Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000148218 Gene ID 210 Accession 395
Symbol ALAD Alias PBGS;ALADH Full Name aminolevulinate dehydratase
Status Confidence Length 14979 bases Strand Minus strand
Position 9 : 113386312 - 113401290 RNA binding domain N.A.
Summary The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ALAD-201 ENST00000409155 3129 330aa ENSP00000386284
ALAD-208 ENST00000482847 3247 No protein -
ALAD-206 ENST00000468504 851 No protein -
ALAD-205 ENST00000464749 563 No protein -
ALAD-203 ENST00000448137 536 120aa ENSP00000392748
ALAD-207 ENST00000482001 562 No protein -
ALAD-204 ENST00000452726 583 59aa ENSP00000415737
ALAD-209 ENST00000494848 547 No protein -
ALAD-202 ENST00000445750 703 14aa ENSP00000398438

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
2875Hemoglobin A, Glycosylated6.57952803608808E-517903298
30384Basophils3.2510000E-005-
63650blood2E-625820613
69978blood4E-1425820613

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001666involved_in response to hypoxia1IEAHomo_sapiens(9606)Process
GO:0003824enables catalytic activity1TASHomo_sapiens(9606)Function
GO:0004655enables porphobilinogen synthase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005634located_in nucleus1HDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0006782involved_in protoporphyrinogen IX biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0006783involved_in heme biosynthetic process2IBA,IDAHomo_sapiens(9606)Process
GO:0006979involved_in response to oxidative stress1IEAHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding2IBA,IDAHomo_sapiens(9606)Function
GO:0009410involved_in response to xenobiotic stimulus1IEAHomo_sapiens(9606)Process
GO:0009635involved_in response to herbicide1IEAHomo_sapiens(9606)Process
GO:0010039involved_in response to iron ion1IEAHomo_sapiens(9606)Process
GO:0010043involved_in response to zinc ion1IEAHomo_sapiens(9606)Process
GO:0010044involved_in response to aluminum ion1IEAHomo_sapiens(9606)Process
GO:0010212involved_in response to ionizing radiation1IEAHomo_sapiens(9606)Process
GO:0010266involved_in response to vitamin B11IEAHomo_sapiens(9606)Process
GO:0010269involved_in response to selenium ion1IEAHomo_sapiens(9606)Process
GO:0014823involved_in response to activity1IEAHomo_sapiens(9606)Process
GO:0032025involved_in response to cobalt ion1IEAHomo_sapiens(9606)Process
GO:0032496involved_in response to lipopolysaccharide1IEAHomo_sapiens(9606)Process
GO:0033197involved_in response to vitamin E1IEAHomo_sapiens(9606)Process
GO:0034774located_in secretory granule lumen1TASHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043200involved_in response to amino acid1IEAHomo_sapiens(9606)Process
GO:0045471involved_in response to ethanol1IEAHomo_sapiens(9606)Process
GO:0046685involved_in response to arsenic-containing substance1IEAHomo_sapiens(9606)Process
GO:0046686involved_in response to cadmium ion1IEAHomo_sapiens(9606)Process
GO:0046689involved_in response to mercury ion1IEAHomo_sapiens(9606)Process
GO:0051260involved_in protein homooligomerization1IPIHomo_sapiens(9606)Process
GO:0051384involved_in response to glucocorticoid1IEAHomo_sapiens(9606)Process
GO:0051597involved_in response to methylmercury1IEAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070541involved_in response to platinum ion1IEAHomo_sapiens(9606)Process
GO:0070542involved_in response to fatty acid1IEAHomo_sapiens(9606)Process
GO:0071284involved_in cellular response to lead ion1IEAHomo_sapiens(9606)Process
GO:0071353involved_in cellular response to interleukin-41IEAHomo_sapiens(9606)Process
GO:1901799involved_in negative regulation of proteasomal protein catabolic process1IDAHomo_sapiens(9606)Process
GO:1904813located_in ficolin-1-rich granule lumen1TASHomo_sapiens(9606)Component
GO:1904854enables proteasome core complex binding1IEAHomo_sapiens(9606)Function

Expression