Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000129538 Gene ID 6035 Accession 10044
Symbol RNASE1 Alias RAC1;RIB1;RNS1 Full Name ribonuclease A family member 1, pancreatic
Status Confidence Length 1628 bases Strand Minus strand
Position 14 : 20801228 - 20802855 RNA binding domain RnaseA
Summary This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000344193 RnaseA PF00074 7.4e-43 1
ENSP00000381057 RnaseA PF00074 7.4e-43 1
ENSP00000381060 RnaseA PF00074 7.4e-43 1
ENSP00000399493 RnaseA PF00074 7.4e-43 1
ENSP00000451058 RnaseA PF00074 1.1e-38 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
RNASE1-202 ENST00000397967 914 156aa ENSP00000381057
RNASE1-201 ENST00000340900 878 156aa ENSP00000344193
RNASE1-204 ENST00000412779 896 156aa ENSP00000399493
RNASE1-205 ENST00000555698 655 116aa ENSP00000451058
RNASE1-203 ENST00000397970 769 156aa ENSP00000381060

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
41298Platelet Function Tests3.2837100E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129538homo_sapiensENSP0000051286734.693920.4082homo_sapiensENSP0000038105732.692319.2308
ENSG00000129538homo_sapiensENSP0000029869051.923134.6154homo_sapiensENSP0000038105751.923134.6154
ENSG00000129538homo_sapiensENSP0000031139848.051935.7143homo_sapiensENSP0000038105747.435935.2564
ENSG00000129538homo_sapiensENSP0000030204648.666732.6667homo_sapiensENSP0000038105746.794931.4103
ENSG00000129538homo_sapiensENSP0000039299628.240718.9815homo_sapiensENSP0000038105739.102626.2821
ENSG00000129538homo_sapiensENSP0000045131827.135715.5779homo_sapiensENSP0000038105734.615419.8718
ENSG00000129538homo_sapiensENSP0000038107746.938833.3333homo_sapiensENSP0000038105744.230831.4103
ENSG00000129538homo_sapiensENSP0000038468327.142916.1905homo_sapiensENSP0000038105736.538521.7949
ENSG00000129538homo_sapiensENSP0000045224565.986446.9388homo_sapiensENSP0000038105762.179544.2308
ENSG00000129538homo_sapiensENSP0000037241037.179521.1538homo_sapiensENSP0000038105737.179521.1538
ENSG00000129538homo_sapiensENSP0000030232440.62526.875homo_sapiensENSP0000038105741.666727.5641
ENSG00000129538homo_sapiensENSP0000030327641.614929.1925homo_sapiensENSP0000038105742.948730.1282

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129538homo_sapiensENSP0000038105797.435996.1538nomascus_leucogenysENSNLEP0000000915097.435996.1538
ENSG00000129538homo_sapiensENSP0000038105798.717998.0769pan_paniscusENSPPAP0000000177398.717998.0769
ENSG00000129538homo_sapiensENSP0000038105798.076996.1538pongo_abeliiENSPPYP0000003752598.076996.1538
ENSG00000129538homo_sapiensENSP0000038105798.717998.0769pan_troglodytesENSPTRP0000001036098.717998.0769
ENSG00000129538homo_sapiensENSP0000038105798.717997.4359gorilla_gorillaENSGGOP0000000273798.717997.4359
ENSG00000129538homo_sapiensENSP0000038105769.871855.7692sarcophilus_harrisiiENSSHAP0000003378970.779256.4935
ENSG00000129538homo_sapiensENSP0000038105783.974475choloepus_hoffmanniENSCHOP0000000386783.974475
ENSG00000129538homo_sapiensENSP0000038105778.205168.5897echinops_telfairiENSETEP0000000911678.205168.5897
ENSG00000129538homo_sapiensENSP0000038105792.948789.1026callithrix_jacchusENSCJAP0000004473592.948789.1026
ENSG00000129538homo_sapiensENSP0000038105792.948786.5385macaca_fascicularisENSMFAP0000005921795.394788.8158
ENSG00000129538homo_sapiensENSP0000038105792.948786.5385macaca_mulattaENSMMUP0000006298695.394788.8158
ENSG00000129538homo_sapiensENSP0000038105781.410371.1538tursiops_truncatusENSTTRP0000001011882.467572.0779
ENSG00000129538homo_sapiensENSP0000038105757.051345.5128vulpes_vulpesENSVVUP0000001231480.180263.964
ENSG00000129538homo_sapiensENSP0000038105778.846267.3077mus_spretusMGP_SPRETEiJ_P003822582.550370.4698
ENSG00000129538homo_sapiensENSP0000038105788.461579.4872equus_asinusENSEASP0000505808567.647160.7843
ENSG00000129538homo_sapiensENSP0000038105758.333351.2821capra_hircusENSCHIP0000002453980.53170.7965
ENSG00000129538homo_sapiensENSP0000038105778.205167.3077capra_hircusENSCHIP0000000958772.61962.5
ENSG00000129538homo_sapiensENSP0000038105777.564168.5897capra_hircusENSCHIP0000001131882.876773.2877
ENSG00000129538homo_sapiensENSP0000038105785.256475.641loxodonta_africanaENSLAFP0000000142085.256475.641
ENSG00000129538homo_sapiensENSP0000038105749.35943.5897panthera_leoENSPLOP0000001117968.141660.177
ENSG00000129538homo_sapiensENSP0000038105778.205166.6667ailuropoda_melanoleucaENSAMEP0000004172981.879269.7987
ENSG00000129538homo_sapiensENSP0000038105776.923166.6667bos_indicus_hybridENSBIXP0000501617271.856362.2754
ENSG00000129538homo_sapiensENSP0000038105778.205169.8718bos_indicus_hybridENSBIXP0000503790662.244955.6122
ENSG00000129538homo_sapiensENSP0000038105775.64161.5385oryctolagus_cuniculusENSOCUP0000000648480.272165.3061
ENSG00000129538homo_sapiensENSP0000038105788.461579.4872equus_caballusENSECAP0000003678054.330748.8189
ENSG00000129538homo_sapiensENSP0000038105776.923164.1026canis_lupus_familiarisENSCAFP0084503234979.470266.2252
ENSG00000129538homo_sapiensENSP0000038105784.615475marmota_marmota_marmotaENSMMMP0000001691485.714375.974
ENSG00000129538homo_sapiensENSP0000038105778.846270.5128balaenoptera_musculusENSBMSP0001001218281.45772.8477
ENSG00000129538homo_sapiensENSP0000038105780.128271.7949cavia_porcellusENSCPOP0000001999181.168872.7273
ENSG00000129538homo_sapiensENSP0000038105779.487266.6667cavia_porcellusENSCPOP0000001500981.578968.4211
ENSG00000129538homo_sapiensENSP0000038105775.64166.6667felis_catusENSFCAP0000006103277.631668.4211
ENSG00000129538homo_sapiensENSP0000038105776.923166.0256ursus_americanusENSUAMP0000001403378.947467.7632
ENSG00000129538homo_sapiensENSP0000038105769.230856.4103monodelphis_domesticaENSMODP0000000861853.465343.5644
ENSG00000129538homo_sapiensENSP0000038105777.564168.5897bison_bison_bisonENSBBBP0000000182480.666771.3333
ENSG00000129538homo_sapiensENSP0000038105776.923166.6667bison_bison_bisonENSBBBP0000000181771.856362.2754
ENSG00000129538homo_sapiensENSP0000038105777.564167.3077bison_bison_bisonENSBBBP0000000178980.666770
ENSG00000129538homo_sapiensENSP0000038105782.051373.0769monodon_monocerosENSMMNP0001501332984.768275.4967
ENSG00000129538homo_sapiensENSP0000038105780.128273.7179sus_scrofaENSSSCP0000004555082.781576.1589
ENSG00000129538homo_sapiensENSP0000038105783.333370.5128octodon_degusENSODEP0000002546684.415671.4286
ENSG00000129538homo_sapiensENSP0000038105769.230857.6923octodon_degusENSODEP0000000215482.442768.7023
ENSG00000129538homo_sapiensENSP0000038105768.589757.0513octodon_degusENSODEP0000000262182.945768.9922
ENSG00000129538homo_sapiensENSP0000038105755.769246.1538ovis_aries_rambouilletENSOARP0002001738368.503956.6929
ENSG00000129538homo_sapiensENSP0000038105779.487267.9487ovis_aries_rambouilletENSOARP0002001732263.917554.6392
ENSG00000129538homo_sapiensENSP0000038105777.564168.5897ovis_aries_rambouilletENSOARP0002001714182.876773.2877
ENSG00000129538homo_sapiensENSP0000038105776.923166.0256ursus_maritimusENSUMAP000000042468068.6667
ENSG00000129538homo_sapiensENSP0000038105781.410373.0769delphinapterus_leucasENSDLEP0000000232384.10675.4967
ENSG00000129538homo_sapiensENSP0000038105780.769273.0769physeter_catodonENSPCTP000050043006357
ENSG00000129538homo_sapiensENSP0000038105780.128267.9487mus_caroliMGP_CAROLIEiJ_P003650583.892671.1409
ENSG00000129538homo_sapiensENSP0000038105778.846267.3077mus_musculusENSMUSP0000007902582.550370.4698
ENSG00000129538homo_sapiensENSP0000038105771.153862.8205dipodomys_ordiiENSDORP0000001806686.046575.969
ENSG00000129538homo_sapiensENSP0000038105771.794957.6923mustela_putorius_furoENSMPUP0000001915872.727358.4416
ENSG00000129538homo_sapiensENSP0000038105757.692346.7949mustela_putorius_furoENSMPUP000000106187258.4
ENSG00000129538homo_sapiensENSP0000038105777.564166.6667mustela_putorius_furoENSMPUP0000001826480.132568.8742
ENSG00000129538homo_sapiensENSP0000038105773.717960.8974mustela_putorius_furoENSMPUP0000001974176.158962.9139
ENSG00000129538homo_sapiensENSP0000038105773.076957.6923vicugna_pacosENSVPAP0000001046978.620762.069
ENSG00000129538homo_sapiensENSP0000038105760.897448.0769vicugna_pacosENSVPAP0000001046581.896664.6552
ENSG00000129538homo_sapiensENSP0000038105792.948787.1795chlorocebus_sabaeusENSCSAP0000001765495.394789.4737
ENSG00000129538homo_sapiensENSP0000038105785.256479.4872tupaia_belangeriENSTBEP0000000143585.256479.4872
ENSG00000129538homo_sapiensENSP0000038105780.128267.9487mesocricetus_auratusENSMAUP0000001710183.892671.1409
ENSG00000129538homo_sapiensENSP0000038105780.769275phocoena_sinusENSPSNP0000001691983.443777.4834
ENSG00000129538homo_sapiensENSP0000038105776.282164.7436camelus_dromedariusENSCDRP0000500259981.506969.1781
ENSG00000129538homo_sapiensENSP0000038105776.923158.9744camelus_dromedariusENSCDRP0000500257975.949458.2278
ENSG00000129538homo_sapiensENSP0000038105773.717959.6154rattus_norvegicusENSRNOP0000006865375.657961.1842
ENSG00000129538homo_sapiensENSP000003810577558.3333rattus_norvegicusENSRNOP000000350957860.6667
ENSG00000129538homo_sapiensENSP0000038105777.564163.4615rattus_norvegicusENSRNOP0000007226379.605365.1316
ENSG00000129538homo_sapiensENSP0000038105788.461584.6154prolemur_simusENSPSMP0000001744089.032385.1613
ENSG00000129538homo_sapiensENSP0000038105781.410369.2308microtus_ochrogasterENSMOCP0000000690385.810872.973
ENSG00000129538homo_sapiensENSP0000038105780.769264.7436sorex_araneusENSSARP0000000374880.769264.7436
ENSG00000129538homo_sapiensENSP0000038105778.205166.6667peromyscus_maniculatus_bairdiiENSPEMP0000001473082.432470.2703
ENSG00000129538homo_sapiensENSP0000038105777.564167.3077bos_mutusENSBMUP0000001589180.666770
ENSG00000129538homo_sapiensENSP0000038105776.282168.5897bos_mutusENSBMUP0000002573679.333371.3333
ENSG00000129538homo_sapiensENSP0000038105776.923166.6667bos_mutusENSBMUP0000002575471.856362.2754
ENSG00000129538homo_sapiensENSP0000038105778.846267.3077mus_spicilegusENSMSIP0000002311782.550370.4698
ENSG00000129538homo_sapiensENSP0000038105778.846267.3077cricetulus_griseus_chok1gshdENSCGRP0000101406582.550370.4698
ENSG00000129538homo_sapiensENSP0000038105787.179576.2821pteropus_vampyrusENSPVAP0000001279287.179576.2821
ENSG00000129538homo_sapiensENSP0000038105783.974473.7179myotis_lucifugusENSMLUP0000001857387.919577.1812
ENSG00000129538homo_sapiensENSP0000038105772.435966.0256myotis_lucifugusENSMLUP0000001591888.976481.1024
ENSG00000129538homo_sapiensENSP0000038105787.179578.8462myotis_lucifugusENSMLUP0000002053287.741979.3548
ENSG00000129538homo_sapiensENSP0000038105783.333375myotis_lucifugusENSMLUP0000001732987.248378.5235
ENSG00000129538homo_sapiensENSP0000038105779.487269.8718myotis_lucifugusENSMLUP000000187548070.3226
ENSG00000129538homo_sapiensENSP0000038105782.051372.4359myotis_lucifugusENSMLUP0000001887482.580672.9032
ENSG00000129538homo_sapiensENSP0000038105766.666750vombatus_ursinusENSVURP0001002605363.803747.8528
ENSG00000129538homo_sapiensENSP0000038105785.897477.5641rhinolophus_ferrumequinumENSRFEP0001002578563.507157.346
ENSG00000129538homo_sapiensENSP0000038105778.205166.0256neovison_visonENSNVIP0000001696180.794768.2119
ENSG00000129538homo_sapiensENSP0000038105771.153855.7692neovison_visonENSNVIP0000001692573.509957.6159
ENSG00000129538homo_sapiensENSP0000038105773.076958.9744neovison_visonENSNVIP0000000972174.02659.7403
ENSG00000129538homo_sapiensENSP0000038105771.794960.2564neovison_visonENSNVIP0000001695472.258160.6452
ENSG00000129538homo_sapiensENSP0000038105776.923169.2308bos_taurusENSBTAP000000360918072
ENSG00000129538homo_sapiensENSP0000038105776.923166.6667bos_taurusENSBTAP0000000651071.856362.2754
ENSG00000129538homo_sapiensENSP0000038105777.564167.3077bos_taurusENSBTAP0000001158680.666770
ENSG00000129538homo_sapiensENSP0000038105786.538576.2821heterocephalus_glaber_femaleENSHGLP0000004194986.538576.2821
ENSG00000129538homo_sapiensENSP0000038105758.333346.1538heterocephalus_glaber_femaleENSHGLP0000006042456.87545
ENSG00000129538homo_sapiensENSP0000038105771.794956.4103canis_lupus_dingoENSCAFP0002001800678.321761.5385
ENSG00000129538homo_sapiensENSP0000038105785.897478.8462sciurus_vulgarisENSSVLP0000500201385.897478.8462
ENSG00000129538homo_sapiensENSP0000038105756.410340.3846phascolarctos_cinereusENSPCIP0000003916571.544751.2195
ENSG00000129538homo_sapiensENSP0000038105783.333371.1538nannospalax_galiliENSNGAP0000000884384.967372.549
ENSG00000129538homo_sapiensENSP0000038105783.974473.7179chinchilla_lanigeraENSCLAP0000000210586.184275.6579
ENSG00000129538homo_sapiensENSP000003810577561.5385chinchilla_lanigeraENSCLAP0000000092771.341558.5366
ENSG00000129538homo_sapiensENSP0000038105777.564166.0256cervus_hanglu_yarkandensisENSCHYP0000002117468.361658.1921
ENSG00000129538homo_sapiensENSP0000038105759.615448.7179cervus_hanglu_yarkandensisENSCHYP000000211457561.2903
ENSG00000129538homo_sapiensENSP0000038105777.564168.5897cervus_hanglu_yarkandensisENSCHYP0000002131080.666771.3333
ENSG00000129538homo_sapiensENSP0000038105783.333375ictidomys_tridecemlineatusENSSTOP0000000664083.333375
ENSG00000129538homo_sapiensENSP0000038105789.743680.1282otolemur_garnettiiENSOGAP0000000980989.17279.6178
ENSG00000129538homo_sapiensENSP0000038105783.333374.359urocitellus_parryiiENSUPAP0001000229284.967375.817
ENSG00000129538homo_sapiensENSP0000038105778.205169.8718moschus_moschiferusENSMMSP0000001129481.333372.6667
ENSG00000129538homo_sapiensENSP0000038105774.35964.7436moschus_moschiferusENSMMSP0000001113477.333367.3333
ENSG00000129538homo_sapiensENSP0000038105779.487267.3077moschus_moschiferusENSMMSP0000001114670.056559.322
ENSG00000129538homo_sapiensENSP0000038105779.487265.3846mus_pahariMGP_PahariEiJ_P008462583.221568.4564
ENSG00000129538homo_sapiensENSP0000038105741.666730.1282erpetoichthys_calabaricusENSECRP0000000586845.454532.8671

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003676enables nucleic acid binding1IEAHomo_sapiens(9606)Function
GO:0004522enables ribonuclease A activity1IEAHomo_sapiens(9606)Function
GO:0004540enables RNA nuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0016829enables lyase activity1IEAHomo_sapiens(9606)Function
GO:0050830involved_in defense response to Gram-positive bacterium1IBAHomo_sapiens(9606)Process
GO:0051607NOT involved_in defense response to virus1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component

Expression