RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000119711	Gene ID	4329	Accession	7179
Symbol	ALDH6A1	Alias	MMSDH;MMSADHA	Full Name	aldehyde dehydrogenase 6 family member A1
Status	Confidence	Length	27607 bases	Strand	Minus strand
Position	14 : 74056847 - 74084453	RNA binding domain	N.A.
Summary	This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
31213602	CAPRI enables comparison of evolutionarily conserved RNA interacting regions.	Amol Panhale	2019-06-18	Nature communications

Name	Transcript ID	bp	Protein	Translation ID
ALDH6A1-202	ENST00000553458	5462	535aa	ENSP00000450436
ALDH6A1-205	ENST00000554501	2221	No protein	-
ALDH6A1-201	ENST00000350259	1869	522aa	ENSP00000342564
ALDH6A1-206	ENST00000555126	1382	252aa	ENSP00000452081
ALDH6A1-204	ENST00000554231	1323	No protein	-
ALDH6A1-203	ENST00000553814	580	No protein	-
ALDH6A1-207	ENST00000556852	726	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
44416	Platelet Function Tests	5.4178840E-010	-
44422	Platelet Function Tests	7.8994069E-007	-
44492	Platelet Function Tests	5.4178840E-010	-
44498	Platelet Function Tests	7.8994069E-007	-
96134	Circadian Rhythm	3E-7	20585627

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000062	enables fatty-acyl-CoA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0004491	enables methylmalonate-semialdehyde dehydrogenase (acylating) activity	4	IBA,IMP,ISS,TAS	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0006210	involved_in thymine catabolic process	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0006573	involved_in valine metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0006574	involved_in valine catabolic process	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0009083	involved_in branched-chain amino acid catabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0018478	enables malonate-semialdehyde dehydrogenase (acetylating) activity	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0019859	involved_in thymine metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0050873	involved_in brown fat cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0102662	enables malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity	1	IEA	Homo_sapiens(9606)	Function