Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000136244 Gene ID 3569 Accession 6018
Symbol IL6 Alias CDF;HGF;HSF;BSF2;IL-6;BSF-2;IFNB2;IFN-beta-2 Full Name interleukin 6
Status Confidence Length 6119 bases Strand Plus strand
Position 7 : 22725884 - 22732002 RNA binding domain N.A.
Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
20929542 Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation. Kenneth Leslie 2010-01-01 Breast cancer research : BCR
35645219 Sarilumab Administration in COVID-19 Patients: Literature Review and Considerations. Andrea Marino 2022-05-11 Infectious disease reports
24524085 Interleukin 6 and rheumatoid arthritis. Yuji Yoshida 2014-01-01 BioMed research international
35562719 Roles of airway basal stem cells in lung homeostasis and regenerative medicine. Meirong Wu 2022-05-13 Respiratory research
37137934 A machine learning method for the identification and characterization of novel COVID-19 drug targets. Bruce Schultz 2023-05-03 Scientific reports
22995520 TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production. Guan-Lin Lee 2012-11-01 Arteriosclerosis, thrombosis, and vascular biology

Transcripts

Name Transcript ID bp Protein Translation ID
IL6-204 ENST00000404625 1527 212aa ENSP00000385675
IL6-207 ENST00000426291 574 152aa ENSP00000405150
IL6-203 ENST00000401651 539 122aa ENSP00000385718
IL6-208 ENST00000464710 3319 No protein -
IL6-209 ENST00000485300 985 266aa ENSP00000512964
IL6-201 ENST00000258743 1127 212aa ENSP00000258743
IL6-206 ENST00000407492 926 136aa ENSP00000385043
IL6-202 ENST00000401630 765 189aa ENSP00000384928
IL6-205 ENST00000406575 649 198aa ENSP00000385227

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
12070Neuroblastoma1.95E-618463370
24909Waist Circumference6.6040000E-005-
25366Waist-Hip Ratio1.6170000E-005-
68615Alzheimer Disease7E-826545630
68616Clusterin7E-826545630
103967Longevity2E-926912274

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001781involved_in neutrophil apoptotic process1IDAHomo_sapiens(9606)Process
GO:0002314involved_in germinal center B cell differentiation1ISSHomo_sapiens(9606)Process
GO:0002384involved_in hepatic immune response2IDA,TASHomo_sapiens(9606)Process
GO:0002446involved_in neutrophil mediated immunity1TASHomo_sapiens(9606)Process
GO:0002548involved_in monocyte chemotaxis1ICHomo_sapiens(9606)Process
GO:0002639involved_in positive regulation of immunoglobulin production2IDA,ISSHomo_sapiens(9606)Process
GO:0002675involved_in positive regulation of acute inflammatory response1IDAHomo_sapiens(9606)Process
GO:0002690involved_in positive regulation of leukocyte chemotaxis1TASHomo_sapiens(9606)Process
GO:0005125enables cytokine activity5IBA,IDA,ISS,NAS,TASHomo_sapiens(9606)Function
GO:0005138contributes_to interleukin-6 receptor binding3IPI,NASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005615is_active_in extracellular space3IBA,IDAHomo_sapiens(9606)Component
GO:0005788located_in endoplasmic reticulum lumen1TASHomo_sapiens(9606)Component
GO:0005896part_of interleukin-6 receptor complex2IBA,IDAHomo_sapiens(9606)Component
GO:0006953involved_in acute-phase response1TASHomo_sapiens(9606)Process
GO:0006954involved_in inflammatory response2IDA,TASHomo_sapiens(9606)Process
GO:0006959involved_in humoral immune response1ICHomo_sapiens(9606)Process
GO:0008083enables growth factor activity2IBA,IDAHomo_sapiens(9606)Function
GO:0008284involved_in positive regulation of cell population proliferation4IBA,IDA,IGI,IMPHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1TASHomo_sapiens(9606)Process
GO:0010573involved_in vascular endothelial growth factor production1IDAHomo_sapiens(9606)Process
GO:0010574involved_in regulation of vascular endothelial growth factor production1IDAHomo_sapiens(9606)Process
GO:0010575involved_in positive regulation of vascular endothelial growth factor production1IMPHomo_sapiens(9606)Process
GO:0010628acts_upstream_of_or_within positive regulation of gene expression4IDA,IGI,ISSHomo_sapiens(9606)Process
GO:0010718involved_in positive regulation of epithelial to mesenchymal transition1IDAHomo_sapiens(9606)Process
GO:0010888involved_in negative regulation of lipid storage1NASHomo_sapiens(9606)Process
GO:0014823involved_in response to activity1ISSHomo_sapiens(9606)Process
GO:0019221involved_in cytokine-mediated signaling pathway1IDAHomo_sapiens(9606)Process
GO:0030168involved_in platelet activation1TASHomo_sapiens(9606)Process
GO:0031018involved_in endocrine pancreas development1ISSHomo_sapiens(9606)Process
GO:0031175involved_in neuron projection development1IMPHomo_sapiens(9606)Process
GO:0032494involved_in response to peptidoglycan1NASHomo_sapiens(9606)Process
GO:0032682involved_in negative regulation of chemokine production1ISSHomo_sapiens(9606)Process
GO:0032722involved_in positive regulation of chemokine production2IDA,NASHomo_sapiens(9606)Process
GO:0032731involved_in positive regulation of interleukin-1 beta production1IGIHomo_sapiens(9606)Process
GO:0032733involved_in positive regulation of interleukin-10 production1IDAHomo_sapiens(9606)Process
GO:0032740involved_in positive regulation of interleukin-17 production1ISSHomo_sapiens(9606)Process
GO:0032745involved_in positive regulation of interleukin-21 production1ISSHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production1IDAHomo_sapiens(9606)Process
GO:0032757involved_in positive regulation of interleukin-8 production1IDAHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1IDAHomo_sapiens(9606)Process
GO:0032966involved_in negative regulation of collagen biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0033138acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0035633acts_upstream_of_or_within maintenance of blood-brain barrier1TASHomo_sapiens(9606)Process
GO:0042102involved_in positive regulation of T cell proliferation1IDAHomo_sapiens(9606)Process
GO:0042531involved_in positive regulation of tyrosine phosphorylation of STAT protein2IDA,IMPHomo_sapiens(9606)Process
GO:0042593involved_in glucose homeostasis1IDAHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043410acts_upstream_of_or_within positive regulation of MAPK cascade2IDAHomo_sapiens(9606)Process
GO:0045599involved_in negative regulation of fat cell differentiation1NASHomo_sapiens(9606)Process
GO:0045669involved_in positive regulation of osteoblast differentiation2IDA,TASHomo_sapiens(9606)Process
GO:0045727involved_in positive regulation of translation1IDAHomo_sapiens(9606)Process
GO:0045765involved_in regulation of angiogenesis1ICHomo_sapiens(9606)Process
GO:0045779involved_in negative regulation of bone resorption1ISSHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription2IDA,IMPHomo_sapiens(9606)Process
GO:0045944acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II3IDA,ISSHomo_sapiens(9606)Process
GO:0046427involved_in positive regulation of receptor signaling pathway via JAK-STAT3IBA,IC,IDAHomo_sapiens(9606)Process
GO:0048661involved_in positive regulation of smooth muscle cell proliferation1IDAHomo_sapiens(9606)Process
GO:0050731acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0050768involved_in negative regulation of neurogenesis1TASHomo_sapiens(9606)Process
GO:0050796involved_in regulation of insulin secretion1IDAHomo_sapiens(9606)Process
GO:0050829involved_in defense response to Gram-negative bacterium1TASHomo_sapiens(9606)Process
GO:0050830involved_in defense response to Gram-positive bacterium1TASHomo_sapiens(9606)Process
GO:0050871involved_in positive regulation of B cell activation1IDAHomo_sapiens(9606)Process
GO:0051091acts_upstream_of positive regulation of DNA-binding transcription factor activity2IDAHomo_sapiens(9606)Process
GO:0051092NOT involved_in positive regulation of NF-kappaB transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0051384involved_in response to glucocorticoid1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IDAHomo_sapiens(9606)Process
GO:0060252involved_in positive regulation of glial cell proliferation1IDAHomo_sapiens(9606)Process
GO:0061470involved_in T follicular helper cell differentiation1ISSHomo_sapiens(9606)Process
GO:0061888involved_in regulation of astrocyte activation1TASHomo_sapiens(9606)Process
GO:0070050involved_in neuron cellular homeostasis1TASHomo_sapiens(9606)Process
GO:0070091involved_in glucagon secretion1ISSHomo_sapiens(9606)Process
GO:0070092involved_in regulation of glucagon secretion1IDAHomo_sapiens(9606)Process
GO:0070102involved_in interleukin-6-mediated signaling pathway2IDA,ISSHomo_sapiens(9606)Process
GO:0070301involved_in cellular response to hydrogen peroxide1IDAHomo_sapiens(9606)Process
GO:0071222acts_upstream_of_or_within cellular response to lipopolysaccharide1IMPHomo_sapiens(9606)Process
GO:0072540involved_in T-helper 17 cell lineage commitment1ISSHomo_sapiens(9606)Process
GO:0072574involved_in hepatocyte proliferation1ISSHomo_sapiens(9606)Process
GO:0090091involved_in positive regulation of extracellular matrix disassembly1IMPHomo_sapiens(9606)Process
GO:0090594involved_in inflammatory response to wounding1IDAHomo_sapiens(9606)Process
GO:0097421involved_in liver regeneration1ISSHomo_sapiens(9606)Process
GO:0098586involved_in cellular response to virus1ISSHomo_sapiens(9606)Process
GO:0150077involved_in regulation of neuroinflammatory response1TASHomo_sapiens(9606)Process
GO:0150078involved_in positive regulation of neuroinflammatory response1TASHomo_sapiens(9606)Process
GO:1900017involved_in positive regulation of cytokine production involved in inflammatory response1IGIHomo_sapiens(9606)Process
GO:1901731acts_upstream_of positive regulation of platelet aggregation1IDAHomo_sapiens(9606)Process
GO:1902512involved_in positive regulation of apoptotic DNA fragmentation1IMPHomo_sapiens(9606)Process
GO:1903978involved_in regulation of microglial cell activation1TASHomo_sapiens(9606)Process
GO:1904894acts_upstream_of positive regulation of receptor signaling pathway via STAT1IGIHomo_sapiens(9606)Process
GO:1904996acts_upstream_of_or_within positive regulation of leukocyte adhesion to vascular endothelial cell1IDAHomo_sapiens(9606)Process
GO:2000553involved_in positive regulation of T-helper 2 cell cytokine production1ISSHomo_sapiens(9606)Process
GO:2000635acts_upstream_of negative regulation of primary miRNA processing1IGIHomo_sapiens(9606)Process
GO:2000660involved_in negative regulation of interleukin-1-mediated signaling pathway1ISSHomo_sapiens(9606)Process
GO:2000676involved_in positive regulation of type B pancreatic cell apoptotic process1TASHomo_sapiens(9606)Process

Expression