RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000140740	Gene ID	7385	Accession	12586
Symbol	UQCRC2	Alias	QCR2;UQCR2;MC3DN5	Full Name	ubiquinol-cytochrome c reductase core protein 2
Status	Confidence	Length	30373 bases	Strand	Plus strand
Position	16 : 21953288 - 21983660	RNA binding domain	N.A.
Summary	The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
35232962	Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF^V600 melanoma.	K Lorey Smith	2022-03-01	Nature communications

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
UQCRC2-213	ENST00000630839	535	132aa	ENSP00000485966
UQCRC2-208	ENST00000565464	929	132aa	ENSP00000457662
UQCRC2-201	ENST00000268379	1914	453aa	ENSP00000268379
UQCRC2-210	ENST00000567757	538	No protein	-
UQCRC2-202	ENST00000561553	1415	412aa	ENSP00000456232
UQCRC2-207	ENST00000565331	565	176aa	ENSP00000455088
UQCRC2-205	ENST00000563898	1406	336aa	ENSP00000456738
UQCRC2-206	ENST00000564095	542	116aa	ENSP00000457600
UQCRC2-212	ENST00000618892	586	70aa	ENSP00000479799
UQCRC2-209	ENST00000567597	312	No protein	-
UQCRC2-204	ENST00000563711	2008	No protein	-
UQCRC2-211	ENST00000567810	582	No protein	-
UQCRC2-203	ENST00000561798	699	No protein	-

Gene Model

Click here to download ENSG00000140740's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
33461	Blood Pressure	1.9039530E-005	-
33624	Blood Pressure	2.0537526E-005	-

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000140740's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004222	enables metalloendopeptidase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	3	HDA,IBA,IDA	Homo_sapiens(9606)	Component
GO:0005743	located_in mitochondrial inner membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0005750	part_of mitochondrial respiratory chain complex III	2	IDA,IPI	Homo_sapiens(9606)	Component
GO:0005751	part_of mitochondrial respiratory chain complex IV	1	IDA	Homo_sapiens(9606)	Component
GO:0006119	involved_in oxidative phosphorylation	1	TAS	Homo_sapiens(9606)	Process
GO:0006122	involved_in mitochondrial electron transport, ubiquinol to cytochrome c	1	NAS	Homo_sapiens(9606)	Process
GO:0006508	involved_in proteolysis	1	IEA	Homo_sapiens(9606)	Process
GO:0009060	involved_in aerobic respiration	1	TAS	Homo_sapiens(9606)	Process
GO:0045333	involved_in cellular respiration	1	NAS	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function

Expression