RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000132256	Gene ID	85363	Accession	16276
Symbol	TRIM5	Alias	RNF88;TRIM5alpha	Full Name	tripartite motif containing 5
Status	Confidence	Length	275425 bases	Strand	Minus strand
Position	11 : 5663195 - 5938619	RNA binding domain	SPRY
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000369373	SPRY	PF00622	1.4e-09	1
ENSP00000507420	SPRY	PF00622	1.4e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TRIM5-202	ENST00000380034	3364	493aa	ENSP00000369373
TRIM5-201	ENST00000380027	2290	326aa	ENSP00000369366
TRIM5-206	ENST00000433961	2759	271aa	ENSP00000393052
TRIM5-214	ENST00000684655	2862	493aa	ENSP00000507420
TRIM5-203	ENST00000396847	3170	347aa	ENSP00000380058
TRIM5-212	ENST00000682968	2669	265aa	ENSP00000506742
TRIM5-207	ENST00000438025	767	187aa	ENSP00000398196
TRIM5-209	ENST00000483835	918	No protein	-
TRIM5-211	ENST00000492086	662	No protein	-
TRIM5-213	ENST00000684417	1317	No protein	-
TRIM5-208	ENST00000465634	602	No protein	-
TRIM5-210	ENST00000487241	756	No protein	-
TRIM5-204	ENST00000412903	1054	209aa	ENSP00000388031
TRIM5-205	ENST00000419850	607	72aa	ENSP00000388150

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
18319	Fetal Hemoglobin	8.839e-005	-
18452	Hemoglobins	1.399e-005	-
61117	Immunoglobulins	2E-6	23382691
62914	Immunoglobulins	3E-6	23382691
77193	Immunoglobulins	1E-6	23382691

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000209	involved_in protein polyubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0000932	located_in P-body	1	IDA	Homo_sapiens(9606)	Component
GO:0002218	involved_in activation of innate immune response	1	IDA	Homo_sapiens(9606)	Process
GO:0003713	enables transcription coactivator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004842	enables ubiquitin-protein transferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	is_active_in nucleoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	2	IBA,TAS	Homo_sapiens(9606)	Component
GO:0006914	involved_in autophagy	1	IDA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0010508	involved_in positive regulation of autophagy	1	IBA	Homo_sapiens(9606)	Process
GO:0019901	enables protein kinase binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0030674	enables protein-macromolecule adaptor activity	1	IPI	Homo_sapiens(9606)	Function
GO:0031664	involved_in regulation of lipopolysaccharide-mediated signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0032880	involved_in regulation of protein localization	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0038187	enables pattern recognition receptor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0043123	involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0043410	involved_in positive regulation of MAPK cascade	1	IMP	Homo_sapiens(9606)	Process
GO:0044790	involved_in suppression of viral release by host	1	IDA	Homo_sapiens(9606)	Process
GO:0045087	involved_in innate immune response	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0046596	involved_in regulation of viral entry into host cell	1	IBA	Homo_sapiens(9606)	Process
GO:0046597	involved_in negative regulation of viral entry into host cell	1	IDA	Homo_sapiens(9606)	Process
GO:0051091	involved_in positive regulation of DNA-binding transcription factor activity	1	IMP	Homo_sapiens(9606)	Process
GO:0051092	involved_in positive regulation of NF-kappaB transcription factor activity	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0051607	involved_in defense response to virus	1	TAS	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0070534	involved_in protein K63-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:1990462	colocalizes_with omegasome	1	IDA	Homo_sapiens(9606)	Component