Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000135114 Gene ID 8638 Accession 8090
Symbol OASL Alias OASL1;OASLd;TRIP14;TRIP-14;p59OASL;p59OASL;p59-OASL Full Name 2'-5'-oligoadenylate synthetase like
Status Confidence Length 21484 bases Strand Minus strand
Position 12 : 121017763 - 121039246 RNA binding domain OAS1_C
Summary Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000506490 OAS1_C PF10421 3.5e-77 1
ENSP00000257570 OAS1_C PF10421 4.3e-77 1
ENSP00000505685 OAS1_C PF10421 4.4e-77 1
ENSP00000341125 OAS1_C PF10421 1e-18 1
ENSP00000444127 OAS1_C PF10421 1e-18 1
ENSP00000479512 OAS1_C PF10421 1.8e-18 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
29499066 The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. A Kendra Bussey 2018-03-01 PLoS pathogens
22448617 Innate immunity and hepatitis C virus infection: a microarray's view. Luigi Buonaguro 2012-03-26 Infectious agents and cancer
35757716 Endogenous Retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS Pathway Directly Control Senescence and Aging as a Consequence of ERV De-Repression? Eros E Di 2022-01-01 Frontiers in immunology
35031583 Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations. Chi-Ping Chan 2022-04-01 RNA (New York, N.Y.)
25544107 What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza? F John Alcorn 2015-02-01 Expert review of respiratory medicine
25620998 Could boosting the oligoadenylate synthetase-like pathway bring a new era of antiviral therapy? N Saumendra Sarkar 2014-01-01 Future virology
35719943 Biological Characterization and Clinical Value of OAS Gene Family in Pancreatic Cancer. Li-Juan Gao 2022-01-01 Frontiers in oncology

Transcripts

Name Transcript ID bp Protein Translation ID
OASL-208 ENST00000680620 2324 366aa ENSP00000505685
OASL-201 ENST00000257570 3270 514aa ENSP00000257570
OASL-204 ENST00000620239 1663 384aa ENSP00000479512
OASL-210 ENST00000681005 1414 No protein -
OASL-211 ENST00000681590 1569 80aa ENSP00000506074
OASL-202 ENST00000339275 1750 255aa ENSP00000341125
OASL-207 ENST00000680485 1284 80aa ENSP00000506721
OASL-206 ENST00000679655 1801 372aa ENSP00000506490
OASL-209 ENST00000680750 2293 No protein -
OASL-205 ENST00000679358 782 80aa ENSP00000505125
OASL-203 ENST00000543677 1065 255aa ENSP00000444127

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17070C-Reactive Protein3.3e-00619060910
17091C-Reactive Protein4.973e-00719060910
36346Platelet Function Tests1.3800000E-007-
36348Platelet Function Tests1.9000000E-006-
50834Child Development Disorders, Pervasive1.8605000E-005-
52247Child Development Disorders, Pervasive3.2000000E-005-
52254Child Development Disorders, Pervasive1.8000000E-005-
61219Diabetes Mellitus, Type 22E-820581827
95816gamma-Glutamyltransferase4E-1521943158
100379Emotions1E-627089181

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000135114homo_sapiensENSP0000037636228.966518.3406homo_sapiensENSP0000025757038.71624.5136
ENSG00000135114homo_sapiensENSP0000022892818.767312.7875homo_sapiensENSP0000025757039.688727.0428
ENSG00000135114homo_sapiensENSP0000020291752.2536.25homo_sapiensENSP0000025757040.661528.2101

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000135114homo_sapiensENSP0000025757098.054596.3035nomascus_leucogenysENSNLEP0000003032698.054596.3035
ENSG00000135114homo_sapiensENSP0000025757099.027298.249pan_paniscusENSPPAP0000002590599.027298.249
ENSG00000135114homo_sapiensENSP0000025757098.443697.0817pongo_abeliiENSPPYP0000000574798.443697.0817
ENSG00000135114homo_sapiensENSP0000025757098.832798.4436pan_troglodytesENSPTRP0000000942398.832798.4436
ENSG00000135114homo_sapiensENSP0000025757099.027298.0545gorilla_gorillaENSGGOP0000001182899.027298.0545
ENSG00000135114homo_sapiensENSP0000025757061.673245.1362sarcophilus_harrisiiENSSHAP0000001726263.527146.493
ENSG00000135114homo_sapiensENSP0000025757035.992225.2918notamacropus_eugeniiENSMEUP0000000377864.236145.1389
ENSG00000135114homo_sapiensENSP0000025757084.824977.4319choloepus_hoffmanniENSCHOP0000000280584.824977.4319
ENSG00000135114homo_sapiensENSP0000025757083.46375.0973dasypus_novemcinctusENSDNOP0000002539683.139574.8062
ENSG00000135114homo_sapiensENSP0000025757051.75142.8016erinaceus_europaeusENSEEUP0000000753352.259343.222
ENSG00000135114homo_sapiensENSP0000025757080.155669.4553echinops_telfairiENSETEP0000001224180.155669.4553
ENSG00000135114homo_sapiensENSP0000025757094.163488.3269callithrix_jacchusENSCJAP0000007669293.980688.1553
ENSG00000135114homo_sapiensENSP0000025757097.665494.358cercocebus_atysENSCATP0000002248097.475794.1748
ENSG00000135114homo_sapiensENSP0000025757097.470893.1907macaca_fascicularisENSMFAP0000002320997.281693.0097
ENSG00000135114homo_sapiensENSP0000025757097.276392.9961macaca_mulattaENSMMUP0000004927197.087492.8155
ENSG00000135114homo_sapiensENSP0000025757097.276392.9961macaca_nemestrinaENSMNEP0000001051497.087492.8155
ENSG00000135114homo_sapiensENSP0000025757097.665494.1634papio_anubisENSPANP0000001116997.475793.9806
ENSG00000135114homo_sapiensENSP0000025757097.665494.1634mandrillus_leucophaeusENSMLEP0000002755197.475793.9806
ENSG00000135114homo_sapiensENSP0000025757048.054542.0233tursiops_truncatusENSTTRP0000000183570.773661.8911
ENSG00000135114homo_sapiensENSP0000025757082.879473.1517vulpes_vulpesENSVVUP0000002956582.879473.1517
ENSG00000135114homo_sapiensENSP0000025757082.295770.8171mus_spretusMGP_SPRETEiJ_P007275582.778971.2329
ENSG00000135114homo_sapiensENSP0000025757086.770479.3774equus_asinusENSEASP0000503475886.770479.3774
ENSG00000135114homo_sapiensENSP0000025757049.221840.0778capra_hircusENSCHIP0000001769173.976660.2339
ENSG00000135114homo_sapiensENSP0000025757085.21477.6265loxodonta_africanaENSLAFP0000001500085.048577.4757
ENSG00000135114homo_sapiensENSP0000025757085.21473.93panthera_leoENSPLOP0000001058985.048573.7864
ENSG00000135114homo_sapiensENSP0000025757085.21473.7354ailuropoda_melanoleucaENSAMEP0000000879975.778565.5709
ENSG00000135114homo_sapiensENSP0000025757052.918344.358bos_indicus_hybridENSBIXP0000502667874.725362.6374
ENSG00000135114homo_sapiensENSP0000025757081.906673.7354oryctolagus_cuniculusENSOCUP0000002699069.817662.8524
ENSG00000135114homo_sapiensENSP0000025757086.381378.7938equus_caballusENSECAP0000001227086.381378.7938
ENSG00000135114homo_sapiensENSP0000025757083.268573.7354canis_lupus_familiarisENSCAFP0084504203683.106873.5922
ENSG00000135114homo_sapiensENSP0000025757085.603174.3191panthera_pardusENSPPRP0000000203285.436974.1748
ENSG00000135114homo_sapiensENSP0000025757084.241273.7354marmota_marmota_marmotaENSMMMP0000002392084.241273.7354
ENSG00000135114homo_sapiensENSP0000025757079.182967.7043balaenoptera_musculusENSBMSP0001001304579.029167.5728
ENSG00000135114homo_sapiensENSP0000025757084.046773.1517cavia_porcellusENSCPOP0000000653281.509470.9434
ENSG00000135114homo_sapiensENSP0000025757085.992274.5136felis_catusENSFCAP0000000894385.825274.3689
ENSG00000135114homo_sapiensENSP0000025757085.797774.5136ursus_americanusENSUAMP0000002917785.631174.3689
ENSG00000135114homo_sapiensENSP0000025757065.758848.6381monodelphis_domesticaENSMODP000000581526548.0769
ENSG00000135114homo_sapiensENSP0000025757052.918344.1634bison_bison_bisonENSBBBP0000000343874.725362.3626
ENSG00000135114homo_sapiensENSP0000025757079.377468.0934monodon_monocerosENSMMNP0001501464976.547865.666
ENSG00000135114homo_sapiensENSP000002575705041.6342sus_scrofaENSSSCP0000001058773.850661.4943
ENSG00000135114homo_sapiensENSP0000025757083.46371.7899microcebus_murinusENSMICP0000004169783.789172.0703
ENSG00000135114homo_sapiensENSP0000025757082.295773.93octodon_degusENSODEP0000000931782.135973.7864
ENSG00000135114homo_sapiensENSP0000025757083.46372.9572jaculus_jaculusENSJJAP0000002213383.30172.8155
ENSG00000135114homo_sapiensENSP000002575705041.8288ovis_aries_rambouilletENSOARP0002002933873.850661.7816
ENSG00000135114homo_sapiensENSP0000025757075.486462.4514ursus_maritimusENSUMAP0000000761574.329561.4943
ENSG00000135114homo_sapiensENSP0000025757069.455359.144ochotona_princepsENSOPRP0000000942379.5167.706
ENSG00000135114homo_sapiensENSP0000025757038.132333.2685ochotona_princepsENSOPRP0000000064465.551857.1906
ENSG00000135114homo_sapiensENSP0000025757079.377467.8988delphinapterus_leucasENSDLEP0000002383676.547865.4784
ENSG00000135114homo_sapiensENSP0000025757078.404767.5097physeter_catodonENSPCTP0000502657178.86567.9061
ENSG00000135114homo_sapiensENSP0000025757082.879471.4008mus_caroliMGP_CAROLIEiJ_P007007383.36671.82
ENSG00000135114homo_sapiensENSP0000025757082.295770.428mus_musculusENSMUSP0000010777182.778970.8415
ENSG00000135114homo_sapiensENSP0000025757084.824972.9572mustela_putorius_furoENSMPUP0000000327484.660272.8155
ENSG00000135114homo_sapiensENSP0000025757064.396959.5331aotus_nancymaaeENSANAP0000001224586.649280.1047
ENSG00000135114homo_sapiensENSP0000025757093.385288.9105saimiri_boliviensis_boliviensisENSSBOP0000003906493.203988.7379
ENSG00000135114homo_sapiensENSP0000025757065.953355.642vicugna_pacosENSVPAP0000000834173.060361.6379
ENSG00000135114homo_sapiensENSP0000025757097.665493.7743chlorocebus_sabaeusENSCSAP0000001581497.475793.5922
ENSG00000135114homo_sapiensENSP0000025757063.618755.4475tupaia_belangeriENSTBEP0000000655972.828563.4744
ENSG00000135114homo_sapiensENSP0000025757048.24942.9961mesocricetus_auratusENSMAUP0000001827683.783874.6622
ENSG00000135114homo_sapiensENSP0000025757079.961168.0934phocoena_sinusENSPSNP0000000797977.110765.666
ENSG00000135114homo_sapiensENSP0000025757078.988367.1206camelus_dromedariusENSCDRP0000502807078.83566.9903
ENSG00000135114homo_sapiensENSP0000025757086.575977.6265carlito_syrichtaENSTSYP0000000855787.598478.5433
ENSG00000135114homo_sapiensENSP0000025757085.603174.1245panthera_tigris_altaicaENSPTIP0000002025385.436973.9806
ENSG00000135114homo_sapiensENSP0000025757084.435873.1517rattus_norvegicusENSRNOP0000000157084.765673.4375
ENSG00000135114homo_sapiensENSP0000025757060.894951.9455prolemur_simusENSPSMP0000000303282.152270.0787
ENSG00000135114homo_sapiensENSP0000025757083.852174.5136microtus_ochrogasterENSMOCP0000001402683.689374.3689
ENSG00000135114homo_sapiensENSP0000025757070.817159.144sorex_araneusENSSARP0000000911177.282464.5435
ENSG00000135114homo_sapiensENSP0000025757083.852174.3191peromyscus_maniculatus_bairdiiENSPEMP0000001701383.689374.1748
ENSG00000135114homo_sapiensENSP0000025757053.112844.1634bos_mutusENSBMUP000000287337562.3626
ENSG00000135114homo_sapiensENSP0000025757082.101270.2335mus_spicilegusENSMSIP0000001187482.583270.6458
ENSG00000135114homo_sapiensENSP0000025757082.879474.1245cricetulus_griseus_chok1gshdENSCGRP0000102257684.523875.5952
ENSG00000135114homo_sapiensENSP0000025757077.042869.0661pteropus_vampyrusENSPVAP0000000759777.042869.0661
ENSG00000135114homo_sapiensENSP0000025757081.32370.0389myotis_lucifugusENSMLUP0000000831380.539569.3642
ENSG00000135114homo_sapiensENSP0000025757064.980546.6926vombatus_ursinusENSVURP0001000879464.354546.2428
ENSG00000135114homo_sapiensENSP0000025757082.295775.6809rhinolophus_ferrumequinumENSRFEP0001002461682.456175.8285
ENSG00000135114homo_sapiensENSP0000025757040.661533.8521neovison_visonENSNVIP0000001141681.960868.2353
ENSG00000135114homo_sapiensENSP0000025757052.334643.9689bos_taurusENSBTAP0000000427076.420564.2045
ENSG00000135114homo_sapiensENSP0000025757084.435875.2918heterocephalus_glaber_femaleENSHGLP0000001639284.435875.2918
ENSG00000135114homo_sapiensENSP0000025757085.019581.9066rhinopithecus_bietiENSRBIP0000000163897.327493.7639
ENSG00000135114homo_sapiensENSP0000025757083.073973.7354canis_lupus_dingoENSCAFP0002002652682.912673.5922
ENSG00000135114homo_sapiensENSP0000025757086.186877.2374sciurus_vulgarisENSSVLP0000500853086.019477.0874
ENSG00000135114homo_sapiensENSP0000025757062.451443.5798phascolarctos_cinereusENSPCIP0000000958563.944244.6215
ENSG00000135114homo_sapiensENSP0000025757083.073972.9572procavia_capensisENSPCAP0000001211183.561673.3855
ENSG00000135114homo_sapiensENSP0000025757083.46375.4864nannospalax_galiliENSNGAP0000001594683.30175.3398
ENSG00000135114homo_sapiensENSP0000025757053.112844.1634bos_grunniensENSBGRP000000422037562.3626
ENSG00000135114homo_sapiensENSP0000025757084.046774.7082chinchilla_lanigeraENSCLAP0000001987783.883574.5631
ENSG00000135114homo_sapiensENSP0000025757074.319160.7004cervus_hanglu_yarkandensisENSCHYP0000000377875.494161.6601
ENSG00000135114homo_sapiensENSP0000025757071.984462.6459catagonus_wagneriENSCWAP0000001662472.978363.5108
ENSG00000135114homo_sapiensENSP0000025757057.003950otolemur_garnettiiENSOGAP0000000814083.238673.0114
ENSG00000135114homo_sapiensENSP0000025757092.996187.7432cebus_imitatorENSCCAP0000002040492.815587.5728
ENSG00000135114homo_sapiensENSP0000025757084.824974.5136urocitellus_parryiiENSUPAP0001002102084.660274.3689
ENSG00000135114homo_sapiensENSP0000025757097.276393.5798rhinopithecus_roxellanaENSRROP0000002414997.087493.3981
ENSG00000135114homo_sapiensENSP0000025757083.073972.179mus_pahariMGP_PahariEiJ_P005829783.561672.6027
ENSG00000135114homo_sapiensENSP0000025757083.268573.93propithecus_coquereliENSPCOP0000002739283.757374.364
ENSG00000135114homo_sapiensENSP0000025757023.540913.4241ciona_intestinalisENSCINP0000003509941.296923.5495
ENSG00000135114homo_sapiensENSP0000025757047.081730.5447callorhinchus_miliiENSCMIP0000003990855.760436.1751
ENSG00000135114homo_sapiensENSP0000025757040.661528.5992latimeria_chalumnaeENSLACP0000001992018.965513.3394
ENSG00000135114homo_sapiensENSP0000025757043.774329.7665latimeria_chalumnaeENSLACP0000002081464.285743.7143
ENSG00000135114homo_sapiensENSP0000025757018.093411.0895chrysemys_picta_belliiENSCPBP0000003931746.268728.3582
ENSG00000135114homo_sapiensENSP0000025757056.225738.5214sphenodon_punctatusENSSPUP0000000200657.455339.3638
ENSG00000135114homo_sapiensENSP0000025757057.003939.8833laticauda_laticaudataENSLLTP0000002313157.677240.3543
ENSG00000135114homo_sapiensENSP0000025757042.412530.9339notechis_scutatusENSNSUP0000000692558.288842.5134
ENSG00000135114homo_sapiensENSP0000025757057.003939.4942pseudonaja_textilisENSPTXP0000001158958.019840.198
ENSG00000135114homo_sapiensENSP0000025757054.669337.3541anas_platyrhynchos_platyrhynchosENSAPLP0000002206255.864838.171
ENSG00000135114homo_sapiensENSP0000025757055.64236.7704gallus_gallusENSGALP0001004095955.426436.6279
ENSG00000135114homo_sapiensENSP0000025757049.027233.0739meleagris_gallopavoENSMGAP0000002534756.629238.2022
ENSG00000135114homo_sapiensENSP0000025757055.64236.965serinus_canariaENSSCAP0000002401255.53436.8932
ENSG00000135114homo_sapiensENSP0000025757055.058436.3813parus_majorENSPMJP0000001660554.84536.2403
ENSG00000135114homo_sapiensENSP0000025757041.828828.7938anolis_carolinensisENSACAP0000003903156.878339.1534
ENSG00000135114homo_sapiensENSP0000025757055.058439.6887naja_najaENSNNAP0000001029858.958342.5
ENSG00000135114homo_sapiensENSP0000025757054.085635.7977geospiza_fortisENSGFOP0000000110854.509836.0784
ENSG00000135114homo_sapiensENSP0000025757054.669335.6031taeniopygia_guttataENSTGUP0000000675654.669335.6031
ENSG00000135114homo_sapiensENSP0000025757058.560337.1595salvator_merianaeENSSMRP0000001017459.368837.6726
ENSG00000135114homo_sapiensENSP0000025757051.556434.6304pelodiscus_sinensisENSPSIP0000000959853.643736.0324
ENSG00000135114homo_sapiensENSP0000025757057.782139.2996gopherus_evgoodeiENSGEVP0000501831959.51940.481
ENSG00000135114homo_sapiensENSP0000025757059.922240.0778chelonoidis_abingdoniiENSCABP0000001110461.723441.2826
ENSG00000135114homo_sapiensENSP0000025757054.474736.1868struthio_camelus_australisENSSCUP0000000885652.141534.6369
ENSG00000135114homo_sapiensENSP0000025757054.863838.5214anser_brachyrhynchusENSABRP0000000200755.511838.9764
ENSG00000135114homo_sapiensENSP0000025757050.389133.6576strigops_habroptilaENSSHBP000050084965033.3977
ENSG00000135114homo_sapiensENSP0000025757055.447537.3541terrapene_carolina_triunguisENSTMTP0000001260051.724134.8457
ENSG00000135114homo_sapiensENSP0000025757057.003938.1323aquila_chrysaetos_chrysaetosENSACCP0002001912857.003938.1323
ENSG00000135114homo_sapiensENSP0000025757056.031137.1595ficedula_albicollisENSFALP0000000917653.731335.6343
ENSG00000135114homo_sapiensENSP0000025757055.252936.7704coturnix_japonicaENSCJPP0000501469254.510636.2764

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001730NOT enables 2-5-oligoadenylate synthetase activity1IDAHomo_sapiens(9606)Function
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654is_active_in nucleoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0009615involved_in response to virus1IDAHomo_sapiens(9606)Process
GO:0016020located_in membrane2HDA,IBAHomo_sapiens(9606)Component
GO:0045071involved_in negative regulation of viral genome replication2IBA,IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0046966enables nuclear thyroid hormone receptor binding1TASHomo_sapiens(9606)Function
GO:0051607involved_in defense response to virus2IBA,IDAHomo_sapiens(9606)Process
GO:0060700involved_in regulation of ribonuclease activity1IBAHomo_sapiens(9606)Process
GO:0070106involved_in interleukin-27-mediated signaling pathway1IEPHomo_sapiens(9606)Process
GO:1900246involved_in positive regulation of RIG-I signaling pathway1IDAHomo_sapiens(9606)Process

Expression