Functions and Diseases

RBP Type Canonical_RBPs
Diseases FlavivirusesHIVSARS-COV-2SINVDengueZika
Drug Drug
Main interacting RNAs rRNA
Moonlighting functions Metabolic enzyme
Localizations Stress granucleP-bodyNucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000143947 Gene ID 6233 Accession 10417
Symbol RPS27A Alias UBC;S27A;eS31;CEP80;UBA80;HEL112;UBCEP1;UBCEP80 Full Name ribosomal protein S27a
Status Confidence Length 3951 bases Strand Plus strand
Position 2 : 55231903 - 55235853 RNA binding domain Ribosomal_S27
Summary Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000272317 Ribosomal_S27 PF01599 5.2e-25 1
ENSP00000383981 Ribosomal_S27 PF01599 5.2e-25 1
ENSP00000385659 Ribosomal_S27 PF01599 5.2e-25 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36945602 Crosstalkr: An open-source R package to facilitate drug target identification. T Davis Weaver 2023-03-10 bioRxiv : the preprint server for biology
34796111 High RPS27A Expression Predicts Poor Prognosis in Patients With HPV Type 16 Cervical Cancer. Qiming Wang 2021-01-01 Frontiers in oncology
33114768 Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma. Xiaogang Zhang 2020-10-26 International journal of molecular sciences
36015519 Design and Immunoinformatic Assessment of Candidate Multivariant mRNA Vaccine Construct against Immune Escape Variants of SARS-CoV-2. Mushtaq Hussain 2022-08-10 Polymers
37371478 RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling. John Matthew Eastham 2023-05-28 Biomolecules

Transcripts

Name Transcript ID bp Protein Translation ID
RPS27A-202 ENST00000402285 705 156aa ENSP00000383981
RPS27A-204 ENST00000449323 422 106aa ENSP00000408482
RPS27A-203 ENST00000404735 796 156aa ENSP00000385659
RPS27A-205 ENST00000463185 590 No protein -
RPS27A-207 ENST00000471772 557 No protein -
RPS27A-201 ENST00000272317 785 156aa ENSP00000272317
RPS27A-208 ENST00000478196 580 No protein -
RPS27A-209 ENST00000494756 535 No protein -
RPS27A-210 ENST00000495843 1159 No protein -
RPS27A-206 ENST00000468810 597 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000143947homo_sapiensENSP0000035867436.942721.6561homo_sapiensENSP0000027231737.179521.7949
ENSG00000143947homo_sapiensENSP0000033948411.82947.70289homo_sapiensENSP0000027231755.128235.8974
ENSG00000143947homo_sapiensENSP0000036624935.151521.2121homo_sapiensENSP0000027231737.179522.4359
ENSG00000143947homo_sapiensENSP0000038790711.76476.61765homo_sapiensENSP0000027231741.025623.0769
ENSG00000143947homo_sapiensENSP0000030469717.030614.4105homo_sapiensENSP000002723172521.1538
ENSG00000143947homo_sapiensENSP0000034481813.430712.5547homo_sapiensENSP0000027231758.974455.1282
ENSG00000143947homo_sapiensENSP0000033404433.333315.5172homo_sapiensENSP0000027231737.179517.3077
ENSG00000143947homo_sapiensENSP0000025049574.074154.321homo_sapiensENSP0000027231738.461528.2051
ENSG00000143947homo_sapiensENSP000003881077567.9688homo_sapiensENSP0000027231761.538555.7692
ENSG00000143947homo_sapiensENSP0000049683227.878818.1818homo_sapiensENSP0000027231729.487219.2308

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000143947homo_sapiensENSP0000027231797.435996.7949nomascus_leucogenysENSNLEP0000002273997.435996.7949
ENSG00000143947homo_sapiensENSP0000027231798.076996.7949nomascus_leucogenysENSNLEP0000004452295.031193.7888
ENSG00000143947homo_sapiensENSP0000027231797.435994.8718nomascus_leucogenysENSNLEP0000003886997.435994.8718
ENSG00000143947homo_sapiensENSP00000272317100100pan_paniscusENSPPAP00000023056100100
ENSG00000143947homo_sapiensENSP0000027231795.512894.8718pongo_abeliiENSPPYP0000002248796.12995.4839
ENSG00000143947homo_sapiensENSP00000272317100100gorilla_gorillaENSGGOP00000007509100100
ENSG00000143947homo_sapiensENSP00000272317100100ornithorhynchus_anatinusENSOANP0000005170245.61445.614
ENSG00000143947homo_sapiensENSP00000272317100100notamacropus_eugeniiENSMEUP00000008141100100
ENSG00000143947homo_sapiensENSP00000272317100100dasypus_novemcinctusENSDNOP0000000371390.697790.6977
ENSG00000143947homo_sapiensENSP0000027231769.871869.8718echinops_telfairiENSETEP0000000837769.871869.8718
ENSG00000143947homo_sapiensENSP0000027231790.384690.3846callithrix_jacchusENSCJAP0000007928379.66179.661
ENSG00000143947homo_sapiensENSP0000027231756.410353.8462callithrix_jacchusENSCJAP0000006914384.615480.7692
ENSG00000143947homo_sapiensENSP0000027231783.974479.4872cercocebus_atysENSCATP0000003476890.972286.1111
ENSG00000143947homo_sapiensENSP0000027231710098.7179cercocebus_atysENSCATP0000000712710098.7179
ENSG00000143947homo_sapiensENSP00000272317100100macaca_fascicularisENSMFAP00000047309100100
ENSG00000143947homo_sapiensENSP0000027231799.35999.359macaca_fascicularisENSMFAP0000004693899.35999.359
ENSG00000143947homo_sapiensENSP00000272317100100macaca_mulattaENSMMUP00000020417100100
ENSG00000143947homo_sapiensENSP00000272317100100macaca_nemestrinaENSMNEP00000027803100100
ENSG00000143947homo_sapiensENSP00000272317100100papio_anubisENSPANP00000022727100100
ENSG00000143947homo_sapiensENSP00000272317100100mandrillus_leucophaeusENSMLEP00000008278100100
ENSG00000143947homo_sapiensENSP00000272317100100tursiops_truncatusENSTTRP00000013220100100
ENSG00000143947homo_sapiensENSP0000027231779.487276.2821vulpes_vulpesENSVVUP0000001476489.208685.6115
ENSG00000143947homo_sapiensENSP0000027231799.35999.359mus_spretusMGP_SPRETEiJ_P002733299.35999.359
ENSG00000143947homo_sapiensENSP0000027231783.333380.1282equus_asinusENSEASP0000500737392.198688.6525
ENSG00000143947homo_sapiensENSP0000027231789.102689.1026loxodonta_africanaENSLAFP0000002126196.527896.5278
ENSG00000143947homo_sapiensENSP0000027231757.051348.7179panthera_leoENSPLOP0000002492470.078759.8425
ENSG00000143947homo_sapiensENSP00000272317100100ailuropoda_melanoleucaENSAMEP00000032097100100
ENSG00000143947homo_sapiensENSP00000272317100100ailuropoda_melanoleucaENSAMEP00000038197100100
ENSG00000143947homo_sapiensENSP0000027231778.846272.4359bos_indicus_hybridENSBIXP0000500845487.23480.1418
ENSG00000143947homo_sapiensENSP0000027231782.051377.5641oryctolagus_cuniculusENSOCUP0000002253374.853870.7602
ENSG00000143947homo_sapiensENSP0000027231789.102687.8205equus_caballusENSECAP0000005588159.913859.0517
ENSG00000143947homo_sapiensENSP00000272317100100canis_lupus_familiarisENSCAFP00845014875100100
ENSG00000143947homo_sapiensENSP00000272317100100panthera_pardusENSPPRP00000011684100100
ENSG00000143947homo_sapiensENSP00000272317100100marmota_marmota_marmotaENSMMMP00000008432100100
ENSG00000143947homo_sapiensENSP0000027231798.076997.4359balaenoptera_musculusENSBMSP0001001362282.702782.1622
ENSG00000143947homo_sapiensENSP00000272317100100cavia_porcellusENSCPOP00000005248100100
ENSG00000143947homo_sapiensENSP00000272317100100ursus_americanusENSUAMP00000025192100100
ENSG00000143947homo_sapiensENSP00000272317100100monodelphis_domesticaENSMODP00000002220100100
ENSG00000143947homo_sapiensENSP0000027231773.076968.5897monodon_monocerosENSMMNP0001501963679.166774.3056
ENSG00000143947homo_sapiensENSP0000027231762.820553.2051sus_scrofaENSSSCP0000002804975.384663.8462
ENSG00000143947homo_sapiensENSP00000272317100100microcebus_murinusENSMICP00000037077100100
ENSG00000143947homo_sapiensENSP0000027231799.35999.359microcebus_murinusENSMICP0000005102899.35999.359
ENSG00000143947homo_sapiensENSP00000272317100100octodon_degusENSODEP00000018046100100
ENSG00000143947homo_sapiensENSP00000272317100100jaculus_jaculusENSJJAP00000014288100100
ENSG00000143947homo_sapiensENSP00000272317100100ovis_aries_rambouilletENSOARP00020000817100100
ENSG00000143947homo_sapiensENSP0000027231798.717998.0769ochotona_princepsENSOPRP0000000955410099.3506
ENSG00000143947homo_sapiensENSP0000027231772.435967.9487delphinapterus_leucasENSDLEP0000000635178.472273.6111
ENSG00000143947homo_sapiensENSP0000027231773.076967.3077physeter_catodonENSPCTP0000500998379.166772.9167
ENSG00000143947homo_sapiensENSP0000027231799.35999.359mus_caroliMGP_CAROLIEiJ_P002599299.35999.359
ENSG00000143947homo_sapiensENSP0000027231799.35999.359mus_musculusENSMUSP0000009990999.35999.359
ENSG00000143947homo_sapiensENSP0000027231787.820584.6154dipodomys_ordiiENSDORP0000002091193.197389.7959
ENSG00000143947homo_sapiensENSP00000272317100100mustela_putorius_furoENSMPUP00000010391100100
ENSG00000143947homo_sapiensENSP0000027231789.102686.5385aotus_nancymaaeENSANAP0000004184696.527893.75
ENSG00000143947homo_sapiensENSP0000027231796.794995.5128aotus_nancymaaeENSANAP0000000328998.051996.7533
ENSG00000143947homo_sapiensENSP00000272317100100saimiri_boliviensis_boliviensisENSSBOP00000039761100100
ENSG00000143947homo_sapiensENSP0000027231795.512892.9487chlorocebus_sabaeusENSCSAP0000001776596.12993.5484
ENSG00000143947homo_sapiensENSP00000272317100100mesocricetus_auratusENSMAUP00000005833100100
ENSG00000143947homo_sapiensENSP0000027231794.230893.5897mesocricetus_auratusENSMAUP000000194319897.3333
ENSG00000143947homo_sapiensENSP00000272317100100phocoena_sinusENSPSNP00000014673100100
ENSG00000143947homo_sapiensENSP0000027231799.35997.4359carlito_syrichtaENSTSYP0000003340399.35997.4359
ENSG00000143947homo_sapiensENSP0000027231798.717997.4359carlito_syrichtaENSTSYP0000002222299.354898.0645
ENSG00000143947homo_sapiensENSP0000027231789.102683.9744rattus_norvegicusENSRNOP0000004728184.242479.3939
ENSG00000143947homo_sapiensENSP00000272317100100prolemur_simusENSPSMP00000022938100100
ENSG00000143947homo_sapiensENSP0000027231798.717998.0769microtus_ochrogasterENSMOCP0000000945999.354898.7097
ENSG00000143947homo_sapiensENSP0000027231792.948792.9487microtus_ochrogasterENSMOCP0000000812293.548493.5484
ENSG00000143947homo_sapiensENSP0000027231767.948766.6667peromyscus_maniculatus_bairdiiENSPEMP0000001781786.178984.5528
ENSG00000143947homo_sapiensENSP00000272317100100bos_mutusENSBMUP00000020797100100
ENSG00000143947homo_sapiensENSP0000027231799.35999.359mus_spicilegusENSMSIP0000002705899.35999.359
ENSG00000143947homo_sapiensENSP00000272317100100cricetulus_griseus_chok1gshdENSCGRP00001027180100100
ENSG00000143947homo_sapiensENSP0000027231796.794995.5128myotis_lucifugusENSMLUP0000002126497.419496.129
ENSG00000143947homo_sapiensENSP0000027231784.615482.6923vombatus_ursinusENSVURP0001002278984.615482.6923
ENSG00000143947homo_sapiensENSP00000272317100100vombatus_ursinusENSVURP00010018583100100
ENSG00000143947homo_sapiensENSP00000272317100100rhinolophus_ferrumequinumENSRFEP00010018007100100
ENSG00000143947homo_sapiensENSP00000272317100100rhinolophus_ferrumequinumENSRFEP00010014603100100
ENSG00000143947homo_sapiensENSP00000272317100100neovison_visonENSNVIP00000002722100100
ENSG00000143947homo_sapiensENSP0000027231778.846272.4359bos_taurusENSBTAP0000006400887.23480.1418
ENSG00000143947homo_sapiensENSP00000272317100100heterocephalus_glaber_femaleENSHGLP00000052361100100
ENSG00000143947homo_sapiensENSP0000027231782.051380.7692rhinopithecus_bietiENSRBIP0000002917377.108475.9036
ENSG00000143947homo_sapiensENSP0000027231771.153862.8205canis_lupus_dingoENSCAFP0002002709475.510266.6667
ENSG00000143947homo_sapiensENSP00000272317100100sciurus_vulgarisENSSVLP00005020656100100
ENSG00000143947homo_sapiensENSP00000272317100100nannospalax_galiliENSNGAP00000020405100100
ENSG00000143947homo_sapiensENSP0000027231778.846273.7179bos_grunniensENSBGRP0000000688187.23481.5603
ENSG00000143947homo_sapiensENSP0000027231766.025662.8205chinchilla_lanigeraENSCLAP0000002191281.102477.1654
ENSG00000143947homo_sapiensENSP00000272317100100cervus_hanglu_yarkandensisENSCHYP00000035747100100
ENSG00000143947homo_sapiensENSP00000272317100100cervus_hanglu_yarkandensisENSCHYP00000020269100100
ENSG00000143947homo_sapiensENSP0000027231766.025660.8974catagonus_wagneriENSCWAP0000000669267.763262.5
ENSG00000143947homo_sapiensENSP00000272317100100ictidomys_tridecemlineatusENSSTOP00000008580100100
ENSG00000143947homo_sapiensENSP0000027231796.153894.8718otolemur_garnettiiENSOGAP0000001582396.774295.4839
ENSG00000143947homo_sapiensENSP0000027231710099.359cebus_imitatorENSCCAP0000000299310099.359
ENSG00000143947homo_sapiensENSP00000272317100100cebus_imitatorENSCCAP00000039769100100
ENSG00000143947homo_sapiensENSP00000272317100100urocitellus_parryiiENSUPAP00010024104100100
ENSG00000143947homo_sapiensENSP00000272317100100moschus_moschiferusENSMMSP00000005408100100
ENSG00000143947homo_sapiensENSP0000027231782.051380.7692rhinopithecus_roxellanaENSRROP0000002177077.108475.9036
ENSG00000143947homo_sapiensENSP0000027231798.717998.7179mus_pahariMGP_PahariEiJ_P002996098.717998.7179
ENSG00000143947homo_sapiensENSP0000027231799.35998.7179propithecus_coquereliENSPCOP0000002737999.35998.7179
ENSG00000143947homo_sapiensENSP0000027231713.46157.69231ciona_intestinalisENSCINP0000002731816.66679.52381
ENSG00000143947homo_sapiensENSP0000027231740.384623.7179ciona_intestinalisENSCINP0000003089126.694915.678
ENSG00000143947homo_sapiensENSP0000027231737.179526.9231callorhinchus_miliiENSCMIP0000003997137.419427.0968
ENSG00000143947homo_sapiensENSP0000027231735.897426.2821salmo_salarENSSSAP0000014410935.897426.2821
ENSG00000143947homo_sapiensENSP0000027231735.897426.2821salmo_salarENSSSAP0000013165135.897426.2821
ENSG00000143947homo_sapiensENSP0000027231735.897426.2821salmo_salarENSSSAP0000010442435.897426.2821
ENSG00000143947homo_sapiensENSP0000027231735.897426.2821salmo_salarENSSSAP0000013356735.897426.2821
ENSG00000143947homo_sapiensENSP0000027231735.897426.2821salmo_truttaENSSTUP0000011550935.897426.2821
ENSG00000143947homo_sapiensENSP0000027231771.153858.9744astatotilapia_callipteraENSACLP0000000403152.358543.3962
ENSG00000143947homo_sapiensENSP0000027231735.897419.8718sparus_aurataENSSAUP0001004811329.473716.3158
ENSG00000143947homo_sapiensENSP00000272317100100xenopus_tropicalisENSXETP00000009809100100
ENSG00000143947homo_sapiensENSP0000027231710099.359sphenodon_punctatusENSSPUP0000001555810099.359
ENSG00000143947homo_sapiensENSP0000027231710099.359crocodylus_porosusENSCPRP0000502003510099.359
ENSG00000143947homo_sapiensENSP0000027231710099.359laticauda_laticaudataENSLLTP0000000635410099.359
ENSG00000143947homo_sapiensENSP0000027231743.589733.3333notechis_scutatusENSNSUP0000000681130.493323.3184
ENSG00000143947homo_sapiensENSP0000027231710099.359anas_platyrhynchos_platyrhynchosENSAPLP0000000498210099.359
ENSG00000143947homo_sapiensENSP0000027231792.307790.3846meleagris_gallopavoENSMGAP0000000184293.506591.5584
ENSG00000143947homo_sapiensENSP0000027231710099.359serinus_canariaENSSCAP0000001964074.285773.8095
ENSG00000143947homo_sapiensENSP0000027231799.35998.7179anolis_carolinensisENSACAP0000000320899.35998.7179
ENSG00000143947homo_sapiensENSP0000027231710099.359naja_najaENSNNAP0000000417810099.359
ENSG00000143947homo_sapiensENSP0000027231710099.359geospiza_fortisENSGFOP0000000628010099.359
ENSG00000143947homo_sapiensENSP0000027231710099.359taeniopygia_guttataENSTGUP0000000728910099.359
ENSG00000143947homo_sapiensENSP0000027231710099.359salvator_merianaeENSSMRP0000001898710099.359
ENSG00000143947homo_sapiensENSP0000027231735.897424.359dicentrarchus_labraxENSDLAP0000507456835.44324.0506
ENSG00000143947homo_sapiensENSP0000027231789.102688.4615pelodiscus_sinensisENSPSIP0000001418499.285798.5714
ENSG00000143947homo_sapiensENSP0000027231710099.359gopherus_evgoodeiENSGEVP0000500247963.414663.0081
ENSG00000143947homo_sapiensENSP0000027231710099.359chelonoidis_abingdoniiENSCABP0000001809610099.359
ENSG00000143947homo_sapiensENSP0000027231710099.359anser_brachyrhynchusENSABRP0000002304510099.359
ENSG00000143947homo_sapiensENSP0000027231733.333320.5128cynoglossus_semilaevisENSCSEP0000001212132.098819.7531
ENSG00000143947homo_sapiensENSP0000027231710099.359terrapene_carolina_triunguisENSTMTP0000002397610099.359
ENSG00000143947homo_sapiensENSP0000027231799.35998.7179aquila_chrysaetos_chrysaetosENSACCP0002000763166.810366.3793
ENSG00000143947homo_sapiensENSP0000027231710099.359coturnix_japonicaENSCJPP0000500084210099.359

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002181involved_in cytoplasmic translation2IC,NASHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003735enables structural constituent of ribosome2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus2HDA,IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1HDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm3HDA,IBA,NASHomo_sapiens(9606)Component
GO:0005741located_in mitochondrial outer membrane1TASHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1TASHomo_sapiens(9606)Component
GO:0006412involved_in translation1ICHomo_sapiens(9606)Process
GO:0010008located_in endosome membrane1TASHomo_sapiens(9606)Component
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016567involved_in protein ubiquitination1IBAHomo_sapiens(9606)Process
GO:0019941involved_in modification-dependent protein catabolic process1IBAHomo_sapiens(9606)Process
GO:0022626located_in cytosolic ribosome1IDAHomo_sapiens(9606)Component
GO:0022627part_of cytosolic small ribosomal subunit2IBA,NASHomo_sapiens(9606)Component
GO:0030666located_in endocytic vesicle membrane1TASHomo_sapiens(9606)Component
GO:0031386enables protein tag activity1IBAHomo_sapiens(9606)Function
GO:0031625enables ubiquitin protein ligase binding1IBAHomo_sapiens(9606)Function
GO:0031982located_in vesicle1HDAHomo_sapiens(9606)Component
GO:0032040part_of small-subunit processome1IDAHomo_sapiens(9606)Component
GO:0045202located_in synapse1IEAHomo_sapiens(9606)Component
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression