RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000141582	Gene ID	8535	Accession	1554
Symbol	CBX4	Alias	PC2;NBP16	Full Name	chromobox 4
Status	Confidence	Length	6285 bases	Strand	Minus strand
Position	17 : 79833156 - 79839440	RNA binding domain	N.A.
Summary	Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
34522711	The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses.	Yi Pan	2021-11-01	Genes & diseases
32358485	Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression.	M Jessica Silva-Fisher	2020-05-01	Nature communications

Name	Transcript ID	bp	Protein	Translation ID
CBX4-201	ENST00000269397	2675	560aa	ENSP00000269397
CBX4-202	ENST00000448310	718	60aa	ENSP00000415348
CBX4-204	ENST00000495122	490	90aa	ENSP00000461198
CBX4-203	ENST00000494546	432	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
27284	Cardiovascular System	6.3420000E-006	-
27289	Cardiovascular System	4.3870000E-006	-
79343	Glucocorticoids	3E-6	26265699
79344	Osteonecrosis	3E-6	26265699
89079	Alpha Rhythm	6E-6	25387704
89080	Brain Waves	6E-6	25387704

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0000976	enables transcription cis-regulatory region binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003682	enables chromatin binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003714	enables transcription corepressor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0003727	enables single-stranded RNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006325	involved_in chromatin organization	1	IEA	Homo_sapiens(9606)	Process
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0016607	located_in nuclear speck	1	IEA	Homo_sapiens(9606)	Component
GO:0016925	involved_in protein sumoylation	3	IBA,IEA,TAS	Homo_sapiens(9606)	Process
GO:0019789	enables SUMO transferase activity	1	EXP	Homo_sapiens(9606)	Function
GO:0019899	enables enzyme binding	1	IPI	Homo_sapiens(9606)	Function
GO:0031519	part_of PcG protein complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032183	enables SUMO binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0035064	enables methylated histone binding	1	IEA	Homo_sapiens(9606)	Function
GO:0035102	part_of PRC1 complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0043066	involved_in negative regulation of apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0051219	enables phosphoprotein binding	1	IEA	Homo_sapiens(9606)	Function
GO:0061665	enables SUMO ligase activity	2	IBA,IDA	Homo_sapiens(9606)	Function