RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000155368	Gene ID	1622	Accession	2690
Symbol	DBI	Alias	EP;ACBP;ACBD1;CCK-RP	Full Name	diazepam binding inhibitor, acyl-CoA binding protein
Status	Confidence	Length	5627 bases	Strand	Plus strand
Position	2 : 119366924 - 119372550	RNA binding domain	N.A.
Summary	This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
DBI-202	ENST00000355857	564	87aa	ENSP00000348116
DBI-207	ENST00000492375	784	No protein	-
DBI-210	ENST00000627093	554	129aa	ENSP00000486281
DBI-204	ENST00000409094	576	104aa	ENSP00000386486
DBI-201	ENST00000311521	714	104aa	ENSP00000311117
DBI-205	ENST00000460901	774	No protein	-
DBI-211	ENST00000627305	620	148aa	ENSP00000486361
DBI-203	ENST00000393103	599	88aa	ENSP00000376815
DBI-206	ENST00000475783	842	No protein	-
DBI-209	ENST00000535757	740	104aa	ENSP00000439012
DBI-208	ENST00000535617	654	97aa	ENSP00000442917

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
71375	Energy Intake	9E-7	23251661

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000062	enables fatty-acyl-CoA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005783	located_in endoplasmic reticulum	1	IDA	Homo_sapiens(9606)	Component
GO:0005788	located_in endoplasmic reticulum lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0006631	involved_in fatty acid metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0030156	enables benzodiazepine receptor binding	1	TAS	Homo_sapiens(9606)	Function
GO:0032994	part_of protein-lipid complex	1	IDA	Homo_sapiens(9606)	Component
GO:0036042	enables long-chain fatty acyl-CoA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0036151	involved_in phosphatidylcholine acyl-chain remodeling	1	IDA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:1903060	involved_in negative regulation of protein lipidation	1	IDA	Homo_sapiens(9606)	Process
GO:1905920	involved_in positive regulation of CoA-transferase activity	1	IDA	Homo_sapiens(9606)	Process
GO:2001140	involved_in positive regulation of phospholipid transport	1	IDA	Homo_sapiens(9606)	Process