RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000131269	Gene ID	22	Accession	48
Symbol	ABCB7	Alias	ABC7;ASAT;Atm1p;EST140535	Full Name	ATP binding cassette subfamily B member 7
Status	Confidence	Length	105685 bases	Strand	Minus strand
Position	X : 75051048 - 75156732	RNA binding domain	N.A.
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
ABCB7-203	ENST00000373394	4592	752aa	ENSP00000362492
ABCB7-201	ENST00000253577	4595	753aa	ENSP00000253577
ABCB7-215	ENST00000666534	3883	No protein	-
ABCB7-217	ENST00000669573	2377	693aa	ENSP00000499543
ABCB7-212	ENST00000644766	2304	651aa	ENSP00000493713
ABCB7-202	ENST00000339447	2234	712aa	ENSP00000343849
ABCB7-213	ENST00000645829	2361	757aa	ENSP00000496526
ABCB7-210	ENST00000620875	2142	713aa	ENSP00000479985
ABCB7-214	ENST00000663420	2106	No protein	-
ABCB7-207	ENST00000529949	2116	702aa	ENSP00000436586
ABCB7-205	ENST00000490858	530	No protein	-
ABCB7-216	ENST00000669388	1836	No protein	-
ABCB7-209	ENST00000534570	805	47aa	ENSP00000494779
ABCB7-204	ENST00000469368	630	No protein	-
ABCB7-208	ENST00000534524	580	188aa	ENSP00000435521
ABCB7-206	ENST00000526404	550	159aa	ENSP00000432813
ABCB7-211	ENST00000643632	561	159aa	ENSP00000493617

Gene Model

Click here to download ENSG00000131269's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000131269's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005743	is_active_in mitochondrial inner membrane	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0006879	involved_in intracellular iron ion homeostasis	3	IBA,IMP,ISS	Homo_sapiens(9606)	Process
GO:0015232	enables heme transmembrane transporter activity	1	TAS	Homo_sapiens(9606)	Function
GO:0015886	involved_in heme transport	1	IEA	Homo_sapiens(9606)	Process
GO:0016226	involved_in iron-sulfur cluster assembly	1	ISS	Homo_sapiens(9606)	Process
GO:0016887	enables ATP hydrolysis activity	1	IEA	Homo_sapiens(9606)	Function
GO:0034755	involved_in iron ion transmembrane transport	1	IDA	Homo_sapiens(9606)	Process
GO:0042626	enables ATPase-coupled transmembrane transporter activity	1	IBA	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0055085	involved_in transmembrane transport	1	IBA	Homo_sapiens(9606)	Process
GO:0070455	involved_in positive regulation of heme biosynthetic process	2	IMP,ISS	Homo_sapiens(9606)	Process
GO:0140466	involved_in iron-sulfur cluster export from the mitochondrion	1	IMP	Homo_sapiens(9606)	Process
GO:0140481	enables ABC-type iron-sulfur cluster transporter activity	1	IMP	Homo_sapiens(9606)	Function
GO:1903331	involved_in positive regulation of iron-sulfur cluster assembly	2	IMP,ISS	Homo_sapiens(9606)	Process
GO:1903427	involved_in negative regulation of reactive oxygen species biosynthetic process	1	ISS	Homo_sapiens(9606)	Process

Expression