Functions and Diseases

RBP Type Canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000140968 Gene ID 3394 Accession 5358
Symbol IRF8 Alias ICSBP;IRF-8;ICSBP1;IMD32A;IMD32B;H-ICSBP Full Name interferon regulatory factor 8
Status Confidence Length 23491 bases Strand Plus strand
Position 16 : 85899116 - 85922606 RNA binding domain IRF-3
Summary Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000268638 IRF-3 PF10401 2.1e-64 1
ENSP00000456992 IRF-3 PF10401 2.1e-64 1
ENSP00000512953 IRF-3 PF10401 2.1e-64 1
ENSP00000455452 IRF-3 PF10401 2.5e-64 1
ENSP00000456395 IRF-3 PF10401 2.5e-64 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30840779 Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption. Vivek Thumbigere-Math 2019-06-01 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Transcripts

Name Transcript ID bp Protein Translation ID
IRF8-212 ENST00000696884 2608 153aa ENSP00000512951
IRF8-201 ENST00000268638 2668 426aa ENSP00000268638
IRF8-207 ENST00000565552 522 47aa ENSP00000455816
IRF8-208 ENST00000566369 2068 209aa ENSP00000455048
IRF8-213 ENST00000696885 3526 130aa ENSP00000512952
IRF8-214 ENST00000696886 4742 No protein -
IRF8-211 ENST00000570088 553 No protein -
IRF8-215 ENST00000696887 2624 426aa ENSP00000512953
IRF8-203 ENST00000563180 1394 126aa ENSP00000458047
IRF8-205 ENST00000564617 531 159aa ENSP00000455784
IRF8-206 ENST00000564803 2670 426aa ENSP00000456992
IRF8-216 ENST00000696888 1038 No protein -
IRF8-217 ENST00000696889 782 No protein -
IRF8-204 ENST00000564056 514 No protein -
IRF8-218 ENST00000696890 2552 No protein -
IRF8-210 ENST00000569607 2693 222aa ENSP00000456395
IRF8-209 ENST00000569145 289 20aa ENSP00000455760
IRF8-202 ENST00000562492 946 222aa ENSP00000455452

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
57653Monocytes1.2730000E-00621738480
57677Monocytes2.5860000E-00721738480
57679Monocytes4.2580000E-00721738480
57684Monocytes4.2610000E-00721738480
62884Leukemia, Lymphocytic, Chronic, B-Cell1E-924292274
65291Leukemia, Lymphocytic, Chronic, B-Cell3E-921131588
80807Monocytes3E-1623314186
86313Gestational Age5E-627490719
86314Live Birth5E-627490719
98593Monocytes8E-628193307

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific2IBA,ISAHomo_sapiens(9606)Function
GO:0001227enables DNA-binding transcription repressor activity, RNA polymerase II-specific1IDAHomo_sapiens(9606)Function
GO:0002273involved_in plasmacytoid dendritic cell differentiation1ISSHomo_sapiens(9606)Process
GO:0002314involved_in germinal center B cell differentiation1IEAHomo_sapiens(9606)Process
GO:0002316involved_in follicular B cell differentiation1IEAHomo_sapiens(9606)Process
GO:0002376involved_in immune system process1IBAHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0006909involved_in phagocytosis1IEAHomo_sapiens(9606)Process
GO:0006914involved_in autophagy1IEAHomo_sapiens(9606)Process
GO:0006955involved_in immune response1TASHomo_sapiens(9606)Process
GO:0030099involved_in myeloid cell differentiation1IEAHomo_sapiens(9606)Process
GO:0032479involved_in regulation of type I interferon production1ISSHomo_sapiens(9606)Process
GO:0032729involved_in positive regulation of type II interferon production1IEAHomo_sapiens(9606)Process
GO:0032735involved_in positive regulation of interleukin-12 production1IEAHomo_sapiens(9606)Process
GO:0042742involved_in defense response to bacterium1IEAHomo_sapiens(9606)Process
GO:0042832involved_in defense response to protozoan1IEAHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0071222involved_in cellular response to lipopolysaccharide1IEAHomo_sapiens(9606)Process
GO:0071346involved_in cellular response to type II interferon1IDAHomo_sapiens(9606)Process
GO:0097028involved_in dendritic cell differentiation1ISSHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function

Expression