RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000127838	Gene ID	25953	Accession	9153
Symbol	PNKD	Alias	R1;MR1;PDC;DYT8;FPD1;MR-1;BRP17;MR-1S;PKND1;PNKD1;FKSG19;TAHCCP2;KIPP1184	Full Name	PNKD metallo-beta-lactamase domain containing
Status	Confidence	Length	76402 bases	Strand	Plus strand
Position	2 : 218270392 - 218346793	RNA binding domain	Lactamase_B
Summary	This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000258362	Lactamase_B	PF00753	1.1e-09	1
ENSP00000273077	Lactamase_B	PF00753	1.4e-09	1
ENSP00000508635	Lactamase_B	PF00753	1.5e-09	1
ENSP00000510415	Lactamase_B	PF00753	2.1e-09	1
ENSP00000508450	Lactamase_B	PF00753	5.9e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PNKD-217	ENST00000691799	2203	No protein	-
PNKD-201	ENST00000248451	758	142aa	ENSP00000248451
PNKD-206	ENST00000472650	1235	No protein	-
PNKD-211	ENST00000688179	2832	344aa	ENSP00000508635
PNKD-214	ENST00000689816	2919	373aa	ENSP00000508450
PNKD-209	ENST00000685415	3100	424aa	ENSP00000510415
PNKD-204	ENST00000436005	2974	382aa	ENSP00000414400
PNKD-203	ENST00000273077	2987	385aa	ENSP00000273077
PNKD-205	ENST00000469689	1372	No protein	-
PNKD-218	ENST00000692260	1630	No protein	-
PNKD-208	ENST00000684905	3719	No protein	-
PNKD-210	ENST00000687736	2753	325aa	ENSP00000509627
PNKD-215	ENST00000690891	3106	78aa	ENSP00000509744
PNKD-216	ENST00000691220	2580	258aa	ENSP00000509580
PNKD-207	ENST00000494954	248	No protein	-
PNKD-202	ENST00000258362	2991	361aa	ENSP00000258362
PNKD-220	ENST00000693423	2308	56aa	ENSP00000508705
PNKD-219	ENST00000692295	2601	265aa	ENSP00000509392
PNKD-212	ENST00000689098	3625	No protein	-
PNKD-213	ENST00000689693	3758	No protein	-
PNKD-221	ENST00000693556	2255	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
62041	Inflammatory Bowel Diseases	4E-12	23128233
80107	Colitis, Ulcerative	2E-8	26192919
94552	Crohn Disease	4E-9	26192919
100689	Inflammatory Bowel Diseases	2E-7	28067908

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004416	enables hydroxyacylglutathione hydrolase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IEA	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0016020	located_in membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0019243	involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	1	IEA	Homo_sapiens(9606)	Process
GO:0032225	involved_in regulation of synaptic transmission, dopaminergic	1	IEA	Homo_sapiens(9606)	Process
GO:0042053	involved_in regulation of dopamine metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0046929	involved_in negative regulation of neurotransmitter secretion	1	IMP	Homo_sapiens(9606)	Process
GO:0050884	involved_in neuromuscular process controlling posture	1	IEA	Homo_sapiens(9606)	Process
GO:0099523	located_in presynaptic cytosol	1	IEA	Homo_sapiens(9606)	Component