RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
N.A.
Localizations
Nucleoli
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000141456 Gene ID
27043 Accession
30134
Symbol
PELP1
Alias
MNAR;P160
Full Name
proline, glutamate and leucine rich protein 1
Status
Confidence
Length
34564 bases
Strand
Minus strand
Position
17 : 4669774 - 4704337
RNA binding domain
RIX1
Summary
This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000460959
RIX1
PF08167 2e-25
1
ENSP00000460300
RIX1
PF08167 1.6e-24
1
ENSP00000461625
RIX1
PF08167 1.6e-24
1
ENSP00000301396
RIX1
PF08167 1.7e-24
1
ENSP00000461419
RIX1
PF08167 6.1e-10
1
ENSP00000416231
RIX1
PF08167 2.6e-08
1
ENSP00000461380
RIX1
PF08167 1.2e-06
1
ENSP00000458985
RIX1
PF08167 1.7e-06
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
22190735 LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis.
D Christopher Castle
2012-02-01
Molecular biology of the cell
24447537 PELP1 oncogenic functions involve alternative splicing via PRMT6.
Monica Mann
2014-03-01
Molecular oncology
26997260 PELP1: Structure, biological function and clinical significance.
Reddy Gangadhara Sareddy
2016-07-01
Gene
17525794 Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.
K Ratna Vadlamudi
2007-05-17
Nuclear receptor signaling
Name
Transcript ID
bp
Protein
Translation ID
PELP1-208
ENST00000572293
5084
1130aa
ENSP00000460300
PELP1-212
ENST00000574876
3465
1130aa
ENSP00000461625
PELP1-201
ENST00000301396
3673
1180aa
ENSP00000301396
PELP1-202
ENST00000436683
3524
906aa
ENSP00000416231
PELP1-211
ENST00000573523
3878
No protein
-
PELP1-214
ENST00000575329
3280
156aa
ENSP00000461380
PELP1-209
ENST00000573242
574
No protein
-
PELP1-215
ENST00000575534
601
No protein
-
PELP1-204
ENST00000570571
902
301aa
ENSP00000460959
PELP1-210
ENST00000573506
415
No protein
-
PELP1-203
ENST00000570387
567
99aa
ENSP00000461419
PELP1-213
ENST00000575101
442
148aa
ENSP00000458985
PELP1-206
ENST00000571170
555
No protein
-
PELP1-205
ENST00000570823
484
No protein
-
PELP1-207
ENST00000571347
708
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
16641 Alcoholism 2.01E-05 -
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000141456
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000141456 homo_sapiens ENSP00000460300 98.0531 97.6106 nomascus_leucogenys ENSNLEP00000041531 93.4233 93.0017 ENSG00000141456 homo_sapiens ENSP00000460300 99.646 99.3805 pan_paniscus ENSPPAP00000031839 95.5857 95.3311 ENSG00000141456 homo_sapiens ENSP00000460300 98.4956 98.4956 pongo_abelii ENSPPYP00000023917 94.8041 94.8041 ENSG00000141456 homo_sapiens ENSP00000460300 99.823 99.5575 pan_troglodytes ENSPTRP00000014683 95.6743 95.4198 ENSG00000141456 homo_sapiens ENSP00000460300 99.823 99.823 gorilla_gorilla ENSGGOP00000004688 95.5932 95.5932 ENSG00000141456 homo_sapiens ENSP00000460300 75.3097 66.0177 ornithorhynchus_anatinus ENSOANP00000035182 76.5977 67.1467 ENSG00000141456 homo_sapiens ENSP00000460300 79.469 74.3363 sarcophilus_harrisii ENSSHAP00000000844 83.2252 77.8499 ENSG00000141456 homo_sapiens ENSP00000460300 72.3894 68.5841 notamacropus_eugenii ENSMEUP00000001796 70.7612 67.0415 ENSG00000141456 homo_sapiens ENSP00000460300 91.2389 88.4956 dasypus_novemcinctus ENSDNOP00000008307 87.8194 85.1789 ENSG00000141456 homo_sapiens ENSP00000460300 50.885 48.8496 erinaceus_europaeus ENSEEUP00000001173 63.1175 60.5928 ENSG00000141456 homo_sapiens ENSP00000460300 72.1239 67.8761 echinops_telfairi ENSETEP00000014127 65.2522 61.4091 ENSG00000141456 homo_sapiens ENSP00000460300 97.6991 96.2832 callithrix_jacchus ENSCJAP00000022595 97.0976 95.6904 ENSG00000141456 homo_sapiens ENSP00000460300 97.2566 95.9292 cercocebus_atys ENSCATP00000014891 86.4673 85.2872 ENSG00000141456 homo_sapiens ENSP00000460300 98.938 98.3186 macaca_fascicularis ENSMFAP00000006133 94.7458 94.1525 ENSG00000141456 homo_sapiens ENSP00000460300 98.938 98.2301 macaca_mulatta ENSMMUP00000064203 89.0127 88.3758 ENSG00000141456 homo_sapiens ENSP00000460300 98.938 98.3186 macaca_nemestrina ENSMNEP00000012640 94.7458 94.1525 ENSG00000141456 homo_sapiens ENSP00000460300 98.6726 97.9646 papio_anubis ENSPANP00000019537 94.5717 93.8931 ENSG00000141456 homo_sapiens ENSP00000460300 98.7611 98.1416 mandrillus_leucophaeus ENSMLEP00000033086 95.0596 94.4634 ENSG00000141456 homo_sapiens ENSP00000460300 91.7699 88.6726 tursiops_truncatus ENSTTRP00000007209 83.0264 80.2242 ENSG00000141456 homo_sapiens ENSP00000460300 86.0177 81.8584 vulpes_vulpes ENSVVUP00000038664 79.2822 75.4486 ENSG00000141456 homo_sapiens ENSP00000460300 90.6195 86.5487 mus_spretus MGP_SPRETEiJ_P0029194 91.5103 87.3995 ENSG00000141456 homo_sapiens ENSP00000460300 94.8673 92.2124 equus_asinus ENSEASP00005035231 92.1754 89.5959 ENSG00000141456 homo_sapiens ENSP00000460300 91.8584 87.0796 capra_hircus ENSCHIP00000032966 93.0942 88.2511 ENSG00000141456 homo_sapiens ENSP00000460300 93.9823 90.4425 loxodonta_africana ENSLAFP00000029069 94.1489 90.6028 ENSG00000141456 homo_sapiens ENSP00000460300 92.1239 88.0531 panthera_leo ENSPLOP00000018852 89.3562 85.4077 ENSG00000141456 homo_sapiens ENSP00000460300 68.3186 64.5133 ailuropoda_melanoleuca ENSAMEP00000042824 83.3693 78.7257 ENSG00000141456 homo_sapiens ENSP00000460300 91.7699 87.3451 bos_indicus_hybrid ENSBIXP00005025293 85.2095 81.1011 ENSG00000141456 homo_sapiens ENSP00000460300 93.5398 90.9734 oryctolagus_cuniculus ENSOCUP00000012799 83.0322 80.7541 ENSG00000141456 homo_sapiens ENSP00000460300 93.0089 90.177 equus_caballus ENSECAP00000053659 92.5176 89.7007 ENSG00000141456 homo_sapiens ENSP00000460300 91.6814 88.0531 canis_lupus_familiaris ENSCAFP00845022907 83.1461 79.8555 ENSG00000141456 homo_sapiens ENSP00000460300 70.354 67.6991 panthera_pardus ENSPPRP00000000653 93.75 90.2123 ENSG00000141456 homo_sapiens ENSP00000460300 95.9292 93.1858 marmota_marmota_marmota ENSMMMP00000019821 95.4225 92.6937 ENSG00000141456 homo_sapiens ENSP00000460300 93.3628 90.9734 balaenoptera_musculus ENSBMSP00010027975 93.1979 90.8127 ENSG00000141456 homo_sapiens ENSP00000460300 93.4513 89.0266 cavia_porcellus ENSCPOP00000000182 92.7944 88.4007 ENSG00000141456 homo_sapiens ENSP00000460300 93.2743 89.115 felis_catus ENSFCAP00000048921 82.2795 78.6105 ENSG00000141456 homo_sapiens ENSP00000460300 88.4071 84.7788 ursus_americanus ENSUAMP00000012438 87.3252 83.7413 ENSG00000141456 homo_sapiens ENSP00000460300 78.938 73.7168 monodelphis_domestica ENSMODP00000007076 82.6691 77.2011 ENSG00000141456 homo_sapiens ENSP00000460300 91.2389 86.9911 bison_bison_bison ENSBBBP00000005532 92.5494 88.2406 ENSG00000141456 homo_sapiens ENSP00000460300 92.6549 89.5575 monodon_monoceros ENSMMNP00015027509 92.8191 89.7163 ENSG00000141456 homo_sapiens ENSP00000460300 93.5398 90.4425 sus_scrofa ENSSSCP00000068939 89.881 86.9048 ENSG00000141456 homo_sapiens ENSP00000460300 96.1947 93.6283 microcebus_murinus ENSMICP00000001488 96.0247 93.4629 ENSG00000141456 homo_sapiens ENSP00000460300 93.5398 89.9115 octodon_degus ENSODEP00000023506 93.1278 89.5154 ENSG00000141456 homo_sapiens ENSP00000460300 92.2124 88.1416 jaculus_jaculus ENSJJAP00000009067 91.8062 87.7533 ENSG00000141456 homo_sapiens ENSP00000460300 92.0354 87.1681 ovis_aries_rambouillet ENSOARP00020031771 89.7325 84.9871 ENSG00000141456 homo_sapiens ENSP00000460300 59.646 57.4336 ursus_maritimus ENSUMAP00000019853 71.474 68.8229 ENSG00000141456 homo_sapiens ENSP00000460300 54.6903 51.6814 ochotona_princeps ENSOPRP00000001695 50.5315 47.7514 ENSG00000141456 homo_sapiens ENSP00000460300 92.8319 89.646 delphinapterus_leucas ENSDLEP00000025535 92.9141 89.7254 ENSG00000141456 homo_sapiens ENSP00000460300 69.823 68.3186 physeter_catodon ENSPCTP00005024975 94.9458 92.9001 ENSG00000141456 homo_sapiens ENSP00000460300 91.062 86.8142 mus_caroli MGP_CAROLIEiJ_P0027815 91.548 87.2776 ENSG00000141456 homo_sapiens ENSP00000460300 91.062 86.8142 mus_musculus ENSMUSP00000019065 91.6296 87.3553 ENSG00000141456 homo_sapiens ENSP00000460300 90.0885 85.7522 dipodomys_ordii ENSDORP00000012842 89.5339 85.2243 ENSG00000141456 homo_sapiens ENSP00000460300 86.9027 82.7434 mustela_putorius_furo ENSMPUP00000010697 91.1792 86.8152 ENSG00000141456 homo_sapiens ENSP00000460300 98.1416 96.9027 aotus_nancymaae ENSANAP00000032743 97.5374 96.3061 ENSG00000141456 homo_sapiens ENSP00000460300 98.0531 97.2566 saimiri_boliviensis_boliviensis ENSSBOP00000012747 92.953 92.198 ENSG00000141456 homo_sapiens ENSP00000460300 98.2301 97.6106 chlorocebus_sabaeus ENSCSAP00000009277 90.8347 90.2619 ENSG00000141456 homo_sapiens ENSP00000460300 74.9557 71.7699 tupaia_belangeri ENSTBEP00000008922 81.8357 78.3575 ENSG00000141456 homo_sapiens ENSP00000460300 89.646 85.3097 mesocricetus_auratus ENSMAUP00000012652 89.4876 85.159 ENSG00000141456 homo_sapiens ENSP00000460300 92.8319 89.7345 phocoena_sinus ENSPSNP00000024737 93.079 89.9734 ENSG00000141456 homo_sapiens ENSP00000460300 89.0266 86.2832 camelus_dromedarius ENSCDRP00005025688 89.1054 86.3596 ENSG00000141456 homo_sapiens ENSP00000460300 77.3451 75.3097 carlito_syrichta ENSTSYP00000027148 94.8969 92.3996 ENSG00000141456 homo_sapiens ENSP00000460300 91.7699 87.1681 rattus_norvegicus ENSRNOP00000026102 88.1054 83.6873 ENSG00000141456 homo_sapiens ENSP00000460300 96.2832 94.0708 prolemur_simus ENSPSMP00000004208 92.2816 90.1612 ENSG00000141456 homo_sapiens ENSP00000460300 91.2389 85.9292 microtus_ochrogaster ENSMOCP00000010538 91.4007 86.0816 ENSG00000141456 homo_sapiens ENSP00000460300 61.6814 59.0266 sorex_araneus ENSSARP00000007633 59.8797 57.3024 ENSG00000141456 homo_sapiens ENSP00000460300 74.6018 71.5044 peromyscus_maniculatus_bairdii ENSPEMP00000006802 92.1311 88.306 ENSG00000141456 homo_sapiens ENSP00000460300 91.6814 87.3451 bos_mutus ENSBMUP00000006162 85.1274 81.1011 ENSG00000141456 homo_sapiens ENSP00000460300 90.7965 86.7257 mus_spicilegus ENSMSIP00000023910 91.5254 87.4219 ENSG00000141456 homo_sapiens ENSP00000460300 92.2124 87.9646 cricetulus_griseus_chok1gshd ENSCGRP00001001103 91.3234 87.1166 ENSG00000141456 homo_sapiens ENSP00000460300 90.0885 87.0796 pteropus_vampyrus ENSPVAP00000003786 82.899 80.1303 ENSG00000141456 homo_sapiens ENSP00000460300 93.5398 89.9115 myotis_lucifugus ENSMLUP00000002297 89.6522 86.1747 ENSG00000141456 homo_sapiens ENSP00000460300 79.292 74.5133 vombatus_ursinus ENSVURP00010002629 82.8862 77.8908 ENSG00000141456 homo_sapiens ENSP00000460300 93.7168 90.2655 rhinolophus_ferrumequinum ENSRFEP00010021614 91.3719 88.0069 ENSG00000141456 homo_sapiens ENSP00000460300 92.0354 88.1416 neovison_vison ENSNVIP00000026081 93.2735 89.3274 ENSG00000141456 homo_sapiens ENSP00000460300 91.7699 87.3451 bos_taurus ENSBTAP00000028337 85.2095 81.1011 ENSG00000141456 homo_sapiens ENSP00000460300 90.531 86.7257 heterocephalus_glaber_female ENSHGLP00000042805 92.0792 88.2088 ENSG00000141456 homo_sapiens ENSP00000460300 84.4248 81.7699 rhinopithecus_bieti ENSRBIP00000038309 87.2029 84.4607 ENSG00000141456 homo_sapiens ENSP00000460300 93.0089 89.7345 canis_lupus_dingo ENSCAFP00020013733 92.4362 89.1821 ENSG00000141456 homo_sapiens ENSP00000460300 96.0177 93.8053 sciurus_vulgaris ENSSVLP00005012926 94.1023 91.9341 ENSG00000141456 homo_sapiens ENSP00000460300 79.0266 74.0708 phascolarctos_cinereus ENSPCIP00000022829 82.8386 77.6438 ENSG00000141456 homo_sapiens ENSP00000460300 78.4071 75.3097 procavia_capensis ENSPCAP00000010770 69.8188 67.0607 ENSG00000141456 homo_sapiens ENSP00000460300 92.4779 87.9646 nannospalax_galili ENSNGAP00000008596 91.7471 87.2695 ENSG00000141456 homo_sapiens ENSP00000460300 89.3805 84.4248 bos_grunniens ENSBGRP00000040662 91.073 86.0234 ENSG00000141456 homo_sapiens ENSP00000460300 93.5398 90.0885 chinchilla_lanigera ENSCLAP00000014159 92.8007 89.3766 ENSG00000141456 homo_sapiens ENSP00000460300 92.3009 87.6106 cervus_hanglu_yarkandensis ENSCHYP00000028804 93.4588 88.7097 ENSG00000141456 homo_sapiens ENSP00000460300 92.1239 89.2035 catagonus_wagneri ENSCWAP00000002534 89.9741 87.1219 ENSG00000141456 homo_sapiens ENSP00000460300 96.1062 93.2743 ictidomys_tridecemlineatus ENSSTOP00000031786 94.2708 91.4931 ENSG00000141456 homo_sapiens ENSP00000460300 95.8407 93.4513 otolemur_garnettii ENSOGAP00000002710 96.0106 93.617 ENSG00000141456 homo_sapiens ENSP00000460300 98.1416 97.0796 cebus_imitator ENSCCAP00000039894 95.3568 94.325 ENSG00000141456 homo_sapiens ENSP00000460300 93.8938 91.1504 urocitellus_parryii ENSUPAP00010002767 90.4518 87.809 ENSG00000141456 homo_sapiens ENSP00000460300 92.1239 87.2566 moschus_moschiferus ENSMMSP00000010892 93.3632 88.4305 ENSG00000141456 homo_sapiens ENSP00000460300 86.7257 85.8407 rhinopithecus_roxellana ENSRROP00000013212 91.9325 90.9944 ENSG00000141456 homo_sapiens ENSP00000460300 90.885 86.7257 mus_pahari MGP_PahariEiJ_P0034564 91.4515 87.2663 ENSG00000141456 homo_sapiens ENSP00000460300 94.9557 93.0973 propithecus_coquereli ENSPCOP00000022855 91.0866 89.3039 ENSG00000141456 homo_sapiens ENSP00000460300 51.3274 37.6106 latimeria_chalumnae ENSLACP00000008422 54.6654 40.0565 ENSG00000141456 homo_sapiens ENSP00000460300 37.2566 28.0531 salmo_trutta ENSSTUP00000037602 51.7199 38.9435 ENSG00000141456 homo_sapiens ENSP00000460300 42.4779 30.7965 astatotilapia_calliptera ENSACLP00000023417 46.8293 33.9512 ENSG00000141456 homo_sapiens ENSP00000460300 45.2212 38.3186 chrysemys_picta_bellii ENSCPBP00000017806 66.7102 56.5274 ENSG00000141456 homo_sapiens ENSP00000460300 52.9204 42.3009 laticauda_laticaudata ENSLLTP00000015980 52.0453 41.6014 ENSG00000141456 homo_sapiens ENSP00000460300 38.1416 30.885 pseudonaja_textilis ENSPTXP00000018768 56.1198 45.4427 ENSG00000141456 homo_sapiens ENSP00000460300 54.7788 44.0708 naja_naja ENSNNAP00000025118 54.4415 43.7995 ENSG00000141456 homo_sapiens ENSP00000460300 47.2566 39.292 podarcis_muralis ENSPMRP00000036130 66.5006 55.2927 ENSG00000141456 homo_sapiens ENSP00000460300 53.6283 45.4867 taeniopygia_guttata ENSTGUP00000030321 61.3982 52.077 ENSG00000141456 homo_sapiens ENSP00000460300 60.354 43.7168 erpetoichthys_calabaricus ENSECRP00000011573 51.7451 37.481 ENSG00000141456 homo_sapiens ENSP00000460300 57.2566 45.6637 salvator_merianae ENSSMRP00000000833 59.0868 47.1233 ENSG00000141456 homo_sapiens ENSP00000460300 34.9558 24.6903 oryzias_sinensis ENSOSIP00000044631 45.8237 32.3666 ENSG00000141456 homo_sapiens ENSP00000460300 53.1858 44.0708 pelodiscus_sinensis ENSPSIP00000003309 64.2094 53.2051 ENSG00000141456 homo_sapiens ENSP00000460300 40 33.6283 chelonoidis_abingdonii ENSCABP00000027965 63.3053 53.2213 ENSG00000141456 homo_sapiens ENSP00000460300 56.5487 48.3186 terrapene_carolina_triunguis ENSTMTP00000021349 66.6319 56.9343 ENSG00000141456 homo_sapiens ENSP00000460300 51.4159 43.1858 aquila_chrysaetos_chrysaetos ENSACCP00020018825 61.7428 51.8597 ENSG00000141456 homo_sapiens ENSP00000460300 57.4336 42.6549 paramormyrops_kingsleyae ENSPKIP00000012374 51.8785 38.5292
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000791 part_of euchromatin 1 IDA Homo_sapiens(9606) Component GO:0003682 enables chromatin binding 1 IDA Homo_sapiens(9606) Function GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 2 IDA,TAS Homo_sapiens(9606) Component GO:0005730 located_in nucleolus 1 IDA Homo_sapiens(9606) Component GO:0005737 located_in cytoplasm 1 IEA Homo_sapiens(9606) Component GO:0006364 involved_in rRNA processing 1 IBA Homo_sapiens(9606) Process GO:0032183 enables SUMO binding 1 IMP Homo_sapiens(9606) Function GO:0045944 involved_in positive regulation of transcription by RNA polymerase II 1 IDA Homo_sapiens(9606) Process GO:0071339 part_of MLL1 complex 1 IDA Homo_sapiens(9606) Component GO:0071391 involved_in cellular response to estrogen stimulus 1 IDA Homo_sapiens(9606) Process
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