RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	ncRNA
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000141646	Gene ID	4089	Accession	6770
Symbol	SMAD4	Alias	JIP;DPC4;MADH4;MYHRS	Full Name	SMAD family member 4
Status	Confidence	Length	56652 bases	Strand	Plus strand
Position	18 : 51028394 - 51085045	RNA binding domain	N.A.
Summary	This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
27746021	Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β.	Veenu Tripathi	2016-11-03	Molecular cell
20705240	Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.	N Brandi Davis	2010-08-13	Molecular cell
32899767	miR-361-5p Mediates SMAD4 to Promote Porcine Granulosa Cell Apoptosis through VEGFA.	Mengnan Ma	2020-09-04	Biomolecules
35794621	Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression.	Hsin-Yi Chen	2022-07-06	Journal of hematology & oncology
29149681	Mechanistic insight into contextual TGF-β signaling.	E Ying Zhang	2018-04-01	Current opinion in cell biology
30185897	Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop.	Mingtian Zhong	2018-09-05	Scientific reports

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
SMAD4-206	ENST00000588860	8474	552aa	ENSP00000465878
SMAD4-202	ENST00000398417	8495	552aa	ENSP00000381452
SMAD4-207	ENST00000589076	8538	552aa	ENSP00000466934
SMAD4-209	ENST00000589941	8941	552aa	ENSP00000465874
SMAD4-201	ENST00000342988	8772	552aa	ENSP00000341551
SMAD4-210	ENST00000590061	8357	552aa	ENSP00000464772
SMAD4-215	ENST00000593223	4980	493aa	ENSP00000466118
SMAD4-214	ENST00000592911	475	No protein	-
SMAD4-216	ENST00000611848	2906	486aa	ENSP00000478613
SMAD4-205	ENST00000588745	1371	456aa	ENSP00000464901
SMAD4-213	ENST00000592186	1306	320aa	ENSP00000468611
SMAD4-208	ENST00000589706	563	No protein	-
SMAD4-203	ENST00000585448	459	No protein	-
SMAD4-212	ENST00000591126	4970	No protein	-
SMAD4-217	ENST00000684953	5164	No protein	-
SMAD4-220	ENST00000688307	1146	No protein	-
SMAD4-222	ENST00000688903	1963	No protein	-
SMAD4-223	ENST00000690892	1223	No protein	-
SMAD4-219	ENST00000685232	2883	No protein	-
SMAD4-221	ENST00000688574	8307	No protein	-
SMAD4-218	ENST00000685090	4891	No protein	-
SMAD4-224	ENST00000691124	5780	No protein	-
SMAD4-211	ENST00000590499	545	No protein	-
SMAD4-204	ENST00000586253	784	No protein	-

Gene Model

Click here to download ENSG00000141646's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
54565	Beta-Globulins	5.9390000E-005	-
54734	Ferritins	1.0860000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000141646's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000141646	homo_sapiens	ENSP00000369154	54.6039	39.6146	homo_sapiens	ENSP00000341551	46.1957	33.5145
ENSG00000141646	homo_sapiens	ENSP00000262160	53.9615	40.6852	homo_sapiens	ENSP00000341551	45.6522	34.4203
ENSG00000141646	homo_sapiens	ENSP00000332973	60.2353	44.4706	homo_sapiens	ENSP00000341551	46.3768	34.2391
ENSG00000141646	homo_sapiens	ENSP00000305769	55.0538	39.3548	homo_sapiens	ENSP00000341551	46.3768	33.1522
ENSG00000141646	homo_sapiens	ENSP00000441954	56.129	40.6452	homo_sapiens	ENSP00000341551	47.2826	34.2391
ENSG00000141646	homo_sapiens	ENSP00000288840	36.8952	25.6048	homo_sapiens	ENSP00000341551	33.1522	23.0072
ENSG00000141646	homo_sapiens	ENSP00000262158	41.3146	24.1784	homo_sapiens	ENSP00000341551	31.8841	18.6594

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	nomascus_leucogenys	ENSNLEP00000014415	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	pan_paniscus	ENSPPAP00000009478	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	pongo_abelii	ENSPPYP00000010297	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	pan_troglodytes	ENSPTRP00000017047	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	gorilla_gorilla	ENSGGOP00000013332	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	98.5507	97.4638	ornithorhynchus_anatinus	ENSOANP00000012901	98.5507	97.4638
ENSG00000141646	homo_sapiens	ENSP00000341551	86.5942	85.1449	sarcophilus_harrisii	ENSSHAP00000028104	98.3539	96.7078
ENSG00000141646	homo_sapiens	ENSP00000341551	78.9855	78.2609	notamacropus_eugenii	ENSMEUP00000001667	79.1289	78.4029
ENSG00000141646	homo_sapiens	ENSP00000341551	82.971	82.6087	choloepus_hoffmanni	ENSCHOP00000000766	98.4946	98.0645
ENSG00000141646	homo_sapiens	ENSP00000341551	99.0942	98.7319	dasypus_novemcinctus	ENSDNOP00000003926	99.0942	98.7319
ENSG00000141646	homo_sapiens	ENSP00000341551	90.0362	89.1304	erinaceus_europaeus	ENSEEUP00000001427	90.1996	89.2922
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	97.8261	echinops_telfairi	ENSETEP00000006297	98.913	97.8261
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	98.0072	callithrix_jacchus	ENSCJAP00000056533	89.5868	89.4215
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	cercocebus_atys	ENSCATP00000036741	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	macaca_fascicularis	ENSMFAP00000032134	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	macaca_mulatta	ENSMMUP00000024106	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	macaca_nemestrina	ENSMNEP00000013301	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	papio_anubis	ENSPANP00000006643	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	mandrillus_leucophaeus	ENSMLEP00000007644	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	72.6449	72.2826	tursiops_truncatus	ENSTTRP00000011160	98.5258	98.0344
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.913	vulpes_vulpes	ENSVVUP00000019738	99.2754	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.1884	mus_spretus	MGP_SPRETEiJ_P0049055	99.0926	98.3666
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	99.0942	equus_asinus	ENSEASP00005042800	99.2754	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	92.2101	92.029	capra_hircus	ENSCHIP00000020573	99.2203	99.0253
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	99.0942	loxodonta_africana	ENSLAFP00000010529	99.2754	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	panthera_leo	ENSPLOP00000016998	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	ailuropoda_melanoleuca	ENSAMEP00000003072	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	bos_indicus_hybrid	ENSBIXP00005022794	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.7319	oryctolagus_cuniculus	ENSOCUP00000003411	98.913	98.7319
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	99.0942	equus_caballus	ENSECAP00000042762	99.2754	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.1884	canis_lupus_familiaris	ENSCAFP00845004513	99.2727	98.5455
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	panthera_pardus	ENSPPRP00000018849	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	marmota_marmota_marmota	ENSMMMP00000006303	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.7319	balaenoptera_musculus	ENSBMSP00010013498	99.0958	98.5533
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	cavia_porcellus	ENSCPOP00000005827	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	felis_catus	ENSFCAP00000031311	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	ursus_americanus	ENSUAMP00000018392	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	95.471	94.3841	monodelphis_domestica	ENSMODP00000037121	98.6891	97.5655
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	bison_bison_bison	ENSBBBP00000016297	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	monodon_monoceros	ENSMMNP00015000620	99.2767	98.915
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.913	sus_scrofa	ENSSSCP00000004879	99.2754	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	microcebus_murinus	ENSMICP00000038516	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	octodon_degus	ENSODEP00000025235	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	97.1014	96.7391	jaculus_jaculus	ENSJJAP00000004333	99.0758	98.7061
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	ovis_aries_rambouillet	ENSOARP00020020393	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	97.6449	ursus_maritimus	ENSUMAP00000003792	99.2674	98.7179
ENSG00000141646	homo_sapiens	ENSP00000341551	98.7319	98.1884	ochotona_princeps	ENSOPRP00000012406	98.7319	98.1884
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	delphinapterus_leucas	ENSDLEP00000005877	99.2767	98.915
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	physeter_catodon	ENSPCTP00005019284	99.2767	98.915
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.3696	mus_caroli	MGP_CAROLIEiJ_P0047101	99.0926	98.5481
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.3696	mus_musculus	ENSMUSP00000025393	99.0926	98.5481
ENSG00000141646	homo_sapiens	ENSP00000341551	89.4928	86.9565	dipodomys_ordii	ENSDORP00000008535	93.5606	90.9091
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	mustela_putorius_furo	ENSMPUP00000008705	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	99.8188	99.8188	aotus_nancymaae	ENSANAP00000014952	99.8188	99.8188
ENSG00000141646	homo_sapiens	ENSP00000341551	100	100	saimiri_boliviensis_boliviensis	ENSSBOP00000026561	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	98.0072	vicugna_pacos	ENSVPAP00000006278	98.9051	98.7226
ENSG00000141646	homo_sapiens	ENSP00000341551	99.8188	99.8188	chlorocebus_sabaeus	ENSCSAP00000014115	99.8188	99.8188
ENSG00000141646	homo_sapiens	ENSP00000341551	77.1739	76.087	tupaia_belangeri	ENSTBEP00000012234	77.5956	76.5027
ENSG00000141646	homo_sapiens	ENSP00000341551	99.0942	98.913	mesocricetus_auratus	ENSMAUP00000008260	99.0942	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	phocoena_sinus	ENSPSNP00000010840	99.2767	98.915
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	camelus_dromedarius	ENSCDRP00005012694	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.0942	98.7319	carlito_syrichta	ENSTSYP00000009006	99.274	98.9111
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	panthera_tigris_altaica	ENSPTIP00000002665	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.7319	rattus_norvegicus	ENSRNOP00000074882	98.913	98.7319
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.5507	prolemur_simus	ENSPSMP00000029655	99.2754	98.5507
ENSG00000141646	homo_sapiens	ENSP00000341551	99.0942	98.913	microtus_ochrogaster	ENSMOCP00000015787	99.0942	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	84.058	83.5145	sorex_araneus	ENSSARP00000012542	99.1453	98.5043
ENSG00000141646	homo_sapiens	ENSP00000341551	99.0942	98.913	peromyscus_maniculatus_bairdii	ENSPEMP00000013693	99.0942	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	bos_mutus	ENSBMUP00000032268	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	98.913	98.3696	mus_spicilegus	ENSMSIP00000012826	99.0926	98.5481
ENSG00000141646	homo_sapiens	ENSP00000341551	99.0942	98.913	cricetulus_griseus_chok1gshd	ENSCGRP00001024277	99.0942	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	85.3261	85.1449	pteropus_vampyrus	ENSPVAP00000004034	85.3261	85.1449
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	99.0942	myotis_lucifugus	ENSMLUP00000012691	98.917	98.7365
ENSG00000141646	homo_sapiens	ENSP00000341551	98.5507	97.2826	vombatus_ursinus	ENSVURP00010001387	98.5507	97.2826
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	rhinolophus_ferrumequinum	ENSRFEP00010025005	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	neovison_vison	ENSNVIP00000003495	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	bos_taurus	ENSBTAP00000009081	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	99.0942	heterocephalus_glaber_female	ENSHGLP00000007949	99.2754	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	100	99.6377	rhinopithecus_bieti	ENSRBIP00000018874	100	99.6377
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.913	canis_lupus_dingo	ENSCAFP00020027598	99.2754	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	99.0942	sciurus_vulgaris	ENSSVLP00005029879	99.2754	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	98.5507	97.2826	phascolarctos_cinereus	ENSPCIP00000019556	98.5507	97.2826
ENSG00000141646	homo_sapiens	ENSP00000341551	75.3623	74.8188	procavia_capensis	ENSPCAP00000008572	93.4831	92.809
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.913	nannospalax_galili	ENSNGAP00000002152	99.2754	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	95.8333	95.6522	bos_grunniens	ENSBGRP00000039068	97.4217	97.2376
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	chinchilla_lanigera	ENSCLAP00000013454	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	cervus_hanglu_yarkandensis	ENSCHYP00000039168	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.913	catagonus_wagneri	ENSCWAP00000023146	99.2754	98.913
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	ictidomys_tridecemlineatus	ENSSTOP00000016654	99.4565	99.2754
ENSG00000141646	homo_sapiens	ENSP00000341551	99.2754	98.7319	otolemur_garnettii	ENSOGAP00000010810	99.2754	98.7319
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	84.9638	cebus_imitator	ENSCCAP00000030667	100	100
ENSG00000141646	homo_sapiens	ENSP00000341551	94.7464	94.5652	urocitellus_parryii	ENSUPAP00010019327	94.7464	94.5652
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.2754	moschus_moschiferus	ENSMMSP00000007203	99.2767	99.0958
ENSG00000141646	homo_sapiens	ENSP00000341551	100	99.6377	rhinopithecus_roxellana	ENSRROP00000043301	100	99.6377
ENSG00000141646	homo_sapiens	ENSP00000341551	98.3696	98.1884	mus_pahari	MGP_PahariEiJ_P0039673	98.5481	98.3666
ENSG00000141646	homo_sapiens	ENSP00000341551	99.4565	99.0942	propithecus_coquereli	ENSPCOP00000024999	99.4565	99.0942
ENSG00000141646	homo_sapiens	ENSP00000341551	26.8116	15.7609	caenorhabditis_elegans	F37D6.6.1	35.6627	20.9639
ENSG00000141646	homo_sapiens	ENSP00000341551	26.4493	15.3986	caenorhabditis_elegans	F01G10.8b.1	44.1088	25.6798
ENSG00000141646	homo_sapiens	ENSP00000341551	25.7246	15.7609	drosophila_melanogaster	FBpp0428153	21.3534	13.0827
ENSG00000141646	homo_sapiens	ENSP00000341551	25.1812	14.6739	ciona_intestinalis	ENSCINP00000018319	38.5042	22.4377
ENSG00000141646	homo_sapiens	ENSP00000341551	28.0797	19.9275	ciona_intestinalis	ENSCINP00000012287	45.0581	31.9767
ENSG00000141646	homo_sapiens	ENSP00000341551	41.4855	35.6884	petromyzon_marinus	ENSPMAP00000009249	75.082	64.5902
ENSG00000141646	homo_sapiens	ENSP00000341551	26.4493	15.942	eptatretus_burgeri	ENSEBUP00000021174	30.9322	18.6441
ENSG00000141646	homo_sapiens	ENSP00000341551	92.029	86.9565	callorhinchus_milii	ENSCMIP00000031842	91.8626	86.7993
ENSG00000141646	homo_sapiens	ENSP00000341551	69.9275	65.7609	latimeria_chalumnae	ENSLACP00000009312	93.6893	88.1068
ENSG00000141646	homo_sapiens	ENSP00000341551	86.7754	80.9783	lepisosteus_oculatus	ENSLOCP00000015848	87.5686	81.7185
ENSG00000141646	homo_sapiens	ENSP00000341551	85.8696	79.529	clupea_harengus	ENSCHAP00000061349	88.2682	81.7505
ENSG00000141646	homo_sapiens	ENSP00000341551	92.5725	86.7754	clupea_harengus	ENSCHAP00000016001	92.5725	86.7754
ENSG00000141646	homo_sapiens	ENSP00000341551	52.3551	46.0145	danio_rerio	ENSDARP00000099850	87.0482	76.506
ENSG00000141646	homo_sapiens	ENSP00000341551	92.9348	87.6812	danio_rerio	ENSDARP00000097763	93.7843	88.4826
ENSG00000141646	homo_sapiens	ENSP00000341551	92.2101	86.5942	carassius_auratus	ENSCARP00000095408	93.053	87.3857
ENSG00000141646	homo_sapiens	ENSP00000341551	92.5725	86.7754	carassius_auratus	ENSCARP00000012161	93.4186	87.5686
ENSG00000141646	homo_sapiens	ENSP00000341551	75.7246	69.3841	carassius_auratus	ENSCARP00000001331	87.2651	79.9582
ENSG00000141646	homo_sapiens	ENSP00000341551	83.6957	76.9928	carassius_auratus	ENSCARP00000010492	87.1698	80.1887
ENSG00000141646	homo_sapiens	ENSP00000341551	92.2101	86.5942	carassius_auratus	ENSCARP00000084540	93.053	87.3857
ENSG00000141646	homo_sapiens	ENSP00000341551	92.7536	86.7754	carassius_auratus	ENSCARP00000005317	93.6015	87.5686
ENSG00000141646	homo_sapiens	ENSP00000341551	79.3478	73.7319	astyanax_mexicanus	ENSAMXP00000028486	88.8438	82.5558
ENSG00000141646	homo_sapiens	ENSP00000341551	91.1232	85.8696	astyanax_mexicanus	ENSAMXP00000019787	92.4632	87.1324
ENSG00000141646	homo_sapiens	ENSP00000341551	79.529	72.8261	ictalurus_punctatus	ENSIPUP00000035179	83.9388	76.8642
ENSG00000141646	homo_sapiens	ENSP00000341551	91.6667	86.5942	ictalurus_punctatus	ENSIPUP00000007352	92.674	87.5458
ENSG00000141646	homo_sapiens	ENSP00000341551	88.4058	82.4275	esox_lucius	ENSELUP00000020999	90.7063	84.5725
ENSG00000141646	homo_sapiens	ENSP00000341551	89.6739	83.5145	esox_lucius	ENSELUP00000024614	82.7759	77.0903
ENSG00000141646	homo_sapiens	ENSP00000341551	92.029	86.2319	electrophorus_electricus	ENSEEEP00000020048	93.211	87.3394
ENSG00000141646	homo_sapiens	ENSP00000341551	83.8768	76.2681	electrophorus_electricus	ENSEEEP00000016285	88.3588	80.3435
ENSG00000141646	homo_sapiens	ENSP00000341551	82.971	77.8986	oncorhynchus_kisutch	ENSOKIP00005089085	79.5139	74.6528
ENSG00000141646	homo_sapiens	ENSP00000341551	88.587	82.6087	oncorhynchus_kisutch	ENSOKIP00005054839	88.9091	82.9091
ENSG00000141646	homo_sapiens	ENSP00000341551	89.6739	83.3333	oncorhynchus_kisutch	ENSOKIP00005050460	90.1639	83.7887
ENSG00000141646	homo_sapiens	ENSP00000341551	87.5	82.4275	oncorhynchus_kisutch	ENSOKIP00005005862	88.1387	83.0292
ENSG00000141646	homo_sapiens	ENSP00000341551	86.413	80.9783	oncorhynchus_mykiss	ENSOMYP00000142378	86.2568	80.8318
ENSG00000141646	homo_sapiens	ENSP00000341551	84.6014	79.3478	oncorhynchus_mykiss	ENSOMYP00000099836	85.3748	80.0731
ENSG00000141646	homo_sapiens	ENSP00000341551	88.7681	82.4275	oncorhynchus_mykiss	ENSOMYP00000061272	89.4161	83.0292
ENSG00000141646	homo_sapiens	ENSP00000341551	89.4928	82.6087	oncorhynchus_mykiss	ENSOMYP00000058974	89.3309	82.4593
ENSG00000141646	homo_sapiens	ENSP00000341551	84.6014	79.7101	salmo_salar	ENSSSAP00000101532	91.5686	86.2745
ENSG00000141646	homo_sapiens	ENSP00000341551	89.6739	82.7899	salmo_salar	ENSSSAP00000001454	89.3502	82.491
ENSG00000141646	homo_sapiens	ENSP00000341551	89.1304	82.971	salmo_salar	ENSSSAP00000070778	89.781	83.5766
ENSG00000141646	homo_sapiens	ENSP00000341551	87.1377	82.0652	salmo_salar	ENSSSAP00000104615	87.1377	82.0652
ENSG00000141646	homo_sapiens	ENSP00000341551	87.1377	82.0652	salmo_trutta	ENSSTUP00000077093	89.2393	84.0445
ENSG00000141646	homo_sapiens	ENSP00000341551	85.6884	80.4348	salmo_trutta	ENSSTUP00000031260	86.4717	81.17
ENSG00000141646	homo_sapiens	ENSP00000341551	89.1304	82.971	salmo_trutta	ENSSTUP00000035981	89.781	83.5766
ENSG00000141646	homo_sapiens	ENSP00000341551	89.8551	82.7899	salmo_trutta	ENSSTUP00000094230	89.5307	82.491
ENSG00000141646	homo_sapiens	ENSP00000341551	87.8623	82.2464	gadus_morhua	ENSGMOP00000048012	89.6488	83.9187
ENSG00000141646	homo_sapiens	ENSP00000341551	27.5362	25.5435	fundulus_heteroclitus	ENSFHEP00000029923	77.551	71.9388
ENSG00000141646	homo_sapiens	ENSP00000341551	61.0507	55.2536	fundulus_heteroclitus	ENSFHEP00000032911	85.7506	77.6081
ENSG00000141646	homo_sapiens	ENSP00000341551	74.2754	70.8333	poecilia_reticulata	ENSPREP00000027467	93.3941	89.0661
ENSG00000141646	homo_sapiens	ENSP00000341551	84.2391	80.0725	poecilia_reticulata	ENSPREP00000020499	92.4453	87.8728
ENSG00000141646	homo_sapiens	ENSP00000341551	86.413	81.8841	xiphophorus_maculatus	ENSXMAP00000031130	93.1641	88.2812
ENSG00000141646	homo_sapiens	ENSP00000341551	84.4203	80.0725	xiphophorus_maculatus	ENSXMAP00000005074	92.6441	87.8728
ENSG00000141646	homo_sapiens	ENSP00000341551	82.971	77.1739	oryzias_latipes	ENSORLP00000045202	86.7424	80.6818
ENSG00000141646	homo_sapiens	ENSP00000341551	87.3188	81.5217	oryzias_latipes	ENSORLP00000006328	94.5098	88.2353
ENSG00000141646	homo_sapiens	ENSP00000341551	84.6014	77.3551	cyclopterus_lumpus	ENSCLMP00005028472	88.1132	80.566
ENSG00000141646	homo_sapiens	ENSP00000341551	86.7754	82.4275	cyclopterus_lumpus	ENSCLMP00005004514	92.1154	87.5
ENSG00000141646	homo_sapiens	ENSP00000341551	86.5942	80.9783	oreochromis_niloticus	ENSONIP00000050523	90.8745	84.981
ENSG00000141646	homo_sapiens	ENSP00000341551	88.0435	82.4275	oreochromis_niloticus	ENSONIP00000072817	88.3636	82.7273
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.4348	haplochromis_burtoni	ENSHBUP00000019491	93.2406	88.2704
ENSG00000141646	homo_sapiens	ENSP00000341551	86.0507	81.5217	haplochromis_burtoni	ENSHBUP00000008979	93.1373	88.2353
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.4348	astatotilapia_calliptera	ENSACLP00000021363	93.2406	88.2704
ENSG00000141646	homo_sapiens	ENSP00000341551	86.0507	81.5217	astatotilapia_calliptera	ENSACLP00000025950	93.1373	88.2353
ENSG00000141646	homo_sapiens	ENSP00000341551	87.8623	83.3333	sparus_aurata	ENSSAUP00010014730	93.4489	88.632
ENSG00000141646	homo_sapiens	ENSP00000341551	84.4203	79.529	sparus_aurata	ENSSAUP00010059920	91.0156	85.7422
ENSG00000141646	homo_sapiens	ENSP00000341551	86.7754	81.5217	lates_calcarifer	ENSLCAP00010013760	91.4122	85.8779
ENSG00000141646	homo_sapiens	ENSP00000341551	88.9493	83.8768	lates_calcarifer	ENSLCAP00010001596	92.467	87.194
ENSG00000141646	homo_sapiens	ENSP00000341551	95.2899	91.8478	xenopus_tropicalis	ENSXETP00000048372	95.2899	91.8478
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	96.558	chrysemys_picta_bellii	ENSCPBP00000036916	98.3666	96.7332
ENSG00000141646	homo_sapiens	ENSP00000341551	97.4638	95.1087	sphenodon_punctatus	ENSSPUP00000022823	97.4638	95.1087
ENSG00000141646	homo_sapiens	ENSP00000341551	97.6449	94.9275	laticauda_laticaudata	ENSLLTP00000001203	97.6449	94.9275
ENSG00000141646	homo_sapiens	ENSP00000341551	97.6449	94.9275	notechis_scutatus	ENSNSUP00000017870	97.6449	94.9275
ENSG00000141646	homo_sapiens	ENSP00000341551	97.6449	94.9275	pseudonaja_textilis	ENSPTXP00000025616	97.6449	94.9275
ENSG00000141646	homo_sapiens	ENSP00000341551	97.8261	95.8333	anas_platyrhynchos_platyrhynchos	ENSAPLP00000003446	98.0036	96.0073
ENSG00000141646	homo_sapiens	ENSP00000341551	78.8043	75	gallus_gallus	ENSGALP00010012877	90.4366	86.0707
ENSG00000141646	homo_sapiens	ENSP00000341551	91.4855	87.6812	gallus_gallus	ENSGALP00010016770	77.3354	74.1194
ENSG00000141646	homo_sapiens	ENSP00000341551	26.9928	26.2681	meleagris_gallopavo	ENSMGAP00000021285	99.3333	96.6667
ENSG00000141646	homo_sapiens	ENSP00000341551	91.4855	89.6739	serinus_canaria	ENSSCAP00000002622	98.8258	96.8689
ENSG00000141646	homo_sapiens	ENSP00000341551	38.4058	35.6884	parus_major	ENSPMJP00000002454	90.2128	83.8298
ENSG00000141646	homo_sapiens	ENSP00000341551	90.2174	86.0507	anolis_carolinensis	ENSACAP00000026900	83.9798	80.1012
ENSG00000141646	homo_sapiens	ENSP00000341551	86.2319	81.7029	neolamprologus_brichardi	ENSNBRP00000016107	93.3333	88.4314
ENSG00000141646	homo_sapiens	ENSP00000341551	85.5072	80.6159	neolamprologus_brichardi	ENSNBRP00000005979	92.0078	86.7446
ENSG00000141646	homo_sapiens	ENSP00000341551	83.5145	79.7101	naja_naja	ENSNNAP00000019986	94.4672	90.1639
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	96.3768	podarcis_muralis	ENSPMRP00000015240	98.1884	96.3768
ENSG00000141646	homo_sapiens	ENSP00000341551	91.3043	89.3116	geospiza_fortis	ENSGFOP00000006917	98.6301	96.4775
ENSG00000141646	homo_sapiens	ENSP00000341551	88.7681	84.9638	taeniopygia_guttata	ENSTGUP00000032640	95.3307	91.2451
ENSG00000141646	homo_sapiens	ENSP00000341551	93.1159	87.5	erpetoichthys_calabaricus	ENSECRP00000006242	93.6248	87.9781
ENSG00000141646	homo_sapiens	ENSP00000341551	78.442	74.8188	kryptolebias_marmoratus	ENSKMAP00000028560	94.7484	90.372
ENSG00000141646	homo_sapiens	ENSP00000341551	84.7826	79.8913	kryptolebias_marmoratus	ENSKMAP00000013171	93.0417	87.674
ENSG00000141646	homo_sapiens	ENSP00000341551	97.6449	95.6522	salvator_merianae	ENSSMRP00000021246	97.8221	95.8258
ENSG00000141646	homo_sapiens	ENSP00000341551	87.6812	82.0652	oryzias_javanicus	ENSOJAP00000046672	85.968	80.4618
ENSG00000141646	homo_sapiens	ENSP00000341551	84.2391	78.9855	oryzias_javanicus	ENSOJAP00000008797	91.1765	85.4902
ENSG00000141646	homo_sapiens	ENSP00000341551	85.8696	80.9783	amphilophus_citrinellus	ENSACIP00000023940	91.1538	85.9615
ENSG00000141646	homo_sapiens	ENSP00000341551	81.3406	77.3551	amphilophus_citrinellus	ENSACIP00000007188	93.737	89.1441
ENSG00000141646	homo_sapiens	ENSP00000341551	88.2246	82.6087	dicentrarchus_labrax	ENSDLAP00005046845	90.689	84.9162
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.0725	dicentrarchus_labrax	ENSDLAP00005082836	89.1635	84.0304
ENSG00000141646	homo_sapiens	ENSP00000341551	87.1377	82.6087	amphiprion_percula	ENSAPEP00000004950	94.685	89.7638
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.2536	amphiprion_percula	ENSAPEP00000017835	93.2406	88.0716
ENSG00000141646	homo_sapiens	ENSP00000341551	69.7464	64.1304	oryzias_sinensis	ENSOSIP00000006389	92.7711	85.3012
ENSG00000141646	homo_sapiens	ENSP00000341551	85.3261	78.9855	oryzias_sinensis	ENSOSIP00000008590	86.9004	80.4428
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	96.0145	pelodiscus_sinensis	ENSPSIP00000016512	98.1884	96.0145
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	96.558	gopherus_evgoodei	ENSGEVP00005027739	98.3666	96.7332
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	96.558	chelonoidis_abingdonii	ENSCABP00000017324	98.3666	96.7332
ENSG00000141646	homo_sapiens	ENSP00000341551	85.3261	80.6159	seriola_dumerili	ENSSDUP00000007227	93.6382	88.4692
ENSG00000141646	homo_sapiens	ENSP00000341551	88.0435	83.5145	seriola_dumerili	ENSSDUP00000030892	95.2941	90.3922
ENSG00000141646	homo_sapiens	ENSP00000341551	86.2319	79.529	cottoperca_gobio	ENSCGOP00000029950	89.8113	82.8302
ENSG00000141646	homo_sapiens	ENSP00000341551	85.5072	80.6159	cottoperca_gobio	ENSCGOP00000028769	92.0078	86.7446
ENSG00000141646	homo_sapiens	ENSP00000341551	98.0072	96.0145	struthio_camelus_australis	ENSSCUP00000002001	94.9123	92.9825
ENSG00000141646	homo_sapiens	ENSP00000341551	97.8261	95.8333	anser_brachyrhynchus	ENSABRP00000024877	98.0036	96.0073
ENSG00000141646	homo_sapiens	ENSP00000341551	83.3333	75.9058	gasterosteus_aculeatus	ENSGACP00000022267	87.4525	79.6578
ENSG00000141646	homo_sapiens	ENSP00000341551	88.0435	83.1522	gasterosteus_aculeatus	ENSGACP00000009949	88.6861	83.7591
ENSG00000141646	homo_sapiens	ENSP00000341551	85.3261	80.9783	cynoglossus_semilaevis	ENSCSEP00000026341	93.6382	88.8668
ENSG00000141646	homo_sapiens	ENSP00000341551	86.2319	80.4348	cynoglossus_semilaevis	ENSCSEP00000010634	93.3333	87.0588
ENSG00000141646	homo_sapiens	ENSP00000341551	86.5942	81.8841	poecilia_formosa	ENSPFOP00000024750	93.7255	88.6274
ENSG00000141646	homo_sapiens	ENSP00000341551	84.4203	80.0725	poecilia_formosa	ENSPFOP00000019933	92.6441	87.8728
ENSG00000141646	homo_sapiens	ENSP00000341551	86.5942	81.1594	myripristis_murdjan	ENSMMDP00005033818	90.1887	84.5283
ENSG00000141646	homo_sapiens	ENSP00000341551	88.2246	82.4275	myripristis_murdjan	ENSMMDP00005055330	90.1852	84.2593
ENSG00000141646	homo_sapiens	ENSP00000341551	80.4348	75.5435	sander_lucioperca	ENSSLUP00000038549	91.9255	86.3354
ENSG00000141646	homo_sapiens	ENSP00000341551	87.1377	82.6087	sander_lucioperca	ENSSLUP00000016424	90.7547	86.0377
ENSG00000141646	homo_sapiens	ENSP00000341551	97.4638	95.471	strigops_habroptila	ENSSHBP00005000015	97.6407	95.6443
ENSG00000141646	homo_sapiens	ENSP00000341551	91.4855	89.6739	strigops_habroptila	ENSSHBP00005013289	98.8258	96.8689
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.2536	amphiprion_ocellaris	ENSAOCP00000016055	93.2406	88.0716
ENSG00000141646	homo_sapiens	ENSP00000341551	87.5	82.6087	amphiprion_ocellaris	ENSAOCP00000016426	94.7059	89.4118
ENSG00000141646	homo_sapiens	ENSP00000341551	98.1884	96.558	terrapene_carolina_triunguis	ENSTMTP00000000092	98.3666	96.7332
ENSG00000141646	homo_sapiens	ENSP00000341551	89.8551	84.058	hucho_hucho	ENSHHUP00000033303	89.8551	84.058
ENSG00000141646	homo_sapiens	ENSP00000341551	86.413	81.3406	hucho_hucho	ENSHHUP00000026360	89.4934	84.2402
ENSG00000141646	homo_sapiens	ENSP00000341551	90.2174	83.8768	hucho_hucho	ENSHHUP00000068309	90.0543	83.7251
ENSG00000141646	homo_sapiens	ENSP00000341551	83.5145	79.529	hucho_hucho	ENSHHUP00000082227	89.6887	85.4086
ENSG00000141646	homo_sapiens	ENSP00000341551	86.2319	80.6159	betta_splendens	ENSBSLP00000011769	92.607	86.5759
ENSG00000141646	homo_sapiens	ENSP00000341551	86.7754	80.9783	betta_splendens	ENSBSLP00000018322	88.7037	82.7778
ENSG00000141646	homo_sapiens	ENSP00000341551	91.8478	86.9565	pygocentrus_nattereri	ENSPNAP00000013918	92.6874	87.7514
ENSG00000141646	homo_sapiens	ENSP00000341551	88.2246	83.5145	anabas_testudineus	ENSATEP00000021861	93.8343	88.8247
ENSG00000141646	homo_sapiens	ENSP00000341551	85.6884	80.7971	anabas_testudineus	ENSATEP00000067701	90.2672	85.1145
ENSG00000141646	homo_sapiens	ENSP00000341551	24.6377	13.9493	ciona_savignyi	ENSCSAVP00000018932	37.7778	21.3889
ENSG00000141646	homo_sapiens	ENSP00000341551	85.3261	80.6159	seriola_lalandi_dorsalis	ENSSLDP00000014268	93.6382	88.4692
ENSG00000141646	homo_sapiens	ENSP00000341551	88.0435	83.5145	seriola_lalandi_dorsalis	ENSSLDP00000032438	95.2941	90.3922
ENSG00000141646	homo_sapiens	ENSP00000341551	85.6884	80.2536	labrus_bergylta	ENSLBEP00000009797	90.7869	85.0288
ENSG00000141646	homo_sapiens	ENSP00000341551	84.6014	80.0725	labrus_bergylta	ENSLBEP00000023864	92.8429	87.8728
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.4348	pundamilia_nyererei	ENSPNYP00000010707	93.2406	88.2704
ENSG00000141646	homo_sapiens	ENSP00000341551	86.0507	81.5217	pundamilia_nyererei	ENSPNYP00000013790	93.1373	88.2353
ENSG00000141646	homo_sapiens	ENSP00000341551	87.5	82.4275	mastacembelus_armatus	ENSMAMP00000001989	90.9604	85.6874
ENSG00000141646	homo_sapiens	ENSP00000341551	85.8696	80.7971	mastacembelus_armatus	ENSMAMP00000048564	89.2655	83.9925
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.0725	stegastes_partitus	ENSSPAP00000005949	93.2406	87.8728
ENSG00000141646	homo_sapiens	ENSP00000341551	87.3188	82.2464	stegastes_partitus	ENSSPAP00000003348	91.2879	85.9848
ENSG00000141646	homo_sapiens	ENSP00000341551	84.4203	79.1667	oncorhynchus_tshawytscha	ENSOTSP00005009763	87.4296	81.9887
ENSG00000141646	homo_sapiens	ENSP00000341551	89.1304	82.6087	oncorhynchus_tshawytscha	ENSOTSP00005052633	87.5445	81.1388
ENSG00000141646	homo_sapiens	ENSP00000341551	82.971	78.0797	oncorhynchus_tshawytscha	ENSOTSP00005089484	75.8278	71.3576
ENSG00000141646	homo_sapiens	ENSP00000341551	89.3116	82.4275	oncorhynchus_tshawytscha	ENSOTSP00005091052	89.1501	82.2785
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.2536	acanthochromis_polyacanthus	ENSAPOP00000008331	93.2406	88.0716
ENSG00000141646	homo_sapiens	ENSP00000341551	87.6812	82.7899	acanthochromis_polyacanthus	ENSAPOP00000020671	94.902	89.6078
ENSG00000141646	homo_sapiens	ENSP00000341551	98.0072	96.0145	aquila_chrysaetos_chrysaetos	ENSACCP00020013966	98.1851	96.1888
ENSG00000141646	homo_sapiens	ENSP00000341551	84.6014	79.529	nothobranchius_furzeri	ENSNFUP00015031932	88.1132	82.8302
ENSG00000141646	homo_sapiens	ENSP00000341551	87.6812	81.8841	nothobranchius_furzeri	ENSNFUP00015036278	90.8068	84.803
ENSG00000141646	homo_sapiens	ENSP00000341551	87.3188	82.6087	cyprinodon_variegatus	ENSCVAP00000004754	93.4109	88.3721
ENSG00000141646	homo_sapiens	ENSP00000341551	84.7826	79.8913	cyprinodon_variegatus	ENSCVAP00000018520	93.0417	87.674
ENSG00000141646	homo_sapiens	ENSP00000341551	84.7826	78.6232	denticeps_clupeoides	ENSDCDP00000008359	89.313	82.8244
ENSG00000141646	homo_sapiens	ENSP00000341551	81.1594	73.1884	denticeps_clupeoides	ENSDCDP00000016650	74.6667	67.3333
ENSG00000141646	homo_sapiens	ENSP00000341551	85.6884	80.4348	larimichthys_crocea	ENSLCRP00005027948	90.0952	84.5714
ENSG00000141646	homo_sapiens	ENSP00000341551	88.0435	83.3333	larimichthys_crocea	ENSLCRP00005034801	89.6679	84.8708
ENSG00000141646	homo_sapiens	ENSP00000341551	85.6884	80.4348	takifugu_rubripes	ENSTRUP00000048686	90.7869	85.2207
ENSG00000141646	homo_sapiens	ENSP00000341551	32.0652	28.442	takifugu_rubripes	ENSTRUP00000076792	75	66.5254
ENSG00000141646	homo_sapiens	ENSP00000341551	73.3696	67.5725	takifugu_rubripes	ENSTRUP00000053126	72.711	66.9659
ENSG00000141646	homo_sapiens	ENSP00000341551	83.6957	79.529	hippocampus_comes	ENSHCOP00000015228	91.8489	87.2763
ENSG00000141646	homo_sapiens	ENSP00000341551	84.2391	78.9855	hippocampus_comes	ENSHCOP00000022820	91.1765	85.4902
ENSG00000141646	homo_sapiens	ENSP00000341551	92.9348	86.9565	cyprinus_carpio_carpio	ENSCCRP00000045211	93.7843	87.7514
ENSG00000141646	homo_sapiens	ENSP00000341551	70.2899	61.2319	cyprinus_carpio_carpio	ENSCCRP00000037883	85.2747	74.2857
ENSG00000141646	homo_sapiens	ENSP00000341551	92.2101	86.0507	cyprinus_carpio_carpio	ENSCCRP00000156841	92.8832	86.6788
ENSG00000141646	homo_sapiens	ENSP00000341551	85.1449	77.3551	cyprinus_carpio_carpio	ENSCCRP00000106773	86.0806	78.2051
ENSG00000141646	homo_sapiens	ENSP00000341551	74.4565	71.3768	coturnix_japonica	ENSCJPP00005001081	86.5263	82.9474
ENSG00000141646	homo_sapiens	ENSP00000341551	84.4203	80.0725	poecilia_latipinna	ENSPLAP00000003577	92.6441	87.8728
ENSG00000141646	homo_sapiens	ENSP00000341551	86.5942	82.0652	poecilia_latipinna	ENSPLAP00000019866	93.7255	88.8235
ENSG00000141646	homo_sapiens	ENSP00000341551	80.2536	74.4565	sinocyclocheilus_grahami	ENSSGRP00000022575	88.7776	82.3647
ENSG00000141646	homo_sapiens	ENSP00000341551	72.4638	66.1232	sinocyclocheilus_grahami	ENSSGRP00000010396	86.2069	78.6638
ENSG00000141646	homo_sapiens	ENSP00000341551	69.5652	61.0507	sinocyclocheilus_grahami	ENSSGRP00000029869	79.3388	69.6281
ENSG00000141646	homo_sapiens	ENSP00000341551	92.5725	87.5	sinocyclocheilus_grahami	ENSSGRP00000007947	92.9091	87.8182
ENSG00000141646	homo_sapiens	ENSP00000341551	86.0507	81.5217	maylandia_zebra	ENSMZEP00005006313	93.1373	88.2353
ENSG00000141646	homo_sapiens	ENSP00000341551	84.9638	80.4348	maylandia_zebra	ENSMZEP00005024930	93.2406	88.2704
ENSG00000141646	homo_sapiens	ENSP00000341551	85.3261	79.8913	tetraodon_nigroviridis	ENSTNIP00000005773	92.3529	86.4706
ENSG00000141646	homo_sapiens	ENSP00000341551	85.5072	80.6159	tetraodon_nigroviridis	ENSTNIP00000011908	88.5553	83.4897
ENSG00000141646	homo_sapiens	ENSP00000341551	91.8478	86.0507	paramormyrops_kingsleyae	ENSPKIP00000039533	93.0275	87.156
ENSG00000141646	homo_sapiens	ENSP00000341551	89.3116	84.058	scleropages_formosus	ENSSFOP00015015148	89.4737	84.2105
ENSG00000141646	homo_sapiens	ENSP00000341551	94.3841	90.3986	leptobrachium_leishanense	ENSLLEP00000006190	89.8276	86.0345
ENSG00000141646	homo_sapiens	ENSP00000341551	86.9565	82.971	scophthalmus_maximus	ENSSMAP00000001661	93.75	89.4531
ENSG00000141646	homo_sapiens	ENSP00000341551	76.2681	71.3768	scophthalmus_maximus	ENSSMAP00000053749	78.9869	73.9212
ENSG00000141646	homo_sapiens	ENSP00000341551	83.1522	78.2609	oryzias_melastigma	ENSOMEP00000023058	93.1034	87.6268
ENSG00000141646	homo_sapiens	ENSP00000341551	87.6812	81.8841	oryzias_melastigma	ENSOMEP00000021474	94.902	88.6274

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	ISS	Homo_sapiens(9606)	Process
GO:0000785	part_of chromatin	2	IDA,ISA	Homo_sapiens(9606)	Component
GO:0000976	enables transcription cis-regulatory region binding	1	IDA	Homo_sapiens(9606)	Function
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	2	IBA,ISA	Homo_sapiens(9606)	Function
GO:0001223	enables transcription coactivator binding	1	IPI	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0001541	involved_in ovarian follicle development	1	IEA	Homo_sapiens(9606)	Process
GO:0001649	involved_in osteoblast differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0001658	involved_in branching involved in ureteric bud morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0001666	involved_in response to hypoxia	1	IMP	Homo_sapiens(9606)	Process
GO:0001701	involved_in in utero embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0001702	involved_in gastrulation with mouth forming second	1	IEA	Homo_sapiens(9606)	Process
GO:0001837	involved_in epithelial to mesenchymal transition	1	IMP	Homo_sapiens(9606)	Process
GO:0003148	involved_in outflow tract septum morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0003161	involved_in cardiac conduction system development	1	NAS	Homo_sapiens(9606)	Process
GO:0003190	involved_in atrioventricular valve formation	1	ISS	Homo_sapiens(9606)	Process
GO:0003198	involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	1	IEA	Homo_sapiens(9606)	Process
GO:0003220	involved_in left ventricular cardiac muscle tissue morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0003251	involved_in positive regulation of cell proliferation involved in heart valve morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0003360	involved_in brainstem development	1	IEA	Homo_sapiens(9606)	Process
GO:0003677	contributes_to DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003682	enables chromatin binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003700	contributes_to DNA-binding transcription factor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005518	enables collagen binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005667	part_of transcription regulator complex	2	IDA,IPI	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006351	involved_in DNA-templated transcription	2	IDA,NAS	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006366	involved_in transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0006879	involved_in intracellular iron ion homeostasis	1	ISS	Homo_sapiens(9606)	Process
GO:0007179	involved_in transforming growth factor beta receptor signaling pathway	4	IBA,IDA,IMP,ISS	Homo_sapiens(9606)	Process
GO:0007283	involved_in spermatogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0007338	involved_in single fertilization	1	IEA	Homo_sapiens(9606)	Process
GO:0007411	involved_in axon guidance	1	IEA	Homo_sapiens(9606)	Process
GO:0008283	involved_in cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0009653	involved_in anatomical structure morphogenesis	1	IBA	Homo_sapiens(9606)	Process
GO:0010614	involved_in negative regulation of cardiac muscle hypertrophy	1	ISS	Homo_sapiens(9606)	Process
GO:0010631	involved_in epithelial cell migration	1	IMP	Homo_sapiens(9606)	Process
GO:0010666	involved_in positive regulation of cardiac muscle cell apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0010718	involved_in positive regulation of epithelial to mesenchymal transition	1	ISS	Homo_sapiens(9606)	Process
GO:0010862	involved_in positive regulation of pathway-restricted SMAD protein phosphorylation	1	ISS	Homo_sapiens(9606)	Process
GO:0014033	involved_in neural crest cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0017015	involved_in regulation of transforming growth factor beta receptor signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0030154	involved_in cell differentiation	1	IBA	Homo_sapiens(9606)	Process
GO:0030308	involved_in negative regulation of cell growth	1	IDA	Homo_sapiens(9606)	Process
GO:0030325	involved_in adrenal gland development	1	IEA	Homo_sapiens(9606)	Process
GO:0030509	involved_in BMP signaling pathway	3	IBA,IDA,ISS	Homo_sapiens(9606)	Process
GO:0030511	involved_in positive regulation of transforming growth factor beta receptor signaling pathway	1	IDA	Homo_sapiens(9606)	Process
GO:0030513	involved_in positive regulation of BMP signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0031005	enables filamin binding	1	IEA	Homo_sapiens(9606)	Function
GO:0032444	part_of activin responsive factor complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032525	involved_in somite rostral/caudal axis specification	1	IEA	Homo_sapiens(9606)	Process
GO:0032909	involved_in regulation of transforming growth factor beta2 production	1	IMP	Homo_sapiens(9606)	Process
GO:0032924	involved_in activin receptor signaling pathway	1	NAS	Homo_sapiens(9606)	Process
GO:0033686	involved_in positive regulation of luteinizing hormone secretion	1	IEA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	IMP	Homo_sapiens(9606)	Process
GO:0036302	involved_in atrioventricular canal development	1	ISS	Homo_sapiens(9606)	Process
GO:0042118	involved_in endothelial cell activation	1	IEA	Homo_sapiens(9606)	Process
GO:0042177	involved_in negative regulation of protein catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0042733	involved_in embryonic digit morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	IPI	Homo_sapiens(9606)	Function
GO:0043199	enables sulfate binding	1	IMP	Homo_sapiens(9606)	Function
GO:0043565	contributes_to sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0046881	involved_in positive regulation of follicle-stimulating hormone secretion	1	IEA	Homo_sapiens(9606)	Process
GO:0048382	involved_in mesendoderm development	1	IEA	Homo_sapiens(9606)	Process
GO:0048589	involved_in developmental growth	1	IEA	Homo_sapiens(9606)	Process
GO:0048663	involved_in neuron fate commitment	1	IEA	Homo_sapiens(9606)	Process
GO:0048733	involved_in sebaceous gland development	1	IEA	Homo_sapiens(9606)	Process
GO:0048859	involved_in formation of anatomical boundary	1	IEA	Homo_sapiens(9606)	Process
GO:0051098	involved_in regulation of binding	1	IEA	Homo_sapiens(9606)	Process
GO:0051571	involved_in positive regulation of histone H3-K4 methylation	1	ISS	Homo_sapiens(9606)	Process
GO:0051797	involved_in regulation of hair follicle development	1	IEA	Homo_sapiens(9606)	Process
GO:0060065	involved_in uterus development	1	IEA	Homo_sapiens(9606)	Process
GO:0060391	involved_in positive regulation of SMAD protein signal transduction	1	ISS	Homo_sapiens(9606)	Process
GO:0060395	involved_in SMAD protein signal transduction	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0060412	involved_in ventricular septum morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0060956	involved_in endocardial cell differentiation	1	ISS	Homo_sapiens(9606)	Process
GO:0061040	involved_in female gonad morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0061629	enables RNA polymerase II-specific DNA-binding transcription factor binding	1	IEA	Homo_sapiens(9606)	Function
GO:0062009	involved_in secondary palate development	1	ISS	Homo_sapiens(9606)	Process
GO:0070102	involved_in interleukin-6-mediated signaling pathway	1	ISS	Homo_sapiens(9606)	Process
GO:0070371	involved_in ERK1 and ERK2 cascade	1	IEA	Homo_sapiens(9606)	Process
GO:0070373	involved_in negative regulation of ERK1 and ERK2 cascade	1	ISS	Homo_sapiens(9606)	Process
GO:0070411	enables I-SMAD binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0070412	enables R-SMAD binding	1	IPI	Homo_sapiens(9606)	Function
GO:0071141	part_of SMAD protein complex	2	IDA,IMP	Homo_sapiens(9606)	Component
GO:0071144	part_of heteromeric SMAD protein complex	2	IBA,IPI	Homo_sapiens(9606)	Component
GO:0071333	involved_in cellular response to glucose stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0071559	involved_in response to transforming growth factor beta	1	IDA	Homo_sapiens(9606)	Process
GO:0071773	involved_in cellular response to BMP stimulus	1	NAS	Homo_sapiens(9606)	Process
GO:0072133	involved_in metanephric mesenchyme morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0072134	involved_in nephrogenic mesenchyme morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0072520	involved_in seminiferous tubule development	1	IEA	Homo_sapiens(9606)	Process
GO:1901522	involved_in positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	1	TAS	Homo_sapiens(9606)	Process
GO:1902895	involved_in positive regulation of miRNA transcription	1	IEA	Homo_sapiens(9606)	Process
GO:1905305	involved_in negative regulation of cardiac myofibril assembly	1	ISS	Homo_sapiens(9606)	Process
GO:2000617	involved_in positive regulation of histone H3-K9 acetylation	1	ISS	Homo_sapiens(9606)	Process

Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression