RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Dengue
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Description

Ensembl ID	ENSG00000133119	Gene ID	5983	Accession	9971
Symbol	RFC3	Alias	RFC38	Full Name	replication factor C subunit 3
Status	Confidence	Length	148490 bases	Strand	Plus strand
Position	13 : 33818069 - 33966558	RNA binding domain	N.A.
Summary	The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
RFC3-201	ENST00000380071	2306	356aa	ENSP00000369411
RFC3-203	ENST00000616236	612	103aa	ENSP00000484747
RFC3-202	ENST00000434425	1461	305aa	ENSP00000401001

Gene Model

Click here to download ENSG00000133119's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
2403	Body Weights and Measures	5.11969458985379E-6	17903300
2404	Body Weights and Measures	3.49703759575645E-6	17903300

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000133119's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000731	involved_in DNA synthesis involved in DNA repair	1	TAS	Homo_sapiens(9606)	Process
GO:0003677	contributes_to DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003689	contributes_to DNA clamp loader activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005663	part_of DNA replication factor C complex	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0006260	involved_in DNA replication	1	IDA	Homo_sapiens(9606)	Process
GO:0006261	involved_in DNA-templated DNA replication	1	IBA	Homo_sapiens(9606)	Process
GO:0006271	involved_in DNA strand elongation involved in DNA replication	1	TAS	Homo_sapiens(9606)	Process
GO:0006281	involved_in DNA repair	1	IBA	Homo_sapiens(9606)	Process
GO:0008094	enables ATP-dependent activity, acting on DNA	1	IDA	Homo_sapiens(9606)	Function
GO:0017116	contributes_to single-stranded DNA helicase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0031390	part_of Ctf18 RFC-like complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032508	involved_in DNA duplex unwinding	1	IEA	Homo_sapiens(9606)	Process
GO:0046683	involved_in response to organophosphorus	1	IEP	Homo_sapiens(9606)	Process
GO:1900264	involved_in positive regulation of DNA-directed DNA polymerase activity	1	IDA	Homo_sapiens(9606)	Process

Expression