RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000143479	Gene ID	8444	Accession	3094
Symbol	DYRK3	Alias	RED;REDK;DYRK5;hYAK3-2	Full Name	dual specificity tyrosine phosphorylation regulated kinase 3
Status	Confidence	Length	19623 bases	Strand	Plus strand
Position	1 : 206635536 - 206655158	RNA binding domain	N.A.
Summary	This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
31152627	Cellular stress leads to the formation of membraneless stress assemblies in eukaryotic cells.	Wessel W van	2019-09-01	Traffic (Copenhagen, Denmark)

Name	Transcript ID	bp	Protein	Translation ID
DYRK3-203	ENST00000367109	8128	588aa	ENSP00000356076
DYRK3-202	ENST00000367108	2218	568aa	ENSP00000356075
DYRK3-206	ENST00000649163	2183	71aa	ENSP00000497239
DYRK3-205	ENST00000489878	1772	No protein	-
DYRK3-204	ENST00000441486	870	243aa	ENSP00000410187
DYRK3-201	ENST00000367106	2329	568aa	ENSP00000356073

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000242	located_in pericentriolar material	1	IDA	Homo_sapiens(9606)	Component
GO:0000287	enables magnesium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004672	enables protein kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	3	IBA,IDA,IMP	Homo_sapiens(9606)	Function
GO:0004712	enables protein serine/threonine/tyrosine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0004713	enables protein tyrosine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0005856	is_active_in cytoskeleton	1	IBA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0010494	located_in cytoplasmic stress granule	1	IDA	Homo_sapiens(9606)	Component
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0018107	involved_in peptidyl-threonine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0030218	involved_in erythrocyte differentiation	1	IDA	Homo_sapiens(9606)	Process
GO:0035063	involved_in nuclear speck organization	1	IDA	Homo_sapiens(9606)	Process
GO:0035617	involved_in stress granule disassembly	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0043066	involved_in negative regulation of apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0043518	involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	1	IEA	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0080135	involved_in regulation of cellular response to stress	1	IMP	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1902751	involved_in positive regulation of cell cycle G2/M phase transition	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:1903008	involved_in organelle disassembly	1	IDA	Homo_sapiens(9606)	Process
GO:1903432	involved_in regulation of TORC1 signaling	1	IMP	Homo_sapiens(9606)	Process