RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000151726	Gene ID	2180	Accession	3569
Symbol	ACSL1	Alias	ACS1;LACS;FACL1;FACL2;LACS1;LACS2	Full Name	acyl-CoA synthetase long chain family member 1
Status	Confidence	Length	71224 bases	Strand	Minus strand
Position	4 : 184755595 - 184826818	RNA binding domain	N.A.
Summary	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ACSL1-212	ENST00000706366	3712	698aa	ENSP00000516351
ACSL1-201	ENST00000281455	3712	698aa	ENSP00000281455
ACSL1-202	ENST00000454703	3636	527aa	ENSP00000407165
ACSL1-209	ENST00000513001	2796	No protein	-
ACSL1-211	ENST00000515030	3948	698aa	ENSP00000422607
ACSL1-203	ENST00000503407	3791	688aa	ENSP00000425098
ACSL1-213	ENST00000706367	3823	698aa	ENSP00000516352
ACSL1-214	ENST00000706368	3879	698aa	ENSP00000516353
ACSL1-206	ENST00000505492	3641	672aa	ENSP00000425640
ACSL1-215	ENST00000706369	3663	698aa	ENSP00000516354
ACSL1-216	ENST00000706370	2319	659aa	ENSP00000516355
ACSL1-208	ENST00000507295	2490	664aa	ENSP00000426244
ACSL1-207	ENST00000506733	2646	126aa	ENSP00000426491
ACSL1-204	ENST00000504342	2333	698aa	ENSP00000425006
ACSL1-210	ENST00000513317	2469	698aa	ENSP00000426150
ACSL1-205	ENST00000504900	1583	388aa	ENSP00000424935

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
16106	Stroke	8.5355664E-004	19369658
18270	Fetal Hemoglobin	2.241e-007	-
21013	Esthetics	5.241e-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000038	involved_in very long-chain fatty acid metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0001676	involved_in long-chain fatty acid metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0004467	enables long-chain fatty acid-CoA ligase activity	2	IDA,TAS	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0005741	located_in mitochondrial outer membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0005778	located_in peroxisomal membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0005783	is_active_in endoplasmic reticulum	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0007584	involved_in response to nutrient	1	IEA	Homo_sapiens(9606)	Process
GO:0008610	involved_in lipid biosynthetic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0010747	involved_in positive regulation of long-chain fatty acid import across plasma membrane	1	ISS	Homo_sapiens(9606)	Process
GO:0014070	involved_in response to organic cyclic compound	1	IEA	Homo_sapiens(9606)	Process
GO:0015908	involved_in fatty acid transport	1	IMP	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	2	HDA,IBA	Homo_sapiens(9606)	Component
GO:0019432	involved_in triglyceride biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0033211	involved_in adiponectin-activated signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0034201	involved_in response to oleic acid	1	IEA	Homo_sapiens(9606)	Process
GO:0035338	involved_in long-chain fatty-acyl-CoA biosynthetic process	2	IBA,TAS	Homo_sapiens(9606)	Process
GO:0042178	involved_in xenobiotic catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0043539	enables protein serine/threonine kinase activator activity	1	IEA	Homo_sapiens(9606)	Function
GO:0044539	involved_in long-chain fatty acid import into cell	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0047676	enables arachidonate-CoA ligase activity	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0050197	enables phytanate-CoA ligase activity	1	ISS	Homo_sapiens(9606)	Function
GO:0070251	enables pristanate-CoA ligase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0090434	enables oleoyl-CoA ligase activity	1	ISS	Homo_sapiens(9606)	Function
GO:0120162	involved_in positive regulation of cold-induced thermogenesis	1	ISS	Homo_sapiens(9606)	Process