RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000148672	Gene ID	2746	Accession	4335
Symbol	GLUD1	Alias	GDH;GDH1;GLUD;hGDH1	Full Name	glutamate dehydrogenase 1
Status	Confidence	Length	44642 bases	Strand	Minus strand
Position	10 : 87050202 - 87094843	RNA binding domain	N.A.
Summary	This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
GLUD1-201	ENST00000277865	3300	558aa	ENSP00000277865
GLUD1-227	ENST00000684699	5521	No protein	-
GLUD1-205	ENST00000681987	2766	No protein	-
GLUD1-212	ENST00000683256	2719	391aa	ENSP00000507901
GLUD1-213	ENST00000683269	3085	391aa	ENSP00000508107
GLUD1-211	ENST00000683022	2949	47aa	ENSP00000508288
GLUD1-207	ENST00000682396	2919	73aa	ENSP00000506764
GLUD1-203	ENST00000474574	4498	No protein	-
GLUD1-217	ENST00000683813	2651	No protein	-
GLUD1-214	ENST00000683647	6257	No protein	-
GLUD1-218	ENST00000684032	2759	43aa	ENSP00000506969
GLUD1-220	ENST00000684338	2979	532aa	ENSP00000507457
GLUD1-204	ENST00000487058	2643	No protein	-
GLUD1-226	ENST00000684690	3119	No protein	-
GLUD1-219	ENST00000684201	2623	466aa	ENSP00000507887
GLUD1-208	ENST00000682507	2533	391aa	ENSP00000508098
GLUD1-215	ENST00000683649	1673	No protein	-
GLUD1-225	ENST00000684665	1781	No protein	-
GLUD1-216	ENST00000683783	2570	391aa	ENSP00000507881
GLUD1-206	ENST00000681988	2777	391aa	ENSP00000507316
GLUD1-223	ENST00000684434	2281	39aa	ENSP00000507505
GLUD1-209	ENST00000682622	2958	153aa	ENSP00000506732
GLUD1-224	ENST00000684546	2491	391aa	ENSP00000507729
GLUD1-221	ENST00000684372	2037	391aa	ENSP00000508244
GLUD1-210	ENST00000682833	1732	171aa	ENSP00000507701
GLUD1-202	ENST00000465164	503	No protein	-
GLUD1-222	ENST00000684392	1889	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
20277	Cholesterol, HDL	1.275e-005	-
72562	Nose	3E-7	27560520

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004352	enables glutamate dehydrogenase (NAD+) activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0004353	enables glutamate dehydrogenase [NAD(P)+] activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004354	enables glutamate dehydrogenase (NADP+) activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005525	enables GTP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0005783	located_in endoplasmic reticulum	1	IDA	Homo_sapiens(9606)	Component
GO:0006537	involved_in glutamate biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0006538	involved_in glutamate catabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0006541	involved_in glutamine metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0021762	involved_in substantia nigra development	1	HEP	Homo_sapiens(9606)	Process
GO:0032024	involved_in positive regulation of insulin secretion	1	IMP	Homo_sapiens(9606)	Process
GO:0042803	enables protein homodimerization activity	1	IPI	Homo_sapiens(9606)	Function
GO:0043531	enables ADP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0070403	enables NAD+ binding	1	IDA	Homo_sapiens(9606)	Function
GO:0070728	enables leucine binding	1	IDA	Homo_sapiens(9606)	Function
GO:0072350	involved_in tricarboxylic acid metabolic process	1	ISS	Homo_sapiens(9606)	Process