Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000145335 Gene ID 6622 Accession 11138
Symbol SNCA Alias PD1;NACP;PARK1;PARK4 Full Name synuclein alpha
Status Confidence Length 137971 bases Strand Minus strand
Position 4 : 89700345 - 89838315 RNA binding domain N.A.
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SNCA-216 ENST00000673902 2183 151aa ENSP00000501102
SNCA-213 ENST00000618500 3022 126aa ENSP00000484044
SNCA-206 ENST00000420646 3127 112aa ENSP00000396241
SNCA-205 ENST00000394991 3177 140aa ENSP00000378442
SNCA-201 ENST00000336904 3041 140aa ENSP00000338345
SNCA-204 ENST00000394989 3167 126aa ENSP00000378440
SNCA-215 ENST00000673766 3193 No protein -
SNCA-214 ENST00000673718 3131 140aa ENSP00000500990
SNCA-217 ENST00000674129 2139 159aa ENSP00000501269
SNCA-202 ENST00000345009 1096 112aa ENSP00000343683
SNCA-203 ENST00000394986 1420 140aa ENSP00000378437
SNCA-211 ENST00000508895 905 140aa ENSP00000426955
SNCA-209 ENST00000506244 570 140aa ENSP00000422238
SNCA-208 ENST00000505199 411 126aa ENSP00000421485
SNCA-212 ENST00000611107 297 98aa ENSP00000479604
SNCA-207 ENST00000502987 731 115aa ENSP00000426034
SNCA-210 ENST00000506691 387 66aa ENSP00000423445

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
6901C-Reactive Protein5.09992075077292E-517903293
6922C-Reactive Protein3.21432866712515E-1017903293
6923C-Reactive Protein6.95974558227867E-917903293
13138Parkinson Disease8.41E-521829596
13324Parkinson Disease2.64E-519915575
13337Parkinson Disease5.69E-919915575
13340Parkinson Disease4.43E-619915575
13344Parkinson Disease3.6E-819915575
17666Alcoholism8.29928e-00522978509
53063Cytokine Receptor gp1302.1120000E-005-
53064Cytokine Receptor gp1302.0930000E-005-
53071Cytokine Receptor gp1302.7960000E-005-
53074Cytokine Receptor gp1302.4690000E-005-
70003Parkinson Disease7E-820070850
81988Neuroticism2E-627089181
86695Parkinson Disease1E-719915575
101629Parkinson Disease5E-1122438815
106242Parkinson Disease2E-1619915575

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1TASHomo_sapiens(9606)Process
GO:0000149enables SNARE binding1IDAHomo_sapiens(9606)Function
GO:0000287enables magnesium ion binding1IDAHomo_sapiens(9606)Function
GO:0000976enables transcription cis-regulatory region binding1TASHomo_sapiens(9606)Function
GO:0001774involved_in microglial cell activation1TASHomo_sapiens(9606)Process
GO:0001921involved_in positive regulation of receptor recycling1IDAHomo_sapiens(9606)Process
GO:0001956involved_in positive regulation of neurotransmitter secretion1IEAHomo_sapiens(9606)Process
GO:0003779enables actin binding1IPIHomo_sapiens(9606)Function
GO:0004860enables protein kinase inhibitor activity1TASHomo_sapiens(9606)Function
GO:0005504NOT enables fatty acid binding1IDAHomo_sapiens(9606)Function
GO:0005507enables copper ion binding1IDAHomo_sapiens(9606)Function
GO:0005509enables calcium ion binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005543enables phospholipid binding1IDAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region2IDA,TASHomo_sapiens(9606)Component
GO:0005615located_in extracellular space1IDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1TASHomo_sapiens(9606)Component
GO:0005764located_in lysosome1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0005938located_in cell cortex1IDAHomo_sapiens(9606)Component
GO:0006469involved_in negative regulation of protein kinase activity1TASHomo_sapiens(9606)Process
GO:0006631involved_in fatty acid metabolic process1IEAHomo_sapiens(9606)Process
GO:0006638involved_in neutral lipid metabolic process1IEAHomo_sapiens(9606)Process
GO:0006644involved_in phospholipid metabolic process1IEAHomo_sapiens(9606)Process
GO:0006919involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process1IDAHomo_sapiens(9606)Process
GO:0007006involved_in mitochondrial membrane organization1IEAHomo_sapiens(9606)Process
GO:0007268involved_in chemical synaptic transmission1IBAHomo_sapiens(9606)Process
GO:0008198enables ferrous iron binding1IDAHomo_sapiens(9606)Function
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0008289enables lipid binding2EXP,IDAHomo_sapiens(9606)Function
GO:0008344involved_in adult locomotory behavior1IEAHomo_sapiens(9606)Process
GO:0009410involved_in response to xenobiotic stimulus1IEAHomo_sapiens(9606)Process
GO:0010040involved_in response to iron(II) ion1IDAHomo_sapiens(9606)Process
GO:0010517involved_in regulation of phospholipase activity1IDAHomo_sapiens(9606)Process
GO:0010642involved_in negative regulation of platelet-derived growth factor receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0014048involved_in regulation of glutamate secretion1IEAHomo_sapiens(9606)Process
GO:0014059involved_in regulation of dopamine secretion1TASHomo_sapiens(9606)Process
GO:0015629located_in actin cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0016020located_in membrane1IDAHomo_sapiens(9606)Component
GO:0016079involved_in synaptic vesicle exocytosis1IDAHomo_sapiens(9606)Process
GO:0016082involved_in synaptic vesicle priming1IMPHomo_sapiens(9606)Process
GO:0016234located_in inclusion body1IDAHomo_sapiens(9606)Component
GO:0016491enables oxidoreductase activity1IDAHomo_sapiens(9606)Function
GO:0019894enables kinesin binding1IPIHomo_sapiens(9606)Function
GO:0022898involved_in regulation of transmembrane transporter activity1IGIHomo_sapiens(9606)Process
GO:0030424located_in axon1IDAHomo_sapiens(9606)Component
GO:0030426located_in growth cone1IDAHomo_sapiens(9606)Component
GO:0030544enables Hsp70 protein binding1IPIHomo_sapiens(9606)Function
GO:0030672located_in synaptic vesicle membrane1IEAHomo_sapiens(9606)Component
GO:0031092colocalizes_with platelet alpha granule membrane1IDAHomo_sapiens(9606)Component
GO:0031115involved_in negative regulation of microtubule polymerization1IDAHomo_sapiens(9606)Process
GO:0031623involved_in receptor internalization1IDAHomo_sapiens(9606)Process
GO:0031648involved_in protein destabilization1IDAHomo_sapiens(9606)Process
GO:0032026involved_in response to magnesium ion1IDAHomo_sapiens(9606)Process
GO:0032410involved_in negative regulation of transporter activity1IDAHomo_sapiens(9606)Process
GO:0032496involved_in response to lipopolysaccharide1IDAHomo_sapiens(9606)Process
GO:0032769involved_in negative regulation of monooxygenase activity1IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IMPHomo_sapiens(9606)Component
GO:0033138involved_in positive regulation of peptidyl-serine phosphorylation1ISSHomo_sapiens(9606)Process
GO:0034341involved_in response to type II interferon1IDAHomo_sapiens(9606)Process
GO:0034599involved_in cellular response to oxidative stress1ICHomo_sapiens(9606)Process
GO:0035493involved_in SNARE complex assembly1IDAHomo_sapiens(9606)Process
GO:0035543involved_in positive regulation of SNARE complex assembly1IDAHomo_sapiens(9606)Process
GO:0040012involved_in regulation of locomotion1IEAHomo_sapiens(9606)Process
GO:0042393enables histone binding1IDAHomo_sapiens(9606)Function
GO:0042416involved_in dopamine biosynthetic process1TASHomo_sapiens(9606)Process
GO:0042775involved_in mitochondrial ATP synthesis coupled electron transport1IEAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding2IDA,IPIHomo_sapiens(9606)Function
GO:0043014enables alpha-tubulin binding1IPIHomo_sapiens(9606)Function
GO:0043025is_active_in neuronal cell body1IBAHomo_sapiens(9606)Component
GO:0043027enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process1IDAHomo_sapiens(9606)Function
GO:0043030involved_in regulation of macrophage activation1IEAHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043154involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043524involved_in negative regulation of neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043679is_active_in axon terminus1IBAHomo_sapiens(9606)Component
GO:0045807involved_in positive regulation of endocytosis1IDAHomo_sapiens(9606)Process
GO:0045920involved_in negative regulation of exocytosis1IMPHomo_sapiens(9606)Process
GO:0045921involved_in positive regulation of exocytosis1IMPHomo_sapiens(9606)Process
GO:0048156enables tau protein binding1IDAHomo_sapiens(9606)Function
GO:0048169involved_in regulation of long-term neuronal synaptic plasticity1IEAHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0048488involved_in synaptic vesicle endocytosis2IBA,ISSHomo_sapiens(9606)Process
GO:0048489involved_in synaptic vesicle transport1IEAHomo_sapiens(9606)Process
GO:0050729involved_in positive regulation of inflammatory response1IDAHomo_sapiens(9606)Process
GO:0050808involved_in synapse organization1IBAHomo_sapiens(9606)Process
GO:0050812involved_in regulation of acyl-CoA biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0051179involved_in localization1EXPHomo_sapiens(9606)Process
GO:0051219enables phosphoprotein binding1IDAHomo_sapiens(9606)Function
GO:0051262involved_in protein tetramerization1IDAHomo_sapiens(9606)Process
GO:0051281involved_in positive regulation of release of sequestered calcium ion into cytosol1IDAHomo_sapiens(9606)Process
GO:0051402involved_in neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0051583involved_in dopamine uptake involved in synaptic transmission1TASHomo_sapiens(9606)Process
GO:0051585involved_in negative regulation of dopamine uptake involved in synaptic transmission1IDAHomo_sapiens(9606)Process
GO:0051612involved_in negative regulation of serotonin uptake1IDAHomo_sapiens(9606)Process
GO:0051621involved_in regulation of norepinephrine uptake1IGIHomo_sapiens(9606)Process
GO:0051622involved_in negative regulation of norepinephrine uptake1IDAHomo_sapiens(9606)Process
GO:0055074NOT involved_in calcium ion homeostasis1IDAHomo_sapiens(9606)Process
GO:0060079involved_in excitatory postsynaptic potential1IEAHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1EXPHomo_sapiens(9606)Function
GO:0060291involved_in long-term synaptic potentiation1IEAHomo_sapiens(9606)Process
GO:0060732involved_in positive regulation of inositol phosphate biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0060961NOT enables phospholipase D inhibitor activity1IDAHomo_sapiens(9606)Function
GO:0070495involved_in negative regulation of thrombin-activated receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0070555involved_in response to interleukin-11IDAHomo_sapiens(9606)Process
GO:0070840enables dynein complex binding1IPIHomo_sapiens(9606)Function
GO:0071280involved_in cellular response to copper ion1IDAHomo_sapiens(9606)Process
GO:0071872involved_in cellular response to epinephrine stimulus1TASHomo_sapiens(9606)Process
GO:0071902involved_in positive regulation of protein serine/threonine kinase activity1IDAHomo_sapiens(9606)Process
GO:0097435involved_in supramolecular fiber organization1TASHomo_sapiens(9606)Process
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:0099512located_in supramolecular fiber1IDAHomo_sapiens(9606)Component
GO:1901214involved_in regulation of neuron death1IBAHomo_sapiens(9606)Process
GO:1901215involved_in negative regulation of neuron death1IDAHomo_sapiens(9606)Process
GO:1901216involved_in positive regulation of neuron death1IDAHomo_sapiens(9606)Process
GO:1902957involved_in negative regulation of mitochondrial electron transport, NADH to ubiquinone1TASHomo_sapiens(9606)Process
GO:1903136enables cuprous ion binding2IBA,IMPHomo_sapiens(9606)Function
GO:1903284involved_in positive regulation of glutathione peroxidase activity1IDAHomo_sapiens(9606)Process
GO:1903285involved_in positive regulation of hydrogen peroxide catabolic process1IDAHomo_sapiens(9606)Process
GO:1903421involved_in regulation of synaptic vesicle recycling1TASHomo_sapiens(9606)Process
GO:1903426involved_in regulation of reactive oxygen species biosynthetic process1TASHomo_sapiens(9606)Process
GO:1904715involved_in negative regulation of chaperone-mediated autophagy1IMPHomo_sapiens(9606)Process
GO:1905606involved_in regulation of presynapse assembly1IGIHomo_sapiens(9606)Process
GO:1990000involved_in amyloid fibril formation1EXPHomo_sapiens(9606)Process

Expression