RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000128604	Gene ID	3663	Accession	6120
Symbol	IRF5	Alias	SLEB10	Full Name	interferon regulatory factor 5
Status	Confidence	Length	12582 bases	Strand	Plus strand
Position	7 : 128937457 - 128950038	RNA binding domain	IRF-3
Summary	This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000419950	IRF-3	PF10401	7.7e-72	1
ENSP00000385352	IRF-3	PF10401	9.6e-72	1
ENSP00000419149	IRF-3	PF10401	9.6e-72	1
ENSP00000349770	IRF-3	PF10401	1e-71	1
ENSP00000418037	IRF-3	PF10401	1e-71	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
21745419	Cytokine disturbances in systemic lupus erythematosus.	Noam Jacob	2011-07-06	Arthritis research & therapy
21268286	A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.	Julien Pothlichet	2011-03-01	EMBO molecular medicine
25445206	Interferon regulatory factors: critical mediators of human lupus.	A Mark Jensen	2015-02-01	Translational research : the journal of laboratory and clinical medicine
25010440	Advances in understanding the role of type I interferons in systemic lupus erythematosus.	K Mary Crow	2014-09-01	Current opinion in rheumatology
31101492	Enhancing the ligand efficiency of anti-HIV compounds targeting frameshift-stimulating RNA.	S Viktoriya Anokhina	2019-07-01	Bioorganic & medicinal chemistry
20392290	Potential role of IFNα in adult lupus.	Lars Rönnblom	2010-01-01	Arthritis research & therapy
20467470	Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: from basics to recent advances.	Hin Yat Desmond Yap	2010-01-01	Journal of biomedicine & biotechnology
22066971	The type I interferon system in the etiopathogenesis of autoimmune diseases.	Lars Rönnblom	2011-11-01	Upsala journal of medical sciences
21575916	Interferon regulatory factors in human lupus pathogenesis.	Rafah Salloum	2011-06-01	Translational research : the journal of laboratory and clinical medicine
20392289	Genetic associations in type I interferon related pathways with autoimmunity.	M Angélica Delgado-Vega	2010-01-01	Arthritis research & therapy

Name	Transcript ID	bp	Protein	Translation ID
IRF5-215	ENST00000652525	392	47aa	ENSP00000498293
IRF5-212	ENST00000489702	2988	514aa	ENSP00000418037
IRF5-216	ENST00000700148	2990	No protein	-
IRF5-201	ENST00000357234	2899	514aa	ENSP00000349770
IRF5-211	ENST00000488569	923	No protein	-
IRF5-209	ENST00000477535	1374	412aa	ENSP00000419950
IRF5-210	ENST00000479582	637	141aa	ENSP00000417770
IRF5-204	ENST00000464557	553	106aa	ENSP00000419056
IRF5-203	ENST00000461416	1057	No protein	-
IRF5-202	ENST00000402030	2786	498aa	ENSP00000385352
IRF5-208	ENST00000473787	587	104aa	ENSP00000420274
IRF5-214	ENST00000652142	497	No protein	-
IRF5-213	ENST00000650798	514	No protein	-
IRF5-217	ENST00000700149	313	47aa	ENSP00000514825
IRF5-218	ENST00000700150	200	47aa	ENSP00000514826
IRF5-206	ENST00000467002	560	59aa	ENSP00000417454
IRF5-207	ENST00000473745	2282	498aa	ENSP00000419149
IRF5-205	ENST00000465603	2088	147aa	ENSP00000418534
IRF5-219	ENST00000700151	5256	No protein	-
IRF5-220	ENST00000700152	4796	No protein	-
IRF5-221	ENST00000700153	4170	No protein	-
IRF5-222	ENST00000700154	2324	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
13299	Lupus Erythematosus, Systemic	6.08E-6	18204446
61061	Sjogren's Syndrome	7E-11	28076899
64946	Sjogren's Syndrome	3E-14	28076899
84637	Lupus Erythematosus, Systemic	1E-48	26502338
91972	Arthritis, Rheumatoid	3E-7	21156761
102465	Lupus Erythematosus, Systemic	2E-45	27399966
106713	Lupus Erythematosus, Systemic	1E-60	26502338

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000785	part_of chromatin	1	ISA	Homo_sapiens(9606)	Component
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	3	IBA,IDA,ISA	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	IDA	Homo_sapiens(9606)	Function
GO:0002376	involved_in immune system process	1	IBA	Homo_sapiens(9606)	Process
GO:0002720	involved_in positive regulation of cytokine production involved in immune response	1	IDA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006954	involved_in inflammatory response	1	IEA	Homo_sapiens(9606)	Process
GO:0019221	involved_in cytokine-mediated signaling pathway	1	IDA	Homo_sapiens(9606)	Process
GO:0019901	enables protein kinase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0032481	involved_in positive regulation of type I interferon production	1	IDA	Homo_sapiens(9606)	Process
GO:0032494	involved_in response to peptidoglycan	1	IDA	Homo_sapiens(9606)	Process
GO:0032495	involved_in response to muramyl dipeptide	1	IDA	Homo_sapiens(9606)	Process
GO:0032727	involved_in positive regulation of interferon-alpha production	1	IC	Homo_sapiens(9606)	Process
GO:0032728	involved_in positive regulation of interferon-beta production	1	IC	Homo_sapiens(9606)	Process
GO:0032735	involved_in positive regulation of interleukin-12 production	1	IC	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043065	involved_in positive regulation of apoptotic process	1	IMP	Homo_sapiens(9606)	Process
GO:0043565	enables sequence-specific DNA binding	1	IMP	Homo_sapiens(9606)	Function
GO:0045087	involved_in innate immune response	1	ISS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0051607	involved_in defense response to virus	1	IEA	Homo_sapiens(9606)	Process
GO:0098586	involved_in cellular response to virus	1	IDA	Homo_sapiens(9606)	Process
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function