9606)Process
GO:1903146involved_in regulation of autophagy of mitochondrion1TASHomo_sapiens(9606)Process
GO:1903214involved_in regulation of protein targeting to mitochondrion3IDA,IGI,IMPHomo_sapiens(9606)Process
GO:1903298involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway1IEAHomo_sapiens(9606)Process
GO:1903377involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway1IDAHomo_sapiens(9606)Process
GO:1903384involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway2IDA,IMPHomo_sapiens(9606)Process
GO:1903751involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide1IDAHomo_sapiens(9606)Process
GO:1903852involved_in positive regulation of cristae formation1IMPHomo_sapiens(9606)Process
GO:1903955involved_in positive regulation of protein targeting to mitochondrion1HMPHomo_sapiens(9606)Process
GO:1904544involved_in positive regulation of free ubiquitin chain polymerization1ISSHomo_sapiens(9606)Process
GO:1904783involved_in positive regulation of NMDA glutamate receptor activity1IEAHomo_sapiens(9606)Process
GO:1904841enables TORC2 complex binding1IPIHomo_sapiens(9606)Function
GO:1904881involved_in cellular response to hydrogen sulfide1IEAHomo_sapiens(9606)Process
GO:2000377involved_in regulation of reactive oxygen species metabolic process2IGI,IMPHomo_sapiens(9606)Process
GO:2000378involved_in negative regulation of reactive oxygen species metabolic process1IMPHomo_sapiens(9606)Process
GO:2001171involved_in positive regulation of ATP biosynthetic process1TASHomo_sapiens(9606)Process
GO:2001243involved_in negative regulation of intrinsic apoptotic signaling pathway1IDAHomo_sapiens(9606)Process

Expression