RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000119689	Gene ID	1743	Accession	2911
Symbol	DLST	Alias	DLTS;KGD2;PGL7	Full Name	dihydrolipoamide S-succinyltransferase
Status	Confidence	Length	21853 bases	Strand	Plus strand
Position	14 : 74881891 - 74903743	RNA binding domain	N.A.
Summary	This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
31237920	A repertoire of 124 potential autoantigens for autoimmune kidney diseases identified by dermatan sulfate affinity enrichment of kidney tissue proteins.	Wei Zhang	2019-01-01	PloS one

Name	Transcript ID	bp	Protein	Translation ID
DLST-213	ENST00000556460	563	104aa	ENSP00000451210
DLST-210	ENST00000555492	569	110aa	ENSP00000452417
DLST-215	ENST00000557012	698	No protein	-
DLST-204	ENST00000554612	1479	37aa	ENSP00000451670
DLST-214	ENST00000556582	568	No protein	-
DLST-201	ENST00000238671	1464	67aa	ENSP00000238671
DLST-202	ENST00000334220	2813	453aa	ENSP00000335304
DLST-206	ENST00000555071	1365	No protein	-
DLST-212	ENST00000556190	565	No protein	-
DLST-209	ENST00000555459	567	No protein	-
DLST-208	ENST00000555190	803	No protein	-
DLST-207	ENST00000555089	1078	83aa	ENSP00000452422
DLST-216	ENST00000626051	252	83aa	ENSP00000487251
DLST-205	ENST00000554806	837	279aa	ENSP00000451957
DLST-211	ENST00000555988	718	74aa	ENSP00000451425
DLST-203	ENST00000550473	474	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
69930	Carcinoma, Non-Small-Cell Lung	7E-6	23144319

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004149	enables dihydrolipoyllysine-residue succinyltransferase activity	3	IBA,IMP,ISS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	HDA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006091	involved_in generation of precursor metabolites and energy	1	TAS	Homo_sapiens(9606)	Process
GO:0006099	involved_in tricarboxylic acid cycle	3	IBA,IEA,IMP	Homo_sapiens(9606)	Process
GO:0006103	involved_in 2-oxoglutarate metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0006104	involved_in succinyl-CoA metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016746	enables acyltransferase activity	1	IMP	Homo_sapiens(9606)	Function
GO:0033512	involved_in L-lysine catabolic process to acetyl-CoA via saccharopine	1	IEA	Homo_sapiens(9606)	Process
GO:0045252	part_of oxoglutarate dehydrogenase complex	1	IDA	Homo_sapiens(9606)	Component
GO:0106077	involved_in histone succinylation	1	IDA	Homo_sapiens(9606)	Process