RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	diverse
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000157036	Gene ID	9941	Accession	3347
Symbol	EXOG	Alias	ENGL;ENGLA;ENGLB;ENGL-a;ENGL-b;ENDOGL1;ENDOGL2	Full Name	exo/endonuclease G
Status	Confidence	Length	30177 bases	Strand	Plus strand
Position	3 : 38496127 - 38526303	RNA binding domain	Endonuclease_NS
Summary	This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000287675	Endonuclease_NS	PF01223	2.9e-59	1
ENSP00000404305	Endonuclease_NS	PF01223	4.6e-50	1
ENSP00000397124	Endonuclease_NS	PF01223	8.7e-42	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
30949702	A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.	Chyuan-Chuan Wu	2019-06-04	Nucleic acids research

Name	Transcript ID	bp	Protein	Translation ID
EXOG-202	ENST00000412107	1467	56aa	ENSP00000400239
EXOG-205	ENST00000436414	1679	81aa	ENSP00000413176
EXOG-207	ENST00000443942	576	56aa	ENSP00000412841
EXOG-201	ENST00000287675	3076	368aa	ENSP00000287675
EXOG-217	ENST00000630638	197	56aa	ENSP00000487559
EXOG-204	ENST00000431472	1255	107aa	ENSP00000394977
EXOG-208	ENST00000447573	1750	56aa	ENSP00000406101
EXOG-216	ENST00000489813	580	No protein	-
EXOG-203	ENST00000422077	1317	318aa	ENSP00000404305
EXOG-211	ENST00000454803	1548	146aa	ENSP00000412756
EXOG-206	ENST00000438992	1440	56aa	ENSP00000407641
EXOG-212	ENST00000457367	2075	143aa	ENSP00000402164
EXOG-210	ENST00000453767	576	187aa	ENSP00000397124
EXOG-209	ENST00000450732	710	107aa	ENSP00000415568
EXOG-213	ENST00000470291	455	15aa	ENSP00000421649
EXOG-214	ENST00000474071	1799	No protein	-
EXOG-215	ENST00000483749	871	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
24102	Body Fat Distribution	7.7260000E-005	-
24192	Body Fat Distribution	3.3350000E-005	-
71742	Electrocardiography	1E-12	27659466
86665	Electrocardiography	3E-23	27577874

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000014	enables single-stranded DNA endodeoxyribonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004519	enables endonuclease activity	2	IDA,NAS	Homo_sapiens(9606)	Function
GO:0004521	enables RNA endonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005743	is_active_in mitochondrial inner membrane	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006309	involved_in apoptotic DNA fragmentation	1	IBA	Homo_sapiens(9606)	Process
GO:0008150	involved_in biological_process	1	ND	Homo_sapiens(9606)	Process
GO:0008409	enables 5-3 exonuclease activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0032991	part_of protein-containing complex	1	IDA	Homo_sapiens(9606)	Component
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function