RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000137947	Gene ID	2959	Accession	4648
Symbol	GTF2B	Alias	TF2B;TFIIB	Full Name	general transcription factor IIB
Status	Confidence	Length	38957 bases	Strand	Minus strand
Position	1 : 88852633 - 88891589	RNA binding domain	TF_Zn_Ribbon
Summary	This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000415741	TF_Zn_Ribbon	PF08271	1e-13	1
ENSP00000359531	TF_Zn_Ribbon	PF08271	1.7e-13	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
GTF2B-201	ENST00000370500	1599	316aa	ENSP00000359531
GTF2B-203	ENST00000448623	770	224aa	ENSP00000415741
GTF2B-207	ENST00000494819	893	No protein	-
GTF2B-202	ENST00000418217	783	231aa	ENSP00000402345
GTF2B-206	ENST00000486078	528	No protein	-
GTF2B-204	ENST00000471296	593	No protein	-
GTF2B-205	ENST00000471471	516	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
92639	Intercellular Adhesion Molecule-1	4E-6	23251661

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000776	located_in kinetochore	1	IEA	Homo_sapiens(9606)	Component
GO:0000979	enables RNA polymerase II core promoter sequence-specific DNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0000993	enables RNA polymerase II complex binding	1	IDA	Homo_sapiens(9606)	Function
GO:0001174	involved_in transcriptional start site selection at RNA polymerase II promoter	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0004402	enables histone acetyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005669	part_of transcription factor TFIID complex	1	IDA	Homo_sapiens(9606)	Component
GO:0005694	located_in chromosome	1	IDA	Homo_sapiens(9606)	Component
GO:0006338	involved_in chromatin remodeling	1	IEA	Homo_sapiens(9606)	Process
GO:0006366	involved_in transcription by RNA polymerase II	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0006367	involved_in transcription initiation at RNA polymerase II promoter	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0006473	involved_in protein acetylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0010467	involved_in gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0016251	enables RNA polymerase II general transcription initiation factor activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0016407	enables acetyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0017025	enables TBP-class protein binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0019083	involved_in viral transcription	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0032153	located_in cell division site	1	IEA	Homo_sapiens(9606)	Component
GO:0032993	part_of protein-DNA complex	1	IDA	Homo_sapiens(9606)	Component
GO:0042585	located_in germinal vesicle	1	IEA	Homo_sapiens(9606)	Component
GO:0046966	enables nuclear thyroid hormone receptor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0051123	involved_in RNA polymerase II preinitiation complex assembly	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0051177	involved_in meiotic sister chromatid cohesion	1	IEA	Homo_sapiens(9606)	Process
GO:0051225	involved_in spindle assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0090575	part_of RNA polymerase II transcription regulator complex	2	IDA,IMP	Homo_sapiens(9606)	Component
GO:0097550	part_of transcription preinitiation complex	1	IBA	Homo_sapiens(9606)	Component
GO:0140297	enables DNA-binding transcription factor binding	1	IPI	Homo_sapiens(9606)	Function
GO:1904798	involved_in positive regulation of core promoter binding	1	IDA	Homo_sapiens(9606)	Process
GO:1990114	involved_in RNA polymerase II core complex assembly	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:1990841	enables promoter-specific chromatin binding	1	IDA	Homo_sapiens(9606)	Function