RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000147421	Gene ID	79618	Accession	26137
Symbol	HMBOX1	Alias	HOT1;TAH1;PBHNF;HNF1LA	Full Name	homeobox containing 1
Status	Confidence	Length	174370 bases	Strand	Plus strand
Position	8 : 28890395 - 29064764	RNA binding domain	N.A.
Summary	Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of telomerase activity; and positive regulation of telomere maintenance via telomerase. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
HMBOX1-201	ENST00000287701	3711	420aa	ENSP00000287701
HMBOX1-207	ENST00000519662	811	118aa	ENSP00000429767
HMBOX1-212	ENST00000558662	1765	405aa	ENSP00000453211
HMBOX1-210	ENST00000523613	1730	396aa	ENSP00000452827
HMBOX1-215	ENST00000560599	1426	364aa	ENSP00000453185
HMBOX1-203	ENST00000397358	4082	420aa	ENSP00000380516
HMBOX1-214	ENST00000560357	979	No protein	-
HMBOX1-206	ENST00000519047	1551	386aa	ENSP00000430059
HMBOX1-208	ENST00000521516	2216	304aa	ENSP00000430238
HMBOX1-213	ENST00000560269	569	No protein	-
HMBOX1-202	ENST00000355231	1694	386aa	ENSP00000475196
HMBOX1-211	ENST00000524238	1731	443aa	ENSP00000430110
HMBOX1-205	ENST00000518080	559	No protein	-
HMBOX1-204	ENST00000517386	761	No protein	-
HMBOX1-209	ENST00000522468	817	45aa	ENSP00000429854
HMBOX1-216	ENST00000561377	307	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
4186	Triglycerides	5.21002327071862E-5	17903299
6846	C-Reactive Protein	7.27829925104562E-5	17903293
7141	C-Reactive Protein	2.15687394882202E-5	17903293
23873	Waist-Hip Ratio	2.1440000E-005	-
25323	Waist-Hip Ratio	5.4440000E-005	-
63607	Hormones	6E-6	23251661

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0000781	located_in chromosome, telomeric region	2	HDA,IDA	Homo_sapiens(9606)	Component
GO:0000785	part_of chromatin	1	ISA	Homo_sapiens(9606)	Component
GO:0003691	enables double-stranded telomeric DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0015030	located_in Cajal body	1	IEA	Homo_sapiens(9606)	Component
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0016605	located_in PML body	1	IEA	Homo_sapiens(9606)	Component
GO:0032212	involved_in positive regulation of telomere maintenance via telomerase	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0035563	involved_in positive regulation of chromatin binding	1	ISS	Homo_sapiens(9606)	Process
GO:0042162	enables telomeric DNA binding	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043565	enables sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0044877	enables protein-containing complex binding	1	IPI	Homo_sapiens(9606)	Function
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0051972	involved_in regulation of telomerase activity	1	IDA	Homo_sapiens(9606)	Process
GO:0051973	involved_in positive regulation of telomerase activity	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function