RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000141569	Gene ID	201292	Accession	27316
Symbol	TRIM65	Alias	4732463G12Rik	Full Name	tripartite motif containing 65
Status	Confidence	Length	16617 bases	Strand	Minus strand
Position	17 : 75880335 - 75896951	RNA binding domain	SPRY
Summary	Predicted to enable zinc ion binding activity. Involved in positive regulation of autophagy. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000269383	SPRY	PF00622	2.4e-06	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
33373584	Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.	Kazuki Kato	2021-02-04	Molecular cell

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
TRIM65-205	ENST00000591668	644	137aa	ENSP00000465034
TRIM65-206	ENST00000592642	396	90aa	ENSP00000466353
TRIM65-201	ENST00000269383	3384	517aa	ENSP00000269383
TRIM65-207	ENST00000648382	2049	No protein	-
TRIM65-204	ENST00000543309	865	288aa	ENSP00000441480
TRIM65-202	ENST00000540128	886	244aa	ENSP00000444607
TRIM65-203	ENST00000540812	385	No protein	-

Gene Model

Click here to download ENSG00000141569's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
37125	Platelet Function Tests	4.6000000E-007	-
37506	Platelet Function Tests	1.8600000E-006	-
39462	Platelet Function Tests	6.1800000E-007	-
39486	Platelet Function Tests	6.5200000E-006	-
72720	Brain Mapping	4E-15	21681796

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000141569's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001934	involved_in positive regulation of protein phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0010508	involved_in positive regulation of autophagy	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0032461	involved_in positive regulation of protein oligomerization	1	IEA	Homo_sapiens(9606)	Process
GO:0032727	involved_in positive regulation of interferon-alpha production	1	IEA	Homo_sapiens(9606)	Process
GO:0032728	involved_in positive regulation of interferon-beta production	1	IDA	Homo_sapiens(9606)	Process
GO:0050728	involved_in negative regulation of inflammatory response	1	IDA	Homo_sapiens(9606)	Process
GO:0060337	involved_in type I interferon-mediated signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0070534	involved_in protein K63-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0070936	involved_in protein K48-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0140374	involved_in antiviral innate immune response	1	IEA	Homo_sapiens(9606)	Process

Expression