Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000147162 Gene ID 8473 Accession 8127
Symbol OGT Alias OGT1;HRNT1;MRX106;XLID106;HINCUT-1;O-GLCNAC Full Name O-linked N-acetylglucosamine (GlcNAc) transferase
Status Confidence Length 42806 bases Strand Plus strand
Position X : 71533087 - 71575892 RNA binding domain N.A.
Summary This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34502531 OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGT. Junfeng Ma 2021-09-06 International journal of molecular sciences
35356257 Ogt Demonstrated Conspicuous Clinical Significance in Cancers, from Pan-Cancer to Small-Cell Lung Cancer. Deng Tang 2022-01-01 Journal of oncology

Transcripts

Name Transcript ID bp Protein Translation ID
OGT-215 ENST00000699779 8385 73aa ENSP00000514585
OGT-216 ENST00000699780 4121 264aa ENSP00000514586
OGT-217 ENST00000699781 5094 182aa ENSP00000514587
OGT-218 ENST00000699782 5256 1013aa ENSP00000514588
OGT-210 ENST00000488174 7243 No protein -
OGT-202 ENST00000373719 5435 1046aa ENSP00000362824
OGT-212 ENST00000699749 4193 1023aa ENSP00000514559
OGT-219 ENST00000699783 4105 994aa ENSP00000514589
OGT-213 ENST00000699750 5763 170aa ENSP00000514560
OGT-220 ENST00000699784 5253 997aa ENSP00000514590
OGT-221 ENST00000699785 5969 180aa ENSP00000514591
OGT-201 ENST00000373701 3310 1036aa ENSP00000362805
OGT-208 ENST00000472270 689 No protein -
OGT-211 ENST00000498566 601 No protein -
OGT-203 ENST00000444774 556 156aa ENSP00000399729
OGT-204 ENST00000455587 632 No protein -
OGT-214 ENST00000699751 5401 No protein -
OGT-205 ENST00000459760 541 No protein -
OGT-206 ENST00000462638 400 No protein -
OGT-207 ENST00000466181 421 No protein -
OGT-209 ENST00000474633 564 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1NASHomo_sapiens(9606)Process
GO:0000123part_of histone acetyltransferase complex1IDAHomo_sapiens(9606)Component
GO:0000423involved_in mitophagy1ISSHomo_sapiens(9606)Process
GO:0000432involved_in positive regulation of transcription from RNA polymerase II promoter by glucose1IEAHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005547enables phosphatidylinositol-3,4,5-trisphosphate binding1IDAHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006110involved_in regulation of glycolytic process1IDAHomo_sapiens(9606)Process
GO:0006111involved_in regulation of gluconeogenesis1ISSHomo_sapiens(9606)Process
GO:0006325involved_in chromatin organization1IEAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1IMPHomo_sapiens(9606)Process
GO:0006493involved_in protein O-linked glycosylation3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IDAHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007584involved_in response to nutrient1TASHomo_sapiens(9606)Process
GO:0008375enables acetylglucosaminyltransferase activity1TASHomo_sapiens(9606)Function
GO:0016485involved_in protein processing1IMPHomo_sapiens(9606)Process
GO:0016580part_of Sin3 complex1NASHomo_sapiens(9606)Component
GO:0017122part_of protein N-acetylglucosaminyltransferase complex1IDAHomo_sapiens(9606)Component
GO:0030097involved_in hemopoiesis1ISSHomo_sapiens(9606)Process
GO:0030336involved_in negative regulation of cell migration1NASHomo_sapiens(9606)Process
GO:0030512involved_in negative regulation of transforming growth factor beta receptor signaling pathway1NASHomo_sapiens(9606)Process
GO:0031397involved_in negative regulation of protein ubiquitination2IMP,ISSHomo_sapiens(9606)Process
GO:0031490enables chromatin DNA binding1IEAHomo_sapiens(9606)Function
GO:0031966located_in mitochondrial membrane1IEAHomo_sapiens(9606)Component
GO:0032435involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process1IMPHomo_sapiens(9606)Process
GO:0032868involved_in response to insulin1IDAHomo_sapiens(9606)Process
GO:0032922involved_in circadian regulation of gene expression1ISSHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0035020involved_in regulation of Rac protein signal transduction1IDAHomo_sapiens(9606)Process
GO:0042995located_in cell projection1IEAHomo_sapiens(9606)Component
GO:0043981involved_in histone H4-K5 acetylation1IDAHomo_sapiens(9606)Process
GO:0043982involved_in histone H4-K8 acetylation1IDAHomo_sapiens(9606)Process
GO:0043984involved_in histone H4-K16 acetylation1IDAHomo_sapiens(9606)Process
GO:0044545part_of NSL complex1IDAHomo_sapiens(9606)Component
GO:0045727involved_in positive regulation of translation1IDAHomo_sapiens(9606)Process
GO:0045862involved_in positive regulation of proteolysis1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1NASHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II2IDA,IMPHomo_sapiens(9606)Process
GO:0046626involved_in regulation of insulin receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0046889involved_in positive regulation of lipid biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0048015involved_in phosphatidylinositol-mediated signaling1IDAHomo_sapiens(9606)Process
GO:0051571involved_in positive regulation of histone H3-K4 methylation1IDAHomo_sapiens(9606)Process
GO:0051963involved_in regulation of synapse assembly1IEAHomo_sapiens(9606)Process
GO:0060544involved_in regulation of necroptotic process1TASHomo_sapiens(9606)Process
GO:0097363enables protein O-acetylglucosaminyltransferase activity5EXP,IBA,IDA,IMP,ISSHomo_sapiens(9606)Function
GO:0098696involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane1IEAHomo_sapiens(9606)Process
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0120162involved_in positive regulation of cold-induced thermogenesis1ISSHomo_sapiens(9606)Process
GO:1900095involved_in regulation of dosage compensation by inactivation of X chromosome1ISOHomo_sapiens(9606)Process
GO:1902455involved_in negative regulation of stem cell population maintenance1NASHomo_sapiens(9606)Process
GO:1902459involved_in positive regulation of stem cell population maintenance1NASHomo_sapiens(9606)Process

Expression