RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000117385	Gene ID	64175	Accession	19316
Symbol	P3H1	Alias	OI8;GROS1;LEPRE1	Full Name	prolyl 3-hydroxylase 1
Status	Confidence	Length	20750 bases	Strand	Minus strand
Position	1 : 42746335 - 42767084	RNA binding domain	2OG-FeII_Oxy
Summary	This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000380245	2OG-FeII_Oxy	PF03171	4.9e-09	1
ENSP00000236040	2OG-FeII_Oxy	PF03171	5.3e-09	1
ENSP00000296388	2OG-FeII_Oxy	PF03171	5.4e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
P3H1-204	ENST00000397054	2705	697aa	ENSP00000380245
P3H1-207	ENST00000460031	2726	No protein	-
P3H1-202	ENST00000296388	2591	736aa	ENSP00000296388
P3H1-201	ENST00000236040	2993	804aa	ENSP00000236040
P3H1-214	ENST00000495874	2813	No protein	-
P3H1-209	ENST00000462474	581	No protein	-
P3H1-211	ENST00000472802	646	No protein	-
P3H1-205	ENST00000431412	836	222aa	ENSP00000408056
P3H1-208	ENST00000460831	585	No protein	-
P3H1-212	ENST00000481465	728	No protein	-
P3H1-206	ENST00000447502	453	No protein	-
P3H1-210	ENST00000463465	897	No protein	-
P3H1-203	ENST00000372526	654	207aa	ENSP00000361604
P3H1-213	ENST00000492956	3001	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003674	enables molecular_function	1	ND	Homo_sapiens(9606)	Function
GO:0005506	enables iron ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	ISS	Homo_sapiens(9606)	Function
GO:0005518	contributes_to collagen binding	1	ISS	Homo_sapiens(9606)	Function
GO:0005783	is_active_in endoplasmic reticulum	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005788	located_in endoplasmic reticulum lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0006457	involved_in protein folding	1	IMP	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	NAS	Homo_sapiens(9606)	Process
GO:0010976	involved_in positive regulation of neuron projection development	1	ISS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0018126	involved_in protein hydroxylation	1	IMP	Homo_sapiens(9606)	Process
GO:0019797	enables procollagen-proline 3-dioxygenase activity	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0031418	enables L-ascorbic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0032963	involved_in collagen metabolic process	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0032991	part_of protein-containing complex	1	ISS	Homo_sapiens(9606)	Component
GO:0050708	involved_in regulation of protein secretion	1	IMP	Homo_sapiens(9606)	Process
GO:0050821	involved_in protein stabilization	1	IMP	Homo_sapiens(9606)	Process
GO:0060348	involved_in bone development	1	IMP	Homo_sapiens(9606)	Process
GO:0061077	involved_in chaperone-mediated protein folding	1	ISS	Homo_sapiens(9606)	Process
GO:0062023	colocalizes_with collagen-containing extracellular matrix	1	HDA	Homo_sapiens(9606)	Component
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:1901874	involved_in negative regulation of post-translational protein modification	1	IMP	Homo_sapiens(9606)	Process