Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations P-body
BulkPerturb-seq DataSet_01_225 DataSet_01_308

Description

Ensembl ID ENSG00000115524 Gene ID 23451 Accession 10768
Symbol SF3B1 Alias MDS;PRP10;Hsh155;PRPF10;SAP155;SF3b155 Full Name splicing factor 3b subunit 1
Status Confidence Length 46565 bases Strand Minus strand
Position 2 : 197388515 - 197435079 RNA binding domain SF3b1
Summary This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000335321 SF3b1 PF08920 9.3e-49 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27462443 Involvement of PARP1 in the regulation of alternative splicing. Elena Matveeva 2016-01-01 Cell discovery
34181707 CTCF as a regulator of alternative splicing: new tricks for an old player. B Adel Alharbi 2021-08-20 Nucleic acids research
28188970 Refractory anemia with ring sideroblasts (RARS) and RARS with thrombocytosis (RARS-T): 2017 update on diagnosis, risk-stratification, and management. M Mrinal Patnaik 2017-03-01 American journal of hematology
30618061 Refractory anemia with ring sideroblasts (RARS) and RARS with thrombocytosis: '2019 Update on Diagnosis, Risk-stratification, and Management'. M Mrinal Patnaik 2019-04-01 American journal of hematology
32664474 Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3' Splice-Site Selection. Jana Kralovicova 2020-07-11 Cancers
33203571 Germline Variants That Affect Tumor Progression. Ajay Chatrath 2021-05-01 Trends in genetics : TIG
35471657 Coming of Age: Human Genomics and the Cancer-Immune Set Point. Christian Hammer 2022-06-03 Cancer immunology research
26531823 A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis. Harold Pimentel 2016-01-29 Nucleic acids research
28188128 Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Hannah Carter 2017-04-01 Cancer discovery
28372848 Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures. L Jermaine Jenkins 2017-05-01 Trends in genetics : TIG
33149266 Targeting RNA-binding proteins in acute and chronic leukemia. A Irina Elcheva 2021-02-01 Leukemia
29128695 Insights from structures of cancer-relevant pre-mRNA splicing factors. L Clara Kielkopf 2018-02-01 Current opinion in genetics & development
28545085 Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1. Shuiling Jin 2017-01-01 PloS one
35624337 Dysregulation and therapeutic targeting of RNA splicing in cancer. F Robert Stanley 2022-05-01 Nature cancer
31744877 Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. M Jennifer Pearson 2020-03-01 Molecular cancer research : MCR
35042235 Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs. Georgios Asimomitis 2022-05-24 Blood advances
31448582 Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives. Esmat Abdi 2019-10-01 Cancer medicine
30939845 Splicing Factors Have an Essential Role in Prostate Cancer Progression and Androgen Receptor Signaling. Ken-Ichi Takayama 2019-04-01 Biomolecules
33396957 Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing. M Natasha NM van 2020-12-30 International journal of molecular sciences
35715407 MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS. Fangfang Li 2022-06-17 Cell death & disease
27478938 Emerging concepts of epigenetic dysregulation in hematological malignancies. Panagiotis Ntziachristos 2016-09-01 Nature immunology
26846640 RNA Splicing: Regulation and Dysregulation in the Heart. G M Maarten MM Hoogenhof van 2016-02-05 Circulation research
32354150 In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1K700E Mutant. Asmaa Samy 2020-04-28 Biomolecules
35082828 Sequence Divergence and Functional Specializations of the Ancient Spliceosomal SF3b: Implications in Flexibility and Adaptations of the Multi-Protein Complex. Arangasamy Yazhini 2021-01-01 Frontiers in genetics
31597964 Spliceosomal disruption of the non-canonical BAF complex in cancer. Daichi Inoue 2019-10-01 Nature
22885522 The development and application of small molecule modulators of SF3b as therapeutic agents for cancer. R Thomas Webb 2013-01-01 Drug discovery today

Transcripts

Name Transcript ID bp Protein Translation ID
SF3B1-214 ENST00000652738 8478 161aa ENSP00000499119
SF3B1-213 ENST00000652026 9283 154aa ENSP00000498652
SF3B1-201 ENST00000335508 6463 1304aa ENSP00000335321
SF3B1-208 ENST00000470268 8308 No protein -
SF3B1-209 ENST00000479532 587 No protein -
SF3B1-205 ENST00000424674 723 241aa ENSP00000409435
SF3B1-212 ENST00000496458 475 No protein -
SF3B1-206 ENST00000462613 141 No protein -
SF3B1-207 ENST00000468925 510 No protein -
SF3B1-210 ENST00000482158 772 No protein -
SF3B1-202 ENST00000409915 600 144aa ENSP00000428820
SF3B1-204 ENST00000414963 651 144aa ENSP00000402997
SF3B1-211 ENST00000487698 2127 154aa ENSP00000419896
SF3B1-203 ENST00000414174 593 37aa ENSP00000392117

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
96213Schizophrenia2E-1125056061
97718Schizophrenia5E-1126198764

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000115524

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000115524homo_sapiensENSP00000335321100100nomascus_leucogenysENSNLEP00000033194100100
ENSG00000115524homo_sapiensENSP00000335321100100pan_paniscusENSPPAP00000023837100100
ENSG00000115524homo_sapiensENSP00000335321100100pongo_abeliiENSPPYP00000014574100100
ENSG00000115524homo_sapiensENSP0000033532192.177991.181pan_troglodytesENSPTRP0000002182394.869893.8437
ENSG00000115524homo_sapiensENSP0000033532194.401893.7117gorilla_gorillaENSGGOP0000004147097.08296.3722
ENSG00000115524homo_sapiensENSP0000033532199.923399.6933ornithorhynchus_anatinusENSOANP0000005234510099.7698
ENSG00000115524homo_sapiensENSP0000033532199.616699.3098sarcophilus_harrisiiENSSHAP0000002071099.69399.386
ENSG00000115524homo_sapiensENSP0000033532162.883462.6534notamacropus_eugeniiENSMEUP0000001448965.547665.3078
ENSG00000115524homo_sapiensENSP0000033532172.162672.0859choloepus_hoffmanniENSCHOP0000000875172.832872.7554
ENSG00000115524homo_sapiensENSP00000335321100100dasypus_novemcinctusENSDNOP0000000911499.923499.9234
ENSG00000115524homo_sapiensENSP0000033532176.22776.1503erinaceus_europaeusENSEEUP0000000074576.520476.4434
ENSG00000115524homo_sapiensENSP0000033532182.131982.1319echinops_telfairiENSETEP0000000746399.442999.4429
ENSG00000115524homo_sapiensENSP00000335321100100callithrix_jacchusENSCJAP00000007188100100
ENSG00000115524homo_sapiensENSP00000335321100100cercocebus_atysENSCATP00000024501100100
ENSG00000115524homo_sapiensENSP0000033532199.923399.9233macaca_fascicularisENSMFAP00000055880100100
ENSG00000115524homo_sapiensENSP0000033532199.463299.3098macaca_mulattaENSMMUP0000002952199.007698.855
ENSG00000115524homo_sapiensENSP0000033532199.309899.2331macaca_nemestrinaENSMNEP0000003878499.081999.0054
ENSG00000115524homo_sapiensENSP0000033532199.539999.4632papio_anubisENSPANP0000005060192.58292.5107
ENSG00000115524homo_sapiensENSP0000033532189.877389.1871mandrillus_leucophaeusENSMLEP0000000620897.666796.9167
ENSG00000115524homo_sapiensENSP0000033532186.119686.1196tursiops_truncatusENSTTRP0000000320386.119686.1196
ENSG00000115524homo_sapiensENSP00000335321100100vulpes_vulpesENSVVUP0000003612194.561394.5613
ENSG00000115524homo_sapiensENSP00000335321100100mus_spretusMGP_SPRETEiJ_P0018666100100
ENSG00000115524homo_sapiensENSP0000033532199.923399.9233equus_asinusENSEASP0000502964297.45797.457
ENSG00000115524homo_sapiensENSP0000033532110099.9233capra_hircusENSCHIP0000001412210099.9233
ENSG00000115524homo_sapiensENSP00000335321100100loxodonta_africanaENSLAFP00000001639100100
ENSG00000115524homo_sapiensENSP00000335321100100panthera_leoENSPLOP00000017058100100
ENSG00000115524homo_sapiensENSP0000033532199.693399.6933ailuropoda_melanoleucaENSAMEP0000001457099.846499.8464
ENSG00000115524homo_sapiensENSP0000033532110099.9233bos_indicus_hybridENSBIXP0000500329310099.9233
ENSG00000115524homo_sapiensENSP0000033532110.889610.6595oryctolagus_cuniculusENSOCUP0000004986292.207890.2597
ENSG00000115524homo_sapiensENSP0000033532199.463299.1564equus_caballusENSECAP0000006557193.781693.4924
ENSG00000115524homo_sapiensENSP00000335321100100canis_lupus_familiarisENSCAFP00845036877100100
ENSG00000115524homo_sapiensENSP00000335321100100panthera_pardusENSPPRP00000016970100100
ENSG00000115524homo_sapiensENSP00000335321100100marmota_marmota_marmotaENSMMMP00000012372100100
ENSG00000115524homo_sapiensENSP00000335321100100balaenoptera_musculusENSBMSP00010003527100100
ENSG00000115524homo_sapiensENSP0000033532199.463299.3865cavia_porcellusENSCPOP0000000839599.310999.2343
ENSG00000115524homo_sapiensENSP0000033532199.386599.2331felis_catusENSFCAP0000003796899.082698.9297
ENSG00000115524homo_sapiensENSP0000033532182.438781.9785ursus_americanusENSUAMP0000002432595.811195.2763
ENSG00000115524homo_sapiensENSP0000033532199.156498.773monodelphis_domesticaENSMODP0000004782999.080598.6973
ENSG00000115524homo_sapiensENSP0000033532118.174818.1748bison_bison_bisonENSBBBP0000002051299.579899.5798
ENSG00000115524homo_sapiensENSP0000033532110099.9233bison_bison_bisonENSBBBP0000000468110099.9233
ENSG00000115524homo_sapiensENSP00000335321100100monodon_monocerosENSMMNP00015006990100100
ENSG00000115524homo_sapiensENSP0000033532188.803788.8037sus_scrofaENSSSCP00000047792100100
ENSG00000115524homo_sapiensENSP0000033532110.889610.6595sus_scrofaENSSSCP0000004023097.260395.2055
ENSG00000115524homo_sapiensENSP0000033532199.463299.3098microcebus_murinusENSMICP0000001267299.083398.9305
ENSG00000115524homo_sapiensENSP000003353214.524544.37117octodon_degusENSODEP0000000606890.769287.6923
ENSG00000115524homo_sapiensENSP000003353214.524544.21779octodon_degusENSODEP0000001260566.292161.7978
ENSG00000115524homo_sapiensENSP00000335321100100octodon_degusENSODEP00000015112100100
ENSG00000115524homo_sapiensENSP0000033532198.849798.773jaculus_jaculusENSJJAP0000000621399.613699.5363
ENSG00000115524homo_sapiensENSP0000033532110099.9233ovis_aries_rambouilletENSOARP0002001488610099.9233
ENSG00000115524homo_sapiensENSP00000335321100100ursus_maritimusENSUMAP00000028850100100
ENSG00000115524homo_sapiensENSP0000033532188.266988.1135ochotona_princepsENSOPRP0000000788988.334688.1811
ENSG00000115524homo_sapiensENSP00000335321100100delphinapterus_leucasENSDLEP00000023317100100
ENSG00000115524homo_sapiensENSP00000335321100100physeter_catodonENSPCTP00005000708100100
ENSG00000115524homo_sapiensENSP00000335321100100mus_caroliMGP_CAROLIEiJ_P0017661100100
ENSG00000115524homo_sapiensENSP00000335321100100mus_musculusENSMUSP00000027127100100
ENSG00000115524homo_sapiensENSP0000033532196.625896.6258dipodomys_ordiiENSDORP00000002254100100
ENSG00000115524homo_sapiensENSP00000335321100100mustela_putorius_furoENSMPUP00000007742100100
ENSG00000115524homo_sapiensENSP00000335321100100aotus_nancymaaeENSANAP00000007096100100
ENSG00000115524homo_sapiensENSP00000335321100100saimiri_boliviensis_boliviensisENSSBOP00000006307100100
ENSG00000115524homo_sapiensENSP0000033532191.871291.8712vicugna_pacosENSVPAP0000000538491.941791.9417
ENSG00000115524homo_sapiensENSP00000335321100100chlorocebus_sabaeusENSCSAP00000007703100100
ENSG00000115524homo_sapiensENSP0000033532184.585984.5859tupaia_belangeriENSTBEP0000000755992.923392.9233
ENSG00000115524homo_sapiensENSP0000033532195.475595.2454mesocricetus_auratusENSMAUP0000000749798.496898.2595
ENSG00000115524homo_sapiensENSP0000033532199.846699.8466phocoena_sinusENSPSNP00000028219100100
ENSG00000115524homo_sapiensENSP00000335321100100camelus_dromedariusENSCDRP00005017534100100
ENSG00000115524homo_sapiensENSP0000033532199.463299.2331carlito_syrichtaENSTSYP0000003453499.310999.0812
ENSG00000115524homo_sapiensENSP00000335321100100panthera_tigris_altaicaENSPTIP00000025961100100
ENSG00000115524homo_sapiensENSP00000335321100100rattus_norvegicusENSRNOP00000019126100100
ENSG00000115524homo_sapiensENSP0000033532199.616699.3098prolemur_simusENSPSMP0000003644799.009198.7043
ENSG00000115524homo_sapiensENSP0000033532195.322194.9387microtus_ochrogasterENSMOCP0000000058898.494598.0983
ENSG00000115524homo_sapiensENSP0000033532173.77373.773sorex_araneusENSSARP0000000638673.829673.8296
ENSG00000115524homo_sapiensENSP0000033532196.549196.1656peromyscus_maniculatus_bairdiiENSPEMP0000000936898.667798.2759
ENSG00000115524homo_sapiensENSP0000033532110099.9233bos_mutusENSBMUP0000001303010099.9233
ENSG00000115524homo_sapiensENSP0000033532199.846699.8466mus_spicilegusENSMSIP0000002189295.946995.9469
ENSG00000115524homo_sapiensENSP0000033532199.309899.2331cricetulus_griseus_chok1gshdENSCGRP0000101678299.233799.1571
ENSG00000115524homo_sapiensENSP00000335321100100pteropus_vampyrusENSPVAP00000007842100100
ENSG00000115524homo_sapiensENSP0000033532199.003198.773myotis_lucifugusENSMLUP0000000078299.003198.773
ENSG00000115524homo_sapiensENSP0000033532199.539999.2331vombatus_ursinusENSVURP0001002218999.616399.3093
ENSG00000115524homo_sapiensENSP0000033532110099.9233rhinolophus_ferrumequinumENSRFEP0001003358910099.9233
ENSG00000115524homo_sapiensENSP00000335321100100neovison_visonENSNVIP00000013516100100
ENSG00000115524homo_sapiensENSP0000033532110099.9233bos_taurusENSBTAP0000001173410099.9233
ENSG00000115524homo_sapiensENSP0000033532199.769999.7699heterocephalus_glaber_femaleENSHGLP0000001155392.79692.796
ENSG00000115524homo_sapiensENSP000003353214.984664.7546heterocephalus_glaber_femaleENSHGLP0000003353687.837883.7838
ENSG00000115524homo_sapiensENSP0000033532196.549196.0123rhinopithecus_bietiENSRBIP0000000635898.822698.2732
ENSG00000115524homo_sapiensENSP00000335321100100canis_lupus_dingoENSCAFP00020005812100100
ENSG00000115524homo_sapiensENSP00000335321100100sciurus_vulgarisENSSVLP00005003515100100
ENSG00000115524homo_sapiensENSP0000033532199.539999.2331phascolarctos_cinereusENSPCIP0000001351899.616399.3093
ENSG00000115524homo_sapiensENSP0000033532199.846699.8466procavia_capensisENSPCAP00000008738100100
ENSG00000115524homo_sapiensENSP0000033532199.386599.2331nannospalax_galiliENSNGAP0000002329799.769199.6151
ENSG00000115524homo_sapiensENSP0000033532110099.9233bos_grunniensENSBGRP0000000104510099.9233
ENSG00000115524homo_sapiensENSP0000033532199.233199.2331chinchilla_lanigeraENSCLAP0000002158199.233199.2331
ENSG00000115524homo_sapiensENSP0000033532110099.9233cervus_hanglu_yarkandensisENSCHYP0000002071910099.9233
ENSG00000115524homo_sapiensENSP00000335321100100catagonus_wagneriENSCWAP00000009773100100
ENSG00000115524homo_sapiensENSP00000335321100100ictidomys_tridecemlineatusENSSTOP00000031931100100
ENSG00000115524homo_sapiensENSP0000033532141.717840.2607otolemur_garnettiiENSOGAP0000000023686.762483.7321
ENSG00000115524homo_sapiensENSP00000335321100100cebus_imitatorENSCCAP00000005818100100
ENSG00000115524homo_sapiensENSP00000335321100100urocitellus_parryiiENSUPAP00010019597100100
ENSG00000115524homo_sapiensENSP0000033532199.923399.7699moschus_moschiferusENSMMSP0000001447999.923399.7699
ENSG00000115524homo_sapiensENSP00000335321100100rhinopithecus_roxellanaENSRROP00000014220100100
ENSG00000115524homo_sapiensENSP0000033532110099.9233propithecus_coquereliENSPCOP0000002383910099.9233
ENSG00000115524homo_sapiensENSP0000033532178.297566.7945caenorhabditis_elegansT08A11.2.177.231565.885
ENSG00000115524homo_sapiensENSP0000033532186.503179.1411drosophila_melanogasterFBpp030461784.179177.0149
ENSG00000115524homo_sapiensENSP0000033532158.512353.681ciona_intestinalisENSCINP0000000522384.966677.951
ENSG00000115524homo_sapiensENSP0000033532135.04632.8988ciona_intestinalisENSCINP0000000521594.813389.0042
ENSG00000115524homo_sapiensENSP0000033532195.09290.7975petromyzon_marinusENSPMAP0000000145994.368390.1065
ENSG00000115524homo_sapiensENSP0000033532192.254687.7301eptatretus_burgeriENSEBUP0000000654694.205289.585
ENSG00000115524homo_sapiensENSP0000033532196.779194.3252callorhinchus_miliiENSCMIP0000002953994.958692.5508
ENSG00000115524homo_sapiensENSP0000033532195.245492.3313latimeria_chalumnaeENSLACP0000001683994.954192.0489
ENSG00000115524homo_sapiensENSP0000033532197.929595.6288lepisosteus_oculatusENSLOCP0000000466396.962894.6849
ENSG00000115524homo_sapiensENSP0000033532196.472493.5583clupea_harengusENSCHAP0000004306396.030593.1298
ENSG00000115524homo_sapiensENSP0000033532197.162694.4018danio_rerioENSDARP0000007302996.349893.6122
ENSG00000115524homo_sapiensENSP0000033532197.085994.5552carassius_auratusENSCARP0000010258596.567594.0503
ENSG00000115524homo_sapiensENSP0000033532195.628893.1748carassius_auratusENSCARP0000006131996.591894.1131
ENSG00000115524homo_sapiensENSP0000033532197.085994.4785carassius_auratusENSCARP0000005486895.619393.0514
ENSG00000115524homo_sapiensENSP0000033532197.315994.862astyanax_mexicanusENSAMXP0000000226696.501994.0684
ENSG00000115524homo_sapiensENSP0000033532197.315994.7086ictalurus_punctatusENSIPUP0000001950396.575393.9878
ENSG00000115524homo_sapiensENSP0000033532197.162694.4018esox_luciusENSELUP0000002914793.921491.2528
ENSG00000115524homo_sapiensENSP0000033532196.702594.2485electrophorus_electricusENSEEEP0000004061096.039693.6024
ENSG00000115524homo_sapiensENSP0000033532197.162694.3252oncorhynchus_kisutchENSOKIP0000504889495.550592.7602
ENSG00000115524homo_sapiensENSP0000033532197.162694.2485oncorhynchus_kisutchENSOKIP0000500086795.550592.6848
ENSG00000115524homo_sapiensENSP0000033532197.162694.3252oncorhynchus_mykissENSOMYP0000004241395.406692.6205
ENSG00000115524homo_sapiensENSP0000033532196.31993.4816oncorhynchus_mykissENSOMYP0000003892794.223691.4479
ENSG00000115524homo_sapiensENSP0000033532197.085994.2485salmo_salarENSSSAP0000012020595.04592.2673
ENSG00000115524homo_sapiensENSP0000033532197.162694.2485salmo_salarENSSSAP0000005576495.550592.6848
ENSG00000115524homo_sapiensENSP0000033532197.085994.1718salmo_truttaENSSTUP0000002822795.331392.4699
ENSG00000115524homo_sapiensENSP0000033532197.162694.2485salmo_truttaENSSTUP0000002703695.550592.6848
ENSG00000115524homo_sapiensENSP0000033532197.239394.1718gadus_morhuaENSGMOP0000000721696.279493.2422
ENSG00000115524homo_sapiensENSP0000033532196.779193.9417fundulus_heteroclitusENSFHEP0000001282995.969693.1559
ENSG00000115524homo_sapiensENSP0000033532197.162694.4018poecilia_reticulataENSPREP0000002909096.349893.6122
ENSG00000115524homo_sapiensENSP0000033532197.085994.3252xiphophorus_maculatusENSXMAP0000000741296.273893.5361
ENSG00000115524homo_sapiensENSP0000033532197.009294.2485oryzias_latipesENSORLP0000002507696.270993.5312
ENSG00000115524homo_sapiensENSP0000033532197.085994.4785cyclopterus_lumpusENSCLMP0000503750196.054693.475
ENSG00000115524homo_sapiensENSP0000033532196.165693.5583oreochromis_niloticusENSONIP0000001730795.652293.0587
ENSG00000115524homo_sapiensENSP0000033532196.08993.4816haplochromis_burtoniENSHBUP0000002558295.648993.0534
ENSG00000115524homo_sapiensENSP0000033532196.165693.5583astatotilapia_callipteraENSACLP0000003480594.427791.8675
ENSG00000115524homo_sapiensENSP0000033532197.085994.4018sparus_aurataENSSAUP0001006176896.34793.6834
ENSG00000115524homo_sapiensENSP0000033532197.392694.4785lates_calcariferENSLCAP0001005987296.577993.6882
ENSG00000115524homo_sapiensENSP0000033532110.65959.43252lates_calcariferENSLCAP0001004947576.373667.5824
ENSG00000115524homo_sapiensENSP0000033532195.015391.7945lates_calcariferENSLCAP0001004684894.006190.8194
ENSG00000115524homo_sapiensENSP0000033532198.77397.3159xenopus_tropicalisENSXETP0000007003198.848897.3906
ENSG00000115524homo_sapiensENSP0000033532199.463299.2331chrysemys_picta_belliiENSCPBP0000003120299.692599.462
ENSG00000115524homo_sapiensENSP0000033532199.156498.8497sphenodon_punctatusENSSPUP0000000043799.385199.0776
ENSG00000115524homo_sapiensENSP0000033532199.616699.4632crocodylus_porosusENSCPRP0000501313699.846399.6925
ENSG00000115524homo_sapiensENSP0000033532175.613575.3834laticauda_laticaudataENSLLTP0000000340299.898799.5947
ENSG00000115524homo_sapiensENSP0000033532110.506110.3528laticauda_laticaudataENSLLTP0000000125695.804294.4056
ENSG00000115524homo_sapiensENSP0000033532199.539999.2331notechis_scutatusENSNSUP0000001896099.692899.3856
ENSG00000115524homo_sapiensENSP0000033532199.539999.3098pseudonaja_textilisENSPTXP0000000606299.692899.4624
ENSG00000115524homo_sapiensENSP0000033532190.260790.1841anas_platyrhynchos_platyrhynchosENSAPLP0000000351799.915199.8302
ENSG00000115524homo_sapiensENSP0000033532199.463299.3865gallus_gallusENSGALP0001001447799.692599.6157
ENSG00000115524homo_sapiensENSP0000033532198.77398.6196meleagris_gallopavoENSMGAP0000000714297.207697.0566
ENSG00000115524homo_sapiensENSP0000033532190.260790.1841serinus_canariaENSSCAP0000000341999.915199.8302
ENSG00000115524homo_sapiensENSP0000033532199.463299.3865parus_majorENSPMJP0000000455691.660891.5901
ENSG00000115524homo_sapiensENSP0000033532199.156498.6196anolis_carolinensisENSACAP0000000947799.308898.7711
ENSG00000115524homo_sapiensENSP0000033532192.331389.7239neolamprologus_brichardiENSNBRP0000002061293.989191.3349
ENSG00000115524homo_sapiensENSP0000033532199.539999.3098naja_najaENSNNAP0000001058499.692899.4624
ENSG00000115524homo_sapiensENSP0000033532199.463299.1564podarcis_muralisENSPMRP0000000778190.953790.6732
ENSG00000115524homo_sapiensENSP0000033532190.260790.1841geospiza_fortisENSGFOP0000000050199.915199.8302
ENSG00000115524homo_sapiensENSP0000033532199.463299.3098taeniopygia_guttataENSTGUP0000002002299.692599.5388
ENSG00000115524homo_sapiensENSP0000033532196.242393.7883erpetoichthys_calabaricusENSECRP0000002783796.761894.2945
ENSG00000115524homo_sapiensENSP0000033532197.162694.0951kryptolebias_marmoratusENSKMAP0000000532396.130593.0956
ENSG00000115524homo_sapiensENSP0000033532199.463299.2331salvator_merianaeENSSMRP0000002624699.61699.3856
ENSG00000115524homo_sapiensENSP0000033532196.31993.7117amphilophus_citrinellusENSACIP0000002702592.899490.3846
ENSG00000115524homo_sapiensENSP0000033532110.12279.43252dicentrarchus_labraxENSDLAP0000506273685.714379.8701
ENSG00000115524homo_sapiensENSP0000033532197.239394.4785amphiprion_perculaENSAPEP0000001816296.425993.6882
ENSG00000115524homo_sapiensENSP0000033532197.54697.1626pelodiscus_sinensisENSPSIP0000001947998.375997.9892
ENSG00000115524homo_sapiensENSP0000033532199.463299.2331gopherus_evgoodeiENSGEVP0000502172399.692599.462
ENSG00000115524homo_sapiensENSP0000033532199.463299.2331chelonoidis_abingdoniiENSCABP0000000931299.692599.462
ENSG00000115524homo_sapiensENSP0000033532197.162694.1718seriola_dumeriliENSSDUP0000002399396.423193.4551
ENSG00000115524homo_sapiensENSP0000033532197.085994.4018cottoperca_gobioENSCGOP0000000734296.127693.47
ENSG00000115524homo_sapiensENSP0000033532190.260790.1074struthio_camelus_australisENSSCUP0000000149899.915199.7453
ENSG00000115524homo_sapiensENSP0000033532198.849798.3129anser_brachyrhynchusENSABRP0000001059098.849798.3129
ENSG00000115524homo_sapiensENSP0000033532196.779194.0951gasterosteus_aculeatusENSGACP0000001167696.18993.5213
ENSG00000115524homo_sapiensENSP0000033532193.86590.5675cynoglossus_semilaevisENSCSEP0000000598794.810291.4795
ENSG00000115524homo_sapiensENSP0000033532197.162694.3252poecilia_formosaENSPFOP0000000008096.276693.465
ENSG00000115524homo_sapiensENSP0000033532197.392694.7086myripristis_murdjanENSMMDP0000502985296.504693.845
ENSG00000115524homo_sapiensENSP0000033532197.239394.1718sander_luciopercaENSSLUP0000003930995.770492.7492
ENSG00000115524homo_sapiensENSP0000033532199.463299.3865strigops_habroptilaENSSHBP0000502308599.692599.6157
ENSG00000115524homo_sapiensENSP0000033532197.239394.4785amphiprion_ocellarisENSAOCP0000002038596.425993.6882
ENSG00000115524homo_sapiensENSP0000033532199.463299.2331terrapene_carolina_triunguisENSTMTP0000001226099.692599.462
ENSG00000115524homo_sapiensENSP0000033532197.162694.3252hucho_huchoENSHHUP0000004199595.550592.7602
ENSG00000115524homo_sapiensENSP0000033532196.472493.635hucho_huchoENSHHUP0000008940893.462190.7132
ENSG00000115524homo_sapiensENSP0000033532196.932594.3252betta_splendensENSBSLP0000005202095.180792.6205
ENSG00000115524homo_sapiensENSP0000033532197.315994.862pygocentrus_nattereriENSPNAP0000000163096.501994.0684
ENSG00000115524homo_sapiensENSP0000033532197.162694.4785anabas_testudineusENSATEP0000002969296.423193.7595
ENSG00000115524homo_sapiensENSP0000033532187.730180.5215ciona_savignyiENSCSAVP0000000432185.692978.6517
ENSG00000115524homo_sapiensENSP0000033532150.460137.5saccharomyces_cerevisiaeYMR288W67.765250.3605
ENSG00000115524homo_sapiensENSP0000033532197.085994.0951seriola_lalandi_dorsalisENSSLDP0000002507396.34793.379
ENSG00000115524homo_sapiensENSP0000033532196.779193.865labrus_bergyltaENSLBEP0000002936396.483293.578
ENSG00000115524homo_sapiensENSP0000033532196.165693.4816pundamilia_nyerereiENSPNYP0000001980495.652292.9825
ENSG00000115524homo_sapiensENSP0000033532196.702593.7117mastacembelus_armatusENSMAMP0000001517094.104591.194
ENSG00000115524homo_sapiensENSP0000033532197.315994.5552stegastes_partitusENSSPAP0000001387195.341992.6371
ENSG00000115524homo_sapiensENSP0000033532197.162694.2485oncorhynchus_tshawytschaENSOTSP0000503709995.550592.6848
ENSG00000115524homo_sapiensENSP0000033532193.558390.4908oncorhynchus_tshawytschaENSOTSP0000510333694.720591.6149
ENSG00000115524homo_sapiensENSP0000033532196.932594.4018acanthochromis_polyacanthusENSAPOP0000000959594.469492.003
ENSG00000115524homo_sapiensENSP0000033532199.463299.3865aquila_chrysaetos_chrysaetosENSACCP0002000322099.692599.6157
ENSG00000115524homo_sapiensENSP0000033532196.702593.4816nothobranchius_furzeriENSNFUP0001501051096.259593.0534
ENSG00000115524homo_sapiensENSP0000033532193.481690.9509cyprinodon_variegatusENSCVAP0000000254796.135693.5331
ENSG00000115524homo_sapiensENSP0000033532197.162694.5552denticeps_clupeoidesENSDCDP0000001422294.130891.6048
ENSG00000115524homo_sapiensENSP0000033532197.162694.5552larimichthys_croceaENSLCRP0000504321596.423193.8356
ENSG00000115524homo_sapiensENSP0000033532197.009293.9417takifugu_rubripesENSTRUP0000003972196.270993.2268
ENSG00000115524homo_sapiensENSP0000033532199.463299.4632ficedula_albicollisENSFALP0000000445699.692599.6925
ENSG00000115524homo_sapiensENSP0000033532197.085994.2485hippocampus_comesENSHCOP0000002610795.76492.9652
ENSG00000115524homo_sapiensENSP0000033532197.085994.5552cyprinus_carpio_carpioENSCCRP0000001121296.567594.0503
ENSG00000115524homo_sapiensENSP0000033532196.702594.0951cyprinus_carpio_carpioENSCCRP0000001127293.131590.6204
ENSG00000115524homo_sapiensENSP0000033532198.542998.3896coturnix_japonicaENSCJPP0000500458299.227899.0734
ENSG00000115524homo_sapiensENSP0000033532197.162694.3252poecilia_latipinnaENSPLAP0000000122196.349893.5361
ENSG00000115524homo_sapiensENSP0000033532197.085994.3252sinocyclocheilus_grahamiENSSGRP0000010520496.71593.9649
ENSG00000115524homo_sapiensENSP0000033532197.239394.5552sinocyclocheilus_grahamiENSSGRP0000010598296.720194.0503
ENSG00000115524homo_sapiensENSP0000033532196.165693.5583maylandia_zebraENSMZEP0000502850695.652293.0587
ENSG00000115524homo_sapiensENSP0000033532132.975532.9755tetraodon_nigroviridisENSTNIP00000022988100100
ENSG00000115524homo_sapiensENSP0000033532197.622795.4755paramormyrops_kingsleyaeENSPKIP0000001333596.953594.821
ENSG00000115524homo_sapiensENSP0000033532197.622795.6288scleropages_formosusENSSFOP0001503378696.806194.8289
ENSG00000115524homo_sapiensENSP0000033532198.236296.6258leptobrachium_leishanenseENSLLEP0000004123497.340495.7447
ENSG00000115524homo_sapiensENSP0000033532196.702593.7883scophthalmus_maximusENSSMAP0000002293294.669791.8168
ENSG00000115524homo_sapiensENSP0000033532197.162694.3252oryzias_melastigmaENSOMEP0000001753496.349893.5361

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000245involved_in spliceosomal complex assembly1IBAHomo_sapiens(9606)Process
GO:0000375involved_in RNA splicing, via transesterification reactions1NASHomo_sapiens(9606)Process
GO:0000398involved_in mRNA splicing, via spliceosome4IC,IDA,NASHomo_sapiens(9606)Process
GO:0003723enables RNA binding2HDA,IDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005681part_of spliceosomal complex1NASHomo_sapiens(9606)Component
GO:0005684part_of U2-type spliceosomal complex1IPIHomo_sapiens(9606)Component
GO:0005686part_of U2 snRNP3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0005689part_of U12-type spliceosomal complex2IBA,IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1NASHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling1NASHomo_sapiens(9606)Process
GO:0008380involved_in RNA splicing1ICHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0034693part_of U11/U12 snRNP1IDAHomo_sapiens(9606)Component
GO:0035066involved_in positive regulation of histone acetylation1NASHomo_sapiens(9606)Process
GO:0045943involved_in positive regulation of transcription by RNA polymerase I1NASHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1NASHomo_sapiens(9606)Process
GO:0045945involved_in positive regulation of transcription by RNA polymerase III1IDAHomo_sapiens(9606)Process
GO:0071004part_of U2-type prespliceosome1IBAHomo_sapiens(9606)Component
GO:0071005part_of U2-type precatalytic spliceosome1IDAHomo_sapiens(9606)Component
GO:0071013part_of catalytic step 2 spliceosome2IBA,IDAHomo_sapiens(9606)Component
GO:0110016part_of B-WICH complex1IDAHomo_sapiens(9606)Component
GO:1903241involved_in U2-type prespliceosome assembly1NASHomo_sapiens(9606)Process
GO:1990935enables splicing factor binding1IDAHomo_sapiens(9606)Function

Expression