RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000115750	Gene ID	9014	Accession	11533
Symbol	TAF1B	Alias	SL1;RAF1B;RAFI63;TAFI63;MGC:9349	Full Name	TATA-box binding protein associated factor, RNA polymerase I subunit B
Status	Confidence	Length	90974 bases	Strand	Plus strand
Position	2 : 9843443 - 9934416	RNA binding domain	zf-RRN7
Summary	Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000402955	zf-RRN7	PF11781	1.1e-11	1
ENSP00000486572	zf-RRN7	PF11781	1.1e-11	1
ENSP00000414184	zf-RRN7	PF11781	7.2e-11	1
ENSP00000263663	zf-RRN7	PF11781	6.4e-10	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
35539910	In silico functional and tumor suppressor role of hypothetical protein PCNXL2 with regulation of the Notch signaling pathway.	Muhammad Naveed	2018-06-08	RSC advances
20600450	Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance.	Wen Fury	2010-09-01	Human immunology
25614765	Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease.	Truong Long Hoang	2014-01-01	Genome medicine
21127203	Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.	Chisato Shimizu	2011-02-01	Circulation. Cardiovascular genetics
24324693	Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G.	Shohei Ogata	2013-01-01	PloS one
19583510	Gene transcript abundance profiles distinguish Kawasaki disease from adenovirus infection.	J Stephen Popper	2009-08-15	The Journal of infectious diseases
18067656	Gene-expression patterns reveal underlying biological processes in Kawasaki disease.	J Stephen Popper	2007-01-01	Genome biology
30692935	Normal Ribosomal Biogenesis but Shortened Protein Synthetic Response to Acute Eccentric Resistance Exercise in Old Skeletal Muscle.	D W Daniel West	2018-01-01	Frontiers in physiology

Name	Transcript ID	bp	Protein	Translation ID
TAF1B-211	ENST00000625239	273	57aa	ENSP00000486572
TAF1B-201	ENST00000263663	2267	588aa	ENSP00000263663
TAF1B-202	ENST00000402170	715	No protein	-
TAF1B-203	ENST00000404869	505	No protein	-
TAF1B-210	ENST00000497182	642	No protein	-
TAF1B-205	ENST00000434858	1592	194aa	ENSP00000414184
TAF1B-204	ENST00000416181	297	57aa	ENSP00000402955
TAF1B-206	ENST00000469895	681	No protein	-
TAF1B-207	ENST00000480197	554	No protein	-
TAF1B-208	ENST00000490432	620	No protein	-
TAF1B-209	ENST00000492648	1045	216aa	ENSP00000475608

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001164	enables RNA polymerase I core promoter sequence-specific DNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0001188	involved_in RNA polymerase I preinitiation complex assembly	1	IDA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005668	part_of RNA polymerase transcription factor SL1 complex	1	IBA	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0006351	involved_in DNA-templated transcription	1	NAS	Homo_sapiens(9606)	Process
GO:0017025	enables TBP-class protein binding	1	TAS	Homo_sapiens(9606)	Function
GO:0042790	involved_in nucleolar large rRNA transcription by RNA polymerase I	1	IBA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0070860	part_of RNA polymerase I core factor complex	2	IBA,IDA	Homo_sapiens(9606)	Component