RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzymeTransmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000135587	Gene ID	6610	Accession	11121
Symbol	SMPD2	Alias	ISC1;NSMASE;NSMASE1	Full Name	sphingomyelin phosphodiesterase 2
Status	Confidence	Length	3196 bases	Strand	Plus strand
Position	6 : 109440724 - 109443919	RNA binding domain	Exo_endo_phos
Summary	This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000258052	Exo_endo_phos	PF03372	4.4e-12	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004767	enables sphingomyelin phosphodiesterase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005783	is_active_in endoplasmic reticulum	1	IBA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	2	ISS,TAS	Homo_sapiens(9606)	Component
GO:0005901	is_active_in caveola	1	IBA	Homo_sapiens(9606)	Component
GO:0006684	involved_in sphingomyelin metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0006685	involved_in sphingomyelin catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0008081	enables phosphoric diester hydrolase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0030149	involved_in sphingolipid catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0046513	involved_in ceramide biosynthetic process	1	IBA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0071944	is_active_in cell periphery	1	IBA	Homo_sapiens(9606)	Component