RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

Ensembl ID	ENSG00000151883	Gene ID	79668	Accession	26124
Symbol	PARP8	Alias	ARTD16;pART16	Full Name	poly(ADP-ribose) polymerase family member 8
Status	Confidence	Length	180621 bases	Strand	Plus strand
Position	5 : 50665899 - 50846519	RNA binding domain	PARP
Summary	Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000424814	PARP	PF00644	5.7e-14	1
ENSP00000423946	PARP	PF00644	6.2e-14	1
ENSP00000281631	PARP	PF00644	6.4e-14	1
ENSP00000422217	PARP	PF00644	6.4e-14	1
ENSP00000439022	PARP	PF00644	1.3e-13	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PARP8-208	ENST00000503790	597	No protein	-
PARP8-212	ENST00000505697	2747	854aa	ENSP00000422217
PARP8-216	ENST00000511363	2860	No protein	-
PARP8-213	ENST00000507812	554	49aa	ENSP00000422183
PARP8-209	ENST00000503888	577	45aa	ENSP00000421503
PARP8-215	ENST00000510303	615	91aa	ENSP00000422288
PARP8-202	ENST00000502524	332	77aa	ENSP00000426243
PARP8-201	ENST00000281631	7475	854aa	ENSP00000281631
PARP8-222	ENST00000515175	513	105aa	ENSP00000423133
PARP8-217	ENST00000513414	484	No protein	-
PARP8-214	ENST00000510040	1728	No protein	-
PARP8-218	ENST00000513738	596	133aa	ENSP00000422355
PARP8-206	ENST00000503665	572	57aa	ENSP00000427138
PARP8-207	ENST00000503707	576	96aa	ENSP00000426679
PARP8-219	ENST00000514067	2829	812aa	ENSP00000424814
PARP8-203	ENST00000503046	464	116aa	ENSP00000421708
PARP8-204	ENST00000503193	574	57aa	ENSP00000424916
PARP8-221	ENST00000515166	2730	253aa	ENSP00000424485
PARP8-211	ENST00000505554	3825	833aa	ENSP00000423946
PARP8-210	ENST00000505180	521	No protein	-
PARP8-205	ENST00000503561	2818	No protein	-
PARP8-220	ENST00000514342	2384	494aa	ENSP00000439022

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
3331	Cholesterol, HDL	1.19910656590947E-5	17903299
3332	Cholesterol, HDL	7.89166108192398E-6	17903299
5525	Lipoproteins, VLDL	1.95519905352958E-8	17903299
5536	Lipoproteins, VLDL	5.4434968041542E-10	17903299
32959	Glomerular Filtration Rate	9.5134241E-005	-
38664	Platelet Function Tests	1.0924500E-005	-
44117	Platelet Function Tests	2.4068832E-006	-
44334	Platelet Function Tests	2.3778783E-006	-
57764	Plaque, Atherosclerotic	1.5700000E-006	21909108
57769	Plaque, Atherosclerotic	1.3080000E-005	21909108
63942	Memory	1E-6	25648963
63943	Neuropsychological Tests	1E-6	25648963
64159	Memory	3E-8	25648963
64160	Neuropsychological Tests	3E-8	25648963
85065	Myopia, Degenerative	4E-6	22685421
106412	Amyloidosis, Cerebral, with Spongiform Encephalopathy	8E-8	26252872
106825	Behavior	5E-6	23874384

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003950	enables NAD+ ADP-ribosyltransferase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005635	is_active_in nuclear envelope	1	IBA	Homo_sapiens(9606)	Component
GO:0016779	enables nucleotidyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0019900	enables kinase binding	1	IBA	Homo_sapiens(9606)	Function
GO:0030968	involved_in endoplasmic reticulum unfolded protein response	1	IBA	Homo_sapiens(9606)	Process
GO:0043539	enables protein serine/threonine kinase activator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0070213	involved_in protein auto-ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0071782	is_active_in endoplasmic reticulum tubular network	1	IBA	Homo_sapiens(9606)	Component
GO:0140803	enables NAD+- protein-cysteine ADP-ribosyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1990404	enables NAD+-protein ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function