Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesIAVRVSARS-COV-2
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions TF
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_01_239 DataSet_01_406

Description

Ensembl ID ENSG00000130254 Gene ID 9667 Accession 21605
Symbol SAFB2 Alias NA Full Name scaffold attachment factor B2
Status Confidence Length 37048 bases Strand Minus strand
Position 19 : 5586999 - 5624046 RNA binding domain SAP , RRM_1
Summary The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000252542 RRM_1 PF00076 1.8e-13 1
ENSP00000252542 SAP PF02037 1.2e-09 2
ENSP00000468505 SAP PF02037 9.7e-11 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
26273616 Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells. Elaine Hong 2015-01-01 BioMed research international
36834708 Insight into the Structural Basis for Dual Nucleic Acid-Recognition by the Scaffold Attachment Factor B2 Protein. M Sophie Korn 2023-02-07 International journal of molecular sciences
25155612 The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites. A Jason West 2014-09-04 Molecular cell
32502422 SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts. Katharina Hutter 2020-06-04 Molecular cell
26482227 Tumor size, stage and grade alterations of urinary peptidome in RCC. Clizia Chinello 2015-10-20 Journal of translational medicine

Transcripts

Name Transcript ID bp Protein Translation ID
SAFB2-201 ENST00000252542 3167 953aa ENSP00000252542
SAFB2-203 ENST00000587802 583 No protein -
SAFB2-204 ENST00000589925 506 No protein -
SAFB2-205 ENST00000590000 633 No protein -
SAFB2-202 ENST00000585449 443 No protein -
SAFB2-209 ENST00000591123 836 87aa ENSP00000467981
SAFB2-211 ENST00000592599 2260 No protein -
SAFB2-207 ENST00000591101 551 No protein -
SAFB2-210 ENST00000591310 722 No protein -
SAFB2-208 ENST00000591120 1298 115aa ENSP00000468505
SAFB2-206 ENST00000590262 564 124aa ENSP00000468454

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
26414Blood Pressure5.6630000E-005-
26415Blood Pressure7.3950000E-005-
83608Obsessive-Compulsive Disorder7E-626859814

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000130254homo_sapiensENSP0000036988748.452633.8491homo_sapiensENSP0000025254252.570836.7261
ENSG00000130254homo_sapiensENSP0000046742383.860473.0643homo_sapiensENSP0000025254280.692670.3043

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000130254homo_sapiensENSP0000025254298.216297.6915nomascus_leucogenysENSNLEP0000001640298.526398
ENSG00000130254homo_sapiensENSP0000025254299.790199.7901pan_paniscusENSPPAP0000004154799.790199.7901
ENSG00000130254homo_sapiensENSP0000025254299.265599.0556pongo_abeliiENSPPYP0000001057199.265599.0556
ENSG00000130254homo_sapiensENSP0000025254294.333793.7041pan_troglodytesENSPTRP0000008755197.294496.645
ENSG00000130254homo_sapiensENSP0000025254297.586697.0619gorilla_gorillaENSGGOP0000001474097.894797.3684
ENSG00000130254homo_sapiensENSP0000025254279.643267.681ornithorhynchus_anatinusENSOANP0000003561164.376654.7074
ENSG00000130254homo_sapiensENSP0000025254282.896172.8227sarcophilus_harrisiiENSSHAP0000001488974.108865.1032
ENSG00000130254homo_sapiensENSP0000025254274.711464.7429notamacropus_eugeniiENSMEUP0000000224681.464570.595
ENSG00000130254homo_sapiensENSP0000025254259.601356.7681choloepus_hoffmanniENSCHOP0000000946381.375477.5072
ENSG00000130254homo_sapiensENSP0000025254240.083937.4607dasypus_novemcinctusENSDNOP0000002739187.015981.3212
ENSG00000130254homo_sapiensENSP0000025254242.077638.6149echinops_telfairiENSETEP0000001360050.062445.9426
ENSG00000130254homo_sapiensENSP0000025254295.592994.5435callithrix_jacchusENSCJAP0000008504695.894794.8421
ENSG00000130254homo_sapiensENSP0000025254297.691597.2718cercocebus_atysENSCATP0000003297198.310597.8881
ENSG00000130254homo_sapiensENSP0000025254252.885652.361macaca_fascicularisENSMFAP0000004181996.923195.9615
ENSG00000130254homo_sapiensENSP0000025254299.055698.6359macaca_mulattaENSMMUP0000002361999.055698.6359
ENSG00000130254homo_sapiensENSP0000025254294.123893.0745macaca_nemestrinaENSMNEP0000001598794.520593.4668
ENSG00000130254homo_sapiensENSP0000025254299.055698.6359papio_anubisENSPANP0000001045799.055698.6359
ENSG00000130254homo_sapiensENSP0000025254299.160598.7408mandrillus_leucophaeusENSMLEP0000002072499.160598.7408
ENSG00000130254homo_sapiensENSP0000025254280.902475.7608tursiops_truncatusENSTTRP0000001289381.41576.2408
ENSG00000130254homo_sapiensENSP0000025254293.284488.8772vulpes_vulpesENSVVUP0000001863493.186688.7841
ENSG00000130254homo_sapiensENSP0000025254273.137565.0577mus_spretusMGP_SPRETEiJ_P004723577.616969.0423
ENSG00000130254homo_sapiensENSP0000025254287.932882.7912equus_asinusENSEASP0000503351184.561179.6165
ENSG00000130254homo_sapiensENSP0000025254289.611883.7356capra_hircusENSCHIP0000002941690.658284.7134
ENSG00000130254homo_sapiensENSP0000025254288.247682.3715loxodonta_africanaENSLAFP0000000320990.430184.4086
ENSG00000130254homo_sapiensENSP0000025254292.444987.8279panthera_leoENSPLOP0000000923393.227588.5714
ENSG00000130254homo_sapiensENSP0000025254293.179488.6674ailuropoda_melanoleucaENSAMEP0000001288986.381382.1984
ENSG00000130254homo_sapiensENSP0000025254290.346384.3652bos_indicus_hybridENSBIXP0000503237081.844176.4259
ENSG00000130254homo_sapiensENSP0000025254240.923436.7261oryctolagus_cuniculusENSOCUP0000000136978.156370.1403
ENSG00000130254homo_sapiensENSP0000025254279.328474.3966equus_caballusENSECAP0000003503380.169775.1856
ENSG00000130254homo_sapiensENSP0000025254293.389388.9822canis_lupus_familiarisENSCAFP0084501893493.291488.8889
ENSG00000130254homo_sapiensENSP0000025254292.549887.8279panthera_pardusENSPPRP0000002015393.333388.5714
ENSG00000130254homo_sapiensENSP0000025254282.476477.8594marmota_marmota_marmotaENSMMMP0000002131986.946982.0796
ENSG00000130254homo_sapiensENSP0000025254292.025286.7786balaenoptera_musculusENSBMSP0001000475992.315887.0526
ENSG00000130254homo_sapiensENSP0000025254286.463881.3221cavia_porcellusENSCPOP0000001024186.736881.5789
ENSG00000130254homo_sapiensENSP0000025254292.3487.9328felis_catusENSFCAP0000001098083.969579.9618
ENSG00000130254homo_sapiensENSP0000025254292.3487.723ursus_americanusENSUAMP0000003233191.571386.9927
ENSG00000130254homo_sapiensENSP0000025254283.840573.5572monodelphis_domesticaENSMODP0000005182383.31673.097
ENSG00000130254homo_sapiensENSP0000025254290.451284.3652bison_bison_bisonENSBBBP0000001398690.928384.8101
ENSG00000130254homo_sapiensENSP0000025254292.23586.7786monodon_monocerosENSMMNP0001500557992.42986.9611
ENSG00000130254homo_sapiensENSP0000025254289.926585.8342sus_scrofaENSSSCP0000007086687.807483.8115
ENSG00000130254homo_sapiensENSP0000025254294.228891.0808microcebus_murinusENSMICP0000004015994.1390.9853
ENSG00000130254homo_sapiensENSP0000025254287.513183.3158octodon_degusENSODEP0000001998587.974783.7553
ENSG00000130254homo_sapiensENSP0000025254222.980121.7209jaculus_jaculusENSJJAP0000001308189.754184.8361
ENSG00000130254homo_sapiensENSP0000025254289.611883.7356ovis_aries_rambouilletENSOARP0002001161290.658284.7134
ENSG00000130254homo_sapiensENSP0000025254280.272875.0262ursus_maritimusENSUMAP0000001301685.858680.2469
ENSG00000130254homo_sapiensENSP0000025254282.266576.0756ochotona_princepsENSOPRP0000001052882.094275.9162
ENSG00000130254homo_sapiensENSP0000025254288.457582.4764delphinapterus_leucasENSDLEP0000002088074.142569.1293
ENSG00000130254homo_sapiensENSP0000025254249.21345.8552physeter_catodonENSPCTP0000501862490.019283.8772
ENSG00000130254homo_sapiensENSP0000025254281.636973.0325mus_caroliMGP_CAROLIEiJ_P004534378.427470.1613
ENSG00000130254homo_sapiensENSP0000025254281.636973.2424mus_musculusENSMUSP0000007495378.506670.4339
ENSG00000130254homo_sapiensENSP0000025254278.908773.5572dipodomys_ordiiENSDORP0000001523984.971779.209
ENSG00000130254homo_sapiensENSP0000025254292.444987.3033mustela_putorius_furoENSMPUP0000000605585.617180.8552
ENSG00000130254homo_sapiensENSP0000025254298.111296.6422aotus_nancymaaeENSANAP0000002822898.111296.6422
ENSG00000130254homo_sapiensENSP0000025254296.747195.2781saimiri_boliviensis_boliviensisENSSBOP0000003233297.773196.2884
ENSG00000130254homo_sapiensENSP0000025254264.218361.8048vicugna_pacosENSVPAP0000001120577.468474.557
ENSG00000130254homo_sapiensENSP0000025254299.055698.3211chlorocebus_sabaeusENSCSAP0000000620099.055698.3211
ENSG00000130254homo_sapiensENSP0000025254262.644359.4963tupaia_belangeriENSTBEP0000001104070.484166.9421
ENSG00000130254homo_sapiensENSP0000025254266.946560.1259mesocricetus_auratusENSMAUP0000001081179.254771.1801
ENSG00000130254homo_sapiensENSP0000025254292.130186.8835phocoena_sinusENSPSNP0000002286492.323987.0662
ENSG00000130254homo_sapiensENSP0000025254292.23588.5624camelus_dromedariusENSCDRP0000503229991.467287.8252
ENSG00000130254homo_sapiensENSP0000025254278.069373.2424panthera_tigris_altaicaENSPTIP0000001631387.735882.3113
ENSG00000130254homo_sapiensENSP0000025254281.322172.7177rattus_norvegicusENSRNOP0000009332378.12569.8589
ENSG00000130254homo_sapiensENSP0000025254293.91490.5561prolemur_simusENSPSMP0000002111394.210590.8421
ENSG00000130254homo_sapiensENSP0000025254279.223571.5635microtus_ochrogasterENSMOCP0000000709379.140571.4885
ENSG00000130254homo_sapiensENSP0000025254264.952860.2309sorex_araneusENSSARP0000000060384.217778.0952
ENSG00000130254homo_sapiensENSP0000025254279.643270.9339peromyscus_maniculatus_bairdiiENSPEMP0000001697977.926169.4045
ENSG00000130254homo_sapiensENSP0000025254289.29783.4208bos_mutusENSBMUP0000001115889.767983.8608
ENSG00000130254homo_sapiensENSP0000025254250.472245.8552mus_spicilegusENSMSIP0000001302483.652276
ENSG00000130254homo_sapiensENSP0000025254281.217272.9276cricetulus_griseus_chok1gshdENSCGRP0000101515178.899170.8461
ENSG00000130254homo_sapiensENSP0000025254253.725149.9475pteropus_vampyrusENSPVAP0000000464165.64161.0256
ENSG00000130254homo_sapiensENSP0000025254290.241384.2602myotis_lucifugusENSMLUP0000000097890.717384.7046
ENSG00000130254homo_sapiensENSP0000025254283.10672.8227vombatus_ursinusENSVURP0001003216979.438369.6088
ENSG00000130254homo_sapiensENSP0000025254291.815387.5131rhinolophus_ferrumequinumENSRFEP0001002681980.496876.7249
ENSG00000130254homo_sapiensENSP0000025254292.130186.9885neovison_visonENSNVIP0000001812392.226987.0798
ENSG00000130254homo_sapiensENSP0000025254290.241384.1553bos_taurusENSBTAP0000004218090.717384.5992
ENSG00000130254homo_sapiensENSP0000025254269.569866.3169heterocephalus_glaber_femaleENSHGLP0000002447189.112984.9462
ENSG00000130254homo_sapiensENSP0000025254281.007380.5876rhinopithecus_bietiENSRBIP0000001891598.721298.2097
ENSG00000130254homo_sapiensENSP0000025254293.389388.9822canis_lupus_dingoENSCAFP0002002406093.291488.8889
ENSG00000130254homo_sapiensENSP0000025254292.23588.6674sciurus_vulgarisENSSVLP0000502623092.42988.8538
ENSG00000130254homo_sapiensENSP0000025254283.210972.8227phascolarctos_cinereusENSPCIP0000001404384.903674.3041
ENSG00000130254homo_sapiensENSP0000025254287.513181.532procavia_capensisENSPCAP0000000599188.912682.8358
ENSG00000130254homo_sapiensENSP0000025254222.035719.937nannospalax_galiliENSNGAP0000001828988.98380.5085
ENSG00000130254homo_sapiensENSP0000025254287.408280.9024bos_grunniensENSBGRP0000000418489.473782.8142
ENSG00000130254homo_sapiensENSP0000025254224.65924.2392chinchilla_lanigeraENSCLAP0000001411294.758193.1452
ENSG00000130254homo_sapiensENSP0000025254290.241384.2602cervus_hanglu_yarkandensisENSCHYP0000000115382.061176.6221
ENSG00000130254homo_sapiensENSP0000025254277.964374.1868catagonus_wagneriENSCWAP0000002041877.882674.109
ENSG00000130254homo_sapiensENSP0000025254225.498424.9738ictidomys_tridecemlineatusENSSTOP0000000247296.812894.8207
ENSG00000130254homo_sapiensENSP0000025254292.654890.0315otolemur_garnettiiENSOGAP0000000613993.936291.2766
ENSG00000130254homo_sapiensENSP0000025254297.586696.7471cebus_imitatorENSCCAP0000000307797.791896.9506
ENSG00000130254homo_sapiensENSP0000025254291.920287.723urocitellus_parryiiENSUPAP0001003008490.871486.722
ENSG00000130254homo_sapiensENSP0000025254220.251818.1532moschus_moschiferusENSMMSP0000002934787.330378.2805
ENSG00000130254homo_sapiensENSP0000025254293.91492.8646rhinopithecus_roxellanaENSRROP0000000169790.040289.0342
ENSG00000130254homo_sapiensENSP0000025254280.902472.298mus_pahariMGP_PahariEiJ_P004484978.194769.8783
ENSG00000130254homo_sapiensENSP0000025254291.185787.723propithecus_coquereliENSPCOP0000002234594.149590.5742
ENSG00000130254homo_sapiensENSP0000025254240.188923.085caenorhabditis_elegansF32B4.4a.135.694320.5033
ENSG00000130254homo_sapiensENSP0000025254243.12727.5971drosophila_melanogasterFBpp008407844.288828.3405

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IEAHomo_sapiens(9606)Component
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0043565enables sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0050684involved_in regulation of mRNA processing1IBAHomo_sapiens(9606)Process
GO:0060008involved_in Sertoli cell differentiation1IEAHomo_sapiens(9606)Process
GO:0060765involved_in regulation of androgen receptor signaling pathway1IBAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression