Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000148308 Gene ID 9328 Accession 4668
Symbol GTF3C5 Alias TFIIIC63;TFiiiC2-63;TFIIICepsilon Full Name general transcription factor IIIC subunit 5
Status Confidence Length 27829 bases Strand Plus strand
Position 9 : 133030675 - 133058503 RNA binding domain Tau95_N , Tau95
Summary Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000339530 Tau95_N PF17682 1.1e-28 1
ENSP00000339530 Tau95 PF09734 9.6e-13 2
ENSP00000361169 Tau95_N PF17682 1.5e-28 1
ENSP00000361169 Tau95 PF09734 8.7e-39 2
ENSP00000361180 Tau95_N PF17682 1.5e-28 1
ENSP00000361180 Tau95 PF09734 8.8e-39 2
ENSP00000389498 Tau95_N PF17682 1.3e-17 1
ENSP00000389498 Tau95 PF09734 2.1e-18 2
ENSP00000393207 Tau95 PF09734 1.9e-39 1
ENSP00000361171 Tau95 PF09734 5.5e-32 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
GTF3C5-203 ENST00000372099 1999 345aa ENSP00000361171
GTF3C5-207 ENST00000440319 920 244aa ENSP00000389498
GTF3C5-202 ENST00000372097 2098 519aa ENSP00000361169
GTF3C5-204 ENST00000372108 2110 526aa ENSP00000361180
GTF3C5-201 ENST00000342018 1905 457aa ENSP00000339530
GTF3C5-206 ENST00000439697 823 224aa ENSP00000393207
GTF3C5-209 ENST00000485692 827 No protein -
GTF3C5-208 ENST00000461871 623 No protein -
GTF3C5-205 ENST00000435745 736 90aa ENSP00000397961
GTF3C5-210 ENST00000489842 696 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000127part_of transcription factor TFIIIC complex2IBA,IDAHomo_sapiens(9606)Component
GO:0000995enables RNA polymerase III general transcription initiation factor activity1IDAHomo_sapiens(9606)Function
GO:0001002contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0001003contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0003677contributes_to DNA binding1ICHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0006383involved_in transcription by RNA polymerase III1ICHomo_sapiens(9606)Process
GO:0006384involved_in transcription initiation at RNA polymerase III promoter1IEAHomo_sapiens(9606)Process
GO:0035914involved_in skeletal muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0042791involved_in 5S class rRNA transcription by RNA polymerase III1ICHomo_sapiens(9606)Process
GO:0042797involved_in tRNA transcription by RNA polymerase III1ICHomo_sapiens(9606)Process

Expression