RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000146453	Gene ID	154197	Accession	21185
Symbol	PNLDC1	Alias	SPGF57;Trimmer;HsPNLDC1	Full Name	PARN like ribonuclease domain containing exonuclease 1
Status	Confidence	Length	20456 bases	Strand	Plus strand
Position	6 : 159800249 - 159820704	RNA binding domain	CAF1
Summary	Enables poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening. Located in endoplasmic reticulum. Implicated in spermatogenic failure. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000376007	CAF1	PF04857	2.5e-77	1
ENSP00000476448	CAF1	PF04857	3.6e-70	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
25403	Waist-Hip Ratio	8.5180000E-005	-
25417	Waist-Hip Ratio	7.8980000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000146453	homo_sapiens	ENSP00000387911	39.4366	23.0047	homo_sapiens	ENSP00000376007	47.4576	27.6836
ENSG00000146453	homo_sapiens	ENSP00000361162	28.8235	16.8627	homo_sapiens	ENSP00000376007	27.6836	16.1959

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000146453	homo_sapiens	ENSP00000376007	94.3503	92.8437	nomascus_leucogenys	ENSNLEP00000013740	96.3462	94.8077
ENSG00000146453	homo_sapiens	ENSP00000376007	99.435	98.6817	pan_paniscus	ENSPPAP00000007402	99.435	98.6817
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	93.597	pongo_abelii	ENSPPYP00000019204	96.9231	95.5769
ENSG00000146453	homo_sapiens	ENSP00000376007	99.435	98.6817	pan_troglodytes	ENSPTRP00000086881	99.435	98.6817
ENSG00000146453	homo_sapiens	ENSP00000376007	99.2467	99.0584	gorilla_gorilla	ENSGGOP00000019214	99.2467	99.0584
ENSG00000146453	homo_sapiens	ENSP00000376007	75.5179	59.887	ornithorhynchus_anatinus	ENSOANP00000019312	73.9852	58.6716
ENSG00000146453	homo_sapiens	ENSP00000376007	87.9473	75.8945	sarcophilus_harrisii	ENSSHAP00000017896	80.2405	69.244
ENSG00000146453	homo_sapiens	ENSP00000376007	53.1073	42.9379	notamacropus_eugenii	ENSMEUP00000010863	61.3043	49.5652
ENSG00000146453	homo_sapiens	ENSP00000376007	41.0546	36.1582	notamacropus_eugenii	ENSMEUP00000012803	75.6944	66.6667
ENSG00000146453	homo_sapiens	ENSP00000376007	93.7853	85.6874	dasypus_novemcinctus	ENSDNOP00000010642	93.609	85.5263
ENSG00000146453	homo_sapiens	ENSP00000376007	51.2241	46.516	erinaceus_europaeus	ENSEEUP00000005233	65.7005	59.6618
ENSG00000146453	homo_sapiens	ENSP00000376007	79.096	70.2448	echinops_telfairi	ENSETEP00000006165	84.6774	75.2016
ENSG00000146453	homo_sapiens	ENSP00000376007	97.3635	92.467	callithrix_jacchus	ENSCJAP00000021837	97.5472	92.6415
ENSG00000146453	homo_sapiens	ENSP00000376007	98.8701	96.2335	cercocebus_atys	ENSCATP00000018797	98.8701	96.2335
ENSG00000146453	homo_sapiens	ENSP00000376007	85.1224	80.6026	macaca_fascicularis	ENSMFAP00000063433	80.8587	76.5653
ENSG00000146453	homo_sapiens	ENSP00000376007	98.6817	96.2335	macaca_mulatta	ENSMMUP00000005596	92.0914	89.8067
ENSG00000146453	homo_sapiens	ENSP00000376007	98.6817	96.0452	macaca_nemestrina	ENSMNEP00000020978	98.6817	96.0452
ENSG00000146453	homo_sapiens	ENSP00000376007	98.6817	96.4218	papio_anubis	ENSPANP00000018601	98.6817	96.4218
ENSG00000146453	homo_sapiens	ENSP00000376007	95.1036	92.6554	mandrillus_leucophaeus	ENSMLEP00000040071	98.4405	95.9064
ENSG00000146453	homo_sapiens	ENSP00000376007	67.9849	62.3352	tursiops_truncatus	ENSTTRP00000009872	68.1132	62.4528
ENSG00000146453	homo_sapiens	ENSP00000376007	93.597	86.064	vulpes_vulpes	ENSVVUP00000008803	83.67	76.936
ENSG00000146453	homo_sapiens	ENSP00000376007	93.2203	85.3107	mus_spretus	MGP_SPRETEiJ_P0044613	93.2203	85.3107
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	88.1356	equus_asinus	ENSEASP00005049918	94.9153	88.1356
ENSG00000146453	homo_sapiens	ENSP00000376007	93.2203	85.4991	capra_hircus	ENSCHIP00000001655	93.3962	85.6604
ENSG00000146453	homo_sapiens	ENSP00000376007	58.1921	52.7307	loxodonta_africana	ENSLAFP00000023776	90.6158	82.1114
ENSG00000146453	homo_sapiens	ENSP00000376007	94.7269	87.7589	panthera_leo	ENSPLOP00000005220	94.7269	87.7589
ENSG00000146453	homo_sapiens	ENSP00000376007	94.3503	87.0057	ailuropoda_melanoleuca	ENSAMEP00000016228	94.3503	87.0057
ENSG00000146453	homo_sapiens	ENSP00000376007	95.1036	87.0057	bos_indicus_hybrid	ENSBIXP00005010828	84.4482	77.2575
ENSG00000146453	homo_sapiens	ENSP00000376007	93.597	86.2524	oryctolagus_cuniculus	ENSOCUP00000011929	93.597	86.2524
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	88.1356	equus_caballus	ENSECAP00000044818	94.9153	88.1356
ENSG00000146453	homo_sapiens	ENSP00000376007	95.1036	87.9473	canis_lupus_familiaris	ENSCAFP00845002791	95.1036	87.9473
ENSG00000146453	homo_sapiens	ENSP00000376007	94.7269	87.5706	panthera_pardus	ENSPPRP00000022252	94.7269	87.5706
ENSG00000146453	homo_sapiens	ENSP00000376007	95.8569	88.3239	marmota_marmota_marmota	ENSMMMP00000010809	95.8569	88.3239
ENSG00000146453	homo_sapiens	ENSP00000376007	93.597	86.064	balaenoptera_musculus	ENSBMSP00010015123	93.7736	86.2264
ENSG00000146453	homo_sapiens	ENSP00000376007	87.9473	78.7194	cavia_porcellus	ENSCPOP00000015543	90.1544	80.695
ENSG00000146453	homo_sapiens	ENSP00000376007	94.7269	87.5706	felis_catus	ENSFCAP00000002621	94.7269	87.5706
ENSG00000146453	homo_sapiens	ENSP00000376007	83.9925	75.7062	ursus_americanus	ENSUAMP00000019976	84.31	75.9924
ENSG00000146453	homo_sapiens	ENSP00000376007	87.5706	75.3296	monodelphis_domestica	ENSMODP00000009208	87.242	75.0469
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	86.8173	bison_bison_bison	ENSBBBP00000018311	95.0943	86.9811
ENSG00000146453	homo_sapiens	ENSP00000376007	94.5386	86.8173	monodon_monoceros	ENSMMNP00015015463	94.5386	86.8173
ENSG00000146453	homo_sapiens	ENSP00000376007	95.2919	87.5706	sus_scrofa	ENSSSCP00000004372	95.2919	87.5706
ENSG00000146453	homo_sapiens	ENSP00000376007	96.6102	88.3239	microcebus_murinus	ENSMICP00000007317	96.6102	88.3239
ENSG00000146453	homo_sapiens	ENSP00000376007	92.8437	83.6158	octodon_degus	ENSODEP00000010800	92.8437	83.6158
ENSG00000146453	homo_sapiens	ENSP00000376007	88.7006	79.8493	jaculus_jaculus	ENSJJAP00000004985	90.9266	81.8533
ENSG00000146453	homo_sapiens	ENSP00000376007	93.7853	86.2524	ovis_aries_rambouillet	ENSOARP00020008283	94.6768	87.0722
ENSG00000146453	homo_sapiens	ENSP00000376007	84.3691	77.0245	ursus_maritimus	ENSUMAP00000016200	90.1408	82.2938
ENSG00000146453	homo_sapiens	ENSP00000376007	72.8814	67.2316	ochotona_princeps	ENSOPRP00000003519	72.8814	67.2316
ENSG00000146453	homo_sapiens	ENSP00000376007	87.5706	80.226	delphinapterus_leucas	ENSDLEP00000018257	88.9101	81.4532
ENSG00000146453	homo_sapiens	ENSP00000376007	58.1921	53.6723	physeter_catodon	ENSPCTP00005031030	90.3509	83.3333
ENSG00000146453	homo_sapiens	ENSP00000376007	93.597	85.4991	mus_caroli	MGP_CAROLIEiJ_P0042659	93.597	85.4991
ENSG00000146453	homo_sapiens	ENSP00000376007	93.4087	85.4991	mus_musculus	ENSMUSP00000129377	93.4087	85.4991
ENSG00000146453	homo_sapiens	ENSP00000376007	89.0772	79.661	dipodomys_ordii	ENSDORP00000010825	90.2672	80.7252
ENSG00000146453	homo_sapiens	ENSP00000376007	94.3503	86.629	mustela_putorius_furo	ENSMPUP00000004880	94.3503	86.629
ENSG00000146453	homo_sapiens	ENSP00000376007	97.7401	92.8437	aotus_nancymaae	ENSANAP00000034158	97.7401	92.8437
ENSG00000146453	homo_sapiens	ENSP00000376007	97.7401	93.9736	saimiri_boliviensis_boliviensis	ENSSBOP00000004909	97.7401	93.9736
ENSG00000146453	homo_sapiens	ENSP00000376007	94.7269	91.9021	chlorocebus_sabaeus	ENSCSAP00000008628	96.3602	93.4866
ENSG00000146453	homo_sapiens	ENSP00000376007	80.6026	74.0113	tupaia_belangeri	ENSTBEP00000007918	82.3077	75.5769
ENSG00000146453	homo_sapiens	ENSP00000376007	74.7646	66.1017	mesocricetus_auratus	ENSMAUP00000011823	84.4681	74.6809
ENSG00000146453	homo_sapiens	ENSP00000376007	94.3503	86.2524	phocoena_sinus	ENSPSNP00000024809	94.3503	86.2524
ENSG00000146453	homo_sapiens	ENSP00000376007	93.7853	84.1808	camelus_dromedarius	ENSCDRP00005021232	93.7853	84.1808
ENSG00000146453	homo_sapiens	ENSP00000376007	96.0452	90.2072	carlito_syrichta	ENSTSYP00000005137	96.0452	90.2072
ENSG00000146453	homo_sapiens	ENSP00000376007	89.6422	82.6742	panthera_tigris_altaica	ENSPTIP00000010922	92.0696	84.913
ENSG00000146453	homo_sapiens	ENSP00000376007	93.597	85.3107	rattus_norvegicus	ENSRNOP00000057157	93.597	85.3107
ENSG00000146453	homo_sapiens	ENSP00000376007	96.4218	88.5122	prolemur_simus	ENSPSMP00000027618	96.4218	88.5122
ENSG00000146453	homo_sapiens	ENSP00000376007	93.9736	86.064	microtus_ochrogaster	ENSMOCP00000014948	93.621	85.7411
ENSG00000146453	homo_sapiens	ENSP00000376007	93.9736	86.064	peromyscus_maniculatus_bairdii	ENSPEMP00000017363	93.797	85.9023
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	86.8173	bos_mutus	ENSBMUP00000003740	94.9153	86.8173
ENSG00000146453	homo_sapiens	ENSP00000376007	93.4087	85.4991	mus_spicilegus	ENSMSIP00000031937	93.4087	85.4991
ENSG00000146453	homo_sapiens	ENSP00000376007	92.0904	81.1676	cricetulus_griseus_chok1gshd	ENSCGRP00001005664	91.9173	81.015
ENSG00000146453	homo_sapiens	ENSP00000376007	74.7646	66.1017	cricetulus_griseus_chok1gshd	ENSCGRP00001009980	86.8709	76.8053
ENSG00000146453	homo_sapiens	ENSP00000376007	73.4463	67.7966	pteropus_vampyrus	ENSPVAP00000005042	73.5849	67.9245
ENSG00000146453	homo_sapiens	ENSP00000376007	95.1036	86.2524	myotis_lucifugus	ENSMLUP00000000680	95.1036	86.2524
ENSG00000146453	homo_sapiens	ENSP00000376007	71.5631	60.6403	vombatus_ursinus	ENSVURP00010024865	83.3333	70.614
ENSG00000146453	homo_sapiens	ENSP00000376007	87.7589	75.5179	vombatus_ursinus	ENSVURP00010023580	87.2659	75.0936
ENSG00000146453	homo_sapiens	ENSP00000376007	92.0904	85.1224	rhinolophus_ferrumequinum	ENSRFEP00010009505	95.3216	88.1092
ENSG00000146453	homo_sapiens	ENSP00000376007	94.3503	87.194	neovison_vison	ENSNVIP00000013171	94.3503	87.194
ENSG00000146453	homo_sapiens	ENSP00000376007	91.9021	83.6158	bos_taurus	ENSBTAP00000020180	92.2495	83.9319
ENSG00000146453	homo_sapiens	ENSP00000376007	93.7853	84.7458	heterocephalus_glaber_female	ENSHGLP00000009604	82.5871	74.6269
ENSG00000146453	homo_sapiens	ENSP00000376007	98.4934	96.2335	rhinopithecus_bieti	ENSRBIP00000019642	98.4934	96.2335
ENSG00000146453	homo_sapiens	ENSP00000376007	92.6554	86.064	canis_lupus_dingo	ENSCAFP00020022484	94.0727	87.3805
ENSG00000146453	homo_sapiens	ENSP00000376007	89.2655	81.5443	sciurus_vulgaris	ENSSVLP00005016617	91.3295	83.4297
ENSG00000146453	homo_sapiens	ENSP00000376007	95.2919	87.194	sciurus_vulgaris	ENSSVLP00005018552	95.2919	87.194
ENSG00000146453	homo_sapiens	ENSP00000376007	88.3239	75.3296	phascolarctos_cinereus	ENSPCIP00000031501	87.9925	75.0469
ENSG00000146453	homo_sapiens	ENSP00000376007	84.7458	76.2712	procavia_capensis	ENSPCAP00000013288	84.9057	76.4151
ENSG00000146453	homo_sapiens	ENSP00000376007	93.7853	87.194	nannospalax_galili	ENSNGAP00000017224	93.609	87.0301
ENSG00000146453	homo_sapiens	ENSP00000376007	93.032	84.9341	bos_grunniens	ENSBGRP00000042311	95.5513	87.234
ENSG00000146453	homo_sapiens	ENSP00000376007	93.2203	83.8041	chinchilla_lanigera	ENSCLAP00000004536	93.2203	83.8041
ENSG00000146453	homo_sapiens	ENSP00000376007	95.2919	87.3823	cervus_hanglu_yarkandensis	ENSCHYP00000034115	95.2919	87.3823
ENSG00000146453	homo_sapiens	ENSP00000376007	95.1036	87.5706	catagonus_wagneri	ENSCWAP00000003859	95.1036	87.5706
ENSG00000146453	homo_sapiens	ENSP00000376007	95.4802	88.3239	ictidomys_tridecemlineatus	ENSSTOP00000005012	95.4802	88.3239
ENSG00000146453	homo_sapiens	ENSP00000376007	95.8569	89.2655	otolemur_garnettii	ENSOGAP00000006568	96.2193	89.603
ENSG00000146453	homo_sapiens	ENSP00000376007	97.7401	93.9736	cebus_imitator	ENSCCAP00000016857	97.7401	93.9736
ENSG00000146453	homo_sapiens	ENSP00000376007	95.1036	88.3239	urocitellus_parryii	ENSUPAP00010008455	95.1036	88.3239
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	85.1224	moschus_moschiferus	ENSMMSP00000003100	94.9153	85.1224
ENSG00000146453	homo_sapiens	ENSP00000376007	94.9153	92.2787	rhinopithecus_roxellana	ENSRROP00000041418	96.9231	94.2308
ENSG00000146453	homo_sapiens	ENSP00000376007	94.162	85.8757	mus_pahari	MGP_PahariEiJ_P0054949	94.162	85.8757
ENSG00000146453	homo_sapiens	ENSP00000376007	96.0452	89.0772	propithecus_coquereli	ENSPCOP00000026645	96.0452	89.0772
ENSG00000146453	homo_sapiens	ENSP00000376007	41.6196	21.0923	caenorhabditis_elegans	K10C8.1.1	39.0459	19.788
ENSG00000146453	homo_sapiens	ENSP00000376007	50.0942	29.9435	eptatretus_burgeri	ENSEBUP00000012801	50.7634	30.3435
ENSG00000146453	homo_sapiens	ENSP00000376007	77.5895	63.0885	chrysemys_picta_bellii	ENSCPBP00000005027	81.1024	65.9449
ENSG00000146453	homo_sapiens	ENSP00000376007	47.2693	37.0998	sphenodon_punctatus	ENSSPUP00000006097	82.0261	64.3791
ENSG00000146453	homo_sapiens	ENSP00000376007	79.8493	65.1601	crocodylus_porosus	ENSCPRP00005025582	79.8493	65.1601
ENSG00000146453	homo_sapiens	ENSP00000376007	24.4821	17.3258	notechis_scutatus	ENSNSUP00000021640	71.0383	50.2732
ENSG00000146453	homo_sapiens	ENSP00000376007	39.1714	29.1902	pseudonaja_textilis	ENSPTXP00000001909	71.2329	53.0822
ENSG00000146453	homo_sapiens	ENSP00000376007	74.5763	58.7571	anas_platyrhynchos_platyrhynchos	ENSAPLP00000006629	74.1573	58.427
ENSG00000146453	homo_sapiens	ENSP00000376007	72.8814	57.8154	gallus_gallus	ENSGALP00010006002	68.1338	54.0493
ENSG00000146453	homo_sapiens	ENSP00000376007	64.0301	50.4708	meleagris_gallopavo	ENSMGAP00000013139	66.7976	52.6523
ENSG00000146453	homo_sapiens	ENSP00000376007	46.8927	35.5932	serinus_canaria	ENSSCAP00000015370	75.2266	57.0997
ENSG00000146453	homo_sapiens	ENSP00000376007	74.1996	57.4388	parus_major	ENSPMJP00000012138	74.3396	57.5472
ENSG00000146453	homo_sapiens	ENSP00000376007	75.1412	59.887	anolis_carolinensis	ENSACAP00000013430	75.4253	60.1134
ENSG00000146453	homo_sapiens	ENSP00000376007	58.3804	44.6328	naja_naja	ENSNNAP00000021463	71.9258	54.9884
ENSG00000146453	homo_sapiens	ENSP00000376007	68.3616	52.919	podarcis_muralis	ENSPMRP00000001173	71.3163	55.2063
ENSG00000146453	homo_sapiens	ENSP00000376007	62.1469	45.5744	geospiza_fortis	ENSGFOP00000008265	70.3625	51.5991
ENSG00000146453	homo_sapiens	ENSP00000376007	74.5763	57.8154	taeniopygia_guttata	ENSTGUP00000011772	74.5763	57.8154
ENSG00000146453	homo_sapiens	ENSP00000376007	65.1601	51.2241	salvator_merianae	ENSSMRP00000028880	58.7436	46.18
ENSG00000146453	homo_sapiens	ENSP00000376007	43.6912	34.8399	pelodiscus_sinensis	ENSPSIP00000012678	77.8523	62.0805
ENSG00000146453	homo_sapiens	ENSP00000376007	76.4595	63.2768	gopherus_evgoodei	ENSGEVP00005029492	80.7157	66.7992
ENSG00000146453	homo_sapiens	ENSP00000376007	48.7759	38.0414	chelonoidis_abingdonii	ENSCABP00000024657	79.6923	62.1538
ENSG00000146453	homo_sapiens	ENSP00000376007	62.3352	48.7759	struthio_camelus_australis	ENSSCUP00000024749	72.9075	57.0485
ENSG00000146453	homo_sapiens	ENSP00000376007	75.3296	59.322	anser_brachyrhynchus	ENSABRP00000020416	75.0469	59.0994
ENSG00000146453	homo_sapiens	ENSP00000376007	44.0678	32.7684	strigops_habroptila	ENSSHBP00005013179	70.9091	52.7273
ENSG00000146453	homo_sapiens	ENSP00000376007	69.3032	55.5556	terrapene_carolina_triunguis	ENSTMTP00000000909	75.102	60.2041
ENSG00000146453	homo_sapiens	ENSP00000376007	74.3879	58.7571	aquila_chrysaetos_chrysaetos	ENSACCP00020007239	73.8318	58.3178
ENSG00000146453	homo_sapiens	ENSP00000376007	70.4331	54.8023	ficedula_albicollis	ENSFALP00000012612	74.2064	57.7381
ENSG00000146453	homo_sapiens	ENSP00000376007	72.8814	57.6271	coturnix_japonica	ENSCJPP00005005585	66.041	52.2184

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000184	involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1	IEA	Homo_sapiens(9606)	Process
GO:0000289	involved_in nuclear-transcribed mRNA poly(A) tail shortening	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0001825	involved_in blastocyst formation	1	IEA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0004535	enables poly(A)-specific ribonuclease activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005783	is_active_in endoplasmic reticulum	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0007283	involved_in spermatogenesis	1	IMP	Homo_sapiens(9606)	Process
GO:0034587	involved_in piRNA processing	1	IMP	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function