RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000143228	Gene ID	83540	Accession	14621
Symbol	NUF2	Alias	CDCA1;CT106;NUF2R	Full Name	NUF2 component of NDC80 kinetochore complex
Status	Confidence	Length	89189 bases	Strand	Plus strand
Position	1 : 163266576 - 163355764	RNA binding domain	N.A.
Summary	This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
NUF2-212	ENST00000534289	567	124aa	ENSP00000433533
NUF2-204	ENST00000450453	861	145aa	ENSP00000403252
NUF2-208	ENST00000524800	1845	417aa	ENSP00000436888
NUF2-203	ENST00000442820	1133	202aa	ENSP00000392652
NUF2-202	ENST00000367900	1842	464aa	ENSP00000356875
NUF2-201	ENST00000271452	1964	464aa	ENSP00000271452
NUF2-206	ENST00000490881	695	No protein	-
NUF2-205	ENST00000487578	779	No protein	-
NUF2-207	ENST00000497990	885	221aa	ENSP00000436473
NUF2-210	ENST00000527439	940	No protein	-
NUF2-209	ENST00000527120	351	No protein	-
NUF2-211	ENST00000531529	255	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
382	Respiratory Function Tests	3.08634497827468E-5	17903307
4359	Cholesterol, LDL	3.04599638960568E-5	17903299
40820	Platelet Function Tests	9.2544658E-006	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000775	located_in chromosome, centromeric region	1	NAS	Homo_sapiens(9606)	Component
GO:0000776	located_in kinetochore	1	IDA	Homo_sapiens(9606)	Component
GO:0003674	enables molecular_function	1	ND	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0007052	involved_in mitotic spindle organization	1	IBA	Homo_sapiens(9606)	Process
GO:0007059	involved_in chromosome segregation	1	NAS	Homo_sapiens(9606)	Process
GO:0007094	involved_in mitotic spindle assembly checkpoint signaling	1	NAS	Homo_sapiens(9606)	Process
GO:0008608	involved_in attachment of spindle microtubules to kinetochore	1	IDA	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0031262	part_of Ndc80 complex	3	IBA,IDA,IPI	Homo_sapiens(9606)	Component
GO:0044877	enables protein-containing complex binding	1	IBA	Homo_sapiens(9606)	Function
GO:0045132	involved_in meiotic chromosome segregation	1	IBA	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0051315	involved_in attachment of mitotic spindle microtubules to kinetochore	1	IBA	Homo_sapiens(9606)	Process
GO:0051383	involved_in kinetochore organization	1	IBA	Homo_sapiens(9606)	Process